Current Opinion in Toxicology最新文献_第6页

Mixture math: Deciding what to add in a cumulative risk assessment 混合数学:决定在累积风险评估中添加什么

IF 4.6

Current Opinion in Toxicology Pub Date : 2022-09-01 DOI: 10.1016/j.cotox.2022.100358

Cynthia V. Rider

引用次数: 2

Modeling the kidney with human pluripotent cells: Applications for toxicology and organ repair 用人类多能细胞模拟肾脏:毒理学和器官修复的应用

IF 4.6

Current Opinion in Toxicology Pub Date : 2022-09-01 DOI: 10.1016/j.cotox.2022.100345

SooWan Lee , Evan M. McCabe , Theodore P. Rasmussen

{"title":"Modeling the kidney with human pluripotent cells: Applications for toxicology and organ repair","authors":"SooWan Lee , Evan M. McCabe , Theodore P. Rasmussen","doi":"10.1016/j.cotox.2022.100345","DOIUrl":"10.1016/j.cotox.2022.100345","url":null,"abstract":"<div>Acute kidney damage and dysfunction is a significant medical problem that is brought about by disease or by drug-induced toxicity. Though this problem has long been recognized, our understanding of human kidney damage has relied heavily upon the use of animal models and the study of human kidneys after damage has already occurred. Recent advances in the field of stem cell research now make it possible to investigate the dynamic mechanisms of damage that occur in the kidneyin human renal cells derived from human pluripotent stem cells (hPSCs). In this review, we briefly summarize normal human kidney development and describe how this knowledge has been used to inform strategies for the directed differentiation of hPSCs to renal cell types and kidney organoids. We also review recent translational advances in the use of such platforms to investigate molecular and cellular mechanisms of nephrotoxicity and elucidation of modes of action of drug-induced kidney toxicity as mediated by specific drugs of concern. Finally, we discuss the prospects for the use of cell-based therapeutics to reverse extant kidney damage in vivo, and eventually, the goal of restoration of renal function with stem-cell-derived organs.</div>","PeriodicalId":37736,"journal":{"name":"Current Opinion in Toxicology","volume":"31 ","pages":"Article 100345"},"PeriodicalIF":4.6,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45819955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cellular and functional biomarkers of renal injury and disease 肾损伤和疾病的细胞和功能生物标志物

IF 4.6

Current Opinion in Toxicology Pub Date : 2022-09-01 DOI: 10.1016/j.cotox.2022.100348

Lawrence H. Lash

引用次数: 0

Stem cells and hormesis 干细胞和激效

IF 4.6

Current Opinion in Toxicology Pub Date : 2022-06-01 DOI: 10.1016/j.cotox.2022.03.001

Edward J. Calabrese , Evgenios Agathokleous , Rachna Kapoor , Gaurav Dhawan , Vittorio Calabrese

{"title":"Stem cells and hormesis","authors":"Edward J. Calabrese , Evgenios Agathokleous , Rachna Kapoor , Gaurav Dhawan , Vittorio Calabrese","doi":"10.1016/j.cotox.2022.03.001","DOIUrl":"10.1016/j.cotox.2022.03.001","url":null,"abstract":"<div>This paper summarizes recent findings on the occurrence of hormesis in a wide range of adult stem cells, embryonic stem cells, and induced pluripotent stem cells and their derived cells. These areas of biomedical and toxicological research are quite new, with the strong majority of hormesis publications for most of these stem cells being published within the last five years. Hormetic responses were typically assessed for key biological priorities of stem cells, including cell proliferation, cell differentiation, cell migration, and enhanced resilience in highly inflammatory micro-environments. The quantitative features of the hormesis dose/concentration responses of all types of stem cells were similar with respect to amplitude and width of the stimulation. This was also the case with non-stem cells. Mechanistic pathways for hormetic dose responses were commonly reported and assessed for general patterns across inducing agents, culture conditions, and stem cell types. The use of hormetic strategies can enhance stem-cell performance on multiple key parameters in an integrated manner that has the potential to impact public health. For example, it can affect exercise that targets muscle stem cells (satellite cells) to prevent or decelerate down age-related fragility, medical applications (preconditioning of stem cells that target damaged tissues, for example, following stroke or heart attack), and the expression and timing of age-related degenerative processes and diseases.</div>","PeriodicalId":37736,"journal":{"name":"Current Opinion in Toxicology","volume":"30 ","pages":"Article 100340"},"PeriodicalIF":4.6,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49005236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Diet and exercise in lifestyle medicine: The hormetic effects of bioactive compounds on human health 生活方式医学中的饮食和运动:生物活性化合物对人体健康的激效作用

