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Physiological Importance of the Vitaminoid Thiocyanate and Its Influence on Hair Growth 类维生素硫氰酸酯的生理重要性及其对头发生长的影响
JOJ Dermatology & Cosmetics Pub Date : 2023-10-16 DOI: 10.19080/jojdc.2023.05.555669
Axel Kramer
{"title":"Physiological Importance of the Vitaminoid Thiocyanate and Its Influence on Hair Growth","authors":"Axel Kramer","doi":"10.19080/jojdc.2023.05.555669","DOIUrl":"https://doi.org/10.19080/jojdc.2023.05.555669","url":null,"abstract":"Thiocyanate is a physiologically and biochemically active metabolite that is not sufficiently formed by endogenous synthesis in the case of diseases, stress, malnutrition, infection, toxic influences or loss through washing out during hair washing. In these siuations, alimentary supplementation or local application become necessary depending on the objective. An important effect of thiocyanate is the stimulation of new cell formation, initially proven in cell culture and in plants by the increase in yield, later also in the animal species mink (improved coat quality), sheep (increased wool yield) and guinea pigs (stimulation of the anagen phase of hair formation). Therapeutic efficacy was even demonstrated in human alopecia areata, with 51% showing complete to good remission 12 months after completion of treatment. The growth-promoting effect was confirmed in the trichogram. The biological activity of the vitaminoid is not based on a uniform mechanism of action but is to be understood as the sum of various partial effects","PeriodicalId":377666,"journal":{"name":"JOJ Dermatology & Cosmetics","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136183443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cutaneous Adverse Drug Reactions to Antibiotics: How Much is the Extent of the Problem? 皮肤抗生素药物不良反应:问题的严重程度有多大?
JOJ Dermatology & Cosmetics Pub Date : 2023-08-25 DOI: 10.19080/jojdc.2023.05.555666
Badar Uddin Umar
{"title":"Cutaneous Adverse Drug Reactions to Antibiotics: How Much is the Extent of the Problem?","authors":"Badar Uddin Umar","doi":"10.19080/jojdc.2023.05.555666","DOIUrl":"https://doi.org/10.19080/jojdc.2023.05.555666","url":null,"abstract":"Medication-related harm or adverse drug reaction is a great global health concern today. They are frequent and, most often, devastating. With the rising incidences of drug-related adverse outcomes, it is imperative that clinicians have the knowledge and understanding of these occurrences to prevent, diagnose, and manage them properly. Skin is a very commonly affected organ system, and incidences of cutaneous adverse drug reactions are between 1-5% depending on the geographic location. Up to 60% or more of all adverse drug reactions may represent cutaneous reactions. These may fall into either of the dose-dependent or dose-independent categories. Being the most prescribed and utilized drug group, antibiotics have been implicated as one of the major drug groups causing cutaneous drug reactions. There is ample evidence that antibiotics cause severe and non-severe cutaneous adverse drug reactions. A review of the present literature was done using MEDLINE/PubMed, Google Scholar, and other search engines to gather evidence to find how extensive the problem is and how much the burden is. Which will enlighten clinicians from all backgrounds and medical students and help them deal with cutaneous adverse drug reactions more prudently","PeriodicalId":377666,"journal":{"name":"JOJ Dermatology & Cosmetics","volume":"165 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134930532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Onychomycosis: Etiopathogenesis and Clinical Characteristics 甲真菌病:病因与临床特征
JOJ Dermatology & Cosmetics Pub Date : 2021-07-02 DOI: 10.19080/jojdc.2020.04.555632
A. Romero
{"title":"Onychomycosis: Etiopathogenesis and Clinical Characteristics","authors":"A. Romero","doi":"10.19080/jojdc.2020.04.555632","DOIUrl":"https://doi.org/10.19080/jojdc.2020.04.555632","url":null,"abstract":"Onychomycosis is the most common nail disease globally, can occur at any age and is related to persistent trauma of the nail, immunosuppression, hyperhidrosis and other risk factors. Onychomycosis can be caused by dermatophytes, non-dermatophyte molds and yeasts. Recent evidence supports the presence of fungal biofilms that protect them from the immune system as well as antifungal drugs. Biofilm may explain fungal resistance and the inability to eradicate fungal chronic infection. Clinically it presents with onycholysis, nail thickening, brittleness and discoloration. This disease can have a negative and significant effect on the quality of life of patients.","PeriodicalId":377666,"journal":{"name":"JOJ Dermatology & Cosmetics","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115543441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Use of the Plasma Jet and Laser Photobiomodulation in the Treatment of Alopecia areata: Case Study 等离子体喷射和激光光生物调节在治疗斑秃中的应用:案例研究
JOJ Dermatology & Cosmetics Pub Date : 2021-04-28 DOI: 10.19080/jojdc.2021.04.555629
Alena Ribeiro Alves Peixoto Medrado
