OpenNano最新文献

{"title":"A recent advances in antimicrobial activity of green synthesized selenium nanoparticle","authors":"Durgadevi Ravi ,&nbsp;Bhuvaneshwari Gunasekar ,&nbsp;Vishwanathan Kaliyaperumal ,&nbsp;Shyamaladevi Babu","doi":"10.1016/j.onano.2024.100219","DOIUrl":"10.1016/j.onano.2024.100219","url":null,"abstract":"<div><div>Green technologies have gained prominence, particularly in the environmentally friendly synthesis of compounds, with Selenium nanoparticles (SeNPs) emerging as a key area of interest due to their potential in drug development. The sustainable production of SeNPs using microorganisms and plants enhances their physical, chemical, and biological properties, improving their catalytic efficiency. Recent advancements in nanotechnology, especially in medicine and antimicrobial research, highlight the growing significance of green synthesis methods. These eco-conscious approaches aim to preserve natural resources while promoting sustainable nanoparticle production techniques. This review focuses on SeNPs' antimicrobial action as well as the factors that influence their green production, such as pH, temperature, and precursor concentration, all of which affect their morphology, size, and stability. SeNPs' antimicrobial activity against a diverse range of bacteria, fungi, and viruses is extensively tested, with a focus on their capacity to battle drug-resistant infections and biofilms. The mechanisms of SeNPs' antimicrobial effect are investigated, including membrane disruption, reactive oxygen species (ROS) production, and interactions with cellular components. Furthermore, their antiviral characteristics and ability to alter immune responses highlight their medicinal applications. SeNPs represent a significant advancement in green nanotechnology, offering sustainable solutions to pressing biomedical challenges, particularly in the fight against drug-resistant pathogens.</div></div>","PeriodicalId":37785,"journal":{"name":"OpenNano","volume":"20 ","pages":"Article 100219"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142659519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fundamentals behind the success of nanotechnology in cancer treatment and diagnosis","authors":"Mohammed Mehadi Hassan Chowdhury ,&nbsp;Khadizatul Kubra ,&nbsp;Ashekul Islam","doi":"10.1016/j.onano.2024.100215","DOIUrl":"10.1016/j.onano.2024.100215","url":null,"abstract":"<div><div>Nanotechnology is considered one of the most advanced cancer treatment and diagnostic technologies. Due to the numerous benefits of the application of nanoparticles in cancer management, nanotechnology has proven its therapeutic and diagnostic efficiency as an alternative but promising approach against cancer. However, several limitations and challenges continue to pose obstacles to its success. Designing highly precise NPs considering physicochemical factors may lead to successful outcomes in cancer therapy. Besides, the behaviour of NPs with biomolecules in a biological system can be another potential phenomenon of NPs in biomedical applications. Here, we examined the basic aspects, obstacles, and challenges of cancer nanomedicine based on the factors associated with successful clinical outcomes in cancer management to understand this research area comprehensively.</div></div>","PeriodicalId":37785,"journal":{"name":"OpenNano","volume":"20 ","pages":"Article 100215"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142572921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cellular viability in an in vitro model of human ventricular cardiomyocytes (RL-14) exposed to gold nanoparticles biosynthesized using silk fibroin from silk fibrous waste","authors":"Yuliet Montoya ,&nbsp;Wilson Agudelo ,&nbsp;Alejandra Garcia-Garcia ,&nbsp;John Bustamante","doi":"10.1016/j.onano.2024.100218","DOIUrl":"10.1016/j.onano.2024.100218","url":null,"abstract":"<div><div>In nanotechnology, tissue engineering proposes obtaining nanomaterials of natural or synthetic origin, looking to incorporate components that exhibit a defined shape, diameter, colloidal stability, and biological identity to promote and regulate the events that occur in a cardiac cell microenvironment. This research aimed to evaluate cellular viability in an in