Non-coding RNA Research最新文献

{"title":"Research trends and hotspots of circular RNA in cardiovascular disease: A bibliometric analysis","authors":"Zehui Xu ,&nbsp;Chong Guan ,&nbsp;Ziji Cheng ,&nbsp;Houle Zhou ,&nbsp;Wanting Qin ,&nbsp;Jiaming Feng ,&nbsp;Melisandre Wan ,&nbsp;Yihan Zhang ,&nbsp;Chengyao Jia ,&nbsp;Shuijin Shao ,&nbsp;Haidong Guo ,&nbsp;Shaoling Li ,&nbsp;Baonian Liu","doi":"10.1016/j.ncrna.2024.04.002","DOIUrl":"https://doi.org/10.1016/j.ncrna.2024.04.002","url":null,"abstract":"<div><p>From a global perspective, cardiovascular diseases (CVDs), the leading factor accounting for population mortality, and circRNAs, RNA molecules with stable closed-loop structures, have been proven to be closely related. The latent clinical value and the potential role of circRNAs in CVDs have been attracting increasing, active research interest, but bibliometric studies in this field are still lacking. Thus, in this study, we conducted a bibliometric analysis by using software such as VOSviewer, CiteSpace, Microsoft Excel, and the R package to determine the current research progress and hotspots and ultimately provide an overview of the development trends and future frontiers in this field. In our study, based on our search strategy, a total of 1206 publications published before July 31, 2023 were accessed from the WOSCC database. According to our findings, there is a notable increasing trend in global publications in the field of circRNA in CVDs. China was found to be the dominant country in terms of publication number, but a lack of high-quality articles was a significant fault. A cluster analysis on the co-cited references indicated that dilated cardiomyopathy, AMI, and cardiac hypertrophy are the greatest objects of concern. In contrast, a keywords analysis indicated that high importance has been ascribed to MI, abdominal aortic aneurysm, cell proliferation, and coronary artery diseases.</p></div>","PeriodicalId":37653,"journal":{"name":"Non-coding RNA Research","volume":"9 3","pages":"Pages 930-944"},"PeriodicalIF":5.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468054024000842/pdfft?md5=65e938041b2e9e3eb9f507cc61745c35&pid=1-s2.0-S2468054024000842-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140618705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the roles of non-coding RNAs in liver regeneration","authors":"Penghui Li ,&nbsp;Xiao Ma ,&nbsp;Di Huang ,&nbsp;Xinyu Gu","doi":"10.1016/j.ncrna.2024.04.003","DOIUrl":"https://doi.org/10.1016/j.ncrna.2024.04.003","url":null,"abstract":"<div><p>Liver regeneration (LR) is a complex process encompassing three distinct phases: priming, proliferation phase and restoration, all influenced by various regulatory factors. After liver damage or partial resection, the liver tissue demonstrates remarkable restorative capacity, driven by cellular proliferation and repair mechanisms. The essential roles of non-coding RNAs (ncRNAs), predominantly microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNA (circRNA), in regulating LR have been vastly studied. Additionally, the impact of ncRNAs on LR and their abnormal expression profiles during this process have been extensively documented. Mechanistic investigations have revealed that ncRNAs interact with genes involved in proliferation to regulate hepatocyte proliferation, apoptosis and differentiation, along with liver progenitor cell proliferation and migration. Given the significant role of ncRNAs in LR, an in-depth exploration of their involvement in the liver's self-repair capacity can reveal promising therapeutic strategies for LR and liver-related diseases. Moreover, understanding the unique regenerative potential of the adult liver and the mechanisms and regulatory factors of ncRNAs in LR are crucial for improving current treatment strategies and exploring new therapeutic approaches for various liver-related diseases. This review provides a brief overview of the LR process and the ncRNA expression profiles during this process. Furthermore, we also elaborate on the specific molecular mechanisms through which multiple key ncRNAs regulate the LR process. Finally, based on the expression characteristics of ncRNAs and their interactions with proliferation-associated genes, we explore their potential clinical application, such as developing predictive indicators reflecting liver regenerative activity and manipulating LR processes for therapeutic purposes.</p></div>","PeriodicalId":37653,"journal":{"name":"Non-coding RNA Research","volume":"9 3","pages":"Pages 945-953"},"PeriodicalIF":5.