Current Opinion in Toxicology最新文献_第5页

Plant vs. kidney: Evaluating nephrotoxicity of botanicals with the latest toxicological tools 植物与肾脏:用最新的毒理学工具评估植物药的肾毒性

IF 4.6

Current Opinion in Toxicology Pub Date : 2022-12-01 DOI: 10.1016/j.cotox.2022.100371

Adam Pearson , Stefan Gafner , Cynthia V. Rider , Michelle R. Embry , Stephen S. Ferguson , Constance A. Mitchell

{"title":"Plant vs. kidney: Evaluating nephrotoxicity of botanicals with the latest toxicological tools","authors":"Adam Pearson , Stefan Gafner , Cynthia V. Rider , Michelle R. Embry , Stephen S. Ferguson , Constance A. Mitchell","doi":"10.1016/j.cotox.2022.100371","DOIUrl":"10.1016/j.cotox.2022.100371","url":null,"abstract":"<div>Botanicals can cause nephrotoxicity via numerous mechanisms, including disrupting renal blood flow, damaging compartments along the nephron, and obstructing urinary flow. While uncommon, there are various reports of botanical-induced nephrotoxicity in the literature, such as from aristolochia (Aristolochia spp.) and rhubarb (Rheum spp.). However, at present, it is a challenge to assess the toxic potential of botanicals because their chemical composition is variable due to factors such as growing conditions and extraction techniques. Therefore, selecting a single representative sample for an in vivo study is difficult. Given the increasing use of botanicals as dietary supplements and herbal medicine, new approach methodologies (NAMs) are needed to evaluate the potential for renal toxicity to ensure public safety. Such approaches include in vitro models that use layers of physiological complexity to emulate the in vivo microenvironment, enhance the functional viability and differentiation of cell cultures, and improve sensitivity to nephrotoxic insults. Furthermore, computational tools such as physiologically based pharmacokinetic (PBPK) modeling can add confidence to these tools by simulating absorption, distribution, metabolism, and excretion. The development and implementation of NAMs for renal toxicity testing will allow specific mechanistic data to be generated, leading to a better understanding of the nephrotoxic potential of botanicals.</div>","PeriodicalId":37736,"journal":{"name":"Current Opinion in Toxicology","volume":"32 ","pages":"Article 100371"},"PeriodicalIF":4.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40433843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nephrotoxicity of flame retardants: An understudied but critical toxic endpoint 阻燃剂的肾毒性：一个尚未研究但关键的毒性终点

IF 4.6

Current Opinion in Toxicology Pub Date : 2022-12-01 DOI: 10.1016/j.cotox.2022.100359

Naomi E. Kramer , Lillie Marie A. Barnett , Brian S. Cummings

引用次数: 1

Epigenetic mechanisms of cadmium-induced nephrotoxicity 镉致肾毒性的表观遗传机制

IF 4.6

Current Opinion in Toxicology Pub Date : 2022-12-01 DOI: 10.1016/j.cotox.2022.100372

Angela H. Guo , Surinder Kumar , David B. Lombard

引用次数: 3

Erratum to “regarding missing Editorial Disclosure statements in previously published articles”–Part II “关于先前发表的文章中缺失的编辑披露声明”的勘误表-第二部分

IF 4.6

Current Opinion in Toxicology Pub Date : 2022-12-01 DOI: 10.1016/j.cotox.2022.100376

引用次数: 0

New Cause for Concern – Emerging Nephrotoxicants and Mechanisms of Renal Injury 令人担忧的新原因——新出现的肾毒性物质和肾损伤机制

IF 4.6

Current Opinion in Toxicology Pub Date : 2022-10-01 DOI: 10.1016/j.cotox.2022.100374

L. Aleksunes, Gary O'Neal Rankin, J. Manautou

引用次数: 0

Nano-encapsulation strategies to circumvent drug-induced kidney injury and targeted nanomedicines to treat kidney diseases 纳米包封策略规避药物性肾损伤和靶向纳米药物治疗肾脏疾病

IF 4.6

Current Opinion in Toxicology Pub Date : 2022-09-01 DOI: 10.1016/j.cotox.2022.100346

Garrett Davis , Anjali Kurse , Anupam Agarwal , David Sheikh-Hamad , M.N.V.Ravi Kumar

引用次数: 0

Immunotherapies and renal injury 免疫疗法和肾损伤

IF 4.6

Current Opinion in Toxicology Pub Date : 2022-09-01 DOI: 10.1016/j.cotox.2022.100362