vitro model of human fetal ventricular cardiomyocytes on interaction with gold nanoparticles biosynthesized using silk fibroin from silk fibrous waste. The Physicochemical properties were characterized by UV–visible spectroscopy, Fourier-transform infrared spectroscopy, electrokinetic potential, and scanning transmission electron microscopy. Moreover, the MTT assay was used to determine the cell viability of cardiomyocytes exposed to gold nanoparticles. The results showed that the variation of the pH of the reaction allows the synthesis of different geometries of nanoparticles with diameters between 6 and 334 nm. Furthermore, it was found that the nanoparticles with a tendency to sphericity favor the cell viability of cardiomyocytes.</div></div>","PeriodicalId":37785,"journal":{"name":"OpenNano","volume":"20 ","pages":"Article 100218"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142659517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication of pyrroloquinoline quinone-loaded small unilamellar vesicles through various downsizing techniques for biomedical applications","authors":"Gerardo Garcia-Zavaleta ,&nbsp;Daniel Mejia-Valdez ,&nbsp;Hamed Hosseinian ,&nbsp;Ciro A. Rodriguez ,&nbsp;Geoffrey A. Cordell ,&nbsp;Yadira I. Vega-Cantu ,&nbsp;Aida Rodriguez-Garcia","doi":"10.1016/j.onano.2024.100216","DOIUrl":"10.1016/j.onano.2024.100216","url":null,"abstract":"<div><div>Treatment of injuries to bone structure represents a significant economic burden for health care institutions and systems worldwide. The development of tissue engineering scaffolds has expanded to include the incorporation of nanotechnology platforms such as liposomes for the efficient delivery of chemotherapeutic agents. Pyrroloquinoline quinone (PQQ) is a naturally occurring quinone with antioxidant and tissue regenerative properties. In this study, the liposome-based encapsulation of PQQ was achieved by studying the effect of different downsizing methods and lipid compositions. Liposomal sonication produced stable vesicles of sizes &lt;200 nm. The incorporation of PQQ into the liposomes and its interactions with the lipids enhanced their stability for up to four weeks and allowed sustained release for seven weeks. The results demonstrate the ability of these systems to encapsulate PQQ with high stability, efficient entrapment, and extended release profiles for their potential use in biomedicine as a delivery system for bone tissue engineering.</div></div>","PeriodicalId":37785,"journal":{"name":"OpenNano","volume":"20 ","pages":"Article 100216"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142659518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of coating chitosan from cuttlefish bone (Sepia Sp.) on the surface of orthodontic mini-screw","authors":"Karima Qurnia Mansjur,&nbsp;Nurnabilla Syfadewi Attaya,&nbsp;Eka Erwansyah,&nbsp;Ardiansyah S Pawinru,&nbsp;Mansjur Nasir","doi":"10.1016/j.onano.2024.100217","DOIUrl":"10.1016/j.onano.2024.100217","url":null,"abstract":"<div><h3>Introduction</h3><div>Peri-implantitis is a significant complication resulting from the failure of orthodontic mini-screws. Recent strategies to address this issue include the application of natural antibacterial coatings to prevent bacterial colonization. Notably, cuttlefish (<em>Sepia</em> sp.) bones are rich in chitosan, which is recognized for its antibacterial effectiveness and biocompatibility.</div></div><div><h3>Objectives</h3><div>To evaluate the effects of a chitosan coating derived from cuttlefish bone (<em>Sepia</em> sp<em>.</em>) on mini-screws against <em>Aggregatibacter actinomycetemcomitans</em> bacteria frequently linked to peri‑implantitis.</div></div><div><h3>Materials and Methods</h3><div>The surface functional groups, phase composition, and crystal morphology of chitosan were analyzed using conventional analytic techniques alongside energy-dispersive X-ray analysis. These prepared were tested for antibacterial activity against <em>A. actinomycetemcomitans</em> by disk diffusion assay; minimum bactericidal concentration (MBC) and minimum inhibitory concentration (MIC) were determined. Stainless steel mini-screws were coated with chitosan, and their surfaces were characterized using scanning electron microscopy (SEM).