纳米包封策略规避药物性肾损伤和靶向纳米药物治疗肾脏疾病

IF 6.1 Q1 TOXICOLOGY

Current Opinion in Toxicology Pub Date : 2022-09-01 DOI:10.1016/j.cotox.2022.100346

Garrett Davis , Anjali Kurse , Anupam Agarwal , David Sheikh-Hamad , M.N.V.Ravi Kumar

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引用次数: 0

摘要

纳米技术支持的药物递送策略近年来取得了重大进展。虽然纳米技术支持的药物递送有许多潜在的应用，但它们在肾脏相关疾病中的作用尤其重要。化学方面的创新使得纳米级的递送策略得以实现。纳米颗粒，在1-100纳米范围内的颗粒，可以用来有效地将药物引入体内，在它们通过肾脏以碎片形式离开系统之前，它们可以持续足够长的时间来引发治疗作用。我们讨论了纳米胶囊策略的最新进展，以避免药物性肾损伤和靶向纳米药物治疗肾脏疾病。

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Nano-encapsulation strategies to circumvent drug-induced kidney injury and targeted nanomedicines to treat kidney diseases

Nanotechnology-enabled drug delivery strategies have made significant advances in recent years. While there are many potential applications for nanotechnology-enabled drug delivery, their role in kidney-related conditions is especially significant. Innovations in chemistry have allowed for the creation of nano-sized delivery strategies. Nanoparticles, particles in the 1–100 nm range, can be used to effectively introduce drugs into the body where they last long enough to elicit therapeutic action before leaving the system in fragments through the kidney. We discuss recent advances in nano-encapsulation strategies to circumvent drug-induced kidney injury and targeted nanomedicines to treat kidney diseases.

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来源期刊

Current Opinion in Toxicology Pharmacology, Toxicology and Pharmaceutics-Toxicology

CiteScore

10.40

自引率

0.00%

发文量

期刊介绍： The aims and scope of Current Opinion in Toxicology is to systematically provide the reader with timely and provocative views and opinions of the highest qualified and recognized experts on current advances in selected topics within the field of toxicology. The goal is that Current Opinion in Toxicology will be an invaluable source of information and perspective for researchers, teachers, managers and administrators, policy makers and students. Division of the subject into sections: For this purpose, the scope of Toxicology is divided into six selected high impact themed sections, each of which is reviewed once a year: Mechanistic Toxicology, Metabolic Toxicology, Risk assessment in Toxicology, Genomic Toxicology, Systems Toxicology, Translational Toxicology.