OpenNano最新文献

{"title":"Transformative approaches for siRNA detection","authors":"Sima Singh ,&nbsp;Ada Raucci ,&nbsp;Wanda Cimmino ,&nbsp;Antonella Miglione ,&nbsp;Panagiota M Kalligosfyri ,&nbsp;Stefano Cinti","doi":"10.1016/j.onano.2024.100214","DOIUrl":"10.1016/j.onano.2024.100214","url":null,"abstract":"<div><p>Small interfering RNA (siRNA) is essential for the process of gene silencing, especially for cancer. Despite its considerable promise, siRNA faces challenges due to stability issues of formulation and undesirable off-target side effects. In order to address these difficulties, it is essential to carefully monitor the levels of siRNA. The existing point-of-care (POC) systems cannot precisely and efficiently detect or monitor siRNA levels. In light of these challenges, this review gives the prospects of siRNA detection by proposing a novel hypothesis of existing electrical and optical-based detection of DNA/RNA with the POC platform. This hypothesis offers an interesting novel perspective to potentially fill the existing gaps, in detecting siRNA. By utilising these technologies, there is high potential to develop a proof-of-concept system that will not only overcome the existing challenges, but it will also allow effective and precise monitoring of siRNA, in real-world healthcare environments. In summary, the prospects for siRNA in the realm of POC platforms are quite encouraging, since it allows precise and effective monitoring.</p></div>","PeriodicalId":37785,"journal":{"name":"OpenNano","volume":"20 ","pages":"Article 100214"},"PeriodicalIF":0.0,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S235295202400015X/pdfft?md5=7f981fcf2ad57330a54f3dc8e587b780&pid=1-s2.0-S235295202400015X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142136135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of biosynthesized silver nanoparticle size on antibacterial and anti-biofilm activity against pathogenic multi-drug resistant bacteria","authors":"Anas Yahya Ali ,&nbsp;Abd-Alrahman Khalid Alani ,&nbsp;Barakat O. Ahmed ,&nbsp;Layth L. Hamid","doi":"10.1016/j.onano.2024.100213","DOIUrl":"10.1016/j.onano.2024.100213","url":null,"abstract":"<div><p>Ag NPs have garnered significant attention in the field of biomedical applications due to their antibacterial, antifungal, antiviral, anti-inflammatory, and antiangiogenic effects. The present study aimed to establish a simple, reliable, cost-effective, and environmentally friendly approach for the synthesis of Ag NPs in different sizes using extracts from <em>Syzygium aromaticum</em> and <em>Laurus nobilis</em> and study the relationship between the size of Ag NPs and their antibacterial and anti-biofilm effectiveness. The synthesized Ag NPs were extensively characterized using various techniques, such as XRD, SEM, UV–vis and FTIR. Importantly, the study evaluated the antibacterial and anti-biofilm activities of Ag NPs in two different size (12 nm and 45 nm) against MDR and biofilm-producing pathogenic bacteria, including <em>Kocuria rosea, Staphylococcus sciuri</em>, and <em>Staphylococcus lentus</em>. The antibacterial activity of the larger Ag NPs-SA (45 nm) ranging between 14–25 mm while for the smaller Ag NPs-LN (12 nm) ranging between 26–48 mm against pathogenic bacteria. The MIC values for Ag NPs-LN were between 16 - 32 µg/ml while for Ag NPs-SA were 64 µg/ml. The MIC value of the Ag NPs decreased as their size decreased, indicating higher potency against the tested bacterial strains. Furthermore, the smaller Ag NPs-LN exhibited a higher rate of biofilm inhibition that reach 88% compared to the larger Ag NPs that reach 70%. This study provides novel evidence that the enhanced antibacterial and anti-biofilm activities of Ag NPs are directly correlated with their decreased nanoscale size. These findings highlight the potential of Ag NPs as a promising adjuvant in the management of bacterial infections, particularly those involving MDR and biofilm-producing pathogens, which pose a significant challenge in clinical settings.