Allergo Journal International最新文献

{"title":"Asthma prevalence trends by sex and mortality rates in the US","authors":"Yoshiyasu Takefuji Ph.D.","doi":"10.1007/s40629-024-00310-y","DOIUrl":"10.1007/s40629-024-00310-y","url":null,"abstract":"","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"34 3","pages":"87 - 88"},"PeriodicalIF":0.0,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143883773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abstracts of the 19th German Allergy Congress, Dresden, September 26–28, 2024","authors":"","doi":"10.1007/s40629-024-00305-9","DOIUrl":"10.1007/s40629-024-00305-9","url":null,"abstract":"","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"33 6","pages":"194 - 245"},"PeriodicalIF":0.0,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142414831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The maternal microbiome in normal pregnancy and at delivery by cesarean section and the early developmental phase of the neonatal microbiome—presentation of a longitudinal pilot study","authors":"Sonja Granser,&nbsp; Philipp Foessleitner BSc","doi":"10.1007/s40629-024-00303-x","DOIUrl":"10.1007/s40629-024-00303-x","url":null,"abstract":"<div><h3>Aim</h3><p>In this study by Foessleitner et al., both the maternal microbiome in the third trimester of pregnancy and the factors that influence the development of the child’s microbiome after cesarean delivery were investigated.</p><h3>Methods</h3><p>Maternal vaginal and rectal swabs were collected at inclusion in the last trimester of pregnancy and on the day of the cesarean section. In addition, placental and intrauterine swabs as well as infant dermal, buccal, and meconium swabs were taken during the cesarean section immediately after birth and subsequently on the second/third day of life. All samples were analyzed for microbial composition using 16s rRNA amplicon sequencing.</p><h3>Results</h3><p>A total of 30 mothers and their newborns were included in the study, with microbiome samples available for all maternal, intrauterine cavity, and placenta samples, as well as for 18 out of the 30 newborns. The vaginal and rectal microbiome was stable over the course of the third trimester and showed no significant changes (permutational multivariate analysis of variance [PERMANOVA]; <i>p</i> &gt; 0.05). Both the intraoperative samples (placental, intrauterine) and the neonatal swabs at the time of birth were consistently sterile. However, rapid infant microbial colonization subsequently occurred, with neonatal buccal mucosa and stool samples showing significantly different microbial colonization from their mothers as early as the second/third day of life (PERMANOVA; <i>p</i> &lt; 0.01).</p><h3>Conclusion</h3><p>The conclusion of the presented study was therefore that the vaginal and rectal microbiome of healthy pregnant women does not change in the last trimester, the infant and the placenta are not microbially colonized at the time of birth, and the development of the newborn’s microbiome after birth appears to be influenced mainly by environmental exposure.</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"33 7","pages":"269 - 273"},"PeriodicalIF":0.0,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-024-00303-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142447347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An update on the clinical implications of the microbiome in the development of allergy diseases","authors":"Larissa Koidl,&nbsp; Eva Untersmayr","doi":"10.1007/s40629-024-00300-0","DOIUrl":"10.1007/s40629-024-00300-0","url":null,"abstract":"<p>This mini-review is an update on a previous review published in 2021 and aims to summarize recent findings on the influence of the microbiome on allergic diseases. We cover the topics of food allergy, airway allergies, and skin allergies with a particular focus on clinical implications. Articles published between January 2021 and March 2024 were screened to be included in this publication.</p>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"33 7","pages":"263 - 268"},"PeriodicalIF":0.0,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-024-00300-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141925178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of fungal sensitization and its association with clinical parameters of asthma—A longitudinal study in a tertiary care center in Tamil Nadu","authors":"Zubair Khan,&nbsp; Jebin Roger,&nbsp; Pushparaj Nilkanth Patil,&nbsp; Devasahayam J. Christopher","doi":"10.1007/s40629-024-00302-y","DOIUrl":"10.1007/s40629-024-00302-y","url":null,"abstract":"<div><h3>Background</h3><p>Studies have shown that asthmatics with sensitization to fungi have worse outcomes, but published data from tropical countries like India are lacking.</p><h3>Objective</h3><p>We studied the prevalence of sensitization to clinically relevant fungi in asthmatics and investigated the impact of these fungi on asthma.</p><h3>Methods</h3><p>This prospective observational study was conducted in a tertiary care hospital in India. The skin prick test was used to check the sensitization status to fungal and non-fungal allergens. The association between fungal sensitization and various asthma outcomes, i.e. lung function, treatment phase, level of control, exacerbations in the previous year, was evaluated.