Allergo Journal International最新文献

{"title":"Prevalence of fungal sensitization and its association with clinical parameters of asthma—A longitudinal study in a tertiary care center in Tamil Nadu","authors":"Zubair Khan, Jebin S Roger, P. Patil, Devasahayam J Christopher","doi":"10.1007/s40629-024-00302-y","DOIUrl":"https://doi.org/10.1007/s40629-024-00302-y","url":null,"abstract":"","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"28 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141928039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heinrich Quincke (1842–1922) and the social hygiene movement","authors":"Beato Suwa","doi":"10.1007/s40629-024-00301-z","DOIUrl":"10.1007/s40629-024-00301-z","url":null,"abstract":"<p>Heinrich Irenaeus Quincke can be considered one of the most versatile and innovative medical scientists and inventors of his time. Both lumbar puncture and the treatment of lung abscesses are largely due to Quincke. Quincke’s edema (angioedema) was also named after him. A historical trace from Quincke’s early Berlin period sheds new light on the personal and political background regarding his two appointments to Bern in 1873 and Kiel in 1878.</p><p>On the one hand, this work is based on a literature search of historical journals and other publications from around 1870. On the other hand, a recently discovered original material is evaluated. This is a letter from Quincke with the place/date “Berlin, 4 August 72”, in which he registers for the “45th Assembly of German Naturalists and Physicians in Leipzig.”</p><p>Quincke had personal contacts with the early social hygiene movement, which was partly rooted in Switzerland. This movement was later popularized by the psychiatrist Auguste Forel (1848–1931), among others.</p><p>A work on the outbreak of the Wrocław relapsing fever epidemic (Febris recurrens, “relapsing fever”) in 1868 may have played an important role in the early social hygiene movement. It describes in a very impressive way the catastrophic social and hygienic conditions in the city’s slum, which were directly linked to the outbreak of the epidemic. The relapsing fever may have had similarities with today’s Lyme disease.</p>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"34 1","pages":"15 - 20"},"PeriodicalIF":0.0,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143109830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mannan‑, VLP-, and flagellin-based adjuvants for allergen-specific immunotherapy: a review of the current literature","authors":"Clara Pignard,&nbsp;Hannah Schiller,&nbsp;Alisa Seyffer,&nbsp;Stefan Schülke PhD","doi":"10.1007/s40629-024-00298-5","DOIUrl":"10.1007/s40629-024-00298-5","url":null,"abstract":"<div><p>Currently, allergen-specific immunotherapy (AIT) with active ingredients derived from the causative allergen source is the only disease-modifying treatment for allergic patients. However, compared to, e.g., live-attenuated vaccines for the prevention of infectious diseases, purified allergens for AIT in many cases display only a low immunogenicity. This reduces treatment efficacy and prolongs treatment duration. Here, adjuvants may be a promising tool, allowing for dose reduction of the respective allergen while increasing immunogenicity of co-applied allergens and/or modulating allergen-specific immune responses toward T helper 1 (Th1) or regulatory phenotypes or the production of blocking antibody isotypes. Currently available adjuvants can be distinguished into first-generation adjuvants (promoting immune responses via aggregation and controlled release of co-applied allergens from a depot) and second-generation adjuvants (triggering immune responses via the activation of pattern recognition receptors expressed by immune cells). This review summarizes the mechanisms and effects of adjuvants currently or previously used for AIT (aluminum hydroxide, calcium phosphate, microcrystalline tyrosine, and monophosphoryl lipid A [MPLA]) and focuses on novel developments using mannan-, virus-like particle (VLP)-, and flagellin-based adjuvants and therapeutics for the treatment of allergic diseases.