</div></div><div><h3>Results</h3><div>The investigation revealed that chitosan exhibited a MIC value of 8 ppm against <em>A. actinomycetemcomitans</em> with MBCs recorded at 16 ppm. Zones of inhibition varied based on concentration; notably, concentrations at 0.4 %, 0.6 %, and 0.8 % produced zones averaging 16.17 ± 1.64 mm collectively while increasing to a mean zone size of 20.99 ± 3.63 mm at the highest tested concentration (0.8 %). SEM analyses further confirmed the successful adhesion of the chitosan compound onto immersed mini-screw surfaces.</div></div><div><h3>Conclusion</h3><div>The prepared chitosan from cuttlefish bone <em>(Sepia</em> sp.<em>)</em> has antibacterial activity against the bacteria <em>A. actinomycetemcomitans</em> in vitro and can successfully coat SS mini-screws to enhance their efficiency.</div></div>","PeriodicalId":37785,"journal":{"name":"OpenNano","volume":"20 ","pages":"Article 100217"},"PeriodicalIF":0.0,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142532650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transformative approaches for siRNA detection","authors":"Sima Singh ,&nbsp;Ada Raucci ,&nbsp;Wanda Cimmino ,&nbsp;Antonella Miglione ,&nbsp;Panagiota M Kalligosfyri ,&nbsp;Stefano Cinti","doi":"10.1016/j.onano.2024.100214","DOIUrl":"10.1016/j.onano.2024.100214","url":null,"abstract":"<div><p>Small interfering RNA (siRNA) is essential for the process of gene silencing, especially for cancer. Despite its considerable promise, siRNA faces challenges due to stability issues of formulation and undesirable off-target side effects. In order to address these difficulties, it is essential to carefully monitor the levels of siRNA. The existing point-of-care (POC) systems cannot precisely and efficiently detect or monitor siRNA levels. In light of these challenges, this review gives the prospects of siRNA detection by proposing a novel hypothesis of existing electrical and optical-based detection of DNA/RNA with the POC platform. This hypothesis offers an interesting novel perspective to potentially fill the existing gaps, in detecting siRNA. By utilising these technologies, there is high potential to develop a proof-of-concept system that will not only overcome the existing challenges, but it will also allow effective and precise monitoring of siRNA, in real-world healthcare environments. In summary, the prospects for siRNA in the realm of POC platforms are quite encouraging, since it allows precise and effective monitoring.</p></div>","PeriodicalId":37785,"journal":{"name":"OpenNano","volume":"20 ","pages":"Article 100214"},"PeriodicalIF":0.0,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S235295202400015X/pdfft?md5=7f981fcf2ad57330a54f3dc8e587b780&pid=1-s2.0-S235295202400015X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142136135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of biosynthesized silver nanoparticle size on antibacterial and anti-biofilm activity against pathogenic multi-drug resistant bacteria","authors":"Anas Yahya Ali ,&nbsp;Abd-Alrahman Khalid Alani ,&nbsp;Barakat O. Ahmed ,&nbsp;Layth L. Hamid","doi":"10.1016/j.onano.2024.100213","DOIUrl":"10.1016/j.onano.2024.100213","url":null,"abstract":"<div><p>Ag NPs have garnered significant attention in the field of biomedical applications due to their antibacterial, antifungal, antiviral, anti-inflammatory, and antiangiogenic effects. The present study aimed to establish a simple, reliable, cost-effective, and environmentally friendly approach for the synthesis of Ag NPs in different sizes using extracts from <em>Syzygium aromaticum</em> and <em>Laurus nobilis</em> and study the relationship between the size of Ag NPs and their antibacterial and anti-biofilm effectiveness. The synthesized Ag NPs were extensively characterized using various techniques, such as XRD, SEM, UV–vis and FTIR. Importantly, the study evaluated the antibacterial and anti-biofilm activities of Ag NPs in two different size (12 nm and 45 nm) against MDR and biofilm-producing pathogenic bacteria, including <em>Kocuria rosea, Staphylococcus sciuri</em>, and <em>Staphylococcus lentus</em>. The antibacterial activity of the larger Ag NPs-SA (45 nm) ranging between 14–25 mm while for the smaller Ag NPs-LN (12 nm) ranging