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Current Opinion in Toxicology最新文献

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Human and ecological health effects of nanoplastics: May not be a tiny problem 纳米塑料对人类和生态健康的影响:可能不是一个小问题
IF 4.6
Current Opinion in Toxicology Pub Date : 2021-12-01 DOI: 10.1016/j.cotox.2021.09.004
Michael F. Hughes , Haley M. Clapper , Robert M. Burgess , Kay T. Ho
{"title":"Human and ecological health effects of nanoplastics: May not be a tiny problem","authors":"Michael F. Hughes ,&nbsp;Haley M. Clapper ,&nbsp;Robert M. Burgess ,&nbsp;Kay T. Ho","doi":"10.1016/j.cotox.2021.09.004","DOIUrl":"10.1016/j.cotox.2021.09.004","url":null,"abstract":"<div><p>Nanoplastics (NPs) are present in food, soil, water, air, and personal care products, resulting in concern regarding exposure and potential adverse effects. NPs principally arise from the degradation of larger-sized plastic particles. The uptake and effects of NPs in humans are not yet known. However, recent laboratory studies have documented the uptake and adverse effects of NPs from the cellular to the community level. As NPs are in the size range of particles that can be absorbed by cells, research on these materials should be accelerated to properly assess their potential risks.</p></div>","PeriodicalId":37736,"journal":{"name":"Current Opinion in Toxicology","volume":"28 ","pages":"Pages 43-48"},"PeriodicalIF":4.6,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39766468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Any behavioral change may have physiological significance: Benign neglect in tier I neurotoxicity testing 任何行为改变都可能具有生理意义:一级神经毒性测试中的良性忽视
IF 4.6
Current Opinion in Toxicology Pub Date : 2021-12-01 DOI: 10.1016/j.cotox.2021.09.001
David V. Gauvin, Zachary J. Zimmermann
{"title":"Any behavioral change may have physiological significance: Benign neglect in tier I neurotoxicity testing","authors":"David V. Gauvin,&nbsp;Zachary J. Zimmermann","doi":"10.1016/j.cotox.2021.09.001","DOIUrl":"10.1016/j.cotox.2021.09.001","url":null,"abstract":"<div><p><span><span>There have been remarkable advances in the early identification of behavioral changes predictive of neurotoxicity induced by </span>xenobiotic administrations in laboratory animals during Tier I safety testing. By definition, this risk assessment is conducted </span><strong>before</strong> formal approval for use in humans. The intent of this regulatory-based drug approval process is to ensure public health, domestic tranquility and provide for the common defense against unwitting exposure to harmful therapeutics and promote the general welfare of human patients seeking the diagnosis, cure, mitigation, treatment, or prevention of disease. There is a contemporary movement by many researchers to diminish the threat to humans for many known toxicants to nullify, diminish and obviate the great advances in drug safety that have been established as the foundation of ‘good science’ in the drug approval process. The biggest threat to contemporary neurotoxicity screening may be emanating from inside the laboratory.</p></div>","PeriodicalId":37736,"journal":{"name":"Current Opinion in Toxicology","volume":"28 ","pages":"Pages 20-31"},"PeriodicalIF":4.6,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49605728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Adverse outcome pathways and in vitro toxicology strategies for microplastics hazard testing 微塑料危害试验的不良后果途径和体外毒理学策略
IF 4.6
Current Opinion in Toxicology Pub Date : 2021-12-01 DOI: 10.1016/j.cotox.2021.09.002
Sabina Halappanavar , Gary Mallach
