Allergo Journal International最新文献

{"title":"Correction to: Anaphylaxis induced by intradermal testing with omeprazole: a case report","authors":"Alice Botta MD, Christian Paolo Ratti, Eleonora Bono, Matteo Cavara, Alessandra Chiei Gallo, Chiara Ghelli, Enrico Iemoli, Valeria Giuseppina Rita Ortolani","doi":"10.1007/s40629-025-00352-w","DOIUrl":"10.1007/s40629-025-00352-w","url":null,"abstract":"","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"34 7","pages":"278 - 278"},"PeriodicalIF":0.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-025-00352-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145341140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous drug reactions: classification, diagnosis, clinical and therapeutic consequences","authors":"Jasmin Paster,&nbsp; Wolfram Hötzenecker,&nbsp;Soo Bin Ahn","doi":"10.1007/s40629-025-00350-y","DOIUrl":"10.1007/s40629-025-00350-y","url":null,"abstract":"<div><h3>Background</h3><p>Cutaneous adverse drug reactions cover a broad clinical and immunological spectrum—from common, mild maculopapular drug exanthema to potentially lethal forms such as Stevens–Johnson syndrome, toxic epidermal necrolysis, or drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. Due to the increasing life expectancy, rising multimorbidity, and growing polypharmacy, there is an increase not only in incidence, but also in diagnostic and therapeutic complexity. Cutaneous adverse drug reactions (CADRs) are highly relevant from a clinical and health economic perspective and require differentiated, guideline-based management.</p><h3>Objective</h3><p>The aim of this study is to provide a comprehensive overview of the pathophysiological mechanisms, clinical manifestations, and current diagnostic and therapeutic strategies for cutaneous drug reactions.</p><h3>Results</h3><p>Analyses of the current literature show that early and differentiated diagnosis is essential for the effective treatment of cutaneous drug reactions. Immunologically, CADRs can be classified predominantly as type IV hypersensitivity reactions. In addition to T‑cell-mediated mechanisms, genetic risk factors and viral reactivations are becoming increasingly important. Advances in biomarker research could further improve early and accurate diagnosis. Depending on the severity, topical or systemic corticosteroids, immunoglobulins, immunomodulatory agents such as ciclosporin or Janus kinase inhibitors are available for treatment.</p><h3>Conclusion</h3><p>Differentiating between cutaneous drug reactions based on their clinical presentation and underlying immunological mechanisms is crucial for choosing an appropriate therapy. Given the increasing prevalence and growing complexity of cutaneous drug reactions, a thorough understanding of pathophysiological relationships is essential. Current research approaches, in particular pharmacogenetic screening and validated biomarkers, offer promising opportunities to individualize diagnosis and therapy, thereby significantly expanding the range of treatment options in the future.</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"34 7","pages":"251 - 261"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-025-00350-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145341189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chlorhexidine: a hidden and often undeclared allergen","authors":"Elias Marquart,&nbsp; Tamar Kinaciyan","doi":"10.1007/s40629-025-00351-x","DOIUrl":"10.1007/s40629-025-00351-x","url":null,"abstract":"<div><p>Chlorhexidine (1:6-di-4’-chlorophenyldiguanidohexane) has been a widely used antiseptic since its introduction in 1954. Alongside alexidine, it belongs to the group of cationic bisbiguanides with a broad spectrum of activity. Due to its diverse applications—such as in skin and mucous membrane disinfection, with use in mouthwashes, wound antiseptics, or catheterization—chlorhexidine has been an integral part of healthcare and beyond as an antiseptic for decades. Despite its generally good tolerability, chlorhexidine is also a potent allergen that can trigger both type I and type IV hypersensitivity reactions. In the following article, we provide an overview of anaphylactic reactions caused by chlorhexidine.</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"34 7","pages":"271 - 275"},"PeriodicalIF":0.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-025-00351-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145341168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence to grass pollen allergen immunotherapy and use of allergy medications in children and adolescents","authors":"Morten Borg,&nbsp;Ole Hilberg,&nbsp;Rikke Ibsen,&nbsp;Anders Løkke","doi":"10.1007/s40629-025-00348-6","DOIUrl":"10.1007/s40629-025-00348-6","url":null,"abstract":"<div><h3>Purpose</h3><p>Allergic rhinitis (AR), which is prevalent among children and adolescents, often impairs quality of life and coexists with asthma. Allergen immunotherapy (AIT), particularly sublingual immunotherapy (SLIT), is recommended for individuals with insufficient response to standard treatments. While adherence is critical to AIT effectiveness, its impact on the use of allergy medications remains unclear. This study aimed to investigate the association between adherence to SLIT for grass pollen and use of prescription allergy medications.</p><h3>Methods</h3><p>A nationwide cohort study was conducted using Danish health registries. Children and adolescents initiating SLIT from 2007–2022 were classified as adherent (≥ 80% of defined daily dose [DDD]) or nonadherent (&lt; 1 year of DDD). Individuals with intermediate adherence were excluded. Primary outcomes were annual use and dosage of prescription oral antihistamines, nasal corticosteroids, and inhaled corticosteroids, analyzed using two-step regression models adjusted for age and sex.