Allergo Journal International最新文献_第2页

Impact of obesity on allergic respiratory diseases and on mental and cognitive performance 肥胖对过敏性呼吸道疾病以及智力和认知能力的影响

Allergo Journal International Pub Date : 2024-10-14 DOI: 10.1007/s40629-024-00308-6

Nora Geissler, Erika Garner-Spitzer, Aleksandra Inic-Kanada, Daniela D. Pollak, Ursula Wiedermann

{"title":"Impact of obesity on allergic respiratory diseases and on mental and cognitive performance","authors":"Nora Geissler, Erika Garner-Spitzer, Aleksandra Inic-Kanada, Daniela D. Pollak,  Ursula Wiedermann","doi":"10.1007/s40629-024-00308-6","DOIUrl":"10.1007/s40629-024-00308-6","url":null,"abstract":"<p>Obesity and allergies are among the most common diseases of our civilization. Given the simultaneous rise in the prevalence of these diseases in recent years, a potential causal link between the two has been proposed. In particular, obese patients are at an increased risk of developing bronchial asthma, likely due to mechanical restrictions but also to metabolic changes that adversely affect immune function. Neuroscience studies have also shown that obesity can lead to impaired brain function and mental health. In the following review, we will take a closer look at our studies that focus on the influence of obesity on allergic diseases and cognitive performance.</p><p>Both human studies and animal models (mice) have shown that obesity leads to increased allergic responses in the airways. Our studies in a mouse model of obesity confirm that an obese phenotype is associated with increased allergic sensitization and manifestation. These changes are associated with significant shifts in the composition of the gut microbial flora. The microbiome changes are further associated with allergic airway inflammation and an increased incidence of T helper 1 (Th1) type pulmonary macrophages. Interestingly, despite the changes in the microbiome, it is possible to effectively prevent allergy development by inducing oral tolerance. Furthermore, it was observed that obese mice show increased signs of anxiety and depression, as well as reduced cognitive performance.</p><p>Obesity is a complex metabolic disease that significantly impacts our body’s gut microbiome and immune system, resulting in an increased incidence of allergic asthma and neurological/psychological changes. Attention should be given to both the prophylactic and therapeutic measures to mitigate the impact of obesity, including oral tolerance for managing existing allergic diseases.</p>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"33 7","pages":"247 - 251"},"PeriodicalIF":0.0,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-024-00308-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142447335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

One health: the impact of environment, detergents and hygiene on barrier, microbiome and allergy 同一健康：环境、清洁剂和卫生对屏障、微生物群和过敏的影响

Allergo Journal International Pub Date : 2024-10-09 DOI: 10.1007/s40629-024-00307-7

Hanna Mayerhofer, Isabella Pali-Schöll PhD

{"title":"One health: the impact of environment, detergents and hygiene on barrier, microbiome and allergy","authors":"Hanna Mayerhofer,  Isabella Pali-Schöll PhD","doi":"10.1007/s40629-024-00307-7","DOIUrl":"10.1007/s40629-024-00307-7","url":null,"abstract":"<p>A variety of body surfaces, such as skin and mucosal membranes—from the nasopharyngeal area to the lungs, uterus, vaginal area, and digestive tract—contain complex microbial ecosystems that are tailored to the specifics of the respective niche [1].</p><p>The so-called dysbiosis—a disadvantageous change in the composition of the microbiome—is associated with the pathogenesis of a variety of diseases [2]. Gastrointestinal as well as cardiovascular, metabolic, neurodegenerative, psychological, oncological, and also allergic diseases have been linked to microbial dysbiosis. Susceptibility to allergies can be due to genetic predisposition; in addition, extrinsic factors from today’s lifestyle increasingly contribute to microbiome changes, but also to the disruption of the skin and mucosal barrier and thus to the development of allergies [3].</p><p>Gisela, a fictional farmer, guides us through this review. She is representative of adults and children of all genders in industrialized countries. During her daily routine, the skin and mucosal microbiome is influenced by a variety of exogenous factors. These include everyday personal hygiene products, detergents for laundry and dishes, food, medication, animal contact, and exposure to various outdoor environments. Gisela’s daily routine will illustrate how the human microbiome and the skin barrier are modified in positive or negative ways, and how this could influence the development of allergies. Furthermore, potential measures for the prevention and management of dysbiosis will be discussed in terms of examples of alternative products and behaviors.</p>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"33 7","pages":"252 - 262"},"PeriodicalIF":0.0,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-024-00307-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142447408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Discharge management after anaphylaxis 过敏性休克后的出院管理

Allergo Journal International Pub Date : 2024-10-02 DOI: 10.1007/s40629-024-00306-8

Valentina Faihs, Johannes Ring, Knut Brockow, Kirsten Beyer, Ernst Rietschel, Sabine Schnadt, Britta Stöcker, Regina Treudler, Margitta Worm, Ludger Klimek

