Allergo Journal International最新文献_第4页

Cyclophilins and gibberellin-regulated proteins in IgE-mediated allergic diseases IgE介导的过敏性疾病中的亲环素和赤霉素调节蛋白

Allergo Journal International Pub Date : 2023-10-04 DOI: 10.1007/s40629-023-00270-9

Ekaterina Potapova, Hélène Sénéchal PhD, Enrico Scala, Paolo Maria Matricardi, Pascal Poncet PhD

{"title":"Cyclophilins and gibberellin-regulated proteins in IgE-mediated allergic diseases","authors":"Ekaterina Potapova,  Hélène Sénéchal PhD,  Enrico Scala,  Paolo Maria Matricardi,  Pascal Poncet PhD","doi":"10.1007/s40629-023-00270-9","DOIUrl":"10.1007/s40629-023-00270-9","url":null,"abstract":"<div><h2>Summary</h2><div><p>The prevalence of immunoglobulin E (IgE)-mediated allergic diseases is currently experiencing an epidemic trend characterized by an increase in both the number of affected individuals and the proportion of patients with multiple sensitizations. The majority of these multiple sensitizations are attributed to IgE reactions to genuine allergenic proteins from unrelated species. However, there is a growing trend of patients becoming sensitized to highly cross-reactive molecules, such as profilins, polcalcins, lipocalins, serum albumins, tropomyosins, and non-specific lipid transfer proteins (nsLTPs). In addition, allergen families that were previously considered of minimal importance are now gaining recognition for their role in the pathogenesis of IgE-mediated allergic diseases. Consequently, these allergen families are increasingly being considered in the diagnostic process. In this review, we aim to provide a comprehensive summary of the biochemical and allergological information about two of these “new” allergen families: cyclophilins (Cyp) and gibberellin-regulated proteins (GRP).</p></div></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-023-00270-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50450576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urticaria in childhood—what’s new? 儿童荨麻疹有什么新进展?

Allergo Journal International Pub Date : 2023-09-22 DOI: 10.1007/s40629-023-00271-8

Ann-Christin E. Brehler, Andrea Bauer, Bettina Wedi

{"title":"Urticaria in childhood—what’s new?","authors":"Ann-Christin E. Brehler, Andrea Bauer, Bettina Wedi","doi":"10.1007/s40629-023-00271-8","DOIUrl":"10.1007/s40629-023-00271-8","url":null,"abstract":"<div><p>Urticaria can manifest at any age, including infants and young children. Urticaria is one of the most prevalent skin diseases in childhood. As in adults, a distinction is made between acute and chronic urticaria, with chronic urticaria further classified into chronic spontaneous urticaria and inducible urticaria. According to the current German S3 guideline for classification, diagnosis, and treatment of urticaria, existing literature suggests that the prevalence, disease characteristics, causes, and also the response to treatment are very similar in children and adults. The clinical hallmark of urticaria is the subjective sensation of itch. In young children who may have difficulty expressing itching, it is crucial to observe their scratching behavior during clinical examinations. Particularly in children, mastocytosis and autoinflammatory syndromes (cryopyrin-associated periodic syndromes [CAPS], especially Muckle–Wells syndrome and childhood Still’s disease) are important differential diagnoses. Autoinflammatory syndromes are characterized by additional symptoms such as fever, bone pain, muscle pain, and joint complaints. Cryopyrin-associated periodic syndromes usually manifest in infancy, so that these diseases must be considered, especially if cold-associated urticarial skin lesions are present. Appropriate and early treatment can prevent serious sequelae. In maculopapular mastocytosis (urticaria pigmentosa), reddish macules are characteristic for the disease; especially after elicitation of the Darier’s sign, differentiation from urticaria can be difficult, but the macules are permanent. Clinically, wheals and/or angioedema are found similarly to adults, indicating that mast cell-induced angioedema is also associated with childhood urticaria. In the case of exclusive angioedema, hereditary angioedema must also be considered, which usually manifests for the first time during puberty, often linked to hormone preparation usage.</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-023-00271-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134797418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abstracts of the 18th German Allergy Congress, Bonn, September 14–16, 2023 第18届德国过敏大会摘要，波恩，2023年9月14日至16日

