Bioprinting最新文献_第4页

Pharmaceutical excipients: Metamorphosis from conventional formulation to 3D printing 药用辅料：从传统配方到3D打印的蜕变

Bioprinting Pub Date : 2025-12-01 Epub Date: 2025-11-12 DOI: 10.1016/j.bprint.2025.e00454

Amit Kumar Das , Akramul Ansary , Bhargab Jyoti Sahariah , Nilutpal Sharma Bora

{"title":"Pharmaceutical excipients: Metamorphosis from conventional formulation to 3D printing","authors":"Amit Kumar Das , Akramul Ansary , Bhargab Jyoti Sahariah , Nilutpal Sharma Bora","doi":"10.1016/j.bprint.2025.e00454","DOIUrl":"10.1016/j.bprint.2025.e00454","url":null,"abstract":"<div><div>Pharmaceutical excipients have undergone a paradigm shift from traditionally inert formulation components to advanced functional materials that play critical roles in drug delivery, stability, manufacturability, and therapeutic efficacy. This review explores the transformation of excipients in the context of modern pharmaceutical manufacturing, with particular emphasis on their integration into additive manufacturing technologies such as 3D printing. Novel excipients—including smart polymers, co-processed materials, bioinspired nanostructures, and environmentally sustainable agents—have demonstrated enhanced rheological, thermal, and structural properties necessary for layer-by-layer drug fabrication. These advancements support the development of complex dosage forms, personalized medicines, and controlled-release systems that cannot be achieved through conventional manufacturing. Additionally, regulatory and analytical challenges associated with novel excipients are discussed, highlighting the need for global harmonization and advanced validation methods. As pharmaceutical manufacturing continues to embrace digital and precision-driven technologies, the strategic design and application of next-generation excipients will be central to enabling scalable, safe, and patient-centric drug delivery systems.</div></div>","PeriodicalId":37770,"journal":{"name":"Bioprinting","volume":"52 ","pages":"Article e00454"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145520807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D bioprinting of self-strengthening living materials using cellulose nanofiber-producing bacteria in sodium alginate hydrogel 利用海藻酸钠水凝胶中产生纤维素纳米纤维的细菌进行自我强化生物材料的3D生物打印

Bioprinting Pub Date : 2025-11-01 Epub Date: 2025-09-26 DOI: 10.1016/j.bprint.2025.e00443

Nan Zhang , Imtiaz Qavi , Marco Araneda , Shaida Sultana Rumi , Noureddine Abidi , Sampa Halder , George Z. Tan

{"title":"3D bioprinting of self-strengthening living materials using cellulose nanofiber-producing bacteria in sodium alginate hydrogel","authors":"Nan Zhang , Imtiaz Qavi , Marco Araneda , Shaida Sultana Rumi , Noureddine Abidi , Sampa Halder , George Z. Tan","doi":"10.1016/j.bprint.2025.e00443","DOIUrl":"10.1016/j.bprint.2025.e00443","url":null,"abstract":"<div><div>Three-dimensional (3D) bioprinting has emerged as a powerful tool for fabricating engineered living materials (ELMs). Despite recent advances in controlling the spatial distribution of bacteria in hydrogel, printing bacteria-laden hydrogels into bulk 3D structures remains a significant challenge. This study presents a partial crosslinking bioprinting strategy for fabricating bacterial cellulose (BC)-based living scaffolds using sodium alginate (SA) hydrogels embedded with <em>Komagataeibacter xylinus</em>. Pre-crosslinked SA was first printed to define the scaffold outline, followed by infilling with uncrosslinked, bacteria-laden SA bioink to enable in situ BC nanofiber production. As BC nanofibers formed within the hydrogel, the scaffolds exhibited self-strengthening and self-hardening property. The effects of SA concentration and culture duration on cellulose yield, rheological properties, printability, and mechanical performance were systematically evaluated. Based on the quantitative relationship between hydrogel formulation, bacterial activity, and scaffold functionality, we optimized the bioinks to enable both high-resolution printing and efficient cellulose formation. This microbial bioprinting technique provides a robust platform for constructing functional BC-based ELMs with potential applications in biomedicine and tissue engineering.</div></div>","PeriodicalId":37770,"journal":{"name":"Bioprinting","volume":"51 ","pages":"Article e00443"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145222757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Towards intelligent cultivated/cultured meat factories: The synergy of AI, 3D bioprinting and automation in next-gen food manufacturing 迈向智能养殖/养殖肉类工厂：人工智能、3D生物打印和自动化在下一代食品制造中的协同作用

