OpenNano最新文献

{"title":"Gold nanoparticles and breast cancer: A bibliometric analysis of the current state of research and future directions","authors":"Yasser Bustanji ,&nbsp;Jalal Taneera ,&nbsp;Mohammad H. Semreen ,&nbsp;Eman Abu-Gharbieh ,&nbsp;Waseem El-Huneidi ,&nbsp;Moez Al-Islam E. Faris ,&nbsp;Karem H. Alzoubi ,&nbsp;Nelson C. Soares ,&nbsp;Basil Albustanji ,&nbsp;Ahmad Y. Abuhelwa ,&nbsp;Rund Abu-Zurayk ,&nbsp;Mohammad A.Y. Alqudah ,&nbsp;Hatim S. AlKhatib","doi":"10.1016/j.onano.2023.100164","DOIUrl":"10.1016/j.onano.2023.100164","url":null,"abstract":"<div><p>Gold nanoparticles (GNPs) are widely searched for their usage in breast cancer research because of their unique features. For example, these particles can deliver drugs to specific sites, making imaging and photothermal therapy possible, thus rendering them suitable particles for theranostic purposes. Bibliometric research is a statistical analytical technique useful for the data systematically found in the literature. In this bibliometric study, the global research output regarding GNPs in breast cancer (BC) research was analyzed, mapped, and evaluated using bibliometric indicators.</p><p>All documents related to the application of GNPs applications in BC research that were published in English-language, peer-reviewed journals over the past 20 years were retrieved from the Scopus database. Bibliometric indicators were extracted using VOSviewer and Biblioshiny. Thematic maps, conceptual maps, and visualization graphs were created.</p><p>A total of 2035 published documents were retrieved. Chinese authors were the most active, having published approximately 27.5% of the total documents, while researchers from the United States (USA) had the most significant scientific impact. The study revealed weak international collaboration in this research area. Keywords mapping identified the main research themes and hotspots in this research field. Multimodal approaches in cancer treatment and diagnostics, targeted and effective cancer treatment, aptamers and biosensors, and green synthesis of GNPs were the four clusters retrieved from theme and hotspot analyses. This study analyzed and mapped the expanding field of GNPs in breast cancer research (GNP-BCR) and identified various applications of GNPs in this field. GNPs were used as drug delivery systems to target specific cancer cells and improve anticancer drug bioavailability. Different treatment and diagnostic modalities were revealed, such as photodynamic therapy (PDT) and photothermal therapy (PTT). Moreover, the development of aptamer-based biosensors using gold nanoparticles was identified as a niche theme in this research, while the green synthesis of GNPs emerged as a new and promising theme. However, clinical research is still warranted to translate this fundamental knowledge into practical and human-useable formulas.</p></div>","PeriodicalId":37785,"journal":{"name":"OpenNano","volume":"12 ","pages":"Article 100164"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41267421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Instantaneous topical drug quantification using a 3D printed microfluidic device and coherent Raman imaging","authors":"Benjamin A. Kuzma ,&nbsp;Dandan Tu ,&nbsp;Avery Goss,&nbsp;Fotis Iliopoulos,&nbsp;Julian Byrne Slade,&nbsp;Anna Wiatrowski,&nbsp;Amin Feizpour,&nbsp;Conor L. Evans","doi":"10.1016/j.onano.2023.100151","DOIUrl":"10.1016/j.onano.2023.100151","url":null,"abstract":"<div><p>Cutaneous drug concentration quantification after topical application remains an active, yet challenging research area for topical drug development. Macroscale approaches quantify cutaneous pharmacokinetics 30  min to hours after application and miss rapid temporal and spatial dynamics that are vital to comprehend drug disposition. We have developed a 3D-printed applicator coupled with an inverted microscope and a rapidly-tunable fiber optic laser to quantify active pharmaceutical ingredients via sparse spectral sampling stimulated Raman scattering. The 3D-printed applicator is cost-effective (<em>&lt;</em> $0.70/applicator) and utilizes a small formulation volume (20 <em>µ</em>L). Ruxolitinib was formulated in two known permeation enhancers (propylene glycol and diethylene glycol monoethyl ether) that are known to display different permeation profiles to validate device capabilities. Results indicated that the applicator enabled relative-concentration monitoring immediately following drug product application. This approach has significant potential for investigating novel excipients, active pharmaceutical ingredients, and formulations to understand the permeation and biodistribution of these compounds.