Allergo Journal International Pub Date : 2023-08-30 DOI: 10.1007/s40629-023-00269-2

引用次数: 0

Eosinophilic esophagitis—from definition to therapy 嗜酸性食管炎——从定义到治疗

Allergo Journal International Pub Date : 2023-08-28 DOI: 10.1007/s40629-023-00265-6

Ulrike von Arnim

{"title":"Eosinophilic esophagitis—from definition to therapy","authors":"Ulrike von Arnim","doi":"10.1007/s40629-023-00265-6","DOIUrl":"10.1007/s40629-023-00265-6","url":null,"abstract":"<p>Eosinophilic esophagitis (EoE) is a chronic immune-mediated disorder that is characterized clinically by symptoms of esophageal dysfunction and histologically by a dense eosinophilic inflammation of the esophagus. This article provides an overview of the current knowledge in the field of EoE. EoE has seen significant progress in its understanding, including its definition, clinical presentation, diagnosis, and treatment. Consensus criteria have been established for diagnosing EoE, with symptoms commonly including dysphagia, food impaction, and reflux-like symptoms. Diagnosis involves clinical evaluation, endoscopy, and histological assessment. Therapeutic strategies for EoE aim to alleviate symptoms, induce and maintain remission, and prevent complications. These strategies include dietary modifications, pharmacotherapy, and endoscopic interventions. Treatment choice depends on disease severity, patient preferences, and comorbidities. Despite progress, challenges persist in EoE management. Long-term outcomes and optimal treatment duration are still under investigation. Research efforts focus on identifying predictive markers for treatment response and developing personalized approaches. In conclusion, EoE is a chronic, progressive and recurrent disease with various clinical manifestations and treatment options. Improved understanding has led to better diagnostic criteria and therapeutic strategies. However, further research is necessary to enhance our understanding of disease pathogenesis, refine treatment algorithms, and optimize long-term outcomes for individuals with EoE.</p>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-023-00265-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46177453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute urticaria—what to do? 急性荨麻疹怎么办?

Allergo Journal International Pub Date : 2023-08-18 DOI: 10.1007/s40629-023-00266-5

Regina Treudler, Julia Zarnowski, Nicola Wagner

引用次数: 0

Anti-allergen monoclonal antibodies for the treatment of allergies 抗过敏原单克隆抗体用于治疗过敏

Allergo Journal International Pub Date : 2023-08-15 DOI: 10.1007/s40629-023-00263-8

Niccolo Pengo PhD, Natascha Wuillemin PhD, Dimitri Bieli PhD, Pascal Gasser PhD

{"title":"Anti-allergen monoclonal antibodies for the treatment of allergies","authors":"Niccolo Pengo PhD, Natascha Wuillemin PhD, Dimitri Bieli PhD, Pascal Gasser PhD","doi":"10.1007/s40629-023-00263-8","DOIUrl":"10.1007/s40629-023-00263-8","url":null,"abstract":"<div><h3>Background</h3><p>To tackle the growing allergy epidemic, novel therapeutic approaches are urgently needed. One promising avenue is the development of anti-allergen antibody therapies. This passive immunization approach stands out from traditional allergen immunotherapy by not exposing patients to the allergen but also by potentially treating patients who are less responsive or even unresponsive to allergen immunotherapies and providing immediate protection.</p><h3>Methods\t</h3><p>After a review of historical and recently published literature on the topic of anti-allergen antibodies, the status quo and recent advancements are presented. Anti-allergen antibody therapies in the context of immunological changes that occur during allergen immunotherapy are also discussed.</p><h3>Results</h3><p>While the protective role of anti-allergen antibodies was recognized decades ago, the advancement of antibody discovery technologies has fueled the field, and now different anti-allergen antibody therapies are approaching clinical use. These developments have also broadened our understanding of the allergens and allergenic epitopes responsible in different allergic diseases, and also the role played by immunoglobulins in shaping the immune system.</p><h3>Conclusion</h3><p>The development of anti-allergen antibody therapies offers great potential for the treatment of allergies. Of interest, the efficacy of passive immunization approaches will likely extend beyond allergen neutralization as in the presence of the allergen they might contribute to long-lasting disease modification.</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-023-00263-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41681351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phenology as a tool to gain more insights into the grass pollen season 物候学是了解草花粉季节的工具