Bioprinting Pub Date : 2025-11-01 Epub Date: 2025-09-17 DOI: 10.1016/j.bprint.2025.e00441

Saumya Saraswat, Twinkle Bhargava, Juhi Landge, Kamalnayan Tibrewal

{"title":"Towards intelligent cultivated/cultured meat factories: The synergy of AI, 3D bioprinting and automation in next-gen food manufacturing","authors":"Saumya Saraswat, Twinkle Bhargava, Juhi Landge, Kamalnayan Tibrewal","doi":"10.1016/j.bprint.2025.e00441","DOIUrl":"10.1016/j.bprint.2025.e00441","url":null,"abstract":"<div><div>Global population growth, urbanization, and growing incomes have increased the need for protein, stressing the urgent need for sustainable alternatives to conventional livestock farming, which presents serious ethical, scalability, and environmental issues. Cultured meat, made by culturing animal cells under a controlled environment, is a possible alternative that can lower greenhouse gas emissions, land use, and animal suffering. However, large-scale production of cultured meat with the same texture, structure, and viability as conventional meat remains highly challenging. Even though three-dimensional (3D) bioprinting has become a crucial technique for precisely engineering meat-like, organized tissues, existing systems have hurdles with automation, repeatability, and throughput. The potential of recent (2020–2025) advancements in automation, Machine Learning (ML), and Artificial Intelligence (AI), primarily from the fields of regenerative medicine and tissue engineering, is examined in this paper along with its relevancy to large-scale cultured meat bioprinting.AI-driven process optimization, predictive modelling of cell viability and growth, real-time feedback through sensor-based control systems, robotic integration for material handling and post-processing, automated bioreactor integration, and early company adoption of AI and automation are some of the main topics. Research highlights advantages including less trial-and-error, improved accuracy with robotic systems, computer vision-based real-time print adjustments, and closed-loop feedback that requires less human engagement. The groundwork for intelligent, high-throughput \"smart bioprinting factories\" is laid by these technologies. This analysis maps out a route toward scalable, affordable cultured meat production with significant promise for industrial use and sustainable protein supply by combining advancements in AI, ML, and robotics.</div></div>","PeriodicalId":37770,"journal":{"name":"Bioprinting","volume":"51 ","pages":"Article e00441"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145098085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vitro evaluation of 3D-printed PCL/forsterite scaffolds with aligned collagen and demineralized bone matrix for cranial bone regeneration 胶原-脱矿骨基质3d打印PCL/forsterite支架用于颅骨再生的体外评价

Bioprinting Pub Date : 2025-11-01 Epub Date: 2025-09-24 DOI: 10.1016/j.bprint.2025.e00442