</p></div>","PeriodicalId":37785,"journal":{"name":"OpenNano","volume":"20 ","pages":"Article 100213"},"PeriodicalIF":0.0,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352952024000148/pdfft?md5=21eddb2fd7a1aacb043580cc2e4a6bc8&pid=1-s2.0-S2352952024000148-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142048669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Date palm pollen: A novel medium for bacterial culture and biosynthesis of antibacterial chromium oxide nanoparticles","authors":"Layth L. Hamid ,&nbsp;Thamer Y. Mutter ,&nbsp;Asmiet Ramizy","doi":"10.1016/j.onano.2024.100212","DOIUrl":"10.1016/j.onano.2024.100212","url":null,"abstract":"<div><p>Medical companies and research centers seek cost-effective alternative culture media containing the necessary nutritional requirements for bacterial cultivation because of high manufacturing and production costs. Date palm pollen (DPP) is an inexpensive and rich natural plant resource that can be easily collected in large quantities. In this study, DPP was used to prepare a novel enriched culture medium that successfully cultivated pathogenic bacteria and <em>Streptomyces</em> spp. without any additives and at a low concentration of 10 g per 1 L of distilled water (DW). Active compounds in DPP were detected by GCMS–, and results show the highest ratio of urea (45 %) among other components. For the first time, DPP was used to synthesize Cr₂O₃ NPs by an environment-friendly and inexpensive green method. DPP urea plays an important role as a reducing and stabilizing agent in the biosynthesis of Cr₂O₃ NPs. The obtained NPs were characterized using UV–Vis, FTIR, XRD and SEM. The results of agar disk diffusion ranging between 12 – 20 mm while the MIC for Cr₂O₃ NPs ranging between 1.56 – 25 U/mL indicated the effectiveness of Cr₂O₃ NPs in antibacterial activity against a wide range of pathogenic bacteria. Cr₂O₃ NPs showed a high inhibition ratio that reach 78 % against biofilms produced by <em>P. aeruginosa</em>. For later studies we expect that DPP can be used to prepare selective and other culture media after adding certain materials or antibiotics. The antibacterial and anti-biofilm activity of Cr₂O₃ NPs could be promising in medical and pharmaceutical applications.</p></div>","PeriodicalId":37785,"journal":{"name":"OpenNano","volume":"19 ","pages":"Article 100212"},"PeriodicalIF":0.0,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352952024000136/pdfft?md5=0a4ce99b15e3612bbff12468c20f6103&pid=1-s2.0-S2352952024000136-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142002177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resveratrol-loaded lipid-based nanocarriers for topical delivery: Comparative physical properties and antioxidant activity","authors":"Wipada Samprasit ,&nbsp;Phuvamin Suriyaamporn ,&nbsp;Pornsak Sriamornsak ,&nbsp;Praneet Opanasopit ,&nbsp;Benchawan Chamsai","doi":"10.1016/j.onano.2024.100211","DOIUrl":"https://doi.org/10.1016/j.onano.2024.100211","url":null,"abstract":"<div><p>Resveratrol (R) is an antioxidant that helps several aspects of aging skin. However, it is slightly soluble in water and unstable under light exposure, necessitating the use of suitable formulations for improved clinical efficacy. Therefore, this study aimed to prepare R-loaded lipid-based nanocarriers for topical delivery, <em>i.e.</em>, nanostructured lipid carriers (NLCs) and nanoemulsions (NEs). R-loaded nanocarrier gels were further prepared to increase R loading. The comparative physical properties and antioxidant activity of nanocarriers were performed in terms of particle size, zeta potential, morphology, rheology, R content, <em>in vitro</em> release, antioxidant activity, cytotoxicity and stability. The results revealed that R was successfully loaded into NLCs and NE gels (NEGs), having different physical properties and antioxidant activity depending on the composition of lipid-based nanocarriers. R could be incorporated into NEs and the aqueous gelling phase, resulting in higher R loading. Furthermore, the gelling network was responsible for pseudoplastic flow behavior. The cumulative amount of R released from NEGs was significantly higher than that from NLCs due to the co-surfactant-like properties of NEGs, which resulted in smaller particle sizes. However, NLCs exhibited significantly more antioxidant activity and less cytotoxicity compared to NEGs. The stability of both nanosystems showed no significant change when stored at refrigerator temperature for over 3 months. In conclusion, the various compositions of lipid-based nanocarriers produced a range of physical properties and antioxidant activity. Nonetheless, these NLCs and NEGs have the potential to be nanocarriers for R, which has antioxidant properties for topical application.