Current Opinion in Toxicology最新文献_第10页

A systematic review of in vitro models of drug-induced kidney injury 药物性肾损伤体外模型的系统综述

IF 4.6

Current Opinion in Toxicology Pub Date : 2021-09-01 DOI: 10.1016/j.cotox.2021.06.001

Alasdair R. Irvine , Damiën van Berlo , Rawan Shekhani , Rosalinde Masereeuw

{"title":"A systematic review of in vitro models of drug-induced kidney injury","authors":"Alasdair R. Irvine , Damiën van Berlo , Rawan Shekhani , Rosalinde Masereeuw","doi":"10.1016/j.cotox.2021.06.001","DOIUrl":"10.1016/j.cotox.2021.06.001","url":null,"abstract":"<div><p>Drug-induced nephrotoxicity is a major cause of kidney dysfunction with potentially fatal consequences and can hamper the research and development of new pharmaceuticals. This emphasises the need for new methods for earlier and more accurate diagnosis to avoid drug-induced kidney injury. Here, we present a systematic review of the available approaches to study drug-induced kidney injury, as one of the most common reasons for drug withdrawal, <em>in vitro</em>. The systematic review approach was selected to ensure that our findings are as objective and reproducible as possible. A novel study quality checklist, named validation score, was developed based on published regulatory guidance and industrial perspectives, and models returned by the search strategy were analysed as per their overall complexity and the kidney region studied. Our search strategy returned 1731 articles supplemented by 337 from secondary sources, of which 57 articles met the inclusion criteria for final analysis. Our results show that the proximal tubule dominates the field (84%), followed by the glomerulus and Bowman's capsule (7%). Of all drugs investigated, the focus was most on cisplatin (n = 29, 50.1% of final inclusions). We found that with increasing model complexity the validation score increased, reflecting the value of innovative <em>in vitro</em> models. Furthermore, although the highly diverse usage of cell lines and modelling approaches prevented a strong statistical verification through a meta-analysis, our findings show the downstream potential of such approaches in personalised medicine and for rare diseases where traditional trials are not feasible.</p></div>","PeriodicalId":37736,"journal":{"name":"Current Opinion in Toxicology","volume":"27 ","pages":"Pages 18-26"},"PeriodicalIF":4.6,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cotox.2021.06.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48318638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Impact of cadmium pollution on food safety and human health 镉污染对食品安全和人体健康的影响

IF 4.6

Current Opinion in Toxicology Pub Date : 2021-09-01 DOI: 10.1016/j.cotox.2021.04.004

Ibha Suhani, Sinha Sahab, Vaibhav Srivastava, Rajeev Pratap Singh

{"title":"Impact of cadmium pollution on food safety and human health","authors":"Ibha Suhani, Sinha Sahab, Vaibhav Srivastava, Rajeev Pratap Singh","doi":"10.1016/j.cotox.2021.04.004","DOIUrl":"10.1016/j.cotox.2021.04.004","url":null,"abstract":"<div><p><span>Owing to modern-day urbanization and industrial activities, heavy metal pollution and its environmental impact have drawn the attention of the scientific community towards itself. Among all the heavy metals, cadmium is known to have no biological function, and its presence harms almost all life forms. Cadmium (Cd) has natural and anthropogenic sources of entry into the ecosystem. It is nonbiodegradable and is present in different trophic levels in the food chain, raising concern over food safety. The bioavailability, bioaccessibility, and accumulation of Cd in soil-plant systems are the main drivers of its transfer to different trophic levels via diverse routes. In the human system, bioaccumulation of Cd disrupts the antioxidant defense system due to induced </span>oxidative stress<span> as a result of reactive oxygen species generation, which further causes different ailments. This review provides an update on the effects of Cd exposure on the soil-plant system, food safety, and human health, focusing on the various mechanisms involved in cellular or molecular alterations.</span></p></div>","PeriodicalId":37736,"journal":{"name":"Current Opinion in Toxicology","volume":"27 ","pages":"Pages 1-7"},"PeriodicalIF":4.6,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cotox.2021.04.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43795173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 102

Population exposure to lead and mercury in Latin America 拉丁美洲人口对铅和汞的暴露

IF 4.6

Current Opinion in Toxicology Pub Date : 2021-09-01 DOI: 10.1016/j.cotox.2021.06.002

Jesus Olivero-Verbel, Neda Alvarez-Ortega, Maria Alcala-Orozco, Karina Caballero-Gallardo

引用次数: 5

The potential of multi-organ-on-chip models for assessment of drug disposition as alternative to animal testing 多器官芯片模型作为替代动物试验的药物处置评估的潜力

