Fabrication of pyrroloquinoline quinone-loaded small unilamellar vesicles through various downsizing techniques for biomedical applications

Q2 Pharmacology, Toxicology and Pharmaceutics

OpenNano Pub Date : 2024-11-01 DOI:10.1016/j.onano.2024.100216

Gerardo Garcia-Zavaleta , Daniel Mejia-Valdez , Hamed Hosseinian , Ciro A. Rodriguez , Geoffrey A. Cordell , Yadira I. Vega-Cantu , Aida Rodriguez-Garcia

{"title":"Fabrication of pyrroloquinoline quinone-loaded small unilamellar vesicles through various downsizing techniques for biomedical applications","authors":"Gerardo Garcia-Zavaleta , Daniel Mejia-Valdez , Hamed Hosseinian , Ciro A. Rodriguez , Geoffrey A. Cordell , Yadira I. Vega-Cantu , Aida Rodriguez-Garcia","doi":"10.1016/j.onano.2024.100216","DOIUrl":null,"url":null,"abstract":"<div><div>Treatment of injuries to bone structure represents a significant economic burden for health care institutions and systems worldwide. The development of tissue engineering scaffolds has expanded to include the incorporation of nanotechnology platforms such as liposomes for the efficient delivery of chemotherapeutic agents. Pyrroloquinoline quinone (PQQ) is a naturally occurring quinone with antioxidant and tissue regenerative properties. In this study, the liposome-based encapsulation of PQQ was achieved by studying the effect of different downsizing methods and lipid compositions. Liposomal sonication produced stable vesicles of sizes <200 nm. The incorporation of PQQ into the liposomes and its interactions with the lipids enhanced their stability for up to four weeks and allowed sustained release for seven weeks. The results demonstrate the ability of these systems to encapsulate PQQ with high stability, efficient entrapment, and extended release profiles for their potential use in biomedicine as a delivery system for bone tissue engineering.</div></div>","PeriodicalId":37785,"journal":{"name":"OpenNano","volume":"20 ","pages":"Article 100216"},"PeriodicalIF":0.0000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"OpenNano","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2352952024000173","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}

引用次数: 0

Abstract

Treatment of injuries to bone structure represents a significant economic burden for health care institutions and systems worldwide. The development of tissue engineering scaffolds has expanded to include the incorporation of nanotechnology platforms such as liposomes for the efficient delivery of chemotherapeutic agents. Pyrroloquinoline quinone (PQQ) is a naturally occurring quinone with antioxidant and tissue regenerative properties. In this study, the liposome-based encapsulation of PQQ was achieved by studying the effect of different downsizing methods and lipid compositions. Liposomal sonication produced stable vesicles of sizes <200 nm. The incorporation of PQQ into the liposomes and its interactions with the lipids enhanced their stability for up to four weeks and allowed sustained release for seven weeks. The results demonstrate the ability of these systems to encapsulate PQQ with high stability, efficient entrapment, and extended release profiles for their potential use in biomedicine as a delivery system for bone tissue engineering.

查看原文本刊更多论文

通过各种缩小尺寸技术制备吡咯并喹啉醌负载的小型单酰胺囊泡，用于生物医学应用

治疗骨结构损伤是全球医疗保健机构和系统的一项重大经济负担。组织工程支架的开发已扩大到包括纳米技术平台，如用于高效输送化疗药物的脂质体。吡咯喹啉醌（PQQ）是一种天然醌，具有抗氧化和组织再生特性。在这项研究中，通过研究不同的缩小方法和脂质成分的影响，实现了基于脂质体的 PQQ 包囊。脂质体超声处理可产生大小为 200 nm 的稳定囊泡。将 PQQ 加入脂质体以及 PQQ 与脂质的相互作用增强了脂质体长达四周的稳定性，并实现了长达七周的持续释放。研究结果表明，这些系统有能力封装 PQQ，使其具有高稳定性、高效夹带和延长释放的特性，从而有可能在生物医学中用作骨组织工程的给药系统。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

OpenNano Medicine-Pharmacology (medical)

CiteScore

4.10

自引率

0.00%

发文量

审稿时长

50 days

期刊介绍： OpenNano is an internationally peer-reviewed and open access journal publishing high-quality review articles and original research papers on the burgeoning area of nanopharmaceutics and nanosized delivery systems for drugs, genes, and imaging agents. The Journal publishes basic, translational and clinical research as well as methodological papers and aims to bring together chemists, biochemists, cell biologists, material scientists, pharmaceutical scientists, pharmacologists, clinicians and all others working in this exciting and challenging area.