Aisha Shaikh

{"title":"Immunotherapies and renal injury","authors":"Aisha Shaikh","doi":"10.1016/j.cotox.2022.100362","DOIUrl":"https://doi.org/10.1016/j.cotox.2022.100362","url":null,"abstract":"<div>Immunotherapy has transformed the landscape of cancer treatment. The goal of immunotherapy is to boost host-protective anti-tumor immunity. Immune checkpoint inhibitor and chimeric antigen receptor T cell (CAR-T cell) therapy have revolutionized cancer care. However, immunotherapies can cause multiorgan dysfunction including acute kidney injury (AKI). Acute tubulointerstitial nephritis (ATIN), the most common cause of AKI associated with immune checkpoint inhibitors, is caused by the overactivation of the immune system due to cytotoxic T lymphocyte-associated antigen 4 and programmed cell death receptor 1/programmed cell death ligand 1 inhibition. Early institution of corticosteroids improves kidney outcomes in immune checkpoint inhibitor-associated ATIN. CAR-T therapy can also cause AKI, and the underlying mechanism for AKI is predominantly hemodynamic, leading to poor renal perfusion. CAR-T therapy-associated AKI tends to be mild and generally reversible with hemodynamic support. Several electrolyte abnormalities have also been reported with immunotherapies. Immunotherapies are highly effective, but their use can be associated with renal toxicities. Prompt recognition and management of renal toxicities are essential in improving outcomes. Future studies are needed to shed light on the pathogenesis and management of immunotherapy-related renal injury.</div>","PeriodicalId":37736,"journal":{"name":"Current Opinion in Toxicology","volume":"31 ","pages":"Article 100362"},"PeriodicalIF":4.6,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468202022000456/pdfft?md5=896a1957b051899c6c37164463c921ed&pid=1-s2.0-S2468202022000456-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136967984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endogenous markers of kidney function and renal drug clearance processes of filtration, secretion, and reabsorption 肾脏功能和肾脏药物清除过程的内源性标志物的过滤、分泌和重吸收

IF 4.6

Current Opinion in Toxicology Pub Date : 2022-09-01 DOI: 10.1016/j.cotox.2022.03.005

Lauren E. Thompson , Melanie S. Joy

引用次数: 6

A contemporary review of nephrotoxicity and e-cigarette use 肾毒性与电子烟使用的当代综述

IF 4.6

Current Opinion in Toxicology Pub Date : 2022-09-01 DOI: 10.1016/j.cotox.2022.100361

Amna Raja , Judith T. Zelikoff , Edgar A. Jaimes

{"title":"A contemporary review of nephrotoxicity and e-cigarette use","authors":"Amna Raja , Judith T. Zelikoff , Edgar A. Jaimes","doi":"10.1016/j.cotox.2022.100361","DOIUrl":"10.1016/j.cotox.2022.100361","url":null,"abstract":"<div>Since the advent of e-cigarettes (e-cigs) as alternatives to conventional cigarette smoking, there has been a dramatic increase in their use especially among adolescents and young adults. Vaping aerosols produced by e-cigs contain a variety of toxic and carcinogenic compounds, such as volatile organic compounds (VOCs), formaldehyde and acrolein, and metals including lead and nickel. General health effects of e-cig use range from respiratory health issues, hypertension and cardiovascular disease, as well as gastrointestinal problems and cognitive and nervous system decline. Unfortunately, there remains very limited information about e-cig use and its association with renal health, despite the fact that chronic kidney disease (CKD) affects about 37 million Americans. It has been reported that cigarette smoking causes the progression of CKD, and that nicotine, a constituent of both conventional cigarettes and e-cig devices, causes renal toxicity by promoting inflammation and injury through oxidative stress-mediated pathways. This contemporary review will discuss the results of current epidemiological and experimental toxicology literature (2016–2022), as well as possible mechanisms of e-cig-induced renal injury.</div>","PeriodicalId":37736,"journal":{"name":"Current Opinion in Toxicology","volume":"31 ","pages":"Article 100361"},"PeriodicalIF":4.6,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49615982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Mechanistic basis of increased susceptibility to nephrotoxicants in chronic liver disease 慢性肝病对肾毒物易感性增加的机制基础

IF 4.6

Current Opinion in Toxicology Pub Date : 2022-09-01 DOI: 10.1016/j.cotox.2022.100347

Kayla L. Frost, Solène Marie, Nathan J. Cherrington

{"title":"Mechanistic basis of increased susceptibility to nephrotoxicants in chronic liver disease","authors":"Kayla L. Frost, Solène Marie, Nathan J. Cherrington","doi":"10.1016/j.cotox.2022.100347","DOIUrl":"10.1016/j.cotox.2022.100347","url":null,"abstract":"<div>The global prevalence of chronic liver disease (CLD) is a major public health concern due to its ability to alter the predicted pharmacokinetics of xenobiotics, which may lead to nephrotoxicity. CLD etiologies include nonalcoholic steatohepatitis (NASH), alcohol-associated liver disease (ALD), and viral hepatitis, which cause a disruption in drug disposition and elimination through hepatic dysfunction, including expression changes in drug metabolizing enzymes and transporters. While altered drug metabolizing enzymes are of critical consideration for xenobiotic disposition in CLD patients, this review will focus on membrane transporters. This altered disposition may lead to an increase in plasma retention, a decrease in biliary excretion, and result in an increase in systemic exposure to nephrotoxic compounds. Additionally, CLD can elicit changes in renal physiology, such as decreased glomerular filtration rate, further influencing the elimination mechanism of xenobiotics. Investigating the variations in pharmacokinetic profiles of nephrotoxicants because of alterations in hepatic and renal elimination processes in CLD patients is critical for the prevention of adverse drug reactions and improvement of patient outcomes.</div>","PeriodicalId":37736,"journal":{"name":"Current Opinion in Toxicology","volume":"31 ","pages":"Article 100347"},"PeriodicalIF":4.6,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48548141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1