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468054024000854/pdfft?md5=3fbc294dace6e8f6b44f33f1a48bc9ee&pid=1-s2.0-S2468054024000854-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140621078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interplay between JAK/STAT pathway and non-coding RNAs in different cancers","authors":"Ammad Ahmad Farooqi ,&nbsp;Abay M. Shepetov ,&nbsp;Venera Rakhmetova ,&nbsp;Zharilkassimov Ruslan ,&nbsp;Aigul Almabayeva ,&nbsp;Saniya Saussakova ,&nbsp;Kaini Baigonova ,&nbsp;Kainish Baimaganbetova ,&nbsp;Kalmakhanov Sundetgali ,&nbsp;Gulnara Kapanova","doi":"10.1016/j.ncrna.2024.04.001","DOIUrl":"10.1016/j.ncrna.2024.04.001","url":null,"abstract":"<div><p>Progress in the identification of core multi-protein modules within JAK/STAT pathway has enabled researchers to develop a better understanding of the linchpin role of deregulated signaling cascade in carcinogenesis and metastasis. More excitingly, complex interplay between JAK/STAT pathway and non-coding RNAs has been shown to reprogramme the outcome of signaling cascade and modulate immunological responses within tumor microenvironment. Wealth of information has comprehensively illustrated that most of this complexity regulates the re-shaping of the immunological responses. Increasingly sophisticated mechanistic insights have illuminated fundamental role of STAT-signaling in polarization of macrophages to M2 phenotype that promotes disease aggressiveness. Overall, JAK/STAT signaling drives different stages of cancer ranging from cancer metastasis to the reshaping of the tumor microenvironment. JAK/STAT signaling has also been found to play role in the regulation of infiltration and activity of natural killer cells and CD4/CD8 cells by PD-L1/PD-1 signaling. In this review, we have attempted to set spotlight on regulation of JAK/STAT pathway by microRNAs, long non-coding RNAs and circular RNAs in primary tumors and metastasizing tumors. Therefore, existing knowledge gaps need to be addressed to propel this fledgling field of research to the forefront and bring lncRNAs and circRNAs to the frontline of clinical practice. Leveraging the growing momentum will enable interdisciplinary researchers to gain transition from segmented view to a fairly detailed conceptual continuum.</p></div>","PeriodicalId":37653,"journal":{"name":"Non-coding RNA Research","volume":"9 4","pages":"Pages 1009-1022"},"PeriodicalIF":5.9,"publicationDate":"2024-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468054024000830/pdfft?md5=92c96bec8288da509dfc5d09a4e70953&pid=1-s2.0-S2468054024000830-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140793804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exosomal long non-coding RNAs in cancer: Interplay, modulation, and therapeutic avenues","authors":"Rahaba Marima ,&nbsp;Afra Basera ,&nbsp;Thabiso Miya ,&nbsp;Botle Precious Damane ,&nbsp;Jeyalakshmi Kandhavelu ,&nbsp;Sheefa Mirza ,&nbsp;Clement Penny ,&nbsp;Zodwa Dlamini","doi":"10.1016/j.ncrna.2024.03.014","DOIUrl":"https://doi.org/10.1016/j.ncrna.2024.03.014","url":null,"abstract":"<div><p>In the intricate field of cancer biology, researchers are increasingly intrigued by the emerging role of exosomal long non-coding RNAs (lncRNAs) due to their multifaceted interactions, complex modulation mechanisms, and potential therapeutic applications. These exosomal lncRNAs, carried within extracellular vesicles, play a vital partin tumorigenesis and disease progression by facilitating communication networks between tumor cells and their local microenvironment, making them an ideal candidates for use in a liquid biopsy approach. However, exosomal lncRNAs remain an understudied area, especially in cancer biology. Therefore this review aims to comprehensively explore the dynamic interplay between exosomal lncRNAs and various cellular components, including interactions with tumor-stroma, immune modulation, and drug resistance mechanisms. Understanding the regulatory functions of exosomal lncRNAs in these processes can potentially unveil novel diagnostic markers and therapeutic targets for cancer. Additionally, the emergence of RNA-based therapeutics presents exciting opportunities for targeting exosomal lncRNAs, offering innovative strategies to combat cancer progression and improve treatment outcomes. Thus, this review provides insights into the current understanding of exosomal lncRNAs in cancer biology, highlighting their crucial roles, regulatory mechanisms, and the evolving landscape of therapeutic interventions. Furthermore, we have also discussed the advantage of exosomes as therapeutic carriers of lncRNAs for the development of personalized targeted therapy for cancer patients.</p></div>","PeriodicalId":37653,"journal":{"name":"Non-coding RNA Research","volume":"9 3","pages":"Pages 887-900"},"PeriodicalIF":5.