Green biogenic fabrication of AgNPs derived from Pulicaria jaubertii leaf extract: Investigation of antimicrobial and cytotoxic properties

Q2 Pharmacology, Toxicology and Pharmaceutics

OpenNano Pub Date : 2025-05-30 DOI:10.1016/j.onano.2025.100248

Ansam Wadia Alshameri , Bilal Abdualgalil , Mahdi Mutahar

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引用次数: 0

Abstract

"Plant-mediated synthesis of nanomaterials offers an eco-friendly and cost-effective alternative for biomedical applications. In this study, silver nanoparticles (AgNPs) were green-synthesized using a leaf extract of Pulicaria jaubertii, which served as both a reducing and stabilizing agent. The biophysical characterization of synthesized AgNPs confirmed their successful fabrication through Ultraviolet-Visible spectroscopy, Dynamic Light Scattering, Fourier Transform Infrared spectroscopy, Transmission Electron Microscopy, and Scanning Electron Microscope- Energy Dispersive X-ray Analysis. The synthesized AgNPs demonstrated potent antibacterial activity against gram-negative (Escherichia coli) and gram-positive (Staphylococcus aureus) pathogens, as evidenced by agar well diffusion, time-kill, and antibiofilm assays. Notably, the nanoparticles exhibited minimal cytotoxicity toward Peripheral Blood Mononuclear Cells and Human Red Blood Cells, underscoring their biocompatibility. These findings highlight the potential of Pulicaria jaubertii-derived AgNPs as promising candidates for antimicrobial therapies and biomedical applications."

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黄芍叶提取物AgNPs的绿色生物制备：抗菌和细胞毒性研究

“植物介导的纳米材料合成为生物医学应用提供了一种环保且具有成本效益的替代方案。在这项研究中，银纳米粒子（AgNPs）是绿色合成的，使用白芍叶提取物，作为还原剂和稳定剂。通过紫外-可见光谱、动态光散射、傅里叶变换红外光谱、透射电子显微镜和扫描电子显微镜-能量色散x射线分析，证实了合成AgNPs的生物物理特性。合成的AgNPs对革兰氏阴性（大肠杆菌）和革兰氏阳性（金黄色葡萄球菌）病原体具有有效的抗菌活性，这一点通过琼脂孔扩散、时间杀伤和抗生素膜实验得到了证明。值得注意的是，纳米颗粒对外周血单核细胞和人红细胞表现出最小的细胞毒性，强调了它们的生物相容性。这些发现突出了黄檗衍生的AgNPs作为抗菌治疗和生物医学应用的有希望的候选者的潜力。”

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

OpenNano Medicine-Pharmacology (medical)

CiteScore

4.10

自引率

0.00%

发文量

审稿时长

50 days

期刊介绍： OpenNano is an internationally peer-reviewed and open access journal publishing high-quality review articles and original research papers on the burgeoning area of nanopharmaceutics and nanosized delivery systems for drugs, genes, and imaging agents. The Journal publishes basic, translational and clinical research as well as methodological papers and aims to bring together chemists, biochemists, cell biologists, material scientists, pharmaceutical scientists, pharmacologists, clinicians and all others working in this exciting and challenging area.