OpenNano最新文献

{"title":"Enhanced oral bioavailability of Irbesartan via nano-bilosomes: A potential breakthrough in hypertension treatment","authors":"Heba A. Ghanem ,&nbsp;Mahmoud M.A. Elsayed ,&nbsp;Shadeed Gad ,&nbsp;Mamdouh Ghorab ,&nbsp;Nashwa H. Abd Elwahab ,&nbsp;Abd El hakim Ramadan ,&nbsp;Maha Alsunbul ,&nbsp;Amira Abdel Motaal ,&nbsp;Ali M. Nasr","doi":"10.1016/j.onano.2025.100255","DOIUrl":"10.1016/j.onano.2025.100255","url":null,"abstract":"<div><div>Irbesartan (IRB), a widely used antihypertensive medication, exhibits limited therapeutic efficacy due to poor solubility and stability characteristics, which compromise patient adherence. This investigation focused on developing and optimizing a nano bilosomal formulation of IRB to enhance oral bioavailability, extend release duration, and improve pharmacological performance. Through D-optimal design methodology, the study examined key formulation variables including bile salt concentration, cholesterol content, bile salt type, edge activator type, and soybean phosphatidylcholine to bile salt ratio (SPC). These parameters were evaluated against key performance indicators: particle size (PS), zeta potential (ZP), and encapsulation efficiency (EE%). Physicochemical characterization included DSC analysis, TEM imaging, and in vitro release studies. The optimized bilosomal formulation demonstrated favorable characteristics with a particle size of 109.99 nm, zeta potential of -30.999 mV, and encapsulation efficiency of 94.54 %. Physicochemical characterization confirmed the absence of IRB-excipient interactions, while DSC analysis revealed IRB amorphization. TEM imaging validated spherical morphology of the formulated structures. The IRB-loaded bilosomes exhibited sustained biphasic release over 24 h, achieving relative bioavailability 1.42-fold and 1.30-fold higher compared to IRB solution and commercial formulation, respectively. The nano bilosomal formulation significantly enhances IRB solubility, stability, and bioavailability, offering a promising approach for improved oral delivery and therapeutic outcomes. Additional research addressing scalability and clinical efficacy is warranted.</div></div>","PeriodicalId":37785,"journal":{"name":"OpenNano","volume":"26 ","pages":"Article 100255"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145050423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green synthesis of antioxidant and low-toxicity gold and silver nanoparticles using floral extracts","authors":"Geovanna Arroyo ,&nbsp;Yolanda Angulo ,&nbsp;Blanca Naranjo ,&nbsp;Fernanda Toscano ,&nbsp;Marbel Torres Arias ,&nbsp;Alexis Debut ,&nbsp;Carlos Reinoso ,&nbsp;Carina Stael ,&nbsp;Joselyn Soria ,&nbsp;Andrés Izquierdo","doi":"10.1016/j.onano.2025.100258","DOIUrl":"10.1016/j.onano.2025.100258","url":null,"abstract":"<div><div>In this study, gold (AuNPs) and silver (AgNPs) nanoparticles were synthesized using floral extracts of <em>H. sabdariffa</em> and <em>P. domesticum</em>, aiming to develop eco-friendly nanomaterials with antioxidant and low toxicity properties. The green synthesis method produced stable nanoparticles larger than 30 nm, which were characterized by high antioxidant activity, low cytotoxicity, and minimal ecotoxic effects compared to those obtained via conventional chemical reducers (trisodium citrate and tannic acid). Among the most promising results, promising results, AuNPs and AgNPs synthesized with <em>H. sabdariffa</em> exhibited the highest antioxidant capacity (up to 43.13% more than <em>P. domesticum</em>) and negligible cytotoxicity in both A549 and HFF cell lines, with AuNPs even enhancing cell viability. AgNPs from <em>P. domesticum</em> showed improved resistance to UV exposure buy slightly higher cytotoxicity. In contrast, chemically synthesized NPs (Q1 and Q2) induced significant cell death and exhibited increased oxidative states under UV–Vis-NIR radiation. Toxicity tests on cyanobacteria (<em>Fisherella musicola</em>) confirmed the biocompatibility of green synthesis NPs, with no significant growth inhibition observed for AuNPs:Hs and AgNPs:Hs. Overall, this work confirms that anthocyanin rich floral extracts can act as effective reducing and stabilizing agents, producing multifunctional nanoparticles suitable for biomedical and cosmetic applications. These findings highlight the potential of green nanotechnology to deliver safer and more sustainable nanoparticle formulations.