</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"33 8","pages":"289 - 303"},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-024-00298-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141827171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physician’s perspectives on skin prick testing and allergy diagnostics in Germany","authors":"Ludger Klimek,&nbsp;Wolfgang Wehrmann,&nbsp;Randolf Brehler,&nbsp;Sven Becker,&nbsp;Mandy Cuevas,&nbsp;Moritz Gröger,&nbsp;Jan Hagemann,&nbsp;Ingrid Casper,&nbsp;Mathias Sulk,&nbsp;Senne Gorris,&nbsp;Sven F. Seys","doi":"10.1007/s40629-024-00297-6","DOIUrl":"10.1007/s40629-024-00297-6","url":null,"abstract":"<p>Novel technologies standardising the testing process of immediate hypersensitivities have been developed and validated in recent years. Meanwhile, challenges with regard to availability of testing agents and shortage of trained personnel have increased. Novel technologies could fight these challenges, but their distribution is at present not known. The current survey, conducted by the German Society for Allergology (AeDA), aimed to assess current practices of allergy diagnostics in Germany.</p><p>Members of AeDA were invited to complete an online questionnaire to obtain information on their perspectives on allergy testing and diagnostics.</p><p>A total of 150 allergologists from different disciplines treating patients with allergy completed the questionnaire. This survey revealed that twice as many skin prick tests (SPT; 21.2 tests/week) compared to serum specific immunoglobulin E tests (IgE; 10.4 tests/week) are being performed. Nasal allergen provocation tests are being performed in 56.0% of hospitals and physicians’ offices. An individual standard allergen panel for SPT is applied in 78.0% of testing cases. Methods used to perform a read out of SPT are variable with measurement of the longest wheal diameter being used most frequently (68.0%), followed by a qualitative evaluation (46.6%) or the longest wheal diameter including pseudopods (34.4%). In all, 66% of allergologists indicated that a device that automating the SPT process would be valuable for clinical practice.</p><p>Skin prick tests and serum IgE tests are still the cornerstones in the diagnostic work-up of immediate-type allergies. Variability in the execution of skin prick tests exists between different hospitals and physicians’ offices in Germany. Inconsistent availability of testing reagents was considered most problematic for maintaining allergy diagnostics in Germany. A majority of allergologists are open to evaluating tools that may contribute to standardize skin prick tests.</p>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"33 5","pages":"159 - 164"},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-024-00297-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141649035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergy skin prick tests with COVID-19 vaccines and their contribution to improve vaccination readiness and reduce anxiety","authors":"Tobias Pindel,&nbsp;Susanne Brandstetter,&nbsp;Wolfgang Sieber,&nbsp; Michael Kabesch M.D.","doi":"10.1007/s40629-024-00296-7","DOIUrl":"10.1007/s40629-024-00296-7","url":null,"abstract":"<div><h3>Background</h3><p>When coronavirus disease 2019 (COVID-19) vaccines were introduced, they were suspected of triggering severe allergic reactions disproportionately often. This contributed to the fear of vaccination, particularly among allergy patients.</p><h3>Methods</h3><p>In an allergy center in eastern Bavaria, we used a skin prick test to investigate how often sensitization to COVID-19 vaccines can be detected and whether appropriate testing could significantly reduce the fear of vaccination.</p><h3>Results</h3><p>Comirnaty® (<i>n</i> <i>=</i> 245 tested/6.93% <i>clearly positive </i>reaction; Biontec/Pfizer, Mainz, Germany/New York City, NY, USA), Spikevax® (56/14.28%; Moderna, Cambridge, MA, USA), Vaxzevria® (208/4.32%; Astra Zeneca, Cambridge, England) and Jcovden® (48/4.16%; Johnson &amp; Johnson, New Brunswick, NJ, USA) were tested by skin prick test. Most participants tested were female (83.6%) and had a history of allergies (94.8%). Depending on the result of the skin prick test, the test subjects were advised on vaccination. In a questionnaire survey approximately 1 year after testing, 75.7% of the <i>N</i> = 70 respondents stated that their fear of vaccination had been greatly or very greatly reduced as a result of the testing and counseling. In the follow-up survey, 88.5% of all respondents had been vaccinated at least once. No notable allergic problems occurred during the COVID-19 vaccination in study participants.</p><h3>Conclusion</h3><p>The study shows that simple skin prick testing could reduce fears and concerns about allergic reactions to COVID-19 vaccines, and thus significantly increase the willingness to vaccinate in the population, especially among allergy patients.