</p></div>","PeriodicalId":37785,"journal":{"name":"OpenNano","volume":"19 ","pages":"Article 100211"},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352952024000124/pdfft?md5=6ea5858529272364e129f259c6db7fc3&pid=1-s2.0-S2352952024000124-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141582757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colchicine-capped ZnO nanoparticles: Elucidation of their cytotoxicity potential against MDA-MB 231 cancer cells","authors":"Zenli Cheng ,&nbsp;Zi Yin Wong ,&nbsp;S. Ramkanth ,&nbsp;Cheng Wan Hee ,&nbsp;Mohamed Saleem TS ,&nbsp;Saminathan Kayarohanam ,&nbsp;M Yasmin Begum ,&nbsp;Kushagra Khanna ,&nbsp;Abhishek Kumar ,&nbsp;Ashok Kumar Janakiraman","doi":"10.1016/j.onano.2024.100210","DOIUrl":"10.1016/j.onano.2024.100210","url":null,"abstract":"<div><p>This research descibes a pioneering approach aimed at preparing zinc oxide nanoparticles (ZnO-NPs) with colchicine as the reducing and capping agent. Colchicine-loaded ZnO-NPs (CHZnO-NPs) were prepared by adding colchicine to the zinc sulfate heptahydrate solution. The CHZnO-NPs formulation was then characterized to determine the morphology, size, crystallinity, elemental composition and vibrational properties. Upon characterization, CHZnO-NPs were studied for their cytotoxic effect against the breast cancer cell line (MDA-MB-231). The successful biosynthesis of CHZnO-NPs was initially confirmed visually by the changes in the mixture color, from light-yellow to white cloudy. The best CHZnO-NPs formulation selected was F3, which possessed 10 mg/mL of colchicine. Formulation (F3) had the smallest mean particle diameter of 43.77 nm and the lowest zeta potential of −19.60 mV. It also had 92.21 ± 0.012 % encapsulation efficiency and 20.86 ± 0.005 % drug loading. Formulation (F3) displayed a hexagonal wurtzite structure with irregular morphology. The observation of colchicine peaks on the FTIR spectra of F3 proved the role of colchicine as a reducing and capping agent during the synthesis of ZnO-NPs. Besides, the <em>in-vitro</em> cell cytotoxicity study on the MDA-MB-231 cell line revealed a significant reduction in cell proliferation at the concentration of 25 μg of colchicine and F3. Further, studies on the cellular migration potential also demonstrated concentration-dependent activity. Overall, CHZnO-NPs were shown to be successfully synthesized via an environmental-friendly procedure and colchicine acted as a capping agent to regulate the particle size, and aggregation, in addition to its anticancer properties.</p></div>","PeriodicalId":37785,"journal":{"name":"OpenNano","volume":"18 ","pages":"Article 100210"},"PeriodicalIF":0.0,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352952024000112/pdfft?md5=cbf873dad602013c256184e72ed60d02&pid=1-s2.0-S2352952024000112-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141279759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nucleic acid nano-carriers for delivery of antisense and RNAi therapeutics","authors":"Himanshu Sekhar Panda,&nbsp;Samraggi Choudhury,&nbsp;Jiban Jyoti Panda","doi":"10.1016/j.onano.2024.100208","DOIUrl":"10.1016/j.onano.2024.100208","url":null,"abstract":"<div><p>Nucleic acid nanotechnology presents an exciting approach for manufacturing tailored nanoscale biomaterials with precise structures, spatial precision, and exceptional biocompatibility. These nucleic acid-based nanomaterials, here referred as nano-carriers can have versatile applications in bio-imaging, diagnostics, and therapy. In this review, we have surveyed the progress made in the field of multifunctional nucleic acid nano-carriers, particularly in the context of delivering antisense and RNA interference (RNAi) therapeutics. RNAi technology has emerged as a potent modality for conducting functional genomic analyses and holds potential as an effective approach for crafting targeted gene-silencing treatments for viral infections, cancer, and other diseases in the future. Our focus is on exploring RNAi as a therapeutic avenue, taking into account challenges such as the expense of RNAi triggers, delivering RNAi efficiently to the target site, and addressing off-target and nontarget effects, while also recognizing promising opportunities within the field of biomedical research.