New Treatment for Psoriasis: Therapeutic Efficiency in Patients and Antiinflammatory Effect in Vitro

I. Umbert, Leonardo Márquez-Kisinousky, Consol Farrera, Jordi. Valls, Annabel Valledor Fernández, Laura Fernández-Fernández
{"title":"New Treatment for Psoriasis: Therapeutic Efficiency in Patients and Antiinflammatory Effect in Vitro","authors":"I. Umbert, Leonardo Márquez-Kisinousky, Consol Farrera, Jordi. Valls, Annabel Valledor Fernández, Laura Fernández-Fernández","doi":"10.19080/jojdc.2020.03.555604","DOIUrl":null,"url":null,"abstract":"Psoriasis is a chronic inflammatory disease with predominant skin and joint involvement and a worldwide distribution affecting both sexes, of any age, but more frequently in the 3rd and 4th decades of life [1]. The disease is characterized by disfiguring scaling and erythematous plaques. The severity of psoriasis is defined by the clinical form, the proportion of body surface area affected and the severity of the symptoms. Psoriatic plaques may be painful and often severely pruritic, causing a deterioration in the quality of life [2]. Medical therapy for psoriasis has classically included topical and systemic treatments such as phototherapy, retinoids, methotrexate, and cyclosporine [3]. In the last few years, biologic treatment has become the established therapeutic standard for significant improvement of the quality of life of patients with moderate to severe psoriasis [4]. The involvement of oxidative stress in the pathogenesis of psoriasis has been recently proposed. Oxidative stress is an imbalance between Abstract","PeriodicalId":377666,"journal":{"name":"JOJ Dermatology & Cosmetics","volume":"68 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"JOJ Dermatology & Cosmetics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.19080/jojdc.2020.03.555604","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1

Abstract

Psoriasis is a chronic inflammatory disease with predominant skin and joint involvement and a worldwide distribution affecting both sexes, of any age, but more frequently in the 3rd and 4th decades of life [1]. The disease is characterized by disfiguring scaling and erythematous plaques. The severity of psoriasis is defined by the clinical form, the proportion of body surface area affected and the severity of the symptoms. Psoriatic plaques may be painful and often severely pruritic, causing a deterioration in the quality of life [2]. Medical therapy for psoriasis has classically included topical and systemic treatments such as phototherapy, retinoids, methotrexate, and cyclosporine [3]. In the last few years, biologic treatment has become the established therapeutic standard for significant improvement of the quality of life of patients with moderate to severe psoriasis [4]. The involvement of oxidative stress in the pathogenesis of psoriasis has been recently proposed. Oxidative stress is an imbalance between Abstract
银屑病新疗法的临床疗效及体外抗炎作用
牛皮癣是一种慢性炎症性疾病,主要累及皮肤和关节,在世界范围内分布,影响男女,任何年龄,但更常见于30岁和40岁[1]。这种疾病的特点是毁容的鳞屑和红斑斑块。牛皮癣的严重程度由临床表现、受影响的体表面积比例和症状的严重程度来定义。银屑病斑块可能是疼痛的,经常严重瘙痒,导致生活质量恶化[2]。银屑病的医学治疗通常包括局部和全身治疗,如光疗、类维生素a、甲氨蝶呤和环孢素[3]。近年来,生物治疗已成为中重度牛皮癣患者生活质量显著改善的既定治疗标准[4]。氧化应激参与牛皮癣的发病机制最近被提出。氧化应激是一种不平衡
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信