Allergo Journal International Pub Date : 2023-08-14 DOI: 10.1007/s40629-023-00264-7

Katharina Bastl, Maximilian Bastl, Markus Berger, Lukas Dirr, Uwe E. Berger

引用次数: 0

Methods and standards of pollen monitoring—significance of pollen measurements at different altitudes 花粉监测方法和标准——不同海拔花粉测量的意义

Allergo Journal International Pub Date : 2023-08-07 DOI: 10.1007/s40629-023-00268-3

Maximilian Bastl, Katharina Bastl, Lukas Dirr, Markus Berger, Uwe Berger

{"title":"Methods and standards of pollen monitoring—significance of pollen measurements at different altitudes","authors":"Maximilian Bastl, Katharina Bastl, Lukas Dirr, Markus Berger, Uwe Berger","doi":"10.1007/s40629-023-00268-3","DOIUrl":"10.1007/s40629-023-00268-3","url":null,"abstract":"<div><h3>Background</h3><p>The measurement of pollen concentrations has been performed according to various protocols in recent decades. In all approaches the following questions were of importance: the positioning of the measuring device (whether at roof or nose level), the reliability as well as the comparability of measurements.</p><h3>Methods</h3><p>Current methods for pollen measurements and previous studies on measurement heights are presented and compared.</p><h3>Results</h3><p>The most widely used device is the Hirst pollen and spore trap. Its data is widely used for pollen information, pollen prediction models, and clinical studies. The position of the trap at roof level remains the current standard as the pollen concentrations correlate best with “real world” situation and regional symptom data.</p><h3>Conclusion</h3><p>The guideline for the detection of pollen and spores for allergy networks (EN 16868:2019-09) in Europe was an important step towards standardization. Modern, automated measurement methods are still in experimental stage in terms of validation and comparability. Harmonization of data from different measurement methods is a future challenge.</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-023-00268-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46783829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What inhalant allergens can do and not do?—The cooperation of allergens and their source in Th2 polarization and allergic sensitization 吸入性过敏原能做什么，不能做什么--过敏原及其来源在Th2极化和过敏致敏中的协同作用

Allergo Journal International Pub Date : 2023-07-28 DOI: 10.1007/s40629-023-00262-9

Sophie Grosse-Kathoefer, Lorenz Aglas, Fatima Ferreira, Lisa Pointner

引用次数: 1

Prolonging the period of allergenic burden: late-flowering grasses and local peculiarities 延长致敏负担期：晚花草和当地特点

Allergo Journal International Pub Date : 2023-07-27 DOI: 10.1007/s40629-023-00267-4

Lukas Dirr, Katharina Bastl, Maximilian Bastl, Markus Berger, Uwe E. Berger

{"title":"Prolonging the period of allergenic burden: late-flowering grasses and local peculiarities","authors":"Lukas Dirr, Katharina Bastl, Maximilian Bastl, Markus Berger, Uwe E. Berger","doi":"10.1007/s40629-023-00267-4","DOIUrl":"10.1007/s40629-023-00267-4","url":null,"abstract":"<div><h2>Summary</h2><div><h3>Background</h3><p>The grass pollen season is characterized by a particularly long duration, covering the months May to July in Europe but can vary depending on the altitude and geographical location.</p><h3>Methods</h3><p>Three grass species whose flowering period takes place late in the season are discussed in detail: <i>Phragmites australis </i>(common reed), <i>Miscanthus </i>spp. (silvergrass), and <i>Zea mays </i>(maize).</p><h3>Results</h3><p><i>Phragmites australis </i>flowers between August and September and provides significant pollen concentrations at sites with large reed populations. <i>Miscanthus </i>spp. flowers from August to October and is found as an ornamental plant in urban areas and as a crop plant in rural areas. <i>Zea mays </i>flowers from July to October and can cause discomfort especially in the vicinity of cornfields.</p><h3>Discussion</h3><p>Phenological observations are an important part of aerobiological routine work to gain insights into regional peculiarities like late-flowering grasses, which play a role in prolonging the duration of the grass pollen season.</p></div></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-023-00267-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50518060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0