</p></div>","PeriodicalId":37785,"journal":{"name":"OpenNano","volume":"12 ","pages":"Article 100151"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42336490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanomaterials for diagnosis, treatment, and prevention of human cutaneous leishmaniasis: A review","authors":"Daniela Maza Vega ,&nbsp;Magalí Di Meglio ,&nbsp;Silvia del Valle Alonso ,&nbsp;Fernando Alvira ,&nbsp;Jorge Montanari","doi":"10.1016/j.onano.2023.100158","DOIUrl":"10.1016/j.onano.2023.100158","url":null,"abstract":"<div><p><em>Leishmania</em> parasites are the organisms responsible for one of the most important tropical diseases, leishmaniasis. This neglected disease mainly affects populations in developing or underdeveloped countries, causing nearly one million new cases per year. This article focuses on the cutaneous form of the disease. Common antileishmanial medications have several disadvantages, such as low efficiency, high toxicity, several adverse effects, resistant strains, long treatments, and high costs. As a result, first- and second-line treatments are insufficient. Therefore, there is a need for new antileishmanial agents and strategies, most of which utilize nanotechnology. While novel nano-drug delivery devices can transport antileishmanial drugs to target cells, reducing secondary toxic effects, several advances in nanotechnology and photonics pursue activation of leishmanicidal mechanisms once they reach their target. Here is a summary of recent nanotechnology approaches to the treatment, diagnosis, and prevention of human cutaneous leishmaniasis, including promising techniques still in development.</p></div>","PeriodicalId":37785,"journal":{"name":"OpenNano","volume":"12 ","pages":"Article 100158"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42306215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computational nanoscience and technology","authors":"Amarjitsing Rajput ,&nbsp;Ganesh Shevalkar ,&nbsp;Krutika Pardeshi ,&nbsp;Prashant Pingale","doi":"10.1016/j.onano.2023.100147","DOIUrl":"10.1016/j.onano.2023.100147","url":null,"abstract":"<div><p>Nanoscience and nanotechnology are the most widely utilized field of science in human healthcare, tissue engineering, food and agriculture. It has several advantages, such as superior surface area and nano-sized molecular structure. Nanomaterial properties like elasticity, mechanical characteristics like hardness, tensile strength, and magnetic and optical properties. It has capability to store high energy, which makes them applicable in the healthcare system. “Executable biology” is applied to the computational model of physiological processes. These models have the advantage of computer science and simulation of pharmacokinetic study. Because of their high potential and computational power, they are widely accepted in pharmaceutical research. US-FDA has tested and utilized computational models in manufacturing various pharmaceutical equipment's that also can be used in drug discovery and manufacturing. These models can create exact validated in vitro and in vivo pharmacological systems, which helps to obtain faster, accurate and more pertinent human data. These models suffer from simplicity, versatility and lack of cumulative research. Multiscale simulations, like the ones based on coarse-graining, are important areas for future research. More significantly, a collaboration between the pharmaceutical industry and computational scientists involved in this field could assist in work in areas wherein molecular dynamic simulations can influence substantially. In this review, different drug target identification models via chemo genomic methods are explained, and the advantages of computational modeling over mathematical model is studied. It also focuses on a wide range of simulation techniques, biomedical applications and challenges of computational modelling. Finally, it gives a brief account of compounds studied using computational modeling and its future perspectives.</p></div>","PeriodicalId":37785,"journal":{"name":"OpenNano","volume":"12 ","pages":"Article 100147"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48159063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights into microfabrication and implementation of microfluidics in pharmaceutical drug delivery and analysis","authors":"Omnia A. Al-wdan ,&nbsp;Omnya A. Sharallah ,&nbsp;Nada A. Abdelwahab ,&nbsp;Alshimaa O. Mohammed ,&nbsp;Enas Elmowafy ,&nbsp;Mahmoud E. Soliman","doi":"10.1016/j.onano.2023.100156","DOIUrl":"10.1016/j.onano.2023.100156","url":null,"abstract":"<div><p>Microfluidics are systems that set forth valuable means to efficiently control fluid movement and dynamics in specially fabricated micro-channel systems. The advancement of the unique design and microfluidics technology can offer an alternative to the traditional systems used in many pharmaceutical applications. In this context, this review presents a vivid depiction of microfluidics and an overview of the various mixing techniques and mechanisms. Insights on how microfluidic methodologies can be utilized in the efficient manufacture of various drug delivery systems e.g., liposomes, microparticles, nanoparticles, and nano-in-microparticles are provided. Moreover, the different analytical applications of microfluidic systems such as lab-on-chip, dielectrophoresis, droplet microfluidic, and digital microfluidics are addressed. Specifically, the pharmaceutical approaches for antibody screening technology and Cell-free protein synthesis system are highlighted. Lastly, the modular microfluidic approach in planning and constructing microfluidic systems is explored as a key player for implementing futuristic custom-made microfluidic systems. Collectively, microfluidic systems hold the potential in various domains including biosensors, point-of-care diagnostics, health monitoring and patient care management.