JOJ Dermatology & Cosmetics最新文献

{"title":"Induced Auto-Regeneration with Adipose Tissue in Humans – Beyond Frontiers of Healing","authors":"M. A. Pellon","doi":"10.19080/jojdc.2020.03.555617","DOIUrl":"https://doi.org/10.19080/jojdc.2020.03.555617","url":null,"abstract":"The search for regeneration of the face and other structures of the human body has undergone several attempts, based on complex surgical techniques with the use of transplantation of fragments or limbs removed from donors, followed by the administration of immunosuppressive drugs for the rest of the patient’s life. The results of these face transplants are far from ideal and the degree of dissatisfaction in these patients is very high, leading to cases of severe depression, treatment abandonment and even suicide. In addition to technical problems such as recovery of facial mobility, transplantation of an external anatomical unit differs greatly from transplantation of an internal organ, as its immune behavior is very different. The skin represents the interface between the internal environment of our body and the external environment, therefore it has a rich defense system specialized in responding to all sorts of invaders, which makes it extremely antigenic. For this reason, the doses of immunosuppressive drugs need to be higher and constantly adjusted. We know that immunosuppressants have several side effects such as the possibility of bacterial, viral or fungal infections, with the risk of sepsis, kidney failure and even an increased incidence of malignant tumors, which adds an additional risk to a previously healthy patient [1-5].","PeriodicalId":377666,"journal":{"name":"JOJ Dermatology & Cosmetics","volume":"86 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127575544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tyrosine on Cutaneous Pigmentation - A New Therapy Line for Vitiligo","authors":"A. V.","doi":"10.19080/jojdc.2020.03.555614","DOIUrl":"https://doi.org/10.19080/jojdc.2020.03.555614","url":null,"abstract":"The topical effect of tyrosine in altering skin pigmentogenesis was studied using melanin pigment producing strain of Cryptococcus neoformans. Although the biochemical pathway is different in C. neoformans, where phenol oxidase enzyme is involved unlike tyrosinase as in the case of mammalian cell, still the findings prove the method to be reliable and reproducible. Peri-cellular absorption of tyrosine and subsequent melanogenesis were observed in treated cell of C neoformans. Further the quality of pigment produced in the cell of the organism was different from phenol oxidase induced pigment. The pigment thus offered protection to the cells from UV damage. The observation based study on tyrosine based cream in human skin and subsequent sun exposure resulted in minimal erythema and delayed pigment darkening indicating the underlying melanogenesis process. Further, the absence of erythema suggests the possible melanogenesis activation at sub-dermal level and its effect in protecting the skin from sun damage. The clinical usefulness of topical tyrosine and other scientific details are discussed in the paper. extracellular supplementation of tyrosine and its usefulness in the treatment of vitiligo. Details are presented in the paper.","PeriodicalId":377666,"journal":{"name":"JOJ Dermatology & Cosmetics","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130359100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Malignant and Pre-Malignant Skin Lesions through Screening Campaigns in a City in the Midwest of Minas Gerais-Brazil","authors":"Natália Rodrigues de Oliveira","doi":"10.19080/jojdc.2020.03.555612","DOIUrl":"https://doi.org/10.19080/jojdc.2020.03.555612","url":null,"abstract":"The increasing prevalence of skin cancer worldwide can be understood as the result of excessive exposure to solar radiation. The screening and active search of lesions, as early as its initial phase, has been shown to be the main strategy for secondary prevention and treatment of this disease. Therefore, a voluntary extension project was elaborated with the objective to diagnose and treat the main actinic diseases of the skin. The subsequent article seeks to clarify the main outcomes obtained during this process. Methods: Experience report of extension project focusing on dermatological consultation, outpatient procedures and referral to specialized services aiming at diagnosis and early treatment of skin cancer. Results: Nine screening campaigns were conducted, with a total of 332 patients, and 62% of them had some lesion of premalignant or malignant skin. Among these, the most common lesion was actinic keratosis, followed by basal cell carcinoma, squamous cell carcinoma and melanoma. Conclusion: It was evidenced that extension projects are useful tools for social transformation, because in addition to social engagement and specialized qualification for academics, it promotes health education for the population and facilitates access to secondary health care.","PeriodicalId":377666,"journal":{"name":"JOJ Dermatology & Cosmetics","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128468587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Multicenter, Randomized, Double-Blinded, Comparative