Fatemeh Saberi, Shohreh Mashayekhan

{"title":"In vitro evaluation of 3D-printed PCL/forsterite scaffolds with aligned collagen and demineralized bone matrix for cranial bone regeneration","authors":"Fatemeh Saberi, Shohreh Mashayekhan","doi":"10.1016/j.bprint.2025.e00442","DOIUrl":"10.1016/j.bprint.2025.e00442","url":null,"abstract":"<div><div>Developing an appropriate scaffold for cranioplasty applications remains challenging due to the high mechanical strength, controlled degradation, and support for cell migration and proliferation. Despite their common use, traditional materials such as titanium implants, bone allografts, hydroxyapatite, and poly methyl methacrylate have limitations that hinder their effectiveness. Achieving both robust mechanical performance and favorable biological properties in a single scaffold remains a significant challenge. In this study, we introduce a novel fabrication approach that combines 3D printing and directional freeze-casting to create a hybrid scaffold with enhanced structural and biological properties. A composite of polycaprolactone (PCL) and forsterite (FO) was 3D-printed to provide mechanical stability. Meanwhile, collagen and demineralized bone matrix (DBM) were freeze-cast into the pores to form radially aligned microchannels. This design enhances the biological properties and promotes cell migration by mimicking the native extracellular matrix architecture. Our results showed that adding 10 % forsterite to PCL increased the Young's modulus to 100 MPa, with 12 % degradation after one month of immersion in phosphate-buffered saline (PBS). The radially oriented collagen-DBM network supported a 2.4-fold increase in cell proliferation. Furthermore, the in vitro cell migration assay demonstrated enhanced cellular infiltration in aligned versus randomly structured scaffolds. Integrating a directional microstructure, chemical cues from ion release and DBM particles, along with a mechanically robust platform, offers a promising strategy for bone regeneration and cranioplasty applications.</div></div>","PeriodicalId":37770,"journal":{"name":"Bioprinting","volume":"51 ","pages":"Article e00442"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145159103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in polymeric nanoparticles and hydrogels in 3D bioprinting: Enhancing bioinks for tissue engineering and regenerative medicine 高分子纳米粒子和水凝胶在3D生物打印中的进展：增强组织工程和再生医学的生物墨水

Bioprinting Pub Date : 2025-11-01 Epub Date: 2025-09-13 DOI: 10.1016/j.bprint.2025.e00438

B. Pavithra , Prabhakar Singh , V Ramesh Kumar , Siva Durairaj , Saqib Hassan

{"title":"Advances in polymeric nanoparticles and hydrogels in 3D bioprinting: Enhancing bioinks for tissue engineering and regenerative medicine","authors":"B. Pavithra , Prabhakar Singh , V Ramesh Kumar , Siva Durairaj , Saqib Hassan","doi":"10.1016/j.bprint.2025.e00438","DOIUrl":"10.1016/j.bprint.2025.e00438","url":null,"abstract":"<div><div>In tissue engineering and regenerative medicine, 3D bioprinting has become a revolutionary technique that makes it possible to precisely fabricate intricate biological structures. The creation of sophisticated bioinks, especially those that include hydrogels and polymeric nanoparticles, is essential to its success. These substances promote cellular adhesion, proliferation, and differentiation by providing special physicochemical characteristics that closely resemble the natural extracellular matrix. Hydrogels offer a moist, friendly environment that promotes tissue growth, whereas polymeric nanoparticles improve the mechanical strength, printability, and controlled drug administration of bioinks. Recent developments in the creation and use of hydrogels and polymeric nanoparticles in 3D bioprinting are summarized in this review, with an emphasis on their applications in organ regeneration, wound healing, and personalized medicine<strong>.</strong> It also discusses current problems that need to be resolved in order to transform laboratory breakthroughs into clinical treatments, such as biocompatibility, structural fidelity, and standardization. The future of 3D bioprinting holds the possibility of previously unheard-of advances in functional tissue restoration and patient-specific treatment through the integration of nanotechnology, machine learning, and biomaterial science.</div></div>","PeriodicalId":37770,"journal":{"name":"Bioprinting","volume":"51 ","pages":"Article e00438"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145061760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of starch-based support material alternately extruded with gelatin-based bioinks for 3D bioprinting application 开发用于生物3D打印的淀粉基支撑材料与明胶基生物墨水交替挤压

Bioprinting Pub Date : 2025-11-01 Epub Date: 2025-09-15 DOI: 10.1016/j.bprint.2025.e00439