</p><h3>Results</h3><p>Out of 720 patients, 472 (65.6%) were sensitized to one or more fungal allergens; <i>Aspergillus fumigatus </i>was the predominant fungus in these patients. Patients with fungal sensitization (FS) had a lower lung function than those with no fungal sensitization (NFS; mean [SD] FEV₁ [% predicted, post-BD] 73.6% [19.6] vs. 83.2% [15.0]; <i>p</i> &lt; 0.001), were more likely to be on step 4 or 5 of Global Initiative for Asthma (GINA) treatment (78.1% vs. 63.7; <i>p</i> &lt; 0.001), and were more likely to be on high-dose inhaled corticosteroids (28.2% of FS patients vs. 18.1% of NFS; <i>p</i> &lt; 0.001). Furthermore, 11% of FS had uncontrolled asthma versus 4% of the NFS patients (<i>p</i> = 0.003). Persistent significant bronchodilator reversibility of FEV₁ was seen in 37.9% of FS patients vs. 13.4% of NFS patients (<i>p</i> &lt; 0.001).</p><h3>Conclusion</h3><p>Fungal sensitization was associated with poorer asthma outcomes. In patients with FS, the physician needs to anticipate and sensitize the patient about the risk of a severe course of asthma.</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"34 3","pages":"76 - 80"},"PeriodicalIF":0.0,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141928039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heinrich Quincke (1842–1922) and the social hygiene movement","authors":"Beato Suwa","doi":"10.1007/s40629-024-00301-z","DOIUrl":"10.1007/s40629-024-00301-z","url":null,"abstract":"<p>Heinrich Irenaeus Quincke can be considered one of the most versatile and innovative medical scientists and inventors of his time. Both lumbar puncture and the treatment of lung abscesses are largely due to Quincke. Quincke’s edema (angioedema) was also named after him. A historical trace from Quincke’s early Berlin period sheds new light on the personal and political background regarding his two appointments to Bern in 1873 and Kiel in 1878.</p><p>On the one hand, this work is based on a literature search of historical journals and other publications from around 1870. On the other hand, a recently discovered original material is evaluated. This is a letter from Quincke with the place/date “Berlin, 4 August 72”, in which he registers for the “45th Assembly of German Naturalists and Physicians in Leipzig.”</p><p>Quincke had personal contacts with the early social hygiene movement, which was partly rooted in Switzerland. This movement was later popularized by the psychiatrist Auguste Forel (1848–1931), among others.</p><p>A work on the outbreak of the Wrocław relapsing fever epidemic (Febris recurrens, “relapsing fever”) in 1868 may have played an important role in the early social hygiene movement. It describes in a very impressive way the catastrophic social and hygienic conditions in the city’s slum, which were directly linked to the outbreak of the epidemic. The relapsing fever may have had similarities with today’s Lyme disease.</p>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"34 1","pages":"15 - 20"},"PeriodicalIF":0.0,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143109830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mannan‑, VLP-, and flagellin-based adjuvants for allergen-specific immunotherapy: a review of the current literature","authors":"Clara Pignard,&nbsp;Hannah Schiller,&nbsp;Alisa Seyffer,&nbsp;Stefan Schülke PhD","doi":"10.1007/s40629-024-00298-5","DOIUrl":"10.1007/s40629-024-00298-5","url":null,"abstract":"<div><p>Currently, allergen-specific immunotherapy (AIT) with active ingredients derived from the causative allergen source is the only disease-modifying treatment for allergic patients. However, compared to, e.g., live-attenuated vaccines for the prevention of infectious diseases, purified allergens for AIT in many cases display only a low immunogenicity. This reduces treatment efficacy and prolongs treatment duration. Here, adjuvants may be a promising tool, allowing for dose reduction of the respective allergen while increasing immunogenicity of co-applied allergens and/or modulating allergen-specific immune responses toward T helper 1 (Th1) or regulatory phenotypes or the production of blocking antibody isotypes. Currently available adjuvants can be distinguished into first-generation adjuvants (promoting immune responses via aggregation and controlled release of co-applied allergens from a depot) and second-generation adjuvants (triggering immune responses via the activation of pattern recognition receptors expressed by immune cells). This review summarizes the mechanisms and effects of adjuvants currently or previously used for AIT (aluminum hydroxide, calcium phosphate, microcrystalline tyrosine, and monophosphoryl lipid A [MPLA]) and focuses on novel developments using mannan-, virus-like particle (VLP)-, and flagellin-based adjuvants and therapeutics for the treatment of allergic diseases.