IF 4.6

Current Opinion in Toxicology Pub Date : 2021-09-01 DOI: 10.1016/j.cotox.2021.05.001

Damiën van Berlo , Evita van de Steeg , Hossein Eslami Amirabadi , Rosalinde Masereeuw

{"title":"The potential of multi-organ-on-chip models for assessment of drug disposition as alternative to animal testing","authors":"Damiën van Berlo , Evita van de Steeg , Hossein Eslami Amirabadi , Rosalinde Masereeuw","doi":"10.1016/j.cotox.2021.05.001","DOIUrl":"10.1016/j.cotox.2021.05.001","url":null,"abstract":"<div><p>The development of new medicines suffers from attrition, especially in the development pipeline. Eight out of nine drug candidates entering the clinical testing phase fail, mostly due to poor safety and efficacy. The low predictive value of animal models, used in earlier phases of drug development, for effects in humans poses a major problem. In particular, drug disposition can markedly differentiate in experimental animals versus humans. Meanwhile, classic <em>in vitro</em> methods can be used but these models lack the complexity to mimic holistic physiological processes occurring in the human body, especially organ–organ interactions. Therefore, better predictive methods to investigate drug disposition in the preclinical phase are needed, for which recent developments in multiorgan-on-chip methods are very promising. To be able to capture human physiology as good as possible, multiorgan-on-chips should feature 1) human cells endogenously expressing main transporters and metabolizing enzymes; 2) organ models relevant for exposure route; 3) individual organs-on-chip connected in a physiologically relevant manner; 4) a tight cellular barrier between the compartments; 5) organ models properly polarized in 3D; 6) allow for sampling in all major compartments; 7) constructed from materials that do not absorb or adsorb the compound of interest; 8) cells should grow in absence of fetal calf serum and Matrigel; 9) validated with a panel of compounds with known characteristics in humans; 10) an integrated computer model translating concentrations to the human situation. Here, an overview of available systems is presented and the difficult route towards a fully validated system is discussed.</p></div>","PeriodicalId":37736,"journal":{"name":"Current Opinion in Toxicology","volume":"27 ","pages":"Pages 8-17"},"PeriodicalIF":4.6,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cotox.2021.05.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44895930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Monitoring plastic pollution in the oceans 监测海洋中的塑料污染

IF 4.6

Current Opinion in Toxicology Pub Date : 2021-09-01 DOI: 10.1016/j.cotox.2021.08.005

Gal Vered , Noa Shenkar

引用次数: 9

Strength in numbers: How citizen science can upscale assessment of human exposure to plastic pollution 数量优势:公民科学如何提高对人类暴露于塑料污染的评估

IF 4.6

Current Opinion in Toxicology Pub Date : 2021-09-01 DOI: 10.1016/j.cotox.2021.08.003

Nikoline G. Oturai , Maria Bille Nielsen , Lauge Peter Westergaard Clausen , Steffen Foss Hansen , Kristian Syberg

引用次数: 2

Editorial overview: Developmental neurotoxicity of metals: What should we learn from our mistakes 编辑概述:金属的发育神经毒性:我们应该从错误中吸取什么教训

IF 4.6

Current Opinion in Toxicology Pub Date : 2021-09-01 DOI: 10.1016/j.cotox.2021.08.001

Shivani Ghaisas, Dilshan S. Harischandra

引用次数: 0

Routes of human exposure to micro(nano)plastics 人体接触微(纳米)塑料的途径

IF 4.6

Current Opinion in Toxicology Pub Date : 2021-09-01 DOI: 10.1016/j.cotox.2021.08.004

Sajjad Abbasi

引用次数: 6

Investigating the current status of COVID-19 related plastics and their potential impact on human health 调查COVID-19相关塑料的现状及其对人类健康的潜在影响

IF 4.6

Current Opinion in Toxicology Pub Date : 2021-09-01 DOI: 10.1016/j.cotox.2021.08.002

Gabriel Enrique De-la-Torre , Carlos Ivan Pizarro-Ortega , Diana Carolina Dioses-Salinas , Justine Ammendolia , Elvis D. Okoffo

引用次数: 38

Differential impact of heavy metals on neurotoxicity during development and in aging central nervous system 重金属对发育和老化中枢神经系统神经毒性的不同影响

IF 4.6

Current Opinion in Toxicology Pub Date : 2021-06-01 DOI: 10.1016/j.cotox.2021.04.003

Chandrasekhar R. Kothapalli

引用次数: 10