Study of Two Hyaluronic Acid Filler Products for the Correction of Nasolabial Folds","authors":"K. Han","doi":"10.19080/jojdc.2020.03.555611","DOIUrl":"https://doi.org/10.19080/jojdc.2020.03.555611","url":null,"abstract":"Background: Injecting hyaluronic acid (HA) filler has become the most frequently performed minimally invasive procedure for the correction of the nasolabial fold (NLF). Understanding the property of a specific filler product is important when using HA fillers for NLFs since they differ among individuals in shape and dynamics. Objectives: To compare the efficacy and safety of two commercial HA filler products for the correction of NLFs Patients/Methods: This is a randomized, multicenter, double-blind, split-face study involving 21 Korean subjects with varying degrees of NLFs. Subjects were randomized to assign the injection with a 24 mg/mL monophasic HA gel (YS24) and a 20 mg/mL biphasic HA gel (RP20) to each NLF. Blinded independent evaluators assessed the wrinkle severity rating scale (WSRS) at 3, 12, and 24 weeks after injection. Subjects and treating investigators assessed the global aesthetic improvement scale (GAIS) at 3, 12, and 24 weeks. Any adverse events were assessed during the entire study period. Results: The baseline WSRS scores were 3.29 ± 0.56 for both NLFs. At week 24, the mean WSRS score in YS24- and RP20-treated side were 2.29 ± 0.64 and 2.33 ± 0.66, respectively. There was no statistically significant different change between YS24- and RP20-treated sides. At week 24, the mean GAIS scores of YS24- and RP20-side were 2.10 ± 0.77 and 1.57 ± 0.81, respectively. Adverse events related to the local injection site were temporary and self-limited. No serious adverse effects were observed during the entire follow-up period. Conclusion: Both HA filler products were found to be safe and effective for the correction of NLFs. The results of this spilt-face designed study confirm that YS24 is non-inferior to RP20 in correcting moderate to severe NLFs of Korean subjects. scores ≥ in the evaluating and treating WSRS scores week The five-point scale of WSRS represents severity: “none” (1 point), “mild” (2), “moderate” (3), “severe” (4), “extreme” (5). GAIS scores measure the on a five-point scale: “worsened” (-1 point), “no change” (0), “improved” (1), “much improved” (2), much improved” (3). The pretreatment photograph of each participant served as the reference image at each follow-up visit.","PeriodicalId":377666,"journal":{"name":"JOJ Dermatology & Cosmetics","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127236026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of Dystrophic Epidermolysis Bullosa with Transforming Powder Dressing","authors":"Steven P. Smith","doi":"10.19080/jojdc.2020.03.555610","DOIUrl":"https://doi.org/10.19080/jojdc.2020.03.555610","url":null,"abstract":"An 18-year-old white male with dystrophic epidermolysis bullosa predominantly involving both knees, back, buttocks and thighs had undergone long-term wound care with products including a silicone foam (Mepilex, Molnlycke Health Care, Gothenburg, Sweden) and a polymeric membrane dressing (Polymem, Ferris Manufacturing Corp., Fort Worth, TX, USA). Daily dressing changes averaging 1.5 hours in length were performed by wound care nurses, as well as a full bath with antimicrobials twice weekly. In hopes of reducing the length of daily dressing changes, as well as the significant wound pain and pruritus, a new treatment was introduced in February 2015. Transforming powder (Altrazeal, Uluru, Inc., Addison, TX, USA) was applied following the twice-weekly antimicrobial baths, initially to small wounds on the knees (in order to evaluate both patient comfort and product efficacy). By early summer 2015, both knees were completely healed. Re-epithelialization was rapid, with decreased pain and pruritus. After an unrelated hospitalization in late summer 2015 allowed for a flare of the disease, transforming powder application began on the entire knees and the back in October 2015.","PeriodicalId":377666,"journal":{"name":"JOJ Dermatology & Cosmetics","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125039970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Treatment of Ulcers with Honey-Based Topical Preparation: Five Case Reports","authors":"S. Nasrollahi","doi":"10.19080/jojdc.2020.03.555609","DOIUrl":"https://doi.org/10.19080/jojdc.2020.03.555609","url":null,"abstract":"Background and objectives: Ulcers are a global public health problem in the world, and expensive wound dressings are not universally available. Most wound patients suffer injuries that can be treated conservatively. However, the ideal dressing for the wound has not been identified. The aim of the study was to evaluate the changes in physical and morphological properties due to topical application of honey ointment on diabetic foot ulcers or cutaneous wounds. Methods: Honey ointment contained 40% honey in the lanoline base. Five patients of either sex were selected. Site of the wound, shape, size, and margin were recorded on day 0 and observed during weeks 2-3, and also to the