Pekik Wiji Prasetyaningrum, Wildan Mubarok, Takashi Kotani, Shinji Sakai

{"title":"Development of starch-based support material alternately extruded with gelatin-based bioinks for 3D bioprinting application","authors":"Pekik Wiji Prasetyaningrum, Wildan Mubarok, Takashi Kotani, Shinji Sakai","doi":"10.1016/j.bprint.2025.e00439","DOIUrl":"10.1016/j.bprint.2025.e00439","url":null,"abstract":"<div><div>The use of support materials is crucial for the 3D bioprinting of low-viscosity bioinks, which yield soft hydrogel constructs susceptible to deformation under their weight. In this study, we developed a starch-based support material that provides structural support during printing and supplies hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>), for printing cell-laden constructs from low-viscosity bioinks (4.4–53.1 mPa s at 1 s<sup>−1</sup> shear rate) composed of a gelatin derivative possessing phenolic hydroxyl moieties (gelatin-Ph), horseradish peroxidase (HRP), and cells. Importantly, the support material can be selectively and gently removed using α-amylase, a biocompatible enzyme, without harming the construct or encapsulated cells, which is a significant advancement over conventional methods of removing support systems. 3D constructs were fabricated by alternately extruding bioinks containing 5.0 w/v% gelatin-Ph and 10 U/mL HRP with a support material consisting of 16.7 w/w% starch and 10 mM H<sub>2</sub>O<sub>2</sub>. Immortalized human bone marrow-derived mesenchymal stem cells encapsulated within the constructs showed >80 % viability after printing and exhibited an elongated morphology and proliferation, while maintaining their stemness over 14 days of culture. The cells underwent osteogenic differentiation when cultured in a differentiation medium, as evidenced by the calcium deposition, alkaline phosphatase activity, and expression of osteogenic genes, demonstrating the potential of the proposed approach for tissue-engineering applications.</div></div>","PeriodicalId":37770,"journal":{"name":"Bioprinting","volume":"51 ","pages":"Article e00439"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145098084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxidized alginate-gelatin nanocomposite hydrogels incorporating MXene nanosheets for 3D bioprinting 氧化海藻酸盐-明胶纳米复合水凝胶结合MXene纳米片用于3D生物打印

Bioprinting Pub Date : 2025-11-01 Epub Date: 2025-09-17 DOI: 10.1016/j.bprint.2025.e00440

Lisa Schöbel , Mariya Tulchynska , Elmira Mohajeri , Christian Polley , Hermann Seitz , Jesus Gonzalez-Julian , Aldo R. Boccaccini

{"title":"Oxidized alginate-gelatin nanocomposite hydrogels incorporating MXene nanosheets for 3D bioprinting","authors":"Lisa Schöbel , Mariya Tulchynska , Elmira Mohajeri , Christian Polley , Hermann Seitz , Jesus Gonzalez-Julian , Aldo R. Boccaccini","doi":"10.1016/j.bprint.2025.e00440","DOIUrl":"10.1016/j.bprint.2025.e00440","url":null,"abstract":"<div><div>Electrically conductive hydrogels (ECHs) and electrical stimulation effectively regulate osteoblast attachment, proliferation, and differentiation, thus triggering bone tissue regeneration. Here, an alginate dialdehyde-gelatin (ADA-GEL) based hydrogel is modified with an electrically conductive and osteogenic 2D nanomaterial, namely MXene, to produce degradable and 3D printable nanocomposite hydrogels exhibiting electrical conductivity. The effect of MXene filler content on resulting hydrogel characteristics such as morphology, mechanical and electrical properties, swelling and degradation behavior was investigated comprehensively. The results indicate tailorable properties depending on MXene concentration, thus opening a library of ADA-GEL-MXene nanocomposite hydrogels. Moreover, the suitability of ADA-GEL-MXene hydrogels for 3D printing of grid-like scaffolds of up to 10 layers was shown. Additional 3D bioprinting studies demonstrated the applicability of the nanocomposite hydrogels as bioinks for 3D bioprinting of MG-63 osteoblast-like cells. Although the electrical conductivity was increased at higher MXene concentrations, compromised cell behavior was observed. This points to the conclusion that the concentration of MXene nanosheets must be carefully chosen depending on the required properties. Taken together, the presented ADA-GEL-MXene composite hydrogels exhibit significant potential for 3D bioprinting in bone tissue engineering and could be employed for the electrical stimulation of bone cells in the future.</div></div>","PeriodicalId":37770,"journal":{"name":"Bioprinting","volume":"51 ","pages":"Article e00440"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145159102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A systematic study of high-performance hydroxyapatite processed by vat photopolymerization additive manufacturing 还原光聚合增材制造高性能羟基磷灰石的系统研究