between 26–48 mm against pathogenic bacteria. The MIC values for Ag NPs-LN were between 16 - 32 µg/ml while for Ag NPs-SA were 64 µg/ml. The MIC value of the Ag NPs decreased as their size decreased, indicating higher potency against the tested bacterial strains. Furthermore, the smaller Ag NPs-LN exhibited a higher rate of biofilm inhibition that reach 88% compared to the larger Ag NPs that reach 70%. This study provides novel evidence that the enhanced antibacterial and anti-biofilm activities of Ag NPs are directly correlated with their decreased nanoscale size. These findings highlight the potential of Ag NPs as a promising adjuvant in the management of bacterial infections, particularly those involving MDR and biofilm-producing pathogens, which pose a significant challenge in clinical settings.</p></div>","PeriodicalId":37785,"journal":{"name":"OpenNano","volume":"20 ","pages":"Article 100213"},"PeriodicalIF":0.0,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352952024000148/pdfft?md5=21eddb2fd7a1aacb043580cc2e4a6bc8&pid=1-s2.0-S2352952024000148-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142048669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Date palm pollen: A novel medium for bacterial culture and biosynthesis of antibacterial chromium oxide nanoparticles","authors":"Layth L. Hamid ,&nbsp;Thamer Y. Mutter ,&nbsp;Asmiet Ramizy","doi":"10.1016/j.onano.2024.100212","DOIUrl":"10.1016/j.onano.2024.100212","url":null,"abstract":"<div><p>Medical companies and research centers seek cost-effective alternative culture media containing the necessary nutritional requirements for bacterial cultivation because of high manufacturing and production costs. Date palm pollen (DPP) is an inexpensive and rich natural plant resource that can be easily collected in large quantities. In this study, DPP was used to prepare a novel enriched culture medium that successfully cultivated pathogenic bacteria and <em>Streptomyces</em> spp. without any additives and at a low concentration of 10 g per 1 L of distilled water (DW). Active compounds in DPP were detected by GCMS–, and results show the highest ratio of urea (45 %) among other components. For the first time, DPP was used to synthesize Cr₂O₃ NPs by an environment-friendly and inexpensive green method. DPP urea plays an important role as a reducing and stabilizing agent in the biosynthesis of Cr₂O₃ NPs. The obtained NPs were characterized using UV–Vis, FTIR, XRD and SEM. The results of agar disk diffusion ranging between 12 – 20 mm while the MIC for Cr₂O₃ NPs ranging between 1.56 – 25 U/mL indicated the effectiveness of Cr₂O₃ NPs in antibacterial activity against a wide range of pathogenic bacteria. Cr₂O₃ NPs showed a high inhibition ratio that reach 78 % against biofilms produced by <em>P. aeruginosa</em>. For later studies we expect that DPP can be used to prepare selective and other culture media after adding certain materials or antibiotics. The antibacterial and anti-biofilm activity of Cr₂O₃ NPs could be promising in medical and pharmaceutical applications.</p></div>","PeriodicalId":37785,"journal":{"name":"OpenNano","volume":"19 ","pages":"Article 100212"},"PeriodicalIF":0.0,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352952024000136/pdfft?md5=0a4ce99b15e3612bbff12468c20f6103&pid=1-s2.0-S2352952024000136-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142002177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resveratrol-loaded lipid-based nanocarriers for topical delivery: Comparative physical properties and antioxidant activity","authors":"Wipada Samprasit ,&nbsp;Phuvamin Suriyaamporn ,&nbsp;Pornsak Sriamornsak ,&nbsp;Praneet Opanasopit ,&nbsp;Benchawan Chamsai","doi":"10.1016/j.onano.2024.100211","DOIUrl":"https://doi.org/10.1016/j.onano.2024.100211","url":null,"abstract":"<div><p>Resveratrol (R) is an antioxidant that helps several aspects of aging skin. However, it is slightly soluble in water and unstable under light exposure, necessitating the use of suitable formulations for improved clinical efficacy. Therefore, this study aimed to prepare R-loaded lipid-based nanocarriers for topical delivery, <em>i.e.