{"title":"甲真菌病:病因与临床特征","authors":"A. Romero","doi":"10.19080/jojdc.2020.04.555632","DOIUrl":null,"url":null,"abstract":"Onychomycosis is the most common nail disease globally, can occur at any age and is related to persistent trauma of the nail, immunosuppression, hyperhidrosis and other risk factors. Onychomycosis can be caused by dermatophytes, non-dermatophyte molds and yeasts. Recent evidence supports the presence of fungal biofilms that protect them from the immune system as well as antifungal drugs. Biofilm may explain fungal resistance and the inability to eradicate fungal chronic infection. Clinically it presents with onycholysis, nail thickening, brittleness and discoloration. This disease can have a negative and significant effect on the quality of life of patients.","PeriodicalId":377666,"journal":{"name":"JOJ Dermatology & Cosmetics","volume":"5 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2021-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Onychomycosis: Etiopathogenesis and Clinical Characteristics\",\"authors\":\"A. Romero\",\"doi\":\"10.19080/jojdc.2020.04.555632\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Onychomycosis is the most common nail disease globally, can occur at any age and is related to persistent trauma of the nail, immunosuppression, hyperhidrosis and other risk factors. Onychomycosis can be caused by dermatophytes, non-dermatophyte molds and yeasts. Recent evidence supports the presence of fungal biofilms that protect them from the immune system as well as antifungal drugs. Biofilm may explain fungal resistance and the inability to eradicate fungal chronic infection. Clinically it presents with onycholysis, nail thickening, brittleness and discoloration. This disease can have a negative and significant effect on the quality of life of patients.\",\"PeriodicalId\":377666,\"journal\":{\"name\":\"JOJ Dermatology & Cosmetics\",\"volume\":\"5 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-07-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"JOJ Dermatology & Cosmetics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.19080/jojdc.2020.04.555632\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"JOJ Dermatology & Cosmetics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.19080/jojdc.2020.04.555632","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Onychomycosis: Etiopathogenesis and Clinical Characteristics
Onychomycosis is the most common nail disease globally, can occur at any age and is related to persistent trauma of the nail, immunosuppression, hyperhidrosis and other risk factors. Onychomycosis can be caused by dermatophytes, non-dermatophyte molds and yeasts. Recent evidence supports the presence of fungal biofilms that protect them from the immune system as well as antifungal drugs. Biofilm may explain fungal resistance and the inability to eradicate fungal chronic infection. Clinically it presents with onycholysis, nail thickening, brittleness and discoloration. This disease can have a negative and significant effect on the quality of life of patients.
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