Bioprinting Pub Date : 2025-11-01 Epub Date: 2025-09-11 DOI: 10.1016/j.bprint.2025.e00434

Haowen Liang , Tengbo Li , Junpeng Huang , Binbin Guo , Sijing Li , Xiaoteng Chen , Shixiang Yu , Cheng Liu , Guoxian Pei , Jiaming Bai

{"title":"A systematic study of high-performance hydroxyapatite processed by vat photopolymerization additive manufacturing","authors":"Haowen Liang , Tengbo Li , Junpeng Huang , Binbin Guo , Sijing Li , Xiaoteng Chen , Shixiang Yu , Cheng Liu , Guoxian Pei , Jiaming Bai","doi":"10.1016/j.bprint.2025.e00434","DOIUrl":"10.1016/j.bprint.2025.e00434","url":null,"abstract":"<div><div>Vat photopolymerization (VPP) enables the fabrication of hydroxyapatite (HAp) with high resolution, complex geometry and interconnected porous structures. However, the inherent property characterization of the VPP-printed HAp as a comparative benchmark for peer studies is still lacking. This study systematically analyzed the performance of VPP-printed HAp with a 55 vol% solid loading, focusing on printability, fabrication quality, mechanical performance limits, reliability, and biological response. The optimized HAp slurry presented high polymerization reactivity and efficient, precise photocuring performance at 17 mJ/cm<sup>2</sup>. With a high density of 98.98 % and compacted grain boundaries, the bending strength of the HAp reached 127 MPa, surpassing the highest reported value for 3D-printing HAp by 23.3 %. In vitro studies demonstrated that the VPP-printed HAp promoted osteoblast proliferation and osteogenic differentiation. The HAp fabricated via VPP with efficient printability, controllable fabrication accuracy (within 1 %) and quality, good mechanical performance and osteogenic activity showcased its promising potential in implant fabrication for bone tissue repair.</div></div>","PeriodicalId":37770,"journal":{"name":"Bioprinting","volume":"51 ","pages":"Article e00434"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145159104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A collagen-based biomaterial ink for the digital light processing 3D printing of tough, dual-crosslinked hydrogels via post-print tannic acid treatment 一种基于胶原蛋白的生物材料墨水，用于通过打印后单宁酸处理的坚韧双交联水凝胶的数字光处理3D打印

Bioprinting Pub Date : 2025-10-01 Epub Date: 2025-06-11 DOI: 10.1016/j.bprint.2025.e00422

