西非人先前使用镇静剂与卒中发生独立相关：来自SIREN病例对照研究的证据

Q3 Neuroscience

eNeurologicalSci Pub Date : 2025-06-11 DOI:10.1016/j.ensci.2025.100573

Ezinne O. Uvere , Joshua Akinyemi , Fred S. Sarfo , Adekunle Fakunle , Akinkunmi Paul Okekunle , Onoja Akpa , Albert Akpalu , Kolawole Wahab , Reginald Obiako , Morenikeji Komolafe , Lukman Owolabi , Godwin O. Osaigbovo , Godwin Ogbole , Hemant K. Tiwari , Carolyn Jenkins , Samuel Olowookere , Oyedunni Arulogun , Josephine Akpalu , Osahon J. Asowata , Philip Ibinaiye , Mayowa Owolabi

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引用次数: 0

摘要

有几个因素与全球范围内的脑卒中发生独立相关。然而，镇静剂使用与中风风险之间的关系在西非尚未确定。目的评估西非人服用镇静剂与脑卒中的关系。方法年龄≥18岁确诊脑卒中的成年人以及年龄和性别匹配的对照组纳入脑卒中调查研究和教育网络（SIREN）研究。通过对前一年使用任何类型镇静剂的回顾性评估来确定镇静剂的使用，同时通过脑部扫描和临床特征确认中风。采用logistic回归进行单变量和多变量分析，以确定镇静剂使用与卒中之间的关联，同时调整其他卒中危险因素。结果共纳入7104例受试者，其中脑卒中病例3553例，无脑卒中对照3551例。患者平均年龄为60.9±0.78岁，对照组平均年龄为59.8±11.44岁(p <；0.029)。有镇静剂使用史的病例（7.7%）比对照组(4.3%；p & lt;0.001)。在调整了年龄、收入100美元、高血压史、糖尿病史、血脂异常史、吸烟史等因素后；饮酒、缺乏身体活动、食用绿叶蔬菜和肉类、使用镇静剂与卒中风险独立相关(aOR: 1.41；95% ci: 1.01-1.96；p & lt;0.041)。在≥50岁的成年人中，使用镇静剂与卒中的高发生率相关(aOR: 1.53；95% ci: 1.28-2.04；p & lt;0.019)。结论西非成年人使用镇静剂与卒中风险独立相关。它的使用需要进一步的探索和前瞻性研究，以解决与中风发生的新联系。

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Antecedent sedative use is independently associated with stroke occurrence among west Africans: Evidence from the SIREN case-control study

Background

Several factors have been independently associated with stroke occurrence globally. However, the association between sedative use and stroke risk is yet to be established in West Africa.

Objective

To assess the association between sedatives and stroke among West Africans.

Methods

Adults aged ≥18 years with confirmed stroke as well as age- and sex-matched controls were enrolled into the Stroke Investigative Research and Education Network (SIREN) study. Sedative use was determined by retrospective assessment on the use of any type of sedative in the preceding year while stroke was confirmed with brain scan and clinical features. Univariate and multivariate analyses, using logistic regressions, were performed to establish associations between sedative use and stroke while adjusting for other stroke risk factors.

Results

A total of 7104 subjects (3553 stroke cases and 3551 stroke-free controls participated in this study. The mean age was 60.9 ± 0.78 among cases and 59.8 ± 11.44 years among controls (p < 0.029). History of sedative use was more common in cases (7.7 %) compared to controls (4.3 %; p < 0.001). After adjusting for age, income >$100, history of hypertension, diabetes, dyslipidaemia, tobacco & alcohol use, physical inactivity, green leafy vegetable and meat consumption, sedative use was independently associated with stroke risk (aOR: 1.41; 95 %CI: 1.01–1.96; p < 0.041). Sedative use was associated with higher odds of stroke among adults aged ≥50 years (aOR: 1.53; 95 %CI: 1.28–2.04; p < 0.019).

Conclusion

Sedative use was independently associated with stroke risk among adults in West Africa. Its use requires further exploration and prospective study to address the emerging association with stroke occurrence.

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来源期刊

eNeurologicalSci Neuroscience-Neurology

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

62 days

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