</div></div>","PeriodicalId":37785,"journal":{"name":"OpenNano","volume":"26 ","pages":"Article 100258"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145363049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeted gene removal by SpCas9 transduced by a protein-RNA complex transduction system NanoMEDIC","authors":"Mayuko Yagi ,&nbsp;China Tomita ,&nbsp;Minami Hama ,&nbsp;Rafal Krol ,&nbsp;Peter Gee ,&nbsp;Akitsu Hotta ,&nbsp;Jun Komano","doi":"10.1016/j.onano.2025.100257","DOIUrl":"10.1016/j.onano.2025.100257","url":null,"abstract":"<div><div>The CRISPR-Cas9 system offers powerful genome editing capabilities, but off-target effects remain a key limitation. Direct delivery of Cas9 protein complexed with guide RNA (gRNA) can mitigate these effects by limiting exposure time. We previously developed NanoMEDIC, a virus-like particle system shown to deliver Cas9/gRNA ribonucleoprotein (RNP) complexes both in vitro and in vivo. In the present study, we compared NanoMEDIC-mediated delivery with plasmid-based transfection using a gene excision reporter in the human embryonic kidney-derived cell line 293FT and the human glioblastoma-derived cell line NP-2. In this model, the DNA sequence targeted by Cas9/gRNA was derived from a human oncogenic retrovirus, human T-cell leukemia virus type I (HTLV-1). NanoMEDIC achieved efficient gene removal-editing with significantly lower Cas9 input per cell regardless of whether the target DNA was transiently transfected or integrated into chromosomal DNA. Sequencing of edited loci revealed that NanoMEDIC-mediated Cas9/gRNA delivery produced 58.3 – 87.5 % removal-edited DNA without insertions or deletions (indels), compared with 8.3 – 29.4 % using plasmid transfection. These data suggest a high editing precision of NanoMEDIC-mediated Cas9/gRNA delivery. This likely reflects the transient presence of Cas9, which enables rapid repair through non-homologous end joining (NHEJ) without prolonged nuclease activity. Collectively, our findings highlight the potential of NanoMEDIC for applications requiring precise, indel-free genome modifications and support its use as a safer alternative to DNA-based delivery or systems involving sustained Cas9 expression.</div></div>","PeriodicalId":37785,"journal":{"name":"OpenNano","volume":"26 ","pages":"Article 100257"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145159708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical-capped silver nanoparticles from the medicinal plant Embelia laeta disrupting 3D tumorspheres and inducing ROS-mediated apoptosis in MCF-7 breast cancer cells","authors":"Thi Thanh Huong Le ,&nbsp;Van Hung Hoang ,&nbsp;Thi Quynh Nguyen ,&nbsp;Dac Trung Nguyen ,&nbsp;Viet Hoang ,&nbsp;Thu Huong Trinh ,&nbsp;Thi Tam Khieu ,&nbsp;Phu Hung Nguyen","doi":"10.1016/j.onano.2025.100262","DOIUrl":"10.1016/j.onano.2025.100262","url":null,"abstract":"<div><div>Plant-based green nanotechnology provides a promising strategy that integrates phytochemicals with metallic nanoparticles for targeted cancer therapy. In this study, silver nanoparticles (Eml-AgNPs) synthesized using <em>Embelia laeta</em> (L.) Mez. leaf extract were investigated for their anticancer potential. The Eml-AgNPs were spherical, crystalline, and averaged 13.4 ± 4.6 nm in size, as confirmed by UV–Vis spectroscopy (absorption peak at 453 nm), XRD, FTIR, and TEM analyses. UPLC-QToF-MS profiling revealed 13 bioactive molecules bound to the nanoparticle surface, contributing to their stability and anticancer efficacy. Eml-AgNPs demonstrated potent, concentration-dependent cytotoxicity against HepG2, AGS, MCF-7, and MKN45 cancer cell lines, with IC₅₀ values ranging from 0.78 µg/mL to 1.67 µg/mL. In 3D tumorsphere cultures, treatment with Eml-AgNPs (2–5 µg/mL) significantly disrupted spheroid morphology and cellular cohesion. Mechanistic studies indicated ROS-mediated apoptosis, evidenced by a 36.7 % increase in Annexin V-FITC-positive cells (<em>p</em> &lt; 0.01) and a 32.7 % elevation in ROS generation following treatment with 5 µg/mL Eml-AgNPs (<em>p</em> &lt; 0.01). Furthermore, expression of pro-apoptotic genes including <em>CASP8, CASP9, GADD45</em>, and <em>BAX</em> was significantly upregulated. Collectively, these findings highlight the potential of Eml-AgNPs as a green nanotherapeutic platform, leveraging phytochemical synergy to induce oxidative stress-driven apoptosis in cancer cells. Further in vivo studies are needed to confirm the efficacy and safety of Eml-AgNPs for potential biomedical applications.