I. Umbert, Leonardo Márquez-Kisinousky, Consol Farrera, Jordi. Valls, Annabel Valledor Fernández, Laura Fernández-Fernández
{"title":"New Treatment for Psoriasis: Therapeutic Efficiency in Patients and Antiinflammatory Effect in Vitro","authors":"I. Umbert, Leonardo Márquez-Kisinousky, Consol Farrera, Jordi. Valls, Annabel Valledor Fernández, Laura Fernández-Fernández","doi":"10.19080/jojdc.2020.03.555604","DOIUrl":null,"url":null,"abstract":"Psoriasis is a chronic inflammatory disease with predominant skin and joint involvement and a worldwide distribution affecting both sexes, of any age, but more frequently in the 3rd and 4th decades of life [1]. The disease is characterized by disfiguring scaling and erythematous plaques. The severity of psoriasis is defined by the clinical form, the proportion of body surface area affected and the severity of the symptoms. Psoriatic plaques may be painful and often severely pruritic, causing a deterioration in the quality of life [2]. Medical therapy for psoriasis has classically included topical and systemic treatments such as phototherapy, retinoids, methotrexate, and cyclosporine [3]. In the last few years, biologic treatment has become the established therapeutic standard for significant improvement of the quality of life of patients with moderate to severe psoriasis [4]. The involvement of oxidative stress in the pathogenesis of psoriasis has been recently proposed. Oxidative stress is an imbalance between Abstract","PeriodicalId":377666,"journal":{"name":"JOJ Dermatology & Cosmetics","volume":"68 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"JOJ Dermatology & Cosmetics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.19080/jojdc.2020.03.555604","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
Psoriasis is a chronic inflammatory disease with predominant skin and joint involvement and a worldwide distribution affecting both sexes, of any age, but more frequently in the 3rd and 4th decades of life [1]. The disease is characterized by disfiguring scaling and erythematous plaques. The severity of psoriasis is defined by the clinical form, the proportion of body surface area affected and the severity of the symptoms. Psoriatic plaques may be painful and often severely pruritic, causing a deterioration in the quality of life [2]. Medical therapy for psoriasis has classically included topical and systemic treatments such as phototherapy, retinoids, methotrexate, and cyclosporine [3]. In the last few years, biologic treatment has become the established therapeutic standard for significant improvement of the quality of life of patients with moderate to severe psoriasis [4]. The involvement of oxidative stress in the pathogenesis of psoriasis has been recently proposed. Oxidative stress is an imbalance between Abstract