Enhanced Localized Periodontitis Treatment with Azithromycin-Loaded Niosomal Thermosensitive Gels

Q2 Pharmacology, Toxicology and Pharmaceutics

OpenNano Pub Date : 2025-05-01 DOI:10.1016/j.onano.2025.100247

Kunchorn Kerdmanee , Chuencheewit Thongsiri , Nuttawut Supachawaroj , Sucharat Limsitthichaikoon

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引用次数: 0

Abstract

Periodontitis is a chronic inflammatory disease requiring localized drug delivery for sustained therapeutic action. Conventional treatments face challenges such as a rapid drug clearance and poor bioavailability. This study develops and evaluates an azithromycin-loaded niosomal thermoresponsive gel (AZG) to enhance drug retention and treatment efficacy. Azithromycin-loaded niosomes (AZN) were optimized using a 3² full factorial design with Span 60 and cholesterol, achieving nanoscale size, stable zeta potential, and high drug encapsulation. The optimized AZN was incorporated into a poloxamer 407-hyaluronic acid gel, ensuring in situ gelation and prolonged drug retention. AZG exhibited favorable gelation, biocompatibility, accelerated wound closure, enhanced cell proliferation, and significant anti-inflammatory effects (twofold IL-1β and sixfold TNF-α reduction, p < 0.05). By integrating sustained drug release with antibacterial and anti-inflammatory properties, AZG presents a promising adjunctive therapy for periodontitis, addressing key limitations of existing treatments.

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阿奇霉素负载Niosomal热敏凝胶增强局部牙周炎治疗

牙周炎是一种慢性炎症性疾病，需要局部药物输送以维持治疗作用。传统治疗面临着药物快速清除和生物利用度差等挑战。本研究开发并评价了一种装载阿奇霉素的niosomal thermoresponsive gel (AZG)，以增强药物潴留和治疗效果。采用32全因子设计优化阿奇霉素负载niosomes (AZN)，使其具有纳米级尺寸、稳定的zeta电位和高药物包封性。将优化后的AZN加入到poloxam407透明质酸凝胶中，确保原位凝胶化和延长药物保留时间。AZG具有良好的凝胶性、生物相容性、加速伤口愈合、增强细胞增殖和显著的抗炎作用(2倍的IL-1β和6倍的TNF-α减少，p <；0.05)。通过整合持续药物释放与抗菌和抗炎特性，AZG是一种很有前途的牙周炎辅助治疗方法，解决了现有治疗方法的主要局限性。

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来源期刊

OpenNano Medicine-Pharmacology (medical)

CiteScore

4.10

自引率

0.00%

发文量

审稿时长

50 days

期刊介绍： OpenNano is an internationally peer-reviewed and open access journal publishing high-quality review articles and original research papers on the burgeoning area of nanopharmaceutics and nanosized delivery systems for drugs, genes, and imaging agents. The Journal publishes basic, translational and clinical research as well as methodological papers and aims to bring together chemists, biochemists, cell biologists, material scientists, pharmaceutical scientists, pharmacologists, clinicians and all others working in this exciting and challenging area.