Allergo Journal International最新文献_第3页

Biologics in the treatment of atopic dermatitis: approved active substances and monoclonal antibodies in advanced clinical trials 治疗特应性皮炎的生物制剂：已批准的活性物质和单克隆抗体在高级临床试验中

Allergo Journal International Pub Date : 2025-08-05 DOI: 10.1007/s40629-025-00340-0

Svenja Royeck

{"title":"Biologics in the treatment of atopic dermatitis: approved active substances and monoclonal antibodies in advanced clinical trials","authors":"Svenja Royeck","doi":"10.1007/s40629-025-00340-0","DOIUrl":"10.1007/s40629-025-00340-0","url":null,"abstract":"<div><p>Atopic dermatitis (AD) is the most common chronic inflammatory skin disease in industrialized countries and is characterized by heterogeneous (endo)phenotypes and a high disease burden. In Europe, four biologics and three oral Janus kinase (JAK) inhibitors are currently approved by the European Medicines Agency (EMA) for the treatment of moderate to severe AD in adolescents (≥ 12 years) and adults: dupilumab (anti-interleukin [IL]-4Rα; 2017), tralokinumab (anti-IL-13; 2021), lebrikizumab (anti-IL-13; 2023) and nemolizumab (anti-IL-31Rα; 2024) as well as the JAK inhibitors baricitinib (JAK 1/2; 2020), upadacitinib (JAK 1; 2021) and abrocitinib (JAK 1; 2022). Among the abovementioned therapies, baricitinib for moderate and severe AD from the second year of life and dupilumab for severe AD from the sixth month of life are already two approved systemic therapies for early childhood. This narrative review provides an update on the biologics currently approved for treatment of moderate and severe AD. It also provides a brief overview of monoclonal antibodies currently in phase III clinical trials and future issues and opportunities for immunomodulatory systemic therapies for AD.</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"34 6","pages":"159 - 166"},"PeriodicalIF":0.0,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-025-00340-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145037328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rush build-up of venom immunotherapy using a depot preparation: learning from times of shortage 使用储备制剂的快速构建毒液免疫疗法：从短缺时期学习

Allergo Journal International Pub Date : 2025-07-31 DOI: 10.1007/s40629-025-00344-w

Johanna Stoevesandt, Axel Trautmann

{"title":"Rush build-up of venom immunotherapy using a depot preparation: learning from times of shortage","authors":"Johanna Stoevesandt,  Axel Trautmann","doi":"10.1007/s40629-025-00344-w","DOIUrl":"10.1007/s40629-025-00344-w","url":null,"abstract":"<div><h3>Background</h3><p>Aluminum hydroxide-adsorbed venom depot products are promoted for conventional build-up protocols and the maintenance phase of honeybee and <i>Vespula</i> venom immunotherapy (VIT) to improve treatment tolerability and support a sustained immune response. Published data regarding their off-label use during inpatient rush build-up of VIT are scarce.</p><h3>Methods</h3><p>During a recent supply shortage, an aluminum hydroxide-adsorbed depot product instead of the corresponding aqueous venom preparation was used for VIT build-up according to a standardized 3‑day rush protocol in 59 consecutive patients. Side effects during VIT build-up and subsequent transition to the maintenance phase of treatment were retrospectively evaluated.</p><h3>Results</h3><p>Local tolerability of the depot product was excellent; VIT-induced large local reactions exceeding 10 cm in diameter were documented in only 3 patients (5.1%). There was no indication of an increased rate of VIT-induced systemic reactions. One patient developing a moderately severe anaphylactic reaction on day 2 of honeybee VIT build-up promptly stabilized upon antiallergic treatment. No objective systemic reactions were observed during transition to outpatient VIT maintenance using the same depot product.</p><h3>Conclusion</h3><p>Due to their excellent local tolerability, depot preparations represent a promising option for VIT rush build-up.</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"34 8","pages":"290 - 293"},"PeriodicalIF":0.0,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-025-00344-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145698666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anaphylaxis induced by intradermal testing with omeprazole: a case report 奥美拉唑皮内试验致过敏反应1例

Allergo Journal International Pub Date : 2025-07-17 DOI: 10.1007/s40629-025-00343-x

Alice Botta MD, Christian Paolo Ratti, Eleonora Bono, Matteo Cavara, Alessandra Chiei Gallo, Chiara Ghelli, Enrico Iemoli, Valeria Giuseppina Rita Ortolani

