{"title":"含亚硫酸盐肾上腺素自动注射器成功治疗亚硫酸盐过敏反应","authors":"Jolien Isabel Kessels MD, Jan Gutermuth MD PhD, Martine Grosber MD","doi":"10.1007/s40629-025-00328-w","DOIUrl":null,"url":null,"abstract":"<p>Anaphylaxis is a potentially life-threatening type 1 hypersensitivity reaction mediated by specific IgE. Culprit allergens frequently include foods, drugs, and insect venom. Sulfites are widely used as additives in food processing but also occur naturally in high concentrations in certain foods. Additionally, they are added as preservatives to aqueous cosmetic and medical solutions. Sulfites have been reported to cause a variety of allergic reactions including anaphylaxis. Here, we present a case of a patient with repetitive anaphylactic reactions to sulfites in food. An allergy workup showed a positive prick test to sodium metabisulfite and a positive oral provocation test. Our patient was successfully treated for anaphylaxis with a sulfite-containing adrenaline auto-injector, suggesting the benefits of adrenaline outweigh the theoretical risks in an acute anaphylactic setting.</p>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"34 4","pages":"107 - 109"},"PeriodicalIF":0.0000,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Successful treatment of anaphylaxis to sulfites with sulfite-containing adrenaline auto-injector\",\"authors\":\"Jolien Isabel Kessels MD, Jan Gutermuth MD PhD, Martine Grosber MD\",\"doi\":\"10.1007/s40629-025-00328-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Anaphylaxis is a potentially life-threatening type 1 hypersensitivity reaction mediated by specific IgE. Culprit allergens frequently include foods, drugs, and insect venom. Sulfites are widely used as additives in food processing but also occur naturally in high concentrations in certain foods. Additionally, they are added as preservatives to aqueous cosmetic and medical solutions. Sulfites have been reported to cause a variety of allergic reactions including anaphylaxis. Here, we present a case of a patient with repetitive anaphylactic reactions to sulfites in food. An allergy workup showed a positive prick test to sodium metabisulfite and a positive oral provocation test. Our patient was successfully treated for anaphylaxis with a sulfite-containing adrenaline auto-injector, suggesting the benefits of adrenaline outweigh the theoretical risks in an acute anaphylactic setting.</p>\",\"PeriodicalId\":37457,\"journal\":{\"name\":\"Allergo Journal International\",\"volume\":\"34 4\",\"pages\":\"107 - 109\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-04-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Allergo Journal International\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s40629-025-00328-w\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Allergo Journal International","FirstCategoryId":"1085","ListUrlMain":"https://link.springer.com/article/10.1007/s40629-025-00328-w","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
Successful treatment of anaphylaxis to sulfites with sulfite-containing adrenaline auto-injector
Anaphylaxis is a potentially life-threatening type 1 hypersensitivity reaction mediated by specific IgE. Culprit allergens frequently include foods, drugs, and insect venom. Sulfites are widely used as additives in food processing but also occur naturally in high concentrations in certain foods. Additionally, they are added as preservatives to aqueous cosmetic and medical solutions. Sulfites have been reported to cause a variety of allergic reactions including anaphylaxis. Here, we present a case of a patient with repetitive anaphylactic reactions to sulfites in food. An allergy workup showed a positive prick test to sodium metabisulfite and a positive oral provocation test. Our patient was successfully treated for anaphylaxis with a sulfite-containing adrenaline auto-injector, suggesting the benefits of adrenaline outweigh the theoretical risks in an acute anaphylactic setting.
期刊介绍：
Allergo Journal International is the official Journal of the German Society for Applied Allergology (AeDA) and the Austrian Society for Allergology and Immunology (ÖGAI). The journal is a forum for the communication and exchange of ideas concerning the various aspects of allergy (including related fields such as clinical immunology and environmental medicine) and promotes German allergy research in an international context. The aim of Allergo Journal International is to provide state of the art information for all medical and scientific disciplines that deal with allergic, immunological and environmental diseases. Allergo Journal International publishes original articles, reviews, short communications, case reports, and letters to the editor. The articles cover topics such as allergic, immunological and environmental diseases, the latest developments in diagnosis and therapy as well as current research work concerning antigens and allergens and aspects related to occupational and environmental medicine. In addition, it publishes clinical guidelines and position papers approved by expert panels of the German, Austrian and Swiss Allergy Societies.
All submissions are reviewed in single-blind fashion by at least two reviewers.
Originally, the journal started as a German journal called Allergo Journal back in 1992. Throughout the years, English articles amounted to a considerable portion in Allergo Journal. This was one of the reasons to extract the scientific content and publish it in a separate journal. Hence, Allergo Journal International was born and now is the international continuation of the original German journal. Nowadays, all original content is published in Allergo Journal International first. Later, selected manuscripts will be translated and published in German and included in Allergo Journal.
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