{"title":"Adverse outcome pathways and in vitro toxicology strategies for microplastics hazard testing","authors":"Sabina Halappanavar ,&nbsp;Gary Mallach","doi":"10.1016/j.cotox.2021.09.002","DOIUrl":"10.1016/j.cotox.2021.09.002","url":null,"abstract":"<div><p>The human health impacts of microplastics exposure remain uncertain, though they are of growing global concern. The strategic use of the adverse outcome pathways (AOPs) framework will permit leveraging of existing knowledge on disease mechanisms of other stressors to improve our understanding of the toxicological impacts of microplastics and enable identification of key biological events within a causal framework linking microplastic exposures to adverse outcomes. Here, the AOP framework is briefly described. Considering that inflammation, oxidative stress and cytotoxicity are among the reported outcomes of microplastics exposure <em>in vitro</em> or <em>in vivo</em> and because these key events form the AOP for tissue injury, an adverse key event preceding tissue dysfunction and disease, the review describes a tiered microplastics testing strategy targeting these events. Minimum considerations for <em>in vitro</em> testing of microplastics are also summarised.</p></div>","PeriodicalId":37736,"journal":{"name":"Current Opinion in Toxicology","volume":"28 ","pages":"Pages 52-61"},"PeriodicalIF":4.6,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468202021000450/pdfft?md5=37e152a03d51bd0b1ca6d740e4b1e0c6&pid=1-s2.0-S2468202021000450-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43277005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Lipid signaling in chemotherapy-induced peripheral neuropathy 化疗诱导的周围神经病变中的脂质信号传导
IF 4.6
Current Opinion in Toxicology Pub Date : 2021-12-01 DOI: 10.1016/j.cotox.2021.08.007
Shota Yamamoto , Nobuaki Egashira
{"title":"Lipid signaling in chemotherapy-induced peripheral neuropathy","authors":"Shota Yamamoto ,&nbsp;Nobuaki Egashira","doi":"10.1016/j.cotox.2021.08.007","DOIUrl":"10.1016/j.cotox.2021.08.007","url":null,"abstract":"<div><p>Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most debilitating adverse effects observed in patients with cancer treated with neurotoxic anticancer drugs<span>. However, there are few options for the prevention and treatment of CIPN. Lipids<span><span> play essential roles in the body, as structural membrane components, energy sources, signaling molecules, and body surface barriers. Recent improvements in analytical tools and methods relevant to endogenous lipids have enabled investigation of the diverse nature of lipids in normal physiology and pathology, including their roles in acting as activators of ion channels and endogenous ligands of G protein-coupled receptors and how they affect membrane protein conformation. In this report, we summarize the crucial roles of </span>lipid signaling in CIPN pathology.</span></span></p></div>","PeriodicalId":37736,"journal":{"name":"Current Opinion in Toxicology","volume":"28 ","pages":"Pages 1-6"},"PeriodicalIF":4.6,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cotox.2021.08.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48430116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Stem cells, organoids, and organ-on-a-chip models for personalized in vitro drug testing 用于个性化体外药物测试的干细胞、类器官和器官芯片模型
IF 4.6
Current Opinion in Toxicology Pub Date : 2021-12-01 DOI: 10.1016/j.cotox.2021.08.006
Damiën van Berlo , Vivian V.T. Nguyen , Vasiliki Gkouzioti , Kirsten Leineweber , Marianne C. Verhaar , Bas W.M. van Balkom
{"title":"Stem cells, organoids, and organ-on-a-chip models for personalized in vitro drug testing","authors":"Damiën van Berlo ,&nbsp;Vivian V.T. Nguyen ,&nbsp;Vasiliki Gkouzioti ,&nbsp;Kirsten Leineweber ,&nbsp;Marianne C. Verhaar ,&nbsp;Bas W.M. van Balkom","doi":"10.1016/j.cotox.2021.08.006","DOIUrl":"10.1016/j.cotox.2021.08.006","url":null,"abstract":"<div><p>Breakthroughs in stem cell biology and microfluidics technology have opened doors to <em>in vitro</em> screening platforms for personalized testing of safety (pharmaceuticals, nutrients, chemicals) and efficacy (pharmaceuticals, nutraceuticals). Major breakthrough technologies include development of induced pluripotent stem cells, the development of induced pluripotent stem cell-derived organoids and adult stem cell-derived organoids, and the generation of organ-on-a-chip and multi-organ-on-a-chip models to mimic human physiology <em>in vitro</em>. These technologies are highly complementary and offer tremendous potential for improved efficiency in drug development and chemical safety testing. In the current review, we will provide an overview of recent advances in <em>in vitro</em> modeling for personalized drug testing based on stem cell and organ-on-a-chip technologies and illustrate how these developments will eventually lead to the replacement of animal testing. Particular focus will be on multi-organ-on-chip human disease models, which have the potential to be the gold standard of the future for the investigation of safety, toxicity, and efficacy of newly developed medicines.