</p></div>","PeriodicalId":37785,"journal":{"name":"OpenNano","volume":"18 ","pages":"Article 100208"},"PeriodicalIF":0.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352952024000094/pdfft?md5=20366c860ec20135f29b21f3fd554740&pid=1-s2.0-S2352952024000094-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141023454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The nano and artificial intelligence effect: Improved magnetic resonance imaging volumetry for multiple sclerosis","authors":"Alrayan F. Nahhas ,&nbsp;Alaa F. Nahhas ,&nbsp;Thomas J. Webster","doi":"10.1016/j.onano.2024.100209","DOIUrl":"10.1016/j.onano.2024.100209","url":null,"abstract":"<div><p>Magnetic Resonance Imaging (MRI) is a widely established method for monitoring and diagnosing neurological diseases, including multiple sclerosis (MS). MS is a disease that continuously progresses and in due course involves the progressive atrophy of neural structures (such as brain gray and white matter) leading to debilitation. Clearly, the earlier that MS can be detected, the better the chances of eventual treatment to slow down disease progression. While conventional MRI volumetry, as a non-invasive imaging technique that measures the exact volume of different brain structures, has improved the diagnosis of brain atrophy, problems still exist. This review introduces and summarizes the seminal role that nanotechnology (in terms of novel materials for improved MS diagnosis and treatment) and artificial intelligence (in terms of enhancing images via computer algorithms and novel contrast agents) are playing in improving volumetric MRI. In doing so, this one-of-a-kind review manuscript establishes how nanotechnology and artificial intelligence is improving, and will continue to improve, volumetric MRI diagnosis and treatment of MS.</p></div>","PeriodicalId":37785,"journal":{"name":"OpenNano","volume":"18 ","pages":"Article 100209"},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352952024000100/pdfft?md5=bf67a72f48a641e38736e831df3f694f&pid=1-s2.0-S2352952024000100-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141039447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing the efficacy of monolaurin against SARS-CoV-2 and influenza A (H1N1) with a nanoemulsion formulation","authors":"Yotsanan Weerapol ,&nbsp;Suwisit Manmuan ,&nbsp;Sontaya Limmatvapirat ,&nbsp;Chutima Limmatvapirat ,&nbsp;Jitnapa Sirirak ,&nbsp;Poomipat Tamdee ,&nbsp;Sukannika Tubtimsri","doi":"10.1016/j.onano.2024.100207","DOIUrl":"https://doi.org/10.1016/j.onano.2024.100207","url":null,"abstract":"<div><p>Monolaurin was utilized to formulate temperature-driven phase inversion nanoemulsions containing lesser galangal essential oil, fixed oil, and Cremophor RH40, with aim for eradicating enveloped viruses. Results showed that the droplet size of the nanoemulsion depended on lesser galangal essential oil–fixed oil ratio, monolaurin concentration, and oil concentration. Nanoemulsions prepared from lesser galangal essential oil–perilla oil (60:40) exhibited approximately 50-nm nanosized droplets and high entrapment efficiency (98.68 % ± 2.45 %). After storage at 25 °C for 1 year, droplet size did not vary significantly from the initial size, and monolaurin content was &gt;95 %, indicating good physical and chemical stability. The monolaurin was located at the oil–water interface as indicated by a two-dimensional nuclear Overhauser effect nuclear magnetic resonance spectroscope and computer simulation. The 0.2% w/v monolaurin nanoemulsion inhibited SARS-CoV-2 and influenza A (H1N1) viruses with efficacy more than 3 log reduction (99.90 %) and low cytotoxicity. Hence, the monolaurin nanoemulsion can successfully eradicate enveloped viruses, especially SARS-CoV-2 and influenza A (H1N1).