</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"33 5","pages":"153 - 158"},"PeriodicalIF":0.0,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-024-00296-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142413498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Course of growth and nutritional status in Swiss children with food allergies","authors":"Rebekka Gerber,&nbsp;Andre Meichtry,&nbsp;Klazine van der Horst,&nbsp;Alice Koehli,&nbsp;Caroline Roduit,&nbsp;Felicitas Bellutti Enders,&nbsp;Isabel Skypala,&nbsp;Mary Hickson,&nbsp;Julia Eisenblaetter","doi":"10.1007/s40629-024-00289-6","DOIUrl":"10.1007/s40629-024-00289-6","url":null,"abstract":"<p>Studies suggest that children with immunoglobulin E (IgE)-mediated food allergies (FA) are at risk of impaired growth, especially those with cow’s milk or multiple FA. However, there is limited long-term data available on this topic. This analysis presents the growth of Swiss children for the first year after FA diagnosis.</p><p>This is a secondary analysis of data from a multicentered study following food allergic children (0–10 years) over 1 year post diagnosis, comparing those who received dietary counselling with those who did not. Growth z‑scores were calculated based on World Health Organization (WHO) standards, using data reported by caregivers. To analyze data, linear mixed models with between-subject factors related to dietary counselling, number of FA, and cow’s milk allergy were fitted to the data.</p><p>In the 48 children (median age 16 months) studied, we observed an increasing prevalence of wasting (weight-for-length/height z‑score &lt; 2; 2–10%) and a lower prevalence of stunting (length/height-for-age &lt; 2; 0–2%) over the 1‑year period. Twelve months after diagnosis, all median z‑scores showed an increase. Linear mixed model analysis did not find any significant within-subject and between-subject effects on growth.</p><p>Children with IgE-mediated FA can have normal growth if children with cow’s milk allergy or multiple food allergies receive dietary counselling. Routine length/height and weight measurements should be taken to identify individual malnutrition and to initiate tailored nutritional interventions. Larger studies with longer duration are needed to assess further growth development in children with IgE-mediated food allergies.</p>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"33 6","pages":"171 - 179"},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-024-00289-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141356894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Classification of molds and definition of mold contamination","authors":"Thomas Gabrio,&nbsp;Guido Fischer","doi":"10.1007/s40629-024-00292-x","DOIUrl":"10.1007/s40629-024-00292-x","url":null,"abstract":"<div><p>The term “molds” is defined and relevant sources of molds are given. The conditions and growth of mold fungi are explained. The determination of mould spores and colony-forming units (CFU) in the air is briefly explained and it is made clear that the total spore count is relevant for assessing the sensitizing and allergenic effect of moulds. Outdoor air-associated moulds such as <i>Alternaria alternata, Aspergillus fumigatus, Cladosporium herbarum</i> and <i>Penicillium chrysogenum</i> (mx1 mould mixture) are of particular importance due to their high degree of sensitization. Their concentration in the air is determined by the vegetation and is therefore dependent on the season. In people who were tested for mx1, sensitization to <i>Alternaria alternata</i> (m6) was predominantly observed for the individual allergens. For many indoor-associated moulds, no (valid) commercially available test extracts for the detection of sensitization, so-called allergy tests, are available. Allergy test results of mold mixtures, such as mx1, cannot be used to determine an indoor mold allergy, nor can the results of mold measurements in the rooms used by the respective persons be used for a risk assessment in the event of an existing mold infestation in the interior. The classification of mold fungi is explained.