</p></div>","PeriodicalId":37736,"journal":{"name":"Current Opinion in Toxicology","volume":"28 ","pages":"Pages 7-14"},"PeriodicalIF":4.6,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cotox.2021.08.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49658154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Analysis of biofluid lipid changes: potential biomarkers for detecting central nervous system diseases and neurotoxicity 生物流体脂质变化分析:检测中枢神经系统疾病和神经毒性的潜在生物标志物
IF 4.6
Current Opinion in Toxicology Pub Date : 2021-12-01 DOI: 10.1016/j.cotox.2021.08.008
Fang Liu , Cheng Wang , William Slikker Jr.
{"title":"Analysis of biofluid lipid changes: potential biomarkers for detecting central nervous system diseases and neurotoxicity","authors":"Fang Liu ,&nbsp;Cheng Wang ,&nbsp;William Slikker Jr.","doi":"10.1016/j.cotox.2021.08.008","DOIUrl":"10.1016/j.cotox.2021.08.008","url":null,"abstract":"<div><p><span><span>The brain is highly enriched in lipids. A growing body of research has shown that </span>brain lipid content and composition change in various </span>neurological disorders<span><span>. In addition to brain tissues, lipid changes have been detected in cerebrospinal fluid and blood in animal models of various </span>central nervous system diseases<span><span> and patients. Altered lipid metabolism has also been observed to contribute to the development and progression of sevoflurane-induced neurotoxicity. Analyses of </span>lipid profiles have provided significant insights into the underlying mechanisms of central nervous system diseases. Assessing changes in lipid profiles in the cerebrospinal fluid and blood may provide additional information on the status of the brain in clinical settings. This mini-review summarizes the recent updates on lipids in diverse neurological conditions and discusses the application of lipid analysis to neurotoxicity assessment studies.</span></span></p></div>","PeriodicalId":37736,"journal":{"name":"Current Opinion in Toxicology","volume":"28 ","pages":"Pages 15-19"},"PeriodicalIF":4.6,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cotox.2021.08.008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42720643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microplastic pollution in drinking water 饮用水中的微塑料污染
IF 4.6
Current Opinion in Toxicology Pub Date : 2021-12-01 DOI: 10.1016/j.cotox.2021.09.003
Inga V. Kirstein , Alessio Gomiero , Jes Vollertsen
{"title":"Microplastic pollution in drinking water","authors":"Inga V. Kirstein ,&nbsp;Alessio Gomiero ,&nbsp;Jes Vollertsen","doi":"10.1016/j.cotox.2021.09.003","DOIUrl":"10.1016/j.cotox.2021.09.003","url":null,"abstract":"<div><p>Scientists have demonstrated the presence of microplastics (MPs) in tap and bottled water at various locations. On a global scale, there is still very limited information on MP pollution in drinking water. There are huge differences in reported MP concentration, but no clear conclusion can be drawn if MP content is higher in tap or bottled water. Up to date, it is not clear if these discrepancies arise from differences between the examined systems or from differences in quantification limits, the accuracy of the applied analytical techniques, or contamination during sampling, processing, and analysis. Furthermore, information on MP uptake and fate gained through animal and cell toxicity studies is very limited. To define a limit of tolerance for plastic pollution in drinking water, comparable data resulting from quality assured and controlled methods and more information on the potential uptake and fate of MPs in the human body are still needed.</p></div>","PeriodicalId":37736,"journal":{"name":"Current Opinion in Toxicology","volume":"28 ","pages":"Pages 70-75"},"PeriodicalIF":4.6,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468202021000462/pdfft?md5=499ab96ea49126e7643d39908bac2104&pid=1-s2.0-S2468202021000462-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46130127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 29