</p></div>","PeriodicalId":37785,"journal":{"name":"OpenNano","volume":"12 ","pages":"Article 100156"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47884647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoparticle drug delivery systems in hepatocellular carcinoma: A focus on targeting strategies and therapeutic applications","authors":"Sayali Pravin Metkar ,&nbsp;Gasper Fernandes ,&nbsp;Prerana D. Navti ,&nbsp;Ajinkya N. Nikam ,&nbsp;Ritu Kudarha ,&nbsp;Namdev Dhas ,&nbsp;Raviraja N Seetharam ,&nbsp;Krishnan Venkata Santhosh ,&nbsp;Bola Sadashiva Satish Rao ,&nbsp;Srinivas Mutalik","doi":"10.1016/j.onano.2023.100159","DOIUrl":"10.1016/j.onano.2023.100159","url":null,"abstract":"<div><p>Hepatocellular carcinoma (HCC) is recognized as a global health issue accounting for millions of deaths every year. Surgery, liver ablation, and embolization therapy are amongst the conventional methods for treatment of HCC. Chemotherapy plays a major role in HCC therapy, however, owing to its conventional pharmacotherapy limitations, it necessitates the development of novel therapeutic strategies. In contrast, nanomedicines for HCC have shown remarkable prospects for solving these complications in HCC owing to their high stability, controlled release, and high drug loading capacity. This review gives an insight into the nano-constructs used for HCC treatment and its active and passive targeting strategies. This review also inculcates the various approaches for targeting the liver cells, its targeting moieties and the conjugation chemistries involved in surface functionalization. A brief description of various therapeutic approaches in the treatment of HCC has also been discussed.</p></div>","PeriodicalId":37785,"journal":{"name":"OpenNano","volume":"12 ","pages":"Article 100159"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49526079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the potential of microfluidics for next-generation drug delivery systems","authors":"Gargi Bhattacharjee ,&nbsp;Nisarg Gohil ,&nbsp;Malvika Shukla ,&nbsp;Swati Sharma ,&nbsp;Indra Mani ,&nbsp;Alok Pandya ,&nbsp;Dinh-Toi Chu ,&nbsp;Nhat Le Bui ,&nbsp;Yen-Vy Nguyen Thi ,&nbsp;Khushal Khambhati ,&nbsp;Rupesh Maurya ,&nbsp;Suresh Ramakrishna ,&nbsp;Vijai Singh","doi":"10.1016/j.onano.2023.100150","DOIUrl":"10.1016/j.onano.2023.100150","url":null,"abstract":"<div><p>The platform of microfluidics offers a precise control and manipulation over fluids at a small scale and therefore has gained much attention in recent times. This topic is currently applied to automation and high-throughput analysis in several areas, including extraction of DNA, RNA and proteins, gene identification, gene assembly, cloning, single-cell analysis, organs grown on chips, PCR, drug screening, toxicity testing and drug delivery. Conventional methods used for drug delivery are sometimes non-targeted leading to loss of administered drugs and reduced drug effectiveness. Recent advances in microfluidics allow precise dose-dependent delivery of a drug to a targeted location. Several microfluidics designs have been implemented to improve the precision of treatment in clinics. This review highlights currently available tools in microfluidics, designs for drug carriers, delivery methods, robotics and artificial intelligence in the field of microfluidics.</p></div>","PeriodicalId":37785,"journal":{"name":"OpenNano","volume":"12 ","pages":"Article 100150"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44857572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wound healing synergy in Wistar albino rats via green synthesized nanoparticles and topical antibiotic neomycin","authors":"S.V.N. Pammi ,&nbsp;Veerabhadhra Swamy Padavala ,&nbsp;Taraka Sunil Kumar Karumuri ,&nbsp;Chandra Sekhar Kommavari ,&nbsp;Manish Shaik ,&nbsp;Venkata Ramana Murthy Kolapalli ,&nbsp;Lakshmi Kalyani Ruddaraju","doi":"10.1016/j.onano.2023.100135","DOIUrl":"10.1016/j.onano.2023.100135","url":null,"abstract":"<div><p>Raise of antimicrobial resistance and lack of development in novel antibiotics leads to complications in infection control for wound healing. In perspective to search for best alternatives, antibacterial activity of nanomaterials has shown promising strategy, however concentration dependent toxicity became challenge thereof. In this context, green synthesis protocols of nano materials provide benefits of biocompatibility due to presence of bioactive compounds and also economical with proven efficiency. Further nano-antibiotic combinations may enhance antibacterial efficacy by synergetic action and allows to reduce the dosage of both agents. In the current work, nano-antibiotic gels are prepared using green synthesized nanoparticles (Ag &amp; ZnO NPs) with the combination of antibiotic neomycin and also assessed <em>in-vivo</em> wound healing activity on Wistar albino rats. From the results of the tested formulations, combinational formulations exhibited enhanced and speedier wound contraction (92–96%) with prominent synergetic action when compared with neomycin alone (84%) or nanoparticles alone (82–86%) in a 14-day study. These results demonstrated that green-nano-antibiotic combinational formulations provides prominent avenue to combat the multi drug resistant bacteria without toxicity issue.