</div></div>","PeriodicalId":37785,"journal":{"name":"OpenNano","volume":"26 ","pages":"Article 100262"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145363048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidative brain injury ascending from DMBA: Metabolomics and BRAF3/FKBR/A2m molecular signaling crosstalk","authors":"Rehab M. Abdel-Megeed ,&nbsp;Mai O. Kadry ,&nbsp;Abdel-Hamid Z. Abdel-Hamid ,&nbsp;Sherif M. Afifi ,&nbsp;Naglaa M. Ammar","doi":"10.1016/j.onano.2025.100261","DOIUrl":"10.1016/j.onano.2025.100261","url":null,"abstract":"<div><div>The current study explored brain damage that is associated with Dimethylbenz(a)anthracene (DMBA)-induced breast cancer. Induction was occurred in female Sprague-Dawley rats via 50 mg/kg DMBA followed by treatment with liposomal doxorubicin (5mg<strong>/</strong>kg) or titanium dioxide nanoparticles loaded doxorubicin (TiO₂NP-DOX) (2mg<strong>/</strong>kg) for one month. Biochemical, molecular, and histopathological studies were accessed in addition to untargeted metabolomics study using gas chromatography-mass spectrometry. The current study revealed a significant reduction in the total antioxidant capacity besides a significant elevation of lipid peroxide values upon DMBA intoxication. Molecular quantification of FKBP5, A2m, BRAF and NF-kB mRNA gene expression revealed a significant reduction in both FKBP5 and A2M upon DMBA intoxication in contrast to a significant overexpression of BRAF and NF-kB mRNA gene expression. Meanwhile, liposomal doxorubicin and TiO₂NP-DOX treated groups significantly modulate the aforementioned genes, with the superiority of TiO₂NP-DOX treatment regimen. Protein expression of both AKT and PI3K recorded a significant elevation post DMBA intoxication. However, a highly significant downregulation was revealed in the protein expression post TiO₂NP-DOX treatment. Interestingly, we found that various metabolites were downregulated whereas others were unregulated in DMBA intoxicated group. However, TiO₂NP-DOX treatment regulated these altered metabolites. Histopathological examination of brain tissue confirmed the obtained results. In conclusion: TiO₂NP-DOX could be a promising candidate for modulating oxidative stress, gene and protein expression malformation and oxidative brain injury associated with DMBA-induced carcinogenesis in rats and alters metabolites associated with mitigating inflammation and oxidative damage.</div></div>","PeriodicalId":37785,"journal":{"name":"OpenNano","volume":"26 ","pages":"Article 100261"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145363628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A water-soluble, organosilane-based coating blocked acute and sub-chronic respirable crystalline silica-induced lung toxicity and systemic inflammation in an animal model","authors":"James M. Antonini ,&nbsp;Mohammad Shoeb ,&nbsp;Breanna Alman ,&nbsp;Gregory Zarus ,&nbsp;Terry G. Meighan ,&nbsp;Katherine A. Roach ,&nbsp;Aleksandr Stefaniak ,&nbsp;Lauren Bowers ,&nbsp;Gregory Boyce ,&nbsp;Jenny R. Roberts ,&nbsp;Vamsi Kodali","doi":"10.1016/j.onano.2025.100256","DOIUrl":"10.1016/j.onano.2025.100256","url":null,"abstract":"<div><div>Inhalation of respirable crystalline silica can cause pulmonary fibrosis and inflammation. Silica particles have a highly reactive surface that generates cell-damaging reactive oxygen species when fractured. The objective was to evaluate lung toxicity after exposure to silica coated with and without a water-soluble, organosilane-based coating (SIVO160). Male Sprague-Dawley rats were intratracheally instilled with silica (1 mg/rat), silica coated with SIVO160, SIVO160 alone, or saline (vehicle control). At 3, 10, 45, and 90 d after exposure, bronchoalveolar lavage (BAL) and histopathology were performed to assess lung toxicity. Whole blood was collected to evaluate systemic inflammation by differentiating circulating white blood cells. Also, samples of uncoated and coated silica were analyzed [(1) RapiFlex MALDI-ToF/ToF mass spectrometry; (2) digestion in phagolysosomal simulant fluid (PSF) and serum ultrafiltrate (SUF)] to confirm the SIVO160 coating on the surface of the silica particles after incubation in biological media. At each time point, silica significantly increased BAL fluid lactate