</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"33 4","pages":"110 - 123"},"PeriodicalIF":0.0,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141114600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The German guideline on medical clinical diagnostics for indoor mold exposure: key messages","authors":"Julia Hurraß,&nbsp; Gerhard A. Wiesmüller","doi":"10.1007/s40629-024-00294-9","DOIUrl":"10.1007/s40629-024-00294-9","url":null,"abstract":"<div><p>The AWMF S2k guideline “Medical clinical diagnostics for indoor mold exposure” was introduced in 2016. The guideline is based on a standardized procedure of the AWMF including a systematic literature search involving several medical disciplines. The expert group has updated this guideline in accordance with AWMF specifications. For this purpose, a new Medline search was carried out for the current version of the guideline up to June 2022 with additional search terms. The search results were evaluated and further narrowed down by means of abstract screening and, where applicable, evidence-based evaluation of the full texts. Medical guidelines on related topics were also taken into account. The updated guideline is available since October 2023. This is intended to close the existing knowledge gap for rational and efficient medical diagnostics for indoor mold contamination and provides 26 core statements and recommendations, which are presented in detail.</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"33 4","pages":"106 - 109"},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-024-00294-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141002328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What effect do mycotoxins, cell wall components, enzymes and other mold components and metabolites have on our health?","authors":"Julia Hurraß,&nbsp;Rabea Teubel,&nbsp; Guido Fischer,&nbsp; Birger Heinzow,&nbsp; Gerhard A. Wiesmüller","doi":"10.1007/s40629-024-00295-8","DOIUrl":"10.1007/s40629-024-00295-8","url":null,"abstract":"<div><p>The AWMF (Association of the Scientific Medical Societies) mold guideline “Medical clinical diagnostics for indoor mold exposure”—Update 2023 [44] concludes that there is limited or presumed evidence of a link between indoor dampness/mold exposure and health problems. However, there is inadequate or insufficient evidence for an association between indoor dampness/mold exposure and the environmental medical syndromes sick building syndrome (SBS), multiple chemical sensitivity (MCS) and chronic fatigue syndrome (CFS). Newly coined terms, such as biotoxicosis and mold and vapor hypersensitivity syndrome (MDHS) or volatoxins, suggest a nosological specificity of a pathophysiological connection for which, however, there is no evidence to date. The background to this assessment is presented in this paper.</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"33 4","pages":"124 - 132"},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-024-00295-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141005500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergen-specific immunotherapy for mold allergies","authors":"Randolf Brehler,&nbsp;Uta Rabe","doi":"10.1007/s40629-024-00293-w","DOIUrl":"10.1007/s40629-024-00293-w","url":null,"abstract":"<div><p>Molds are ubiquitous in our environment and are considered by the population to be the most important indoor pollutant problem [1]. The current 2023 update to the AWMF mold guideline [1] is intended to allay or channel fears and provide assistance for a sensible diagnosis and treatment decision.</p><p>The detection of an IgE-mediated allergy implies for allergists Allergen immunotherapy (AIT) as an established treatment option. However, compared to the well-validated AIT with pollen and house dust mites, the decision to use AIT with mold extracts must be weighed more heavily between the benefits and risks.</p><p>Spores of <i>Alternaria alternata</i> are found in high concentrations in the outdoor air. Due to the high allergenic potential and the small size of the spores, an Alternaria allergy often leads to bronchial asthma, especially in children. The effectiveness of AIT with Alternaria extracts has been tested in several studies; for other molds, especially those from the indoor environment, the efficacy and applicability is very limited.</p><p>In terms of differential diagnosis, it must be borne in mind that molds can not only cause common allergic reactions but can also be responsible for allergic bronchopulmonary mycoses/aspergillosis (ABPA), Aspergillus bronchitis, exogenous allergic alveolitis (EAA), invasive aspergillosis, mycoses and rhinosinusitis. Very high concentrations, which can occur particularly in workplaces, can also result in toxic effects (“organic dust toxic syndrome”); molds are also held responsible for mucous membrane irritation, odor effects and mood disorders [1].</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"33 4","pages":"101 - 105"},"PeriodicalIF":0.0,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-024-00293-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140669406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}