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468054024000829/pdfft?md5=4acfdc1f84aabd3c8689bb2a33b39452&pid=1-s2.0-S2468054024000829-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140537089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the crosstalk: circRNAs and the wnt signaling pathway in cancers of the digestive system","authors":"Yu Zhang,&nbsp;Cheng Zhang,&nbsp;Chuanhui Peng,&nbsp;Junjun Jia","doi":"10.1016/j.ncrna.2024.03.004","DOIUrl":"https://doi.org/10.1016/j.ncrna.2024.03.004","url":null,"abstract":"<div><p>Circular RNA (circRNA) is a unique type of noncoding RNA molecule characterized by its closed-loop structure. Functionally versatile, circRNAs play pivotal roles in gene expression regulation, protein activity modulation, and participation in cell signaling processes. In the context of cancers of the digestive system, the Wnt signaling pathway holds particular significance. Anomalous activation of the Wnt pathway serves as a primary catalyst for the development of colorectal cancer. Extensive research underscores the notable participation of circRNAs associated with the Wnt pathway in the progression of digestive system tumors. These circRNAs exhibit pronounced dysregulation across esophageal cancer, gastric cancer, liver cancer, colorectal cancer, pancreatic cancer, and cholangiocarcinoma. Furthermore, the altered expression of circRNAs linked to the Wnt pathway correlates with prognostic factors in digestive system tumors. Additionally, circRNAs related to the Wnt pathway showcase potential as diagnostic, therapeutic, and prognostic markers within the realm of digestive system tumors. This comprehensive review outlines the interplay between circRNAs and the Wnt signaling pathway in cancers of the digestive system. It seeks to provide a comprehensive perspective on their association while delving into ongoing research that explores the clinical applications of circRNAs associated with the Wnt pathway.</p></div>","PeriodicalId":37653,"journal":{"name":"Non-coding RNA Research","volume":"9 3","pages":"Pages 853-864"},"PeriodicalIF":5.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468054024000507/pdfft?md5=85ced59c150b43567f5dfc4b145f2ca4&pid=1-s2.0-S2468054024000507-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140341273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"microRNA 21 and long non-coding RNAs interplays underlie cancer pathophysiology: A narrative review","authors":"Roberta Giordo ,&nbsp;Fatemeh Abdullah M. Ahmadi ,&nbsp;Nedal Al Husaini ,&nbsp;Noora Rashid A.M. Al-Nuaimi ,&nbsp;Salma M.S. Ahmad ,&nbsp;Gianfranco Pintus ,&nbsp;Hatem Zayed","doi":"10.1016/j.ncrna.2024.03.013","DOIUrl":"https://doi.org/10.1016/j.ncrna.2024.03.013","url":null,"abstract":"<div><p>Non-coding RNAs (ncRNAs) are a diverse group of functional RNA molecules that lack the ability to code for proteins. Despite missing this traditional role, ncRNAs have emerged as crucial regulators of various biological processes and have been implicated in the development and progression of many diseases, including cancer. MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are two prominent classes of ncRNAs that have emerged as key players in cancer pathophysiology. In particular, miR-21 has been reported to exhibit oncogenic roles in various forms of human cancer, including prostate, breast, lung, and colorectal cancer. In this context, miR-21 overexpression is closely associated with tumor proliferation, growth, invasion, angiogenesis, and chemoresistance, whereas miR-21 inactivation is linked to the regression of most tumor-related processes. Accordingly, miR-21 is a crucial modulator of various canonical oncogenic pathways such as PTEN/PI3K/Akt, Wnt/β-catenin, STAT, p53, MMP2, and MMP9. Moreover, interplays between lncRNA and miRNA further complicate the regulatory mechanisms underlying tumor development and progression. In this regard, several lncRNAs have been found to interact with miR-21 and, by functioning as competitive endogenous RNAs (ceRNAs) or miRNA sponges, can modulate cancer tumorigenesis. This work presents and discusses recent findings highlighting the roles and pathophysiological implications of the miR-21-lncRNA regulatory axis in cancer occurrence, development, and progression. The data collected indicate that specific lncRNAs, such as MEG3, CASC2, and GAS5, are strongly associated with miR-21 in various types of cancer, including gastric, cervical, lung, and glioma. Indeed, these lncRNAs are well-known tumor suppressors and are commonly downregulated in different types of tumors. Conversely, by modulating various mechanisms and oncogenic signaling pathways, their overexpression has been linked with preventing tumor formation and development. This review highlights the significance of these regulatory pathways in cancer and their potential for use in cancer therapy as diagnostic and prognostic markers.