</p></div>","PeriodicalId":37785,"journal":{"name":"OpenNano","volume":"17 ","pages":"Article 100207"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352952024000082/pdfft?md5=7a75428e4f2dea7e4d1354e4ef72f90e&pid=1-s2.0-S2352952024000082-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140815770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of QCT loaded TPGS coated solid lipid nanoparticles for improved in vivo neuroprotective activity in LPS administered adult zebrafish model: A QbD-based approach","authors":"Galal Mohsen Hussein Al-sayadi ,&nbsp;Gurisha Garg ,&nbsp;Arti Singh ,&nbsp;Preeti Patel ,&nbsp;Ghanshyam Das Gupta ,&nbsp;Balak Das Kurmi","doi":"10.1016/j.onano.2024.100206","DOIUrl":"10.1016/j.onano.2024.100206","url":null,"abstract":"<div><p>This work contains the development of QCT-loaded TPGS-coated SLNs by QbD to enhance neuroinflammation potential. Developed SLNs were in the nanometer range (263±3.62 nm) with desired parameters i.e., PDI (0.244±0.003), zeta potential (28.2 ± 0.74 mV), and%EE (74.3 ± 2.45 %) respectively. The release study showed sustained drug release of the developed formulation T-QCT-SLN (83.2 % release in 48 h). The study found QCT can reduce oxidative stress and neuroinflammation in adult zebrafish. Results showed reduced disruption in neuronal cells, decreased TNF-α and IL-1β levels, and reduced LPO, nitrite, and AChEs levels while increasing GSH levels, indicating its potential for treating oxidative stress and neuroinflammation. It can be concluded that QCT-loaded TPGS-coated SLN effectively prevents oxidative damage and neuroinflammation in adult zebrafish exposed to LPS compared to the QCT alone. The suggested work will be a focal paradigm for neuroinflammatory drug delivery.</p></div>","PeriodicalId":37785,"journal":{"name":"OpenNano","volume":"17 ","pages":"Article 100206"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352952024000070/pdfft?md5=2f96f069582f6cd38085cfa670ced3c3&pid=1-s2.0-S2352952024000070-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140762690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative study on the physicochemical properties and gastrointestinal delivery of calcium niosomes produced by low and high-energy techniques","authors":"Jorge Alejandro Barbosa-Nuñez ,&nbsp;Sara Elisa Herrera-Rodríguez ,&nbsp;Eristeo García-Márquez ,&nbsp;Hugo Espinosa-Andrews","doi":"10.1016/j.onano.2024.100205","DOIUrl":"10.1016/j.onano.2024.100205","url":null,"abstract":"<div><p>Since the bioavailability of calcium from foods and supplements is low, its encapsulation in niosomes is proposed as a potential solution to this issue. This study aimed to compare the physiochemical properties and release profiles of niosomes with calcium chloride and calcium lactate produced by injection and sonication methods. The size distribution (200–300 nm), encapsulation efficiency (20–40 %), stability, release profile, cytotoxicity, and calcium bioavailability of the niosomes were characterized. The production method, rather than the calcium salt used, impacted the properties of the niosomes. Calcium release under gastrointestinal conditions was dependent on both the calcium source and the production method, which was characterized by a Peppas-Sahlin release model. Calcium niosomes were not cytotoxic to intestinal cells. All the calcium niosomes showed high bioavailability in cells (5–20 % greater than the control) but lower bioavailability than the non-encapsulated calcium salts (80–110 % above control) due to their high solubility. Nevertheless, the use of niosomes might be a promising approach for improving calcium bioavailability.</p></div>","PeriodicalId":37785,"journal":{"name":"OpenNano","volume":"17 ","pages":"Article 100205"},"PeriodicalIF":0.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352952024000069/pdfft?md5=e1988301879094919cc6233f1db3218c&pid=1-s2.0-S2352952024000069-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140281513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}