{"title":"生物流体脂质变化分析:检测中枢神经系统疾病和神经毒性的潜在生物标志物","authors":"Fang Liu , Cheng Wang , William Slikker Jr.","doi":"10.1016/j.cotox.2021.08.008","DOIUrl":null,"url":null,"abstract":"<div><p><span><span>The brain is highly enriched in lipids. A growing body of research has shown that </span>brain lipid content and composition change in various </span>neurological disorders<span><span>. In addition to brain tissues, lipid changes have been detected in cerebrospinal fluid and blood in animal models of various </span>central nervous system diseases<span><span> and patients. Altered lipid metabolism has also been observed to contribute to the development and progression of sevoflurane-induced neurotoxicity. Analyses of </span>lipid profiles have provided significant insights into the underlying mechanisms of central nervous system diseases. Assessing changes in lipid profiles in the cerebrospinal fluid and blood may provide additional information on the status of the brain in clinical settings. This mini-review summarizes the recent updates on lipids in diverse neurological conditions and discusses the application of lipid analysis to neurotoxicity assessment studies.</span></span></p></div>","PeriodicalId":37736,"journal":{"name":"Current Opinion in Toxicology","volume":"28 ","pages":"Pages 15-19"},"PeriodicalIF":6.1000,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cotox.2021.08.008","citationCount":"0","resultStr":"{\"title\":\"Analysis of biofluid lipid changes: potential biomarkers for detecting central nervous system diseases and neurotoxicity\",\"authors\":\"Fang Liu , Cheng Wang , William Slikker Jr.\",\"doi\":\"10.1016/j.cotox.2021.08.008\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span><span>The brain is highly enriched in lipids. A growing body of research has shown that </span>brain lipid content and composition change in various </span>neurological disorders<span><span>. In addition to brain tissues, lipid changes have been detected in cerebrospinal fluid and blood in animal models of various </span>central nervous system diseases<span><span> and patients. Altered lipid metabolism has also been observed to contribute to the development and progression of sevoflurane-induced neurotoxicity. Analyses of </span>lipid profiles have provided significant insights into the underlying mechanisms of central nervous system diseases. Assessing changes in lipid profiles in the cerebrospinal fluid and blood may provide additional information on the status of the brain in clinical settings. This mini-review summarizes the recent updates on lipids in diverse neurological conditions and discusses the application of lipid analysis to neurotoxicity assessment studies.</span></span></p></div>\",\"PeriodicalId\":37736,\"journal\":{\"name\":\"Current Opinion in Toxicology\",\"volume\":\"28 \",\"pages\":\"Pages 15-19\"},\"PeriodicalIF\":6.1000,\"publicationDate\":\"2021-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.cotox.2021.08.008\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Opinion in Toxicology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2468202021000437\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"TOXICOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Toxicology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468202021000437","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"TOXICOLOGY","Score":null,"Total":0}
Analysis of biofluid lipid changes: potential biomarkers for detecting central nervous system diseases and neurotoxicity
The brain is highly enriched in lipids. A growing body of research has shown that brain lipid content and composition change in various neurological disorders. In addition to brain tissues, lipid changes have been detected in cerebrospinal fluid and blood in animal models of various central nervous system diseases and patients. Altered lipid metabolism has also been observed to contribute to the development and progression of sevoflurane-induced neurotoxicity. Analyses of lipid profiles have provided significant insights into the underlying mechanisms of central nervous system diseases. Assessing changes in lipid profiles in the cerebrospinal fluid and blood may provide additional information on the status of the brain in clinical settings. This mini-review summarizes the recent updates on lipids in diverse neurological conditions and discusses the application of lipid analysis to neurotoxicity assessment studies.
期刊介绍：
The aims and scope of Current Opinion in Toxicology is to systematically provide the reader with timely and provocative views and opinions of the highest qualified and recognized experts on current advances in selected topics within the field of toxicology. The goal is that Current Opinion in Toxicology will be an invaluable source of information and perspective for researchers, teachers, managers and administrators, policy makers and students. Division of the subject into sections: For this purpose, the scope of Toxicology is divided into six selected high impact themed sections, each of which is reviewed once a year: Mechanistic Toxicology, Metabolic Toxicology, Risk assessment in Toxicology, Genomic Toxicology, Systems Toxicology, Translational Toxicology.
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