Exploring the role of noncoding RNAs in cancer diagnosis, prognosis, and precision medicine

IF 5.9 3区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Non-coding RNA Research Pub Date : 2024-07-01 DOI:10.1016/j.ncrna.2024.06.015

Basmah Eldakhakhny , Abdulaziz M. Sutaih , Moaaz A. Siddiqui , Yamin M. Aqeeli , Akram Z. Awan , Mohammad Y. Alsayegh , Salma A. Elsamanoudy , Ayman Elsamanoudy

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引用次数: 0

Abstract

This review article studies the complex field of noncoding RNAs (ncRNAs) in cancer biology, focusing on their potential use as biomarkers and therapeutic targets. NcRNAs include circular RNAs (circRNAs), long noncoding RNAs (lncRNAs), and microRNAs (miRNAs). We discuss how ncRNAs affect gene expression in cancerous cells, the spread of cancer, and metastasis. The article illustrates the complex pathways through which ncRNAs can affect oncogenesis, tumor suppression, and therapeutic resistance. It also assesses the potential clinical uses of non-coding RNAs (ncRNAs), including their utility in cancer diagnosis, and prognosis. Besides, their potential for personalized cancer therapy is documented. Finally, it is concluded that understanding the role of ncRNA is of clinical importance regarding carcinogenesis, cancer diagnosis, and personalized therapy.

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探索非编码 RNA 在癌症诊断、预后和精准医疗中的作用

这篇综述文章研究了癌症生物学中复杂的非编码 RNA（ncRNA）领域，重点关注它们作为生物标记物和治疗靶点的潜在用途。非编码 RNA 包括环状 RNA（circRNA）、长非编码 RNA（lncRNA）和 microRNA（miRNA）。我们讨论了 ncRNA 如何影响癌细胞中的基因表达、癌症扩散和转移。文章阐述了 ncRNA 影响肿瘤发生、肿瘤抑制和治疗耐药性的复杂途径。文章还评估了非编码 RNA（ncRNA）的潜在临床用途，包括它们在癌症诊断和预后中的作用。此外，还记录了它们在个性化癌症治疗中的潜力。最后，文章得出结论：了解 ncRNA 在致癌、癌症诊断和个性化治疗方面的作用具有重要的临床意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Non-coding RNA Research Medicine-Biochemistry (medical)

CiteScore

7.70

自引率

6.00%

发文量

审稿时长

49 days

期刊介绍： Non-coding RNA Research aims to publish high quality research and review articles on the mechanistic role of non-coding RNAs in all human diseases. This interdisciplinary journal will welcome research dealing with all aspects of non-coding RNAs-their biogenesis, regulation and role in disease progression. The focus of this journal will be to publish translational studies as well as well-designed basic studies with translational and clinical implications. The non-coding RNAs of particular interest will be microRNAs (miRNAs), small interfering RNAs (siRNAs), small nucleolar RNAs (snoRNAs), U-RNAs/small nuclear RNAs (snRNAs), exosomal/extracellular RNAs (exRNAs), Piwi-interacting RNAs (piRNAs) and long non-coding RNAs. Topics of interest will include, but not limited to: -Regulation of non-coding RNAs -Targets and regulatory functions of non-coding RNAs -Epigenetics and non-coding RNAs -Biological functions of non-coding RNAs -Non-coding RNAs as biomarkers -Non-coding RNA-based therapeutics -Prognostic value of non-coding RNAs -Pharmacological studies involving non-coding RNAs -Population based and epidemiological studies -Gene expression / proteomics / computational / pathway analysis-based studies on non-coding RNAs with functional validation -Novel strategies to manipulate non-coding RNAs expression and function -Clinical studies on evaluation of non-coding RNAs The journal will strive to disseminate cutting edge research, showcasing the ever-evolving importance of non-coding RNAs in modern day research and medicine.