</p><h3>Results</h3><p>Among 2500 children and adolescents, 1118 were adherent and 446 nonadherent. Over time, the adherent group showed a significant reduction in antihistamine and nasal corticosteroid use compared to the nonadherent group, relative to pretreatment levels (<i>p</i> &lt; 0.05). No significant difference in inhaled corticosteroid use was observed. Among users, mean annual doses of allergy medications were higher in the adherent group, likely reflecting broader adherence behaviors.</p><h3>Conclusion</h3><p>Adherence to SLIT was associated with reduced use of symptomatic allergy medications, highlighting its clinical importance. Strategies to improve adherence—such as patient education and structured follow-up—may enhance outcomes in pediatric AR management.</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"35 4","pages":"116 - 123"},"PeriodicalIF":0.0,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-025-00348-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148141725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Women are more likely to experience adverse reactions to local anesthetics—type I hypersensitivity remains a rarity","authors":"Florian Martycz,&nbsp;Lauritz Pfefferl,&nbsp;Wolfram Hötzenecker,&nbsp; Sabine Altrichter","doi":"10.1007/s40629-025-00341-z","DOIUrl":"10.1007/s40629-025-00341-z","url":null,"abstract":"<div><h3>Background</h3><p>Adverse drug reactions (ADR) associated with local anesthetics (LA) like lidocaine are often interpreted as allergy. This assumption leads to a large number of allergological investigations. There are numerous studies that investigate the frequency of type I allergies to LA, and they all agree that a real type I allergy as the culprit of ADR to LA is extraordinarily rare. Other mechanisms are more likely. Specifically, the unequal sex distribution of patients with ADR is rarely discussed and hardly any studies address this topic.</p><h3>Aim</h3><p>The aim of this paper is to examine sex disparities in ADR to LA. Differences in symptoms, causes and pathomechanisms between men and women are analyzed.</p><h3>Methods</h3><p>This study integrates our own clinical data with a comprehensive literature review. Our data are based on an analysis of 140 patients with suspected allergy to LA. Patient anamnesis, clinical data and skin test results performed with different LA are analyzed in relation to the sex. A PubMed search provides comparative data.</p><h3>Results</h3><p>Our data and literature research show that women are significantly more likely than men to present to allergy centers with suspected allergies to LA. True type I allergies are exceedingly rare in both sexes. Symptoms of ADR can be diverse and there is no pathognomonic symptom and not even a symptom complex that reliably indicates a real type I allergy. Pharmacophysical differences, such as different drug distribution and metabolism, and psychological differences in females could account for a part of the symptoms.</p><h3>Conclusion</h3><p>The reason for the unbalanced sex distribution is still unknown, but probably multifactoral. A research focus on this subject is needed to better understand gender specific aspects, in order to provide more efficient workup in allergological diagnostics.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"34 7","pages":"262 - 270"},"PeriodicalIF":0.0,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-025-00341-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145341329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic therapy of atopic dermatitis with Janus kinase inhibitors","authors":"Thomas Bieber MDRA","doi":"10.1007/s40629-025-00345-9","DOIUrl":"10.1007/s40629-025-00345-9","url":null,"abstract":"<div><h3>Background</h3><p>Over the last 8 years, the treatment of atopic dermatitis (AD) has been revolutionized by the development and approval of novel systemic therapies. In addition to the biologics dupilumab, tralokinumab, lebrikizumab, and nemolizumab, the three Janus kinase inhibitors (JAKi) baricitinib, abrocitinib, and upadacitinib are now also available.</p><h3>Methods and results</h3><p>A selection of the most important publications on the approved JAKi for the systemic treatment of AD and their statements were used as the basis for this review.</p><h3>Conclusion</h3><p>Systemic JAKi have become established as a promising therapeutic option in the guidelines for the treatment of AD. They specifically block the JAK signaling pathways involved in the inflammatory response and provide rapid and effective relief of the inflammatory reaction as well as the symptoms such as itching and pain. Compared to the class of biologics, they have a broader effect on various cytokines. Despite very good efficacy, there are some safety concerns, which is why a careful risk–benefit assessment is required in accordance with European Medicines Agency recommendations.