end of healing to record the progression of granulation, scar type, shape, size, and clinical symptoms. Results: There was significant improvement in the healing process as formulation possesses antibacterial, wound cleansing, and wound healing properties. All patients showed significant improvement after 2-3 weeks with honey ointment. Conclusion: a combination of honey and lanolin may be effective in the treatment of low to moderate wounds.","PeriodicalId":377666,"journal":{"name":"JOJ Dermatology & Cosmetics","volume":"88 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126046494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acantholytic Dermatosis of the Vulva: Case Series and Review of Literature","authors":"A. Ormsby","doi":"10.19080/jojdc.2020.03.555608","DOIUrl":"https://doi.org/10.19080/jojdc.2020.03.555608","url":null,"abstract":"negative for fungi. HSV1 im munostain was negative. There was no personal or family history of Hailey-Hailey or Darier’s disease. There was no associated skin rash or dermatologic papules and vesicles in the axilla, central chest or trunk. Microscopy did not show any dysplasia or atypi cal mitoses. The clinical features personal and family history and microscopic findings were diagnostic of acantholytic dermatosis. also known as acantholytic dermatosis of the vulvocrural area, is a rare inflammatory disorder of the genital location. This review discusses the clinical and pathologic correlation of this rare entity, its differential diagnosis and a recent case series with analysis of all previous reported cases in the literature.","PeriodicalId":377666,"journal":{"name":"JOJ Dermatology & Cosmetics","volume":"101 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124119333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Treatment for Psoriasis: Therapeutic Efficiency in Patients and Antiinflammatory Effect in Vitro","authors":"I. Umbert, Leonardo Márquez-Kisinousky, Consol Farrera, Jordi. Valls, Annabel Valledor Fernández, Laura Fernández-Fernández","doi":"10.19080/jojdc.2020.03.555604","DOIUrl":"https://doi.org/10.19080/jojdc.2020.03.555604","url":null,"abstract":"Psoriasis is a chronic inflammatory disease with predominant skin and joint involvement and a worldwide distribution affecting both sexes, of any age, but more frequently in the 3rd and 4th decades of life [1]. The disease is characterized by disfiguring scaling and erythematous plaques. The severity of psoriasis is defined by the clinical form, the proportion of body surface area affected and the severity of the symptoms. Psoriatic plaques may be painful and often severely pruritic, causing a deterioration in the quality of life [2]. Medical therapy for psoriasis has classically included topical and systemic treatments such as phototherapy, retinoids, methotrexate, and cyclosporine [3]. In the last few years, biologic treatment has become the established therapeutic standard for significant improvement of the quality of life of patients with moderate to severe psoriasis [4]. The involvement of oxidative stress in the pathogenesis of psoriasis has been recently proposed. Oxidative stress is an imbalance between Abstract","PeriodicalId":377666,"journal":{"name":"JOJ Dermatology & Cosmetics","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129547365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acquired Portwine Stain in an Adult: A Case Report and Review","authors":"Sreelakshmi N Nair","doi":"10.19080/jojdc.2020.03.555601","DOIUrl":"https://doi.org/10.19080/jojdc.2020.03.555601","url":null,"abstract":"Port wine stains (PWSs) also known as nevus flammeus are vascular malformations that gets its name from its appearance mimicking “port wine” (a fortified red wine) spilled on the skin. There are congenital PWSs and acquired PWSs. It can be found anywhere on the body, the most common sites being the face, neck, scalp, arms, or legs. Herein, we present a case of an acquired port-wine stain (“Fegeler syndrome) on the lower third of the face.","PeriodicalId":377666,"journal":{"name":"JOJ Dermatology & Cosmetics","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115048993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trichostasis Spinulosa of the Heel: Unique Presentation with Characteristic Morphology","authors":"A. Ormsby","doi":"10.19080/jojdc.2020.02.555600","DOIUrl":"https://doi.org/10.19080/jojdc.2020.02.555600","url":null,"abstract":"Trichostasis Spinulosa is a peculiar lesion of the hair follicle that typically presents on the face. We present a case of a 59 years old Middle-Eastern male who presented with a dark lesion on his heel. Examination revealed a 1.7 cm well-circumscribed black necrotic plaque with surrounding overhanging border with a differential diagnosis of melanoma. Histologically, the lesion was formed by inflamed clusters of numerous small hair shafts, consistent with Trichostasis Spinulosa of the heel. We report this case because of its unusual location and unique presentation.","PeriodicalId":377666,"journal":{"name":"JOJ Dermatology & Cosmetics","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133117639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}