{"title":"The Use of the Plasma Jet and Laser Photobiomodulation in the Treatment of Alopecia areata: Case Study","authors":"Alena Ribeiro Alves Peixoto Medrado","doi":"10.19080/jojdc.2021.04.555629","DOIUrl":"https://doi.org/10.19080/jojdc.2021.04.555629","url":null,"abstract":"Alopecia is a dermatological disease featured by the absence or shortening strand of hair, either transitory or permanent, which negatively impacts on life quality of those people. This study aimed to report by using photo documentation the efficacy of laser photobiomodulation associated to plasma jet in treating alopecia areata of a 38 years-old woman patient. She came to a private clinic of dermo functional treatment in Salvador, Bahia, Brazil claiming for acute hair loss. It was done 14 sessions of treatment along three months associated to laser photobiomodulation therapy and Plasma Jet. As a conclusion, the comparative analysis of pictures has proved that such therapy associated with laser photobiomodulation plus plasma jet in conductive mode was efficient in treating alopecia areata .","PeriodicalId":377666,"journal":{"name":"JOJ Dermatology & Cosmetics","volume":"120 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"113969607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Efficacy and Safety of Autologous Platelet Concentrate in the Treatment of Photoaging on the Back of the Hands 自体浓缩血小板治疗手背光老化的疗效和安全性
JOJ Dermatology & Cosmetics Pub Date : 2021-04-26 DOI: 10.19080/jojdc.2021.04.555628
I. Trujillo
{"title":"Efficacy and Safety of Autologous Platelet Concentrate in the Treatment of Photoaging on the Back of the Hands","authors":"I. Trujillo","doi":"10.19080/jojdc.2021.04.555628","DOIUrl":"https://doi.org/10.19080/jojdc.2021.04.555628","url":null,"abstract":"Introduction: From the fourth decade of life (especially on the back of the hands) the skin becomes dry and brittle, spots appear, the venous network increases and soft tissues decrease. Objective: To evaluate the efficacy and safety of intradermal microinjection of autologous platelet concentrate (APC) in the treatment of rejuvenation of the back of the hands. Method: An observational, analytical and longitudinal study was carried out in 60 patients from the Hospital Clínico Quirúrgico: “Hermanos Ameijeiras”, in the period between March 1, 2017 and March 31, 2020. The treatment was applied monthly for 1 year. The final evaluation was carried out 3 months after the end of the treatment. Results: 51 women with an average age of 45 ± 4.3 years were treated. After treatment, there were significant changes in the Glogau photodamage scale (p = 0.012), in the global scale of aesthetic improvement (p <0.001) and in the scale of the degree of involvement of the volume of the hand (p = 0.018). The adverse events found were pain, inflammation and ecchymosis. The degree of satisfaction reported by the patients was good (26.6%) and very good (73.4%) (p <0.001). Conclusion: The autologous platelet concentrate proved to be effective and safe in reducing the signs of cutaneous aging on the back of the hands, associated with a high degree of patient satisfaction.","PeriodicalId":377666,"journal":{"name":"JOJ Dermatology & Cosmetics","volume":"251 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120881495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment of Brittle Nail Syndrome: Systematic Review 脆甲综合征的治疗:系统回顾
JOJ Dermatology & Cosmetics Pub Date : 2021-04-16 DOI: 10.19080/jojdc.2021.04.555627
N. Biancardi
{"title":"Treatment of Brittle Nail Syndrome: Systematic Review","authors":"N. Biancardi","doi":"10.19080/jojdc.2021.04.555627","DOIUrl":"https://doi.org/10.19080/jojdc.2021.04.555627","url":null,"abstract":"Background: The Brittle Nail Syndrome combines a series of changes in the composition and structure of the nail bed. The nail is an appendix of the skin, forming part of the integumentary system. Clinical signs of weak nail syndrome, occurs by changes in matrix and deeper layer of nails. This study aims to evaluate current treatments for fragile nail syndrome. Methods: Research was performed by consulting the PubMed, Medline and Bireme databases. The articles were selected by the following generated Mesh term: Brittle [All Fields] AND (“nails” [MeSH Terms] OR “nails” [All Fields] OR “nail” [All Fields]), and “Nails” [Mesh] AND (Review [ptyp] AND “humans” [MeSH Terms]). Results: There is no description of a single effective and predominant treatment. Given these results, we can suggest that information regarding lifestyle, profession and clinical examination represent an impact factor in the diagnosis and treatment of fragile nail syndrome. Conclusion: Although the literature is extensive, constantly updated, there is no standard of treatment for the disease. Individual aspects should be evaluated.","PeriodicalId":377666,"journal":{"name":"JOJ Dermatology & Cosmetics","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132767140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discoid Lupus Erythematosus and Vitiligo 盘状红斑狼疮和白癜风
JOJ Dermatology & Cosmetics Pub Date : 2021-03-29 DOI: 10.19080/jojdc.2021.04.555626
M. Khallaayoune