Government policies combatting plastic pollution 政府对抗塑料污染的政策
IF 4.6
Current Opinion in Toxicology Pub Date : 2021-12-01 DOI: 10.1016/j.cotox.2021.10.003
Doris Knoblauch, Linda Mederake
{"title":"Government policies combatting plastic pollution","authors":"Doris Knoblauch,&nbsp;Linda Mederake","doi":"10.1016/j.cotox.2021.10.003","DOIUrl":"https://doi.org/10.1016/j.cotox.2021.10.003","url":null,"abstract":"<div><p>This review analyzes the subject focus of 45 articles (published 2019–2021), dealing with government action to regulate plastic pollution. Policies described in the articles and introduced between 2016 and 2021 are clustered in four categories: production – consumption – disposal – circular approaches. Our results show that most published articles deal with bans on single-use plastic (SUP) items in one or more countries. While SUP bags are still the most regulated items, there is a growing number of regulations on other SUP items, such as Styrofoam products or microbeads. While policies and research focus heavily on the consumption phase, the production phase is not only under-regulated, but also under-researched.</p></div>","PeriodicalId":37736,"journal":{"name":"Current Opinion in Toxicology","volume":"28 ","pages":"Pages 87-96"},"PeriodicalIF":4.6,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468202021000619/pdfft?md5=c418c848c82500892031713a409e7110&pid=1-s2.0-S2468202021000619-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137070440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 20
Editorial overview: Plastic pollution and human health: What we know and what we should focus on 编辑概述:塑料污染与人类健康:我们知道什么，我们应该关注什么
IF 4.6
Current Opinion in Toxicology Pub Date : 2021-12-01 DOI: 10.1016/j.cotox.2021.10.004
Silvia Franzellitti
{"title":"Editorial overview: Plastic pollution and human health: What we know and what we should focus on","authors":"Silvia Franzellitti","doi":"10.1016/j.cotox.2021.10.004","DOIUrl":"10.1016/j.cotox.2021.10.004","url":null,"abstract":"","PeriodicalId":37736,"journal":{"name":"Current Opinion in Toxicology","volume":"28 ","pages":"Pages 84-86"},"PeriodicalIF":4.6,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48014259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Microplastic and nanoplastic transfer, accumulation, and toxicity in humans 微塑料和纳米塑料在人体内的转移、积累和毒性
IF 4.6
Current Opinion in Toxicology Pub Date : 2021-12-01 DOI: 10.1016/j.cotox.2021.10.001
P.A. Stapleton
{"title":"Microplastic and nanoplastic transfer, accumulation, and toxicity in humans","authors":"P.A. Stapleton","doi":"10.1016/j.cotox.2021.10.001","DOIUrl":"10.1016/j.cotox.2021.10.001","url":null,"abstract":"<div><p>Plastics impact our daily lives. Unfortunately, it is the disuse and disposal of these items that may affect us the greatest. Plastic, micro- and nano-sized particles, likely from bulk degradation, have been identified in air pollution and water sources. Recently, plastic particles have also been identified in consumable products. The purpose of this review is to identify the likely routes of human exposure, the toxicological outcomes and concerns currently reported, and provide some considerations for future assessments.</p></div>","PeriodicalId":37736,"journal":{"name":"Current Opinion in Toxicology","volume":"28 ","pages":"Pages 62-69"},"PeriodicalIF":4.6,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39720740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 21
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