dehydrogenase (lung injury) and the number of recovered lung macrophages and neutrophils (lung inflammation). These silica-induced elevations in lung toxicity were completely blocked at each time point when silica was coated with SIVO160 before exposure. At 45 d after exposure to uncoated silica, circulating total white blood cells, neutrophils, and lymphocytes were significantly elevated in the blood compared to the other groups. Lung exposure to silica pretreated with SIVO160 did not cause a significant elevation in any of the peripheral blood cell types at any time point when compared to the saline and SIVO160 alone. As assessed by mass spectrometry, multiple unique spectral peaks were detected on the surface of the silica+SIVO160 particle samples after an overnight incubation in saline. The peaks were absent in the uncoated silica sample spectra, confirming the coating’s presence on the particles. The time it took for removal by digestion of the SIVO160 coating on the silica was reflected by a short-term delay after incubation in both PSF and SUF, suggesting protection could be conveyed to lung cells by the coating during phagocytosis and particle deposition on lung tissue structures. Organosilane materials may be used as a possible mitigation strategy to potentially protect large numbers of workers exposed to respirable crystalline silica in multiple industries is important.</div></div>","PeriodicalId":37785,"journal":{"name":"OpenNano","volume":"26 ","pages":"Article 100256"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145119443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fe3O4/BiOCl photocatalyst with magnetic recovery property for solar-light-responsive removal of Rhodamine B dye","authors":"Sattra Nonthing ,&nbsp;Atchawadee Panchakeaw ,&nbsp;Ruethaithip Dulyasucharit ,&nbsp;Hidaki Nakajima ,&nbsp;Suwat Nanan","doi":"10.1016/j.onano.2025.100260","DOIUrl":"10.1016/j.onano.2025.100260","url":null,"abstract":"<div><div>Binary Fe₃O₄/BiOCl photocatalyst was fabricated successfully via a facile ultrasonic route. The magnetic Fe₃O₄/BiOCl was used for solar-light-driven detoxification of Rhodamine B (RhB) dye. The prepared binary photocatalyst displayed mainly the diffraction peaks of BiOCl. The energy gap of BiOCl and Fe₃O₄/BiOCl was 3.37 eV, and 2.55 eV, respectively. The Fe₃O₄/BiOCl photocatalyst revealed lower fluorescence intensity, compared to the pristine BiOCl, indicating the enhanced carrier separation rate. The result corelates well with the improvement in photocatalytic activity of the magnetic Fe₃O₄/BiOCl photocatalyst. High photocatalytic efficiency of 100% was achieved after 90 min of sunlight irradiation. The degradation of RhB dye fits nicely with the first-order kinetic model revealing the maximum rate constant of 0.0113 min^–1. The binary photocatalyst still maintains the excellent photodegradation activity after the fifth cycle of use. The trapping technique reveals that photogenerated electrons and superoxide anion radicals play a key role in RhB detoxification. The present work provides a promising way to generate the sunlight-active semiconducting catalyst, with magnetic separable property, for detoxification of RhB dye in an aqueous phase.</div></div>","PeriodicalId":37785,"journal":{"name":"OpenNano","volume":"26 ","pages":"Article 100260"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145221815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chitosan-functionalized selenium nanoparticles for targeted cancer therapy: Advances in synthesis, stability, and tumor-specific delivery","authors":"Tubagus Akmal ,&nbsp;Yedi Herdiana ,&nbsp;Ahmed Fouad Abdelwahab Mohammed ,&nbsp;Safwat A. Mahmoud ,&nbsp;Khaled M. Elamin ,&nbsp;Gofarana Wilar ,&nbsp;Nasrul Wathoni","doi":"10.1016/j.onano.2025.100263","DOIUrl":"10.1016/j.onano.2025.100263","url":null,"abstract":"<div><div>Chitosan-functionalized selenium nanoparticles (CS-SeNPs) integrate selenium’s redox-active anticancer potential with chitosan’s stabilization, mucoadhesion, and ligand-ready surface to enable tumor-selective delivery. This review consolidates advances in chemical, physical, and green syntheses; relates processing to size, charge, colloidal stability, and drug loading; and maps these attributes to biodistribution, cellular uptake, and controlled release. Emphasis is placed on modified chitosan derivatives that confer pH or redox responsiveness, enhanced