</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"33 8","pages":"289 - 303"},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-024-00298-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141827171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physician’s perspectives on skin prick testing and allergy diagnostics in Germany","authors":"Ludger Klimek,&nbsp;Wolfgang Wehrmann,&nbsp;Randolf Brehler,&nbsp;Sven Becker,&nbsp;Mandy Cuevas,&nbsp;Moritz Gröger,&nbsp;Jan Hagemann,&nbsp;Ingrid Casper,&nbsp;Mathias Sulk,&nbsp;Senne Gorris,&nbsp;Sven F. Seys","doi":"10.1007/s40629-024-00297-6","DOIUrl":"10.1007/s40629-024-00297-6","url":null,"abstract":"<p>Novel technologies standardising the testing process of immediate hypersensitivities have been developed and validated in recent years. Meanwhile, challenges with regard to availability of testing agents and shortage of trained personnel have increased. Novel technologies could fight these challenges, but their distribution is at present not known. The current survey, conducted by the German Society for Allergology (AeDA), aimed to assess current practices of allergy diagnostics in Germany.</p><p>Members of AeDA were invited to complete an online questionnaire to obtain information on their perspectives on allergy testing and diagnostics.</p><p>A total of 150 allergologists from different disciplines treating patients with allergy completed the questionnaire. This survey revealed that twice as many skin prick tests (SPT; 21.2 tests/week) compared to serum specific immunoglobulin E tests (IgE; 10.4 tests/week) are being performed. Nasal allergen provocation tests are being performed in 56.0% of hospitals and physicians’ offices. An individual standard allergen panel for SPT is applied in 78.0% of testing cases. Methods used to perform a read out of SPT are variable with measurement of the longest wheal diameter being used most frequently (68.0%), followed by a qualitative evaluation (46.6%) or the longest wheal diameter including pseudopods (34.4%). In all, 66% of allergologists indicated that a device that automating the SPT process would be valuable for clinical practice.</p><p>Skin prick tests and serum IgE tests are still the cornerstones in the diagnostic work-up of immediate-type allergies. Variability in the execution of skin prick tests exists between different hospitals and physicians’ offices in Germany. Inconsistent availability of testing reagents was considered most problematic for maintaining allergy diagnostics in Germany. A majority of allergologists are open to evaluating tools that may contribute to standardize skin prick tests.</p>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"33 5","pages":"159 - 164"},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-024-00297-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141649035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eosinophilic esophagitis and gastritis as a result of dust mite sublingual immunotherapy","authors":"Yiwa Suksawat MD,&nbsp;Anundorn Wongteerasut MD","doi":"10.1007/s40629-024-00299-4","DOIUrl":"10.1007/s40629-024-00299-4","url":null,"abstract":"","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"34 3","pages":"84 - 86"},"PeriodicalIF":0.0,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143883723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergy skin prick tests with COVID-19 vaccines and their contribution to improve vaccination readiness and reduce anxiety","authors":"Tobias Pindel,&nbsp;Susanne Brandstetter,&nbsp;Wolfgang Sieber,&nbsp; Michael Kabesch M.D.","doi":"10.1007/s40629-024-00296-7","DOIUrl":"10.1007/s40629-024-00296-7","url":null,"abstract":"<div><h3>Background</h3><p>When coronavirus disease 2019 (COVID-19) vaccines were introduced, they were suspected of triggering severe allergic reactions disproportionately often. This contributed to the fear of vaccination, particularly among allergy patients.</p><h3>Methods</h3><p>In an allergy center in eastern Bavaria, we used a skin prick test to investigate how often sensitization to COVID-19 vaccines can be detected and whether appropriate testing could significantly reduce the fear of vaccination.</p><h3>Results</h3><p>Comirnaty® (<i>n</i> <i>=</i> 245 tested/6.93% <i>clearly positive </i>reaction; Biontec/Pfizer, Mainz, Germany/New York City, NY, USA), Spikevax® (56/14.28%; Moderna, Cambridge, MA, USA), Vaxzevria® (208/4.32%; Astra Zeneca, Cambridge, England) and Jcovden® (48/4.16%; Johnson &amp; Johnson, New Brunswick, NJ, USA) were tested by skin prick test. Most participants tested were female (83.6%) and had a history of allergies (94.8%). Depending on the result of the skin prick test, the test subjects were advised on vaccination. In a questionnaire survey approximately 1 year after testing, 75.7% of the <i>N</i> = 70 respondents stated that their fear of vaccination had been greatly or very greatly reduced as a result of the testing and counseling. In the follow-up survey, 88.5% of all respondents had been vaccinated at least once. No notable allergic problems occurred during the COVID-19 vaccination in study participants.</p><h3>Conclusion</h3><p>The study shows that simple skin prick testing could reduce fears and concerns about allergic reactions to COVID-19 vaccines, and thus significantly increase the willingness to vaccinate in the population, especially among allergy patients.</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"33 5","pages":"153 - 158"},"PeriodicalIF":0.0,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-024-00296-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142413498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}