{"title":"Discharge management after anaphylaxis","authors":"Valentina Faihs,  Johannes Ring, Knut Brockow, Kirsten Beyer, Ernst Rietschel, Sabine Schnadt, Britta Stöcker, Regina Treudler, Margitta Worm, Ludger Klimek","doi":"10.1007/s40629-024-00306-8","DOIUrl":"10.1007/s40629-024-00306-8","url":null,"abstract":"<div><p>People who have suffered from anaphylaxis often experience far-reaching consequences in everyday life. Unfortunately, discharge management after successful acute treatment is often still inadequate. In order to prevent further reactions in the future and improve the patient’s quality of life, there are several points that should be addressed or followed upon discharge from acute treatment. These include taking a detailed medical history to identify potential triggers, documenting the acute therapy, recommending further allergological assessment and prescribing an emergency kit for self-help including an adrenaline auto-injector—with education and practice on how to use it, including a written emergency plan. In addition, recommendations for avoiding potential triggers and information on patient organizations are helpful. This article aims to provide an up-to-date overview of discharge management after successful acute treatment of anaphylaxis. Remember: “After anaphylaxis also means potentially before the next anaphylaxis.”</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"33 8","pages":"275 - 281"},"PeriodicalIF":0.0,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-024-00306-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142714438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of IgG1 and IgG4 as dominant IgE-blocking antibodies during allergen immunotherapy IgG1 和 IgG4 在过敏原免疫疗法中作为主要 IgE 阻断抗体的作用

Allergo Journal International Pub Date : 2024-09-30 DOI: 10.1007/s40629-024-00309-5

Barbara Bohle PhD

引用次数: 0

Asthma prevalence trends by sex and mortality rates in the US 美国按性别和死亡率划分的哮喘流行趋势

Allergo Journal International Pub Date : 2024-09-28 DOI: 10.1007/s40629-024-00310-y

Yoshiyasu Takefuji Ph.D.

引用次数: 0

Abstracts of the 19th German Allergy Congress, Dresden, September 26–28, 2024 第 19 届德国过敏大会摘要，德累斯顿，2024 年 9 月 26-28 日

Allergo Journal International Pub Date : 2024-08-29 DOI: 10.1007/s40629-024-00305-9

引用次数: 0

The maternal microbiome in normal pregnancy and at delivery by cesarean section and the early developmental phase of the neonatal microbiome—presentation of a longitudinal pilot study 正常妊娠和剖宫产时的母体微生物群与新生儿微生物群的早期发育阶段--一项纵向试点研究的结果

Allergo Journal International Pub Date : 2024-08-22 DOI: 10.1007/s40629-024-00303-x

Sonja Granser, Philipp Foessleitner BSc

{"title":"The maternal microbiome in normal pregnancy and at delivery by cesarean section and the early developmental phase of the neonatal microbiome—presentation of a longitudinal pilot study","authors":"Sonja Granser,  Philipp Foessleitner BSc","doi":"10.1007/s40629-024-00303-x","DOIUrl":"10.1007/s40629-024-00303-x","url":null,"abstract":"<div><h3>Aim</h3><p>In this study by Foessleitner et al., both the maternal microbiome in the third trimester of pregnancy and the factors that influence the development of the child’s microbiome after cesarean delivery were investigated.</p><h3>Methods</h3><p>Maternal vaginal and rectal swabs were collected at inclusion in the last trimester of pregnancy and on the day of the cesarean section. In addition, placental and intrauterine swabs as well as infant dermal, buccal, and meconium swabs were taken during the cesarean section immediately after birth and subsequently on the second/third day of life. All samples were analyzed for microbial composition using 16s rRNA amplicon sequencing.</p><h3>Results</h3><p>A total of 30 mothers and their newborns were included in the study, with microbiome samples available for all maternal, intrauterine cavity, and placenta samples, as well as for 18 out of the 30 newborns. The vaginal and rectal microbiome was stable over the course of the third trimester and showed no significant changes (permutational multivariate analysis of variance [PERMANOVA]; <i>p</i> > 0.05). Both the intraoperative samples (placental, intrauterine) and the neonatal swabs at the time of birth were consistently sterile. However, rapid infant microbial colonization subsequently occurred, with neonatal buccal mucosa and stool samples showing significantly different microbial colonization from their mothers as early as the second/third day of life (PERMANOVA; <i>p</i> < 0.01).</p><h3>Conclusion</h3><p>The conclusion of the presented study was therefore that the vaginal and rectal microbiome of healthy pregnant women does not change in the last trimester, the infant and the placenta are not microbially colonized at the time of birth, and the development of the newborn’s microbiome after birth appears to be influenced mainly by environmental exposure.</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"33 7","pages":"269 - 273"},"PeriodicalIF":0.0,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-024-00303-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142447347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An update on the clinical implications of the microbiome in the development of allergy diseases 微生物组对过敏性疾病发生的临床影响的最新进展