permeability and retention, active targeting, and co-delivery of chemotherapeutics or photosensitizers. Anticancer mechanisms encompass mitochondrial apoptosis, ROS modulation, cell-cycle arrest, anti-metastatic activity, and chemo- or photo-synergy. A critical comparison with metal-oxide platforms and discussion of environmental fate, biofilm reactor data, hemocompatibility, and immunotoxicity delineate benefits and remaining risks. Key translational priorities include scalable green synthesis, robust physicochemical and release specifications, in vivo exposure–response models, and regulatory-grade safety packages. CS-SeNPs thus represent a credible path toward precision oncology.</div></div>","PeriodicalId":37785,"journal":{"name":"OpenNano","volume":"26 ","pages":"Article 100263"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145417033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in nanotechnology for sunscreens: Preparation, characterization, and mechanisms of UV protection","authors":"Feggy Yustika Sitinjak ,&nbsp;Nur Aisyah ,&nbsp;Diah Lia Aulifa ,&nbsp;Arif Budiman","doi":"10.1016/j.onano.2025.100259","DOIUrl":"10.1016/j.onano.2025.100259","url":null,"abstract":"<div><div>Nanotechnology based sunscreens have arisen as sophisticated alternatives to conventional formulations, overcoming constraints such as inadequate skin penetration, photoinstability, and potential toxicity of active components. Diverse nanocarrier systems such as liposomes, solid lipid nanoparticles, nanoemulsions, and polymeric nanoparticles exhibit significant advancements, including up to 50 % or more compared to conventional formulations increase in sun protection factor (SPF), particle dimensions ranging from 50 to 200 nm and encapsulation efficiencies surpassing 90 % for UV filters. These systems improve photostability, decrease systemic absorption, and mitigate whitening effects in comparison to conventional sunscreens. Characterization techniques, including dynamic light scattering, electron microscopy, and etc., yield insights into particle size distribution, shape, and stability, which are essential for guaranteeing safety and performance. This study emphasizes recent emphasizes novel developments in the preparation, characterization, and mechanisms of UV protection in nanotechnology based sunscreens, delineating current progress and prospective prospects for safer and more effective solutions.</div></div>","PeriodicalId":37785,"journal":{"name":"OpenNano","volume":"26 ","pages":"Article 100259"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145268551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myco-nanotechnology at the crossroads: eco-friendly synthesis, agricultural applications, and AI-driven risk mitigation of fungal-derived nanoparticles","authors":"Lakshika Sharma ,&nbsp;Abhishek Dadhich ,&nbsp;Irra Dhar ,&nbsp;Rashmi Choudhary ,&nbsp;Mamta Dhiman ,&nbsp;Madan Mohan Sharma","doi":"10.1016/j.onano.2025.100254","DOIUrl":"10.1016/j.onano.2025.100254","url":null,"abstract":"<div><div>Fungal-based nanotechnology is emerging as a promising and sustainable approach in agriculture, environmental cleanup, and biotechnology. Nanoparticles produced by fungi known as Myco-nanoparticles offer a greener method of synthesis, along with good stability and strong biological activity. However, their increasing use has raised concerns about possible environmental risks and long-term effects. This review highlights recent advances in the eco-friendly production of Myco-nanoparticles and their potential to support plant growth, improve nutrient uptake, and boost resistance to stress and disease. While small amounts of these particles may be helpful, higher doses can lead to harmful effects such as oxidative stress and damage to plant DNA. Compared to nanoparticles made by plants or bacteria, fungal-derived particles are often more stable and easier to produce, though they still pose similar safety concerns. This review uniquely connects fungal nanobiotechnology with AI-driven toxicity prediction and omics-based pathway mapping an integrated approach that lays the groundwork for precision myconanotechnology with reduced ecological impact.</div></div>","PeriodicalId":37785,"journal":{"name":"OpenNano","volume":"25 ","pages":"Article 100254"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144931526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}