Christopher R. Fellin , Richard Steiner , Xiaoning Yuan , Shailly H. Jariwala

{"title":"A collagen-based biomaterial ink for the digital light processing 3D printing of tough, dual-crosslinked hydrogels via post-print tannic acid treatment","authors":"Christopher R. Fellin , Richard Steiner , Xiaoning Yuan , Shailly H. Jariwala","doi":"10.1016/j.bprint.2025.e00422","DOIUrl":"10.1016/j.bprint.2025.e00422","url":null,"abstract":"<div><div>Collagen-based biomaterial inks for digital light processing (DLP) 3D printing are particularly attractive due to their inherent biocompatibility, cell-adhesion properties, and biodegradability. However, there have been relatively few examples of collagen-based biomaterial inks without the use of synthetic co-monomers or specialized printing equipment. Furthermore, photo-crosslinked collagen hydrogels are often brittle, limiting their use in biomedical applications and regenerative medicine. In this study, we present the development of a novel collagen-based biomaterial ink for DLP 3D printing, enabling the fabrication of robust hydrogel constructs through a post-print tannic acid (TA) treatment. The biomaterial ink, composed of collagen methacrylate (ColMA) and a natural co-monomer, hyaluronic acid methacrylate (HAMA), achieves high-resolution printing of biomimetic structures. The post-print TA treatment (0.25–30 mg/mL) significantly increases mechanical strength, improves degradation rates, and reduces the size and porosity of the resulting dual-crosslinked, hybrid network structures. The biocompatibility of these constructs was assessed using adult human dermal fibroblasts, revealing optimal cell viability and adhesion at low TA concentrations (0–0.25 mg/mL). Furthermore, the antioxidant capacity of TA-treated biomaterials was evaluated, demonstrating potential for applications in environments with high reactive oxygen species (ROS). Overall, this collagen-based biomaterial ink and post-print TA treatment offers a promising solution for the DLP 3D printing of tough, biodegradable, and biocompatible constructs for biomedical applications in regenerative medicine.</div></div>","PeriodicalId":37770,"journal":{"name":"Bioprinting","volume":"50 ","pages":"Article e00422"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144279434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AI-powered transformation of pharmaceutical 3D printing: enhancing precision, efficiency, and personalization ai驱动的医药3D打印转型：提高精度、效率和个性化

Bioprinting Pub Date : 2025-10-01 Epub Date: 2025-09-03 DOI: 10.1016/j.bprint.2025.e00437

Riya Patel , Shivani Patel , Vanessa James , Yash Raj Singh , Vishruti Shah , Vishvjit Thakar , Bhupendra G. Prajapati

{"title":"AI-powered transformation of pharmaceutical 3D printing: enhancing precision, efficiency, and personalization","authors":"Riya Patel , Shivani Patel , Vanessa James , Yash Raj Singh , Vishruti Shah , Vishvjit Thakar , Bhupendra G. Prajapati","doi":"10.1016/j.bprint.2025.e00437","DOIUrl":"10.1016/j.bprint.2025.e00437","url":null,"abstract":"<div><div>Cloud computing technologies and Internet of Things systems and artificial intelligence (AI) have brought major changes to pharmaceutical 3D printing by promoting new opportunities in designing drugs and manufacturing and personalized medicine delivery. Algorithmic processing through AI improves the modeling of drugs for computation and predicts formulation stability and detects real-time defects in printed dosage forms while boosting operational efficiency. Machine learning systems help optimize printing settings to achieve consistent results and reduce material waste across production batches. The use of artificial intelligence in pharmaceutical 3D printing needs overcoming three major challenges: regulatory hurdles, standards, and data privacy concerns. To overcome these problems, regulatory authorities, pharmaceutical researchers, and technology companies must collaborate to set standards for pharmaceutical data protection as well as compliance frameworks. AI-powered software solutions employ predictive analytics to do quality control in real time, reducing the amount of manufacturing failures. This article discusses regulatory obstacles, data security issues, and standards. Furthermore, identify research gaps so that academics can continue to work on AI-based 3D printing models. The application of AI enables pharmaceutical companies to boost operational efficiency and precision capabilities as well as innovative developments that lead to advanced drug therapies adjusted for individual patients alongside contemporary production methods.</div></div>","PeriodicalId":37770,"journal":{"name":"Bioprinting","volume":"50 ","pages":"Article e00437"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145048573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0