{"title":"Discoid Lupus Erythematosus and Vitiligo","authors":"M. Khallaayoune","doi":"10.19080/jojdc.2021.04.555626","DOIUrl":"https://doi.org/10.19080/jojdc.2021.04.555626","url":null,"abstract":"Patients with autoimmune conditions are more likely than others to develop additional inflammatory or disimmunity affections. Both discoid lupus eryhtematosus (DLE) and vitiligo may associate with various other autoimmune disorders. Coexistence of DLE and vitiligo in the same patient have also been reported. Understanding of this rare pathological association remains unclear and diagnosis may appear challenging as depigmentation manifests in both diseases. Through the clinical, histological and immunochemical findings of a 38-year-old patient with simultaneous DLE and vitiligo, we discuss physiopathology, diagnosis and management of this unlikely association.","PeriodicalId":377666,"journal":{"name":"JOJ Dermatology & Cosmetics","volume":"144 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126933197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vitiligo: Etiopathogenesis and Clinical Characteristics 白癜风:发病机制和临床特征
JOJ Dermatology & Cosmetics Pub Date : 2021-03-17 DOI: 10.19080/jojdc.2021.04.555630
S. Şener
{"title":"Vitiligo: Etiopathogenesis and Clinical Characteristics","authors":"S. Şener","doi":"10.19080/jojdc.2021.04.555630","DOIUrl":"https://doi.org/10.19080/jojdc.2021.04.555630","url":null,"abstract":"Vitiligo is a skin disease which can occur at any age, it is characterized by melanocyte destruction, it is manifested in the form of well-circumscribed, milky white patches of varying numbers and sizes, and although it is acquired, it can also be rarely congenital. Vitiligo is a multifactorial disease associated with genetic and non-genetic factors. Generally accepted view is the functional loss of melanocytes in the skin and its histochemical demonstration. Three basic theories have been put forward about the destruction mechanisms of melanocytes in vitiligo as autoimmune, neural and auto destruction. The most common form of vitiligo is depigmented macules which are surrounded by normal skin, completely amelanotic, milky or chalk white in colour with varying diameters, sharply circumscribed, round or oval, linear or irregular shapes. In the initial and active periods, hypopigmented areas may not be selected better than depigmented areas. Lesions grow slowly or rapidly centrifugally over time. Vitiligo macules and patches have sizes ranging from millimetres to centimetres. In fair-skinned patients, lesions cannot be seen without Wood light examination. In dark-skinned patients, the difference in contrast between the skin with vitiligo and the normal skin surrounding it is very pronounced. Although vitiligo lesions are generally asymptomatic, itching may occur especially in active lesions.","PeriodicalId":377666,"journal":{"name":"JOJ Dermatology & Cosmetics","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125048116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nail Fluorescence in COVID-19 Patients COVID-19患者指甲荧光
JOJ Dermatology & Cosmetics Pub Date : 2021-01-05 DOI: 10.19080/jojdc.2021.03.555619
Ozunal Zg
{"title":"Nail Fluorescence in COVID-19 Patients","authors":"Ozunal Zg","doi":"10.19080/jojdc.2021.03.555619","DOIUrl":"https://doi.org/10.19080/jojdc.2021.03.555619","url":null,"abstract":"and images are de-identified.","PeriodicalId":377666,"journal":{"name":"JOJ Dermatology & Cosmetics","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128449943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Increased Vitamin D Signalling Markers in the Skin of Atopic Dermatitis Patients 特应性皮炎患者皮肤中维生素D信号标志物的增加
JOJ Dermatology & Cosmetics Pub Date : 2020-12-22 DOI: 10.19080/jojdc.2020.03.555618
R. Rühl
{"title":"Increased Vitamin D Signalling Markers in the Skin of Atopic Dermatitis Patients","authors":"R. Rühl","doi":"10.19080/jojdc.2020.03.555618","DOIUrl":"https://doi.org/10.19080/jojdc.2020.03.555618","url":null,"abstract":"Serum vitamin D levels have been described to be positively or negatively affected in atopic dermatitis [1-4]. Endogenous serum as well as skin concentrations of the endogenous bioactive vitamin D receptor (VDR) ligand 1,25-dihydroxy-vitamin D3 (1,25VD3) are hard to determine using analytical techniques due to the low endogenous levels in the range of 10-12M [5]. Just ELISA / RIA techniques in combination with prior chromatography enable a reliable determination of this derivative in serum. Levels of the 1,25VD3-precursor 25-hydroxy-vitamin D3 (25VD3), which is present in higher levels in serum, can routinely be determined in serum samples. Polymorphisms of the VDR are present in patients with severe AD indicating a strong association of vitamin D-mediated signaling and AD [6]. In addition the VDR can heterodimerize with the retinoid X receptor (RXR) which ligands [7-9] were associated with positively influencing VDR-RXR-mediated signalling [10,11].","PeriodicalId":377666,"journal":{"name":"JOJ Dermatology & Cosmetics","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128838524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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