引用次数: 0

Therapeutic approaches to food allergies 食物过敏的治疗方法

Allergo Journal International Pub Date : 2025-07-17 DOI: 10.1007/s40629-025-00337-9

Nora Knappe, Katja Nemat, Christian Vogelberg

引用次数: 0

Safety of switching immunotherapy between different manufacturers in insect venom immunotherapy—a real-world experience 在不同制造商之间切换免疫疗法在昆虫毒液免疫疗法的安全性-一个真实世界的经验

Allergo Journal International Pub Date : 2025-07-14 DOI: 10.1007/s40629-025-00339-7

Janina Noll, Mara Bieg, Benjamin Walz, Eva Akkaya, Joerg Fischer, Manfred Kneilling, Sebastian Volc

引用次数: 0

Epidemiology of food allergy 食物过敏流行病学

Allergo Journal International Pub Date : 2025-07-09 DOI: 10.1007/s40629-025-00336-w

Alisa Arens, Lars Lange, Kristina Stamos

引用次数: 0

Oral contact allergies: a comprehensive narrative review on etiology, clinical manifestations, diagnosis, and management 口腔接触性过敏：对病因、临床表现、诊断和管理的综合叙述综述

Allergo Journal International Pub Date : 2025-06-30 DOI: 10.1007/s40629-025-00338-8

Sreepreeti Champatyray BDS MDS., Saurjya Ranjan Das MBBS MD, Dhiren Kumar Panda M.Sc. Ph.D

{"title":"Oral contact allergies: a comprehensive narrative review on etiology, clinical manifestations, diagnosis, and management","authors":"Sreepreeti Champatyray BDS MDS., Saurjya Ranjan Das MBBS MD, Dhiren Kumar Panda M.Sc. Ph.D","doi":"10.1007/s40629-025-00338-8","DOIUrl":"10.1007/s40629-025-00338-8","url":null,"abstract":"<div><h3>Purpose</h3><p>Oral contact allergies (OCAs) are increasingly recognized in dental practice and commonly manifest as oral lichenoid reactions (OLRs), allergic contact stomatitis (ACS), and burning mouth syndrome (BMS). This narrative review aims to synthesize current knowledge on etiological factors, diagnostic challenges, and management strategies to enhance clinical guidance.</p><h3>Methods</h3><p>A comprehensive literature search was conducted across major medical and dental databases focusing on studies from 2000–2024 addressing OCAs related to dental materials, oral hygiene products, and food allergens. Emphasis was placed on clinical features, diagnostic methodologies—including patch testing and emerging biomarkers—and therapeutic approaches documented in recent literature.</p><h3>Results</h3><p>Common precipitants of OCAs include metals such as nickel, mercury, cobalt, and acrylates, with prevalence estimates ranging from 5 to 20%, predominantly affecting middle-aged women. Diagnosis primarily relies on clinical evaluation supported by patch testing, though emerging techniques such as salivary biomarkers and histopathological analyses show promise. Management centers on allergen avoidance and topical corticosteroids, with immunotherapy approaches such as sublingual immunotherapy (SLIT) gaining preliminary support despite a lack of comprehensive guidelines.</p><h3>Conclusion</h3><p>Enhanced detection and recognition of OCAs are critical to improving patient outcomes and quality of life. Dentists should incorporate OCAs into differential diagnoses for chronic oral mucosal disorders and remain informed about advances in diagnostics and therapeutics.</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"34 6","pages":"180 - 185"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145037181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosis of food allergies 食物过敏的诊断

Allergo Journal International Pub Date : 2025-06-26 DOI: 10.1007/s40629-025-00335-x

Lars Lange

{"title":"Diagnosis of food allergies","authors":"Lars Lange","doi":"10.1007/s40629-025-00335-x","DOIUrl":"10.1007/s40629-025-00335-x","url":null,"abstract":"<p>Diagnosing food allergies requires a well-considered approach from the very first step. The reason for this is the frequent presence of clinically irrelevant immunoglobulin E (IgE) sensitizations in a large proportion of individuals. Equating sensitization detected by skin prick tests or the detection of specific IgE antibodies with clinical relevance can lead to the misdiagnosis of an allergy. Therefore, a thorough patient history is essential as the foundation of the diagnostic process. Another reason is the high rate of self-suspected allergies among patients due to a lack of understanding of the typical symptoms of food allergies. Patients assume that unspecific symptoms or skin changes are the result of food intolerance. However, food allergies trigger clearly defined symptoms that are often easy to ask about. The physician’s task is, therefore, to separate implausible from plausible symptoms by taking a thorough medical history and then subsequently plan a targeted diagnostic work-up. In doing so, the limitations and diagnostic potential of serological testing using allergen extracts and components, as well as those of skin testing, must be clearly understood. This article provides a concise summary of the essential steps in the diagnosis of food allergy.</p>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"34 5","pages":"127 - 133"},"PeriodicalIF":0.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145169849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Severity assessment of food allergies according to DEFASE criteria in the German healthcare system (d-DEFASE) 根据德国卫生保健系统DEFASE标准对食物过敏的严重程度进行评估（d-DEFASE）