</p></div>","PeriodicalId":37653,"journal":{"name":"Non-coding RNA Research","volume":"9 3","pages":"Pages 831-852"},"PeriodicalIF":5.0,"publicationDate":"2024-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468054024000817/pdfft?md5=e87eb180c32dd89144ac6bbe478c13e9&pid=1-s2.0-S2468054024000817-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140341395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exosomal LINC00853 promotes progression of gastric cancer via the MAP17/PDZK1/AKT signaling pathway","authors":"Jung-ho Yoon ,&nbsp;Hyo Joo Byun ,&nbsp;Seo Yeon Kim,&nbsp;Da Hyun Jung,&nbsp;Sang Kil Lee","doi":"10.1016/j.ncrna.2024.03.011","DOIUrl":"https://doi.org/10.1016/j.ncrna.2024.03.011","url":null,"abstract":"<div><p>Although rare, there is ongoing research into biomarkers that predict the onset and recurrence of gastric cancer, particularly focusing on substances found in exosomes. Long non-coding RNAs (lncRNAs) have garnered attention for their potential in diagnosing gastric cancer.</p><p>This study investigates the role of lncRNAs in gastric cancer, focusing on their presence in exosomes as potential biomarkers for the disease's onset and recurrence. We utilized the ArrayStar Human LncRNA array 2.0 to analyze lncRNA expression in tissues from early-stage gastric cancer patients. Our analysis highlighted LINC00853, which was significantly upregulated in cancer tissues and implicated in promoting epithelial-mesenchymal transition via the MAP17/PDZK1/AKT pathway. Functional studies on AGS and MKN74 gastric cancer cell lines demonstrated that LINC00853 facilitates cell proliferation, invasion, and migration. Additionally, RNA immunoprecipitation and electrophoretic mobility shift assays confirmed LINC00853 interaction with MAP17. Importantly, LINC00853 was also detected in exosomes from both patient samples and cell lines, and its downregulation led to decreased tumorigenicity in AGS cells. These findings suggest that both cellular and exosomal LINC00853 contribute to gastric cancer pathogenesis and may serve as valuable biomarkers for the disease.</p></div>","PeriodicalId":37653,"journal":{"name":"Non-coding RNA Research","volume":"9 3","pages":"Pages 876-886"},"PeriodicalIF":5.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468054024000799/pdfft?md5=a8802e49efd6400e67a9b23a9165ab30&pid=1-s2.0-S2468054024000799-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140344160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced approaches of the use of circRNAs as a replacement for cancer therapy","authors":"Goran Sedeeq Hama Faraj ,&nbsp;Bashdar Mahmud Hussen ,&nbsp;Snur Rasool Abdullah ,&nbsp;Mohammed Fatih Rasul ,&nbsp;Yasaman Hajiesmaeili ,&nbsp;Aria Baniahmad ,&nbsp;Mohammad Taheri","doi":"10.1016/j.ncrna.2024.03.012","DOIUrl":"https://doi.org/10.1016/j.ncrna.2024.03.012","url":null,"abstract":"<div><p>Cancer is a broad name for a group of diseases in which abnormal cells grow out of control and are characterized by their complexity and recurrence. Although there has been progress in cancer therapy with the entry of precision medicine and immunotherapy, cancer incidence rates have increased globally. Non-coding RNAs in the form of circular RNAs (circRNAs) play crucial roles in the pathogenesis, clinical diagnosis, and therapy of different diseases, including cancer. According to recent studies, circRNAs appear to serve as accurate indicators and therapeutic targets for cancer treatment. However, circRNAs are promising candidates for cutting-edge cancer therapy because of their distinctive circular structure, stability, and wide range of capabilities; many challenges persist that decrease the applications of circRNA-based cancer therapeutics. Here, we explore the roles of circRNAs as a replacement for cancer therapy, highlight the main challenges facing circRNA-based cancer therapies, and discuss the key strategies to overcome these challenges to improve advanced innovative therapies based on circRNAs with long-term health effects.</p></div>","PeriodicalId":37653,"journal":{"name":"Non-coding RNA Research","volume":"9 3","pages":"Pages 811-830"},"PeriodicalIF":5.