Zubair Khan, Jebin Roger, Pushparaj Nilkanth Patil, Devasahayam J. Christopher
{"title":"泰米尔纳德邦一家三级医疗中心的真菌过敏流行率及其与哮喘临床参数的关系--纵向研究","authors":"Zubair Khan, Jebin Roger, Pushparaj Nilkanth Patil, Devasahayam J. Christopher","doi":"10.1007/s40629-024-00302-y","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Studies have shown that asthmatics with sensitization to fungi have worse outcomes, but published data from tropical countries like India are lacking.</p><h3>Objective</h3><p>We studied the prevalence of sensitization to clinically relevant fungi in asthmatics and investigated the impact of these fungi on asthma.</p><h3>Methods</h3><p>This prospective observational study was conducted in a tertiary care hospital in India. The skin prick test was used to check the sensitization status to fungal and non-fungal allergens. The association between fungal sensitization and various asthma outcomes, i.e. lung function, treatment phase, level of control, exacerbations in the previous year, was evaluated.</p><h3>Results</h3><p>Out of 720 patients, 472 (65.6%) were sensitized to one or more fungal allergens; <i>Aspergillus fumigatus </i>was the predominant fungus in these patients. Patients with fungal sensitization (FS) had a lower lung function than those with no fungal sensitization (NFS; mean [SD] FEV<sub>1</sub> [% predicted, post-BD] 73.6% [19.6] vs. 83.2% [15.0]; <i>p</i> < 0.001), were more likely to be on step 4 or 5 of Global Initiative for Asthma (GINA) treatment (78.1% vs. 63.7; <i>p</i> < 0.001), and were more likely to be on high-dose inhaled corticosteroids (28.2% of FS patients vs. 18.1% of NFS; <i>p</i> < 0.001). Furthermore, 11% of FS had uncontrolled asthma versus 4% of the NFS patients (<i>p</i> = 0.003). Persistent significant bronchodilator reversibility of FEV<sub>1</sub> was seen in 37.9% of FS patients vs. 13.4% of NFS patients (<i>p</i> < 0.001).</p><h3>Conclusion</h3><p>Fungal sensitization was associated with poorer asthma outcomes. In patients with FS, the physician needs to anticipate and sensitize the patient about the risk of a severe course of asthma.</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"34 3","pages":"76 - 80"},"PeriodicalIF":0.0000,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Prevalence of fungal sensitization and its association with clinical parameters of asthma—A longitudinal study in a tertiary care center in Tamil Nadu\",\"authors\":\"Zubair Khan, Jebin Roger, Pushparaj Nilkanth Patil, Devasahayam J. Christopher\",\"doi\":\"10.1007/s40629-024-00302-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Studies have shown that asthmatics with sensitization to fungi have worse outcomes, but published data from tropical countries like India are lacking.</p><h3>Objective</h3><p>We studied the prevalence of sensitization to clinically relevant fungi in asthmatics and investigated the impact of these fungi on asthma.</p><h3>Methods</h3><p>This prospective observational study was conducted in a tertiary care hospital in India. The skin prick test was used to check the sensitization status to fungal and non-fungal allergens. The association between fungal sensitization and various asthma outcomes, i.e. lung function, treatment phase, level of control, exacerbations in the previous year, was evaluated.</p><h3>Results</h3><p>Out of 720 patients, 472 (65.6%) were sensitized to one or more fungal allergens; <i>Aspergillus fumigatus </i>was the predominant fungus in these patients. Patients with fungal sensitization (FS) had a lower lung function than those with no fungal sensitization (NFS; mean [SD] FEV<sub>1</sub> [% predicted, post-BD] 73.6% [19.6] vs. 83.2% [15.0]; <i>p</i> < 0.001), were more likely to be on step 4 or 5 of Global Initiative for Asthma (GINA) treatment (78.1% vs. 63.7; <i>p</i> < 0.001), and were more likely to be on high-dose inhaled corticosteroids (28.2% of FS patients vs. 18.1% of NFS; <i>p</i> < 0.001). Furthermore, 11% of FS had uncontrolled asthma versus 4% of the NFS patients (<i>p</i> = 0.003). Persistent significant bronchodilator reversibility of FEV<sub>1</sub> was seen in 37.9% of FS patients vs. 13.4% of NFS patients (<i>p</i> < 0.001).</p><h3>Conclusion</h3><p>Fungal sensitization was associated with poorer asthma outcomes. In patients with FS, the physician needs to anticipate and sensitize the patient about the risk of a severe course of asthma.</p></div>\",\"PeriodicalId\":37457,\"journal\":{\"name\":\"Allergo Journal International\",\"volume\":\"34 3\",\"pages\":\"76 - 80\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-08-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Allergo Journal International\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s40629-024-00302-y\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Allergo Journal International","FirstCategoryId":"1085","ListUrlMain":"https://link.springer.com/article/10.1007/s40629-024-00302-y","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
Prevalence of fungal sensitization and its association with clinical parameters of asthma—A longitudinal study in a tertiary care center in Tamil Nadu
Background
Studies have shown that asthmatics with sensitization to fungi have worse outcomes, but published data from tropical countries like India are lacking.