Allergo Journal International Pub Date : 2025-06-19 DOI: 10.1007/s40629-025-00334-y

Stefania Arasi, Lars Lange, Katharina Blümchen, Nora Knappe, Katja Nemat, Randolf Brehler, Stefani Röseler, Michael Gerstlauer, Jan Hagemann, Friederike Bärhold, Ingrid Casper, Philippe Eigenmann, Alessandro Fiocchi, Ludger Klimek, Christian Vogelberg

{"title":"Severity assessment of food allergies according to DEFASE criteria in the German healthcare system (d-DEFASE)","authors":"Stefania Arasi, Lars Lange, Katharina Blümchen, Nora Knappe, Katja Nemat, Randolf Brehler, Stefani Röseler, Michael Gerstlauer, Jan Hagemann, Friederike Bärhold, Ingrid Casper, Philippe Eigenmann, Alessandro Fiocchi, Ludger Klimek,  Christian Vogelberg","doi":"10.1007/s40629-025-00334-y","DOIUrl":"10.1007/s40629-025-00334-y","url":null,"abstract":"<p>There is currently no standardized evaluation system in Germany for defining and classifying the severity of IgE-mediated food allergies (FA). Following the development of the international classification system named DEFASE (Definition of Food Allergy Severity), this evaluation system is now also being introduced in Germany and its applicability in the German healthcare system is being tested.</p><p>An international consensus was reached on DEFASE through a two-stage process (systematic literature review followed by an e‑Delphi).</p><p>The DEFASE score is the first comprehensive classification of the severity of a FA that takes into account not only the severity of an individual reaction, but the entire scenario of the disease, including the clinical features alongside patient’s reported outcomes and economic burden. It is important that an international consensus has been reached on a scoring system for FA, which can now also be used in Germany as d‑DEFASE. The scoring system is currently tested in research projects to be introduced soon into clinical practice, targeting these models to various food allergenic sources, populations, and settings.</p>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"34 5","pages":"113 - 120"},"PeriodicalIF":0.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-025-00334-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145167377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recommendations for allergy-friendly urban planting in the context of climate change 气候变化背景下对过敏友好型城市种植的建议

Allergo Journal International Pub Date : 2025-06-02 DOI: 10.1007/s40629-025-00332-0

Karl-Christian Bergmann, Wolfgang Straff, Hans-Guido Mücke, Katarina Stevanovic, Torsten Zuberbier

{"title":"Recommendations for allergy-friendly urban planting in the context of climate change","authors":"Karl-Christian Bergmann, Wolfgang Straff, Hans-Guido Mücke, Katarina Stevanovic, Torsten Zuberbier","doi":"10.1007/s40629-025-00332-0","DOIUrl":"10.1007/s40629-025-00332-0","url":null,"abstract":"<div><p>Climate change is altering temperature patterns and pollen exposure, particularly in cities. Rising summer temperatures are reducing the well-being of urban populations: however, this impact can be partially reduced by suitable planting. Primarily, the issue is that exposure to pollen leads to sensitization and allergic symptoms more frequently in cities than in rural areas. Also, individuals with pollen allergies, especially those reactive to tree (hazelnut, alder, birch, ash) and grass pollen, experience more severe symptoms in cities due to the interaction of pollen with air pollutants. To counteract this trend, urban planting should prioritize nonallergenic, or low-allergenic plant species. Here we present a table categorizing tree species based on their allergic potential: (a) species that should not be planted under any circumstances, (b) species that should be avoided but can be planted with caution, (c) species currently regarded as allergy friendly. Adopting these recommendations should counteract a further increase in tree pollen exposure and, thus, the frequency of sensitization, especially in residential areas. This paper serves as an update of a previous recommendation for planting new trees in public spaces with allergy considerations, incorporating the 2022 GALK street tree list, which is maintained by the “Urban Trees Working Group”.</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"34 4","pages":"95 - 103"},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-025-00332-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145161166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0