</em>, nanostructured lipid carriers (NLCs) and nanoemulsions (NEs). R-loaded nanocarrier gels were further prepared to increase R loading. The comparative physical properties and antioxidant activity of nanocarriers were performed in terms of particle size, zeta potential, morphology, rheology, R content, <em>in vitro</em> release, antioxidant activity, cytotoxicity and stability. The results revealed that R was successfully loaded into NLCs and NE gels (NEGs), having different physical properties and antioxidant activity depending on the composition of lipid-based nanocarriers. R could be incorporated into NEs and the aqueous gelling phase, resulting in higher R loading. Furthermore, the gelling network was responsible for pseudoplastic flow behavior. The cumulative amount of R released from NEGs was significantly higher than that from NLCs due to the co-surfactant-like properties of NEGs, which resulted in smaller particle sizes. However, NLCs exhibited significantly more antioxidant activity and less cytotoxicity compared to NEGs. The stability of both nanosystems showed no significant change when stored at refrigerator temperature for over 3 months. In conclusion, the various compositions of lipid-based nanocarriers produced a range of physical properties and antioxidant activity. Nonetheless, these NLCs and NEGs have the potential to be nanocarriers for R, which has antioxidant properties for topical application.</p></div>","PeriodicalId":37785,"journal":{"name":"OpenNano","volume":"19 ","pages":"Article 100211"},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352952024000124/pdfft?md5=6ea5858529272364e129f259c6db7fc3&pid=1-s2.0-S2352952024000124-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141582757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colchicine-capped ZnO nanoparticles: Elucidation of their cytotoxicity potential against MDA-MB 231 cancer cells","authors":"Zenli Cheng ,&nbsp;Zi Yin Wong ,&nbsp;S. Ramkanth ,&nbsp;Cheng Wan Hee ,&nbsp;Mohamed Saleem TS ,&nbsp;Saminathan Kayarohanam ,&nbsp;M Yasmin Begum ,&nbsp;Kushagra Khanna ,&nbsp;Abhishek Kumar ,&nbsp;Ashok Kumar Janakiraman","doi":"10.1016/j.onano.2024.100210","DOIUrl":"10.1016/j.onano.2024.100210","url":null,"abstract":"<div><p>This research descibes a pioneering approach aimed at preparing zinc oxide nanoparticles (ZnO-NPs) with colchicine as the reducing and capping agent. Colchicine-loaded ZnO-NPs (CHZnO-NPs) were prepared by adding colchicine to the zinc sulfate heptahydrate solution. The CHZnO-NPs formulation was then characterized to determine the morphology, size, crystallinity, elemental composition and vibrational properties. Upon characterization, CHZnO-NPs were studied for their cytotoxic effect against the breast cancer cell line (MDA-MB-231). The successful biosynthesis of CHZnO-NPs was initially confirmed visually by the changes in the mixture color, from light-yellow to white cloudy. The best CHZnO-NPs formulation selected was F3, which possessed 10 mg/mL of colchicine. Formulation (F3) had the smallest mean particle diameter of 43.77 nm and the lowest zeta potential of −19.60 mV. It also had 92.21 ± 0.012 % encapsulation efficiency and 20.86 ± 0.005 % drug loading. Formulation (F3) displayed a hexagonal wurtzite structure with irregular morphology. The observation of colchicine peaks on the FTIR spectra of F3 proved the role of colchicine as a reducing and capping agent during the synthesis of ZnO-NPs. Besides, the <em>in-vitro</em> cell cytotoxicity study on the MDA-MB-231 cell line revealed a significant reduction in cell proliferation at the concentration of 25 μg of colchicine and F3. Further, studies on the cellular migration potential also demonstrated concentration-dependent activity. Overall, CHZnO-NPs were shown to be successfully synthesized via an environmental-friendly procedure and colchicine acted as a capping agent to regulate the particle size, and aggregation, in addition to its anticancer properties.</p></div>","PeriodicalId":37785,"journal":{"name":"OpenNano","volume":"18 ","pages":"Article 100210"},"PeriodicalIF":0.0,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352952024000112/pdfft?md5=cbf873dad602013c256184e72ed60d02&pid=1-s2.0-S2352952024000112-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141279759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}