Allergo Journal International Pub Date : 2024-08-09 DOI: 10.1007/s40629-024-00300-0

Larissa Koidl, Eva Untersmayr

引用次数: 0

Prevalence of fungal sensitization and its association with clinical parameters of asthma—A longitudinal study in a tertiary care center in Tamil Nadu 泰米尔纳德邦一家三级医疗中心的真菌过敏流行率及其与哮喘临床参数的关系--纵向研究

Allergo Journal International Pub Date : 2024-08-08 DOI: 10.1007/s40629-024-00302-y

Zubair Khan, Jebin Roger, Pushparaj Nilkanth Patil, Devasahayam J. Christopher

{"title":"Prevalence of fungal sensitization and its association with clinical parameters of asthma—A longitudinal study in a tertiary care center in Tamil Nadu","authors":"Zubair Khan,  Jebin Roger,  Pushparaj Nilkanth Patil,  Devasahayam J. Christopher","doi":"10.1007/s40629-024-00302-y","DOIUrl":"10.1007/s40629-024-00302-y","url":null,"abstract":"<div><h3>Background</h3><p>Studies have shown that asthmatics with sensitization to fungi have worse outcomes, but published data from tropical countries like India are lacking.</p><h3>Objective</h3><p>We studied the prevalence of sensitization to clinically relevant fungi in asthmatics and investigated the impact of these fungi on asthma.</p><h3>Methods</h3><p>This prospective observational study was conducted in a tertiary care hospital in India. The skin prick test was used to check the sensitization status to fungal and non-fungal allergens. The association between fungal sensitization and various asthma outcomes, i.e. lung function, treatment phase, level of control, exacerbations in the previous year, was evaluated.</p><h3>Results</h3><p>Out of 720 patients, 472 (65.6%) were sensitized to one or more fungal allergens; <i>Aspergillus fumigatus </i>was the predominant fungus in these patients. Patients with fungal sensitization (FS) had a lower lung function than those with no fungal sensitization (NFS; mean [SD] FEV<sub>1</sub> [% predicted, post-BD] 73.6% [19.6] vs. 83.2% [15.0]; <i>p</i> < 0.001), were more likely to be on step 4 or 5 of Global Initiative for Asthma (GINA) treatment (78.1% vs. 63.7; <i>p</i> < 0.001), and were more likely to be on high-dose inhaled corticosteroids (28.2% of FS patients vs. 18.1% of NFS; <i>p</i> < 0.001). Furthermore, 11% of FS had uncontrolled asthma versus 4% of the NFS patients (<i>p</i> = 0.003). Persistent significant bronchodilator reversibility of FEV<sub>1</sub> was seen in 37.9% of FS patients vs. 13.4% of NFS patients (<i>p</i> < 0.001).</p><h3>Conclusion</h3><p>Fungal sensitization was associated with poorer asthma outcomes. In patients with FS, the physician needs to anticipate and sensitize the patient about the risk of a severe course of asthma.</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"34 3","pages":"76 - 80"},"PeriodicalIF":0.0,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141928039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heinrich Quincke (1842–1922) and the social hygiene movement 海因里希·昆克（1842-1922）与社会卫生运动

Allergo Journal International Pub Date : 2024-07-29 DOI: 10.1007/s40629-024-00301-z

Beato Suwa

{"title":"Heinrich Quincke (1842–1922) and the social hygiene movement","authors":"Beato Suwa","doi":"10.1007/s40629-024-00301-z","DOIUrl":"10.1007/s40629-024-00301-z","url":null,"abstract":"<p>Heinrich Irenaeus Quincke can be considered one of the most versatile and innovative medical scientists and inventors of his time. Both lumbar puncture and the treatment of lung abscesses are largely due to Quincke. Quincke’s edema (angioedema) was also named after him. A historical trace from Quincke’s early Berlin period sheds new light on the personal and political background regarding his two appointments to Bern in 1873 and Kiel in 1878.</p><p>On the one hand, this work is based on a literature search of historical journals and other publications from around 1870. On the other hand, a recently discovered original material is evaluated. This is a letter from Quincke with the place/date “Berlin, 4 August 72”, in which he registers for the “45th Assembly of German Naturalists and Physicians in Leipzig.”</p><p>Quincke had personal contacts with the early social hygiene movement, which was partly rooted in Switzerland. This movement was later popularized by the psychiatrist Auguste Forel (1848–1931), among others.</p><p>A work on the outbreak of the Wrocław relapsing fever epidemic (Febris recurrens, “relapsing fever”) in 1868 may have played an important role in the early social hygiene movement. It describes in a very impressive way the catastrophic social and hygienic conditions in the city’s slum, which were directly linked to the outbreak of the epidemic. The relapsing fever may have had similarities with today’s Lyme disease.</p>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"34 1","pages":"15 - 20"},"PeriodicalIF":0.0,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143109830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0