Objective
We studied the prevalence of sensitization to clinically relevant fungi in asthmatics and investigated the impact of these fungi on asthma.
Methods
This prospective observational study was conducted in a tertiary care hospital in India. The skin prick test was used to check the sensitization status to fungal and non-fungal allergens. The association between fungal sensitization and various asthma outcomes, i.e. lung function, treatment phase, level of control, exacerbations in the previous year, was evaluated.
Results
Out of 720 patients, 472 (65.6%) were sensitized to one or more fungal allergens; Aspergillus fumigatus was the predominant fungus in these patients. Patients with fungal sensitization (FS) had a lower lung function than those with no fungal sensitization (NFS; mean [SD] FEV1 [% predicted, post-BD] 73.6% [19.6] vs. 83.2% [15.0]; p < 0.001), were more likely to be on step 4 or 5 of Global Initiative for Asthma (GINA) treatment (78.1% vs. 63.7; p < 0.001), and were more likely to be on high-dose inhaled corticosteroids (28.2% of FS patients vs. 18.1% of NFS; p < 0.001). Furthermore, 11% of FS had uncontrolled asthma versus 4% of the NFS patients (p = 0.003). Persistent significant bronchodilator reversibility of FEV1 was seen in 37.9% of FS patients vs. 13.4% of NFS patients (p < 0.001).
Conclusion
Fungal sensitization was associated with poorer asthma outcomes. In patients with FS, the physician needs to anticipate and sensitize the patient about the risk of a severe course of asthma.
期刊介绍：
Allergo Journal International is the official Journal of the German Society for Applied Allergology (AeDA) and the Austrian Society for Allergology and Immunology (ÖGAI). The journal is a forum for the communication and exchange of ideas concerning the various aspects of allergy (including related fields such as clinical immunology and environmental medicine) and promotes German allergy research in an international context. The aim of Allergo Journal International is to provide state of the art information for all medical and scientific disciplines that deal with allergic, immunological and environmental diseases. Allergo Journal International publishes original articles, reviews, short communications, case reports, and letters to the editor. The articles cover topics such as allergic, immunological and environmental diseases, the latest developments in diagnosis and therapy as well as current research work concerning antigens and allergens and aspects related to occupational and environmental medicine. In addition, it publishes clinical guidelines and position papers approved by expert panels of the German, Austrian and Swiss Allergy Societies.
All submissions are reviewed in single-blind fashion by at least two reviewers.
Originally, the journal started as a German journal called Allergo Journal back in 1992. Throughout the years, English articles amounted to a considerable portion in Allergo Journal. This was one of the reasons to extract the scientific content and publish it in a separate journal. Hence, Allergo Journal International was born and now is the international continuation of the original German journal. Nowadays, all original content is published in Allergo Journal International first. Later, selected manuscripts will be translated and published in German and included in Allergo Journal.
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