</p></div>","PeriodicalId":37785,"journal":{"name":"OpenNano","volume":"11 ","pages":"Article 100135"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45982006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Niosome nanocarrier enhances the ameliorating effects of myrtenol in the lungs of rats with experimental asthma","authors":"Mohammad Amin Rajizadeh ,&nbsp;Mohammad Hadi Nematollahi ,&nbsp;Elham Jafari ,&nbsp;Mohammad Abbas Bejeshk ,&nbsp;Mehrnaz Mehrabani ,&nbsp;Mohammad Sadegh Razeghinia ,&nbsp;Hamid Najafipour","doi":"10.1016/j.onano.2023.100129","DOIUrl":"10.1016/j.onano.2023.100129","url":null,"abstract":"<div><p>We assessed the anti-inflammatory, anti-oxidative and anti-remodeling impacts of a synthesized myrtenol-loaded niosome in rats with allergic asthma. Forty-nine rats were divided into seven groups of control, vacant niosome (VN), Asthma, Asthma+VN, Asthma+SM (simple myrtenol), Asthma+NM (niosomal myrtenol, 8 mg/kg), and Asthma+<em>B</em> (budesonide, 41 μg). Ovalbumin-induced asthmatic animals were exposed to daily inhalation of drug/vehicle for one week. Histopathology and inflammatory and oxidative stress indices in the lungs were assessed. Myrtenol-loaded niosomes showed appropriate physicochemical properties. Airway smooth muscle thickness, inflammatory cell infiltration, goblet cell hyperplasia, NO, IL-17, and MDA level decreased, and IL-10 and TAC levels increased in tissue and/or BALF of treatment groups. Niosomal myrtenol showed high potency comparable to budesonide in alleviating disease parameters. In conclusion, inhalation of niosomal myrtenol ameliorated inflammation, oxidative stress and tissue remodeling in asthmatic animals more potently than simple myrtenol and could be a target for production of an anti-asthmatic medicine.</p></div>","PeriodicalId":37785,"journal":{"name":"OpenNano","volume":"11 ","pages":"Article 100129"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47029919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Promising synthesized bis (arylmethylidene) acetone -polymeric PCL emulsified nanoparticles with enhanced antimicrobial/antioxidant efficacy: in-vitro and in-vivo evaluation","authors":"Sally A. Abou Taleb ,&nbsp;Shaymaa Abdalla Ismail ,&nbsp;Marwan Mohamed ,&nbsp;Reda M. Mourad ,&nbsp;Hadeer A. El-Hashemy","doi":"10.1016/j.onano.2023.100139","DOIUrl":"10.1016/j.onano.2023.100139","url":null,"abstract":"<div><h3>Introduction</h3><p>Recently, bis(arylmethylidene)acetone drugs known as C5-curcumin, were acknowledged for their potent biological effects as a neoteric synthetic alternative to curcumin effectively used to treat many diseases.</p></div><div><h3>Methods</h3><p>In this study, new polymeric emulsified nanoparticles (PENS) carrying biodegradable polycaprolactone (PCL) polymer moieties within their framework were developed as promising carriers for a modern synthesized bis(arylmethylidene)acetone “(1<em>E</em>,4<em>E</em>)-1,5-di(thiophen-2-yl) penta-1,4dien-3-one” (TPO) with improved bioavailability. Such systems were evaluated by studying their; encapsulation efficiency, release behavior, physicochemical evaluations, TEM and SEM measurements and cytotoxicity, besides the in-vitro and in-vivo biological studies screening.</p></div><div><h3>Results</h3><p>The results revealed high encapsulation efficiency ranging between 99.31± 2.15 and 99.55 ± 2.03 %, and a sustained release behavior for up to 24 h with nanosized particle size. TPO emulsified nanoparticles (TPO-ENPs) showed effective antimicrobial activity against <em>Candida albicans</em> and <em>Aspergillus brasiliensis</em> as well as antioxidant efficacy with a higher scavenging activity of 177.6μg TE/ mg against free radicals of 2,2-diphenyl-1-picrylhydrazyl hydrate (DPPH) relatively to the control drug. F1’ and F2’ TPO-ENPs were safe on Vero-cells and proved a significant reduction of hepatocellular alterations and serum ALT levels in control groups.</p></div><div><h3>Conclusion</h3><p>In conclusion, these novel synthesized TPO-ENPs showed pronounced efficacy as antimicrobial/ antioxidant/ anti-inflammatory/ analgesic/ hepatoprotective therapeutic vehicles.</p></div>","PeriodicalId":37785,"journal":{"name":"OpenNano","volume":"11 ","pages":"Article 100139"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47804136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}