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468054024000805/pdfft?md5=b41044cae7041854d1ec44394c7fe920&pid=1-s2.0-S2468054024000805-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140339346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long non-coding RNA LIP interacts with PARP-1 influencing the efficiency of base excision repair","authors":"You Zuo ,&nbsp;Jiaqian He ,&nbsp;Zheng Zhou ,&nbsp;Jingjing Sun ,&nbsp;Can Ouyang ,&nbsp;Hui Huang ,&nbsp;Yajuan Wang ,&nbsp;Hairong Liu ,&nbsp;Simon H. Reed","doi":"10.1016/j.ncrna.2024.03.010","DOIUrl":"https://doi.org/10.1016/j.ncrna.2024.03.010","url":null,"abstract":"<div><p>In recent years, various long non-coding RNAs (lncRNAs) involved in DNA damage response (DDR) have been identified and studied to deepen our understanding. However, there are rare reports on the association between lncRNAs and base excision repair (BER). Our designed DNA microarray identified dozens of functionally unknown lncRNAs, and their transcription levels significantly increased upon exposure to DNA damage inducers. One of them, named <em>LIP</em> (<u>L</u>ong noncoding RNA <u>I</u>nteracts with <u>P</u>ARP-1), exhibited a significant alteration in transcription in response to methyl methanesulfonate (MMS) and temozolomide (TMZ) treatments. <em>LIP</em> knockdown or knockout cell lines are sensitive to MMS and TMZ, indicating that <em>LIP</em> plays a crucial role in DDR. The loss or insufficiency of <em>LIP</em> significantly influences the efficiency of BER in human cells, and it suggests that <em>LIP</em> participates in the BER pathway. The interaction between <em>LIP</em> and a key factor in BER, poly (ADP-ribose) polymerase 1 (PARP-1), has been confirmed. We identified and characterized <em>LIP</em>, a lncRNA, which is involved in DDR, significantly influences BER efficiency, and interacts with the BER key factor PARP-1. This advances our understanding of the connection between lncRNAs and BER, presenting the potential for the discovery of new drug targets.</p></div>","PeriodicalId":37653,"journal":{"name":"Non-coding RNA Research","volume":"9 3","pages":"Pages 649-658"},"PeriodicalIF":5.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S246805402400060X/pdfft?md5=4d3b5f2ca090bfd62f241b1dab10f075&pid=1-s2.0-S246805402400060X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140328853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Crosstalk between non-coding RNAs and transcription factor LRF in non-small cell lung cancer”","authors":"Magda Spella ,&nbsp;Eleftherios Bochalis ,&nbsp;Katerina Athanasopoulou ,&nbsp;Argyri Chroni ,&nbsp;Irene Dereki ,&nbsp;Giannoula Ntaliarda ,&nbsp;Ifigeneia Makariti ,&nbsp;Georgios Psarias ,&nbsp;Caterina Constantinou ,&nbsp;Vasiliki Chondrou ,&nbsp;Argyro Sgourou","doi":"10.1016/j.ncrna.2024.03.009","DOIUrl":"10.1016/j.ncrna.2024.03.009","url":null,"abstract":"<div><p>Epigenetic approaches in direct correlation with assessment of critical genetic mutations in non-small cell lung cancer (NSCLC) are currently very intensive, as the epigenetic components underlying NSCLC development and progression have attained high recognition. In this level of research, established human NSCLC cell lines as well as experimental animals are widely used to detect novel biomarkers and pharmacological targets to treat NSCLC. The epigenetic background holds a great potential for the identification of epi-biomarkers for treatment response however, it is highly complex and requires precise definition as these phenomena are variable between NSCLC subtypes and systems origin.</p><p>We engaged an in-depth characterization of non-coding (nc)RNAs prevalent in human <em>KRAS</em>-mutant NSCLC cell lines A549 and H460 and mouse <em>KRAS</em>-mutant NSCLC tissue by Next Generation Sequencing (NGS) and quantitative Real Time PCRs (qPCRs). Also, the transcription factor (TF) LRF, a known epigenetic silencer, was examined as a modulator of non-coding RNAs expression. Finally, interacting networks underlying epigenetic variations in NSCLC subtypes were created. Data derived from our study highlights the divergent epigenetic profiles of NSCLC of human and mouse origin, as well as the significant contribution of 12qf1: 109,709,060–109,747,960 mouse chromosomal region to micro-RNA upregulated species. Furthermore, the novel epigenetic miR-148b-3p/lnc<em>PVT1/ZBTB7A</em> axis was identified, which differentiates human cell line of lung adenocarcinoma from large cell lung carcinoma, two characteristic NSCLC subtypes.</p><p>The detailed recording of epigenetic events in NSCLC and combinational studies including networking between ncRNAs and TFs validate the identification of significant epigenetic features, prevailing in NSCLC subtypes and among experimental models. Our results enrich knowledge in the field and empower research on the epigenetic prognostic biomarkers of the disease progression, NSCLC subtypes discrimination and advancement to patient-tailored treatments.</p></div>","PeriodicalId":37653,"journal":{"name":"Non-coding RNA Research","volume":"9 3","pages":"Pages 759-771"},"PeriodicalIF":5.0,"publicationDate":"2024-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468054024000593/pdfft?md5=3b252ba437008a97dbb5907104e38f46&pid=1-s2.0-S2468054024000593-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140282347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}