IF 4.6

Current Opinion in Toxicology Pub Date : 2022-06-01 DOI: 10.1016/j.cotox.2022.03.003

Ilaria Peluso

引用次数: 7

The role of preconditioning in the development of resilience: Mechanistic insights 预处理在心理弹性发展中的作用:机制的见解

IF 4.6

Current Opinion in Toxicology Pub Date : 2022-06-01 DOI: 10.1016/j.cotox.2022.02.011

Jack Holcombe, Helen Weavers

引用次数: 1

Editorial overview: Hormesis and dose-response 编辑概述:激效和剂量反应

IF 4.6

Current Opinion in Toxicology Pub Date : 2022-06-01 DOI: 10.1016/j.cotox.2022.03.004

Evgenios Agathokleous, Edward J. Calabrese

引用次数: 4

Novel mechanisms underlying bioactivities of polyphenols via hormesis 多酚通过激效作用生物活性的新机制

IF 4.6

Current Opinion in Toxicology Pub Date : 2022-06-01 DOI: 10.1016/j.cotox.2022.02.010

Akira Murakami

{"title":"Novel mechanisms underlying bioactivities of polyphenols via hormesis","authors":"Akira Murakami","doi":"10.1016/j.cotox.2022.02.010","DOIUrl":"10.1016/j.cotox.2022.02.010","url":null,"abstract":"<div>Polyphenols have been found in both rodent and human studies to exhibit diverse bioactivities though the mechanisms of action underlying those beneficial functions remain to be fully elucidated. Polyphenols in animals are widely recognized as xenobiotics and known to induce adaptive responses. Essential related mechanisms include expressions of antioxidative and xenobiotic-metabolizing enzymes, and heat shock proteins. Additionally, hormesis has been recognized to be an adaptive mechanism by which mild stressors can potentiate the protective capacity of the host, while those at excessive levels are harmful or lethal. Interestingly, the hormesis-related early events in lipolysis induced by polyphenols have recently been identified. For example, both curcumin and (−)-epigallocatechin-3-gallate were found to markedly decrease the amount of triglycerides in differentiated Huh7 mouse hepatoma cells. Interestingly, oxidative and protein stresses induced by those polyphenols were also demonstrated to significantly contribute to their lipolysis effects. Moreover, the key response to lipolysis was identified as a marked decrease in intracellular ATP levels. Taken together, phytochemicals may partially exhibit their bioactivities through hormesis-related mechanisms, and this hypothesis may be supported by the fact that they often show side-effects when given at high doses.</div>","PeriodicalId":37736,"journal":{"name":"Current Opinion in Toxicology","volume":"30 ","pages":"Article 100337"},"PeriodicalIF":4.6,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44620239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Radiation hormesis in plants 植物的辐射激效

IF 4.6

Current Opinion in Toxicology Pub Date : 2022-06-01 DOI: 10.1016/j.cotox.2022.02.007

Polina Yu. Volkova, Ekaterina V. Bondarenko, Elizaveta A. Kazakova

引用次数: 19

Hormesis in plants: Its common occurrence across stresses 植物的激效:它在逆境中的常见现象

IF 4.6

Current Opinion in Toxicology Pub Date : 2022-06-01 DOI: 10.1016/j.cotox.2022.02.006

Elena A. Erofeeva

引用次数: 19