</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"34 6","pages":"167 - 172"},"PeriodicalIF":0.0,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145037447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Update on conventional therapy for atopic dermatitis","authors":"Lisa Anna Perzynski","doi":"10.1007/s40629-025-00346-8","DOIUrl":"10.1007/s40629-025-00346-8","url":null,"abstract":"<div><p>Atopic dermatitis (AD) is the most common chronic inflammatory skin disease and requires therapy that is individualized, yet also based on the current guidelines. This narrative review gives an update on the conventional therapy of AD depending on severity according to the German S3 guideline on AD. AD severity is graded as mild, moderate, and severe AD. Consequent topical basic therapy and avoidance of potential trigger factor is recommended for all patients. Basic therapy should be applied not only during a flare, but also to clear skin to prevent worsening; furthermore, mild/moderate eczema should receive anti-inflammatory therapy with topical corticosteroids/calcineurin inhibitors. Systemic therapy is indicated in moderate-to-severe AD with insufficient response to other measures, if applicable, also ultraviolet therapy. Systemic therapies are grouped into conventional and targeted therapies (biologics and Janus kinase inhibitors). Systemic corticosteroids should only be used as rescue therapy for 3 weeks maximum. Targeted therapies in AD have the highest recommendation grade for long-term therapy. Cyclosporin A (CsA), azathioprine (AZT), methotrexate (MTX), and mycophenolate mofetil (MMF) belong to the conventional steroid-sparing therapies. However, only CsA is licensed for AD. MTX should be and MMF might be considered for AD according to the German S3 guideline, while AZT may be considered in adults.</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"34 6","pages":"173 - 179"},"PeriodicalIF":0.0,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-025-00346-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145037246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abstracts of the 20th German Allergy Congress, Düsseldorf, October 2–4, 2025","authors":"","doi":"10.1007/s40629-025-00347-7","DOIUrl":"10.1007/s40629-025-00347-7","url":null,"abstract":"","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"34 6","pages":"186 - 250"},"PeriodicalIF":0.0,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145037547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biologics in the treatment of atopic dermatitis: approved active substances and monoclonal antibodies in advanced clinical trials","authors":"Svenja Royeck","doi":"10.1007/s40629-025-00340-0","DOIUrl":"10.1007/s40629-025-00340-0","url":null,"abstract":"<div><p>Atopic dermatitis (AD) is the most common chronic inflammatory skin disease in industrialized countries and is characterized by heterogeneous (endo)phenotypes and a high disease burden. In Europe, four biologics and three oral Janus kinase (JAK) inhibitors are currently approved by the European Medicines Agency (EMA) for the treatment of moderate to severe AD in adolescents (≥ 12 years) and adults: dupilumab (anti-interleukin [IL]-4Rα; 2017), tralokinumab (anti-IL-13; 2021), lebrikizumab (anti-IL-13; 2023) and nemolizumab (anti-IL-31Rα; 2024) as well as the JAK inhibitors baricitinib (JAK 1/2; 2020), upadacitinib (JAK 1; 2021) and abrocitinib (JAK 1; 2022). Among the abovementioned therapies, baricitinib for moderate and severe AD from the second year of life and dupilumab for severe AD from the sixth month of life are already two approved systemic therapies for early childhood. This narrative review provides an update on the biologics currently approved for treatment of moderate and severe AD. It also provides a brief overview of monoclonal antibodies currently in phase III clinical trials and future issues and opportunities for immunomodulatory systemic therapies for AD.</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"34 6","pages":"159 - 166"},"PeriodicalIF":0.0,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-025-00340-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145037328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence to Inhaled Corticosteroids among patients with asthma in the United Arab Emirates","authors":"Somayah Solaiman Rashid,&nbsp;Noufal Abdul Kader,&nbsp;Suhaila Mohammed Shareef Alawadhi,&nbsp;Ammar Ali Saleh Jaber,&nbsp;Abhijith K. Shaji,&nbsp; Sarath Chandran C,&nbsp;Malavika Suresh,&nbsp; Zakir Hussain K P","doi":"10.1007/s40629-025-00342-y","DOIUrl":"10.1007/s40629-025-00342-y","url":null,"abstract":"<div><h3>Introduction</h3><p>Asthma is a severe health condition that causes hyperresponsiveness, blockage, and mucus production. Inhaled corticosteroids (ICS) are crucial in asthma therapy and suppress the activation of inflammatory mediators in airway epithelial cells. This study aimed to determine the relationship between ICS adherence and the likelihood of UAE patients with persistent asthma to attain controlled asthma status.</p><h3>Methods</h3><p>A cross-sectional online survey of UAE residents was conducted over one month. The relationships between variables were tested using Pearson’s chi-squared test, whereas the relationships between concerns about ICS side effects and the level of asthma control were tested using Pearson’s correlations. Research reliability was ensured by testing the feasibility of the study tool through a pilot test of 20 patients (≤ 10% of the sample size).</p><h3>Results</h3><p>The study revealed that 72% of the participants had poorly controlled asthma, 22% had well-controlled asthma, and only 6% were completely controlled. UAE nationals had superior asthma control levels than expatriates with UAE residency, while 46% of UAE nationals were provided with health care insurance coverage by the UAE government, but had poorly controlled asthma (62%). Patients with health insurance, higher education, and better self-education about asthma were identified as being completely and well-controlled.</p><h3>Conclusion</h3><p>This study found that better patient education and communication regarding their condition and related medications are essential for improving medication compliance. Knowing their patients’ living circumstances will help healthcare practitioners better assist their patients in self-managing challenging medication regimens.</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"35 4","pages":"124 - 131"},"PeriodicalIF":0.0,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148141726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}