{"title":"Diet and exercise in lifestyle medicine: The hormetic effects of bioactive compounds on human health","authors":"Ilaria Peluso","doi":"10.1016/j.cotox.2022.03.003","DOIUrl":null,"url":null,"abstract":"<div><p><span><span>The present review aims to discuss the role of bioactive compounds in the context of the hormetic-based lifestyle medicine. The dose–response relationships of nutritional hormetins and exercise are non-linear and individual variability was found on the nuclear factor erythroid-2-related factor 2 (Nrf2) pathway in human studies. Other molecular pathways, epigenetic mechanisms, bioactive metabolites of dietary factors, as well as oxygen concentration, are involved in the regulation of </span>hormesis. Studies of the interactions among </span>phytochemicals, other food components, endogenous and microbial metabolites should be performed in individuals with different health, nutritional, and training status. In conclusion, lifestyle medicine implies personalized training and dietary interventions to induce resilience and avoid both oxidative and reductive stress.</p></div>","PeriodicalId":37736,"journal":{"name":"Current Opinion in Toxicology","volume":"30 ","pages":"Article 100342"},"PeriodicalIF":6.1000,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"7","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Toxicology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468202022000195","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"TOXICOLOGY","Score":null,"Total":0}
引用次数: 7
Abstract
The present review aims to discuss the role of bioactive compounds in the context of the hormetic-based lifestyle medicine. The dose–response relationships of nutritional hormetins and exercise are non-linear and individual variability was found on the nuclear factor erythroid-2-related factor 2 (Nrf2) pathway in human studies. Other molecular pathways, epigenetic mechanisms, bioactive metabolites of dietary factors, as well as oxygen concentration, are involved in the regulation of hormesis. Studies of the interactions among phytochemicals, other food components, endogenous and microbial metabolites should be performed in individuals with different health, nutritional, and training status. In conclusion, lifestyle medicine implies personalized training and dietary interventions to induce resilience and avoid both oxidative and reductive stress.
期刊介绍：
The aims and scope of Current Opinion in Toxicology is to systematically provide the reader with timely and provocative views and opinions of the highest qualified and recognized experts on current advances in selected topics within the field of toxicology. The goal is that Current Opinion in Toxicology will be an invaluable source of information and perspective for researchers, teachers, managers and administrators, policy makers and students. Division of the subject into sections: For this purpose, the scope of Toxicology is divided into six selected high impact themed sections, each of which is reviewed once a year: Mechanistic Toxicology, Metabolic Toxicology, Risk assessment in Toxicology, Genomic Toxicology, Systems Toxicology, Translational Toxicology.
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