Induced Auto-Regeneration with Adipose Tissue in Humans – Beyond Frontiers of Healing

Abstract

The search for regeneration of the face and other structures of the human body has undergone several attempts, based on complex surgical techniques with the use of transplantation of fragments or limbs removed from donors, followed by the administration of immunosuppressive drugs for the rest of the patient’s life. The results of these face transplants are far from ideal and the degree of dissatisfaction in these patients is very high, leading to cases of severe depression, treatment abandonment and even suicide. In addition to technical problems such as recovery of facial mobility, transplantation of an external anatomical unit differs greatly from transplantation of an internal organ, as its immune behavior is very different. The skin represents the interface between the internal environment of our body and the external environment, therefore it has a rich defense system specialized in responding to all sorts of invaders, which makes it extremely antigenic. For this reason, the doses of immunosuppressive drugs need to be higher and constantly adjusted. We know that immunosuppressants have several side effects such as the possibility of bacterial, viral or fungal infections, with the risk of sepsis, kidney failure and even an increased incidence of malignant tumors, which adds an additional risk to a previously healthy patient [1-5].