Allergo Journal International最新文献_第5页

Prolonging the period of allergenic burden: late-flowering grasses and local peculiarities 延长致敏负担期:晚花草和地方特性

Allergo Journal International Pub Date : 2023-07-27 DOI: 10.1007/s40629-023-00267-4

Lukas Dirr, K. Bastl, Maximilian Bastl, M. Berger, U. Berger

引用次数: 0

The Molecular Allergology User’s Guide 2.0: Update on relevant new content 分子变态反应学用户指南2.0：相关新内容的更新

Allergo Journal International Pub Date : 2023-07-26 DOI: 10.1007/s40629-023-00260-x

Christiane Hilger PhD, Stephanie Dramburg, Alexandra F. Santos, Leticia de las Vecillas, Karin Hoffmann-Sommergruber

引用次数: 0

Molecular engineering of nanobodies as tools in allergology: diagnostics and beyond 作为过敏症诊断工具的纳米体分子工程

Allergo Journal International Pub Date : 2023-07-13 DOI: 10.1007/s40629-023-00261-w

Josephine Baunvig Aagaard, Anne-Sofie Ravn Ballegaard, Pernille Ommen Andersen, Edzard Spillner

{"title":"Molecular engineering of nanobodies as tools in allergology: diagnostics and beyond","authors":"Josephine Baunvig Aagaard, Anne-Sofie Ravn Ballegaard, Pernille Ommen Andersen, Edzard Spillner","doi":"10.1007/s40629-023-00261-w","DOIUrl":"10.1007/s40629-023-00261-w","url":null,"abstract":"<div><h2>Summary</h2><div><h3>Background</h3><p>Molecular technologies have paved the way to improved understanding of allergic diseases in many ways, ranging from molecular allergens to tailor-made tools for analytical, diagnostic, and therapeutic purposes. Engineering of such molecules has become a mainstay in most biotechnical and biomedical areas. A not so new kid on the block is the nanobody, a single-domain antibody obtained from primarily camelid species. Despite their large promise and potential, it took nanobodies a long time to also enter the stage in allergology.</p><h3>Methods</h3><p>This review summarizes the state of the art and the feasibility of engineering nanobody-based tools for applications in allergology.</p><h3>Results</h3><p>In recent years, nanobodies with specificity for allergens have been increasingly generated. In parallel, their molecular engineering has enabled the development of derivatives that offer many advantages compared to standard antibody approaches. Hence, different application forms of nanobody-based molecules have been developed and reported in proof-of-concept studies.</p><h3>Discussion</h3><p>Recent studies give a first glimpse of the future possibilities of nanobody technologies in a complex system such as allergic diseases. It has become clear that the simplicity of the approaches as compared to regular antibody technologies will both broaden and deepen the scope of applications in allergology.</p></div></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48947422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Update on oral and epicutaneous immunotherapy for children with food allergy 食物过敏儿童口服和表皮免疫治疗的最新进展

Allergo Journal International Pub Date : 2023-07-11 DOI: 10.1007/s40629-023-00256-7

Yoko Miura MD, Sakura Sato MD, Noriyuki Yanagida MD, Motohiro Ebisawa MD, PhD

{"title":"Update on oral and epicutaneous immunotherapy for children with food allergy","authors":"Yoko Miura MD, Sakura Sato MD, Noriyuki Yanagida MD, Motohiro Ebisawa MD, PhD","doi":"10.1007/s40629-023-00256-7","DOIUrl":"10.1007/s40629-023-00256-7","url":null,"abstract":"<div><h3>Purpose</h3><p>Several oral immunotherapies (OITs) are used to treat food allergies. Recently, several protocols have been implemented to ensure the safety of OITs with a growing trend towards implementing them in a larger patient population. Additionally, reports on follow-up immunotherapy using the transdermal route have been reported. In this review, we summarize the evidence on current immunotherapies for food allergy.</p><h3>Methods</h3><p>We selected and reviewed studies on OIT and epicutaneous immunotherapy (EPIT) that showed evidence of clinical efficacy and safety in patients with an immediate type of food allergy.</p><h3>Results</h3><p>Continuation of low-dose OIT is considered relatively safe in patients with severe food allergies with a gradual increase in the daily dose of the immunotherapeutic agents. OIT products could be introduced through desensitization protocols to prevent serious adverse reactions; however, appropriate methods should be used to continue their use. Combining omalizumab, antihistamines, or probiotics with OITs improves the safety. Compared to OIT, EPIT is generally safer but has a lower efficacy. Furthermore, OIT is effective in some young patients. However, the selection of participants in such cases is critical from a safety perspective. Long-term OIT at relatively high target doses is associated with serious safety concerns.</p><h3>Conclusion</h3><p>The implementation of recent treatment protocols has significantly improved the safety of OIT. Therefore, its continuation using safety protocols can be considered in the selection of the optimal OIT for individual patients, as provision of safe and effective treatment is crucial for the success of OIT.</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45070846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How molecular diagnostics help us to correctly identify pet allergies 分子诊断如何帮助我们正确识别宠物过敏

Allergo Journal International Pub Date : 2023-07-05 DOI: 10.1007/s40629-023-00255-8

Wolfgang Hemmer PhD

{"title":"How molecular diagnostics help us to correctly identify pet allergies","authors":"Wolfgang Hemmer PhD","doi":"10.1007/s40629-023-00255-8","DOIUrl":"10.1007/s40629-023-00255-8","url":null,"abstract":"<div><h2>Summary</h2><div><p>Simultaneous sensitization to two or more animal species is common and represents a regular diagnostic problem during conventional extract-based allergy diagnosis. The use of single allergen molecules reveals the underlying cause of polysensitization and enables the distinction between primary sensitization and cross-reaction as a prerequisite for the selection of appropriate immunotherapy vaccines. Individual sensitization patterns can be valuable predictors of clinical relevance, symptom severity and asthma risk, and in part reflect current or past animal exposure. The concept of “marker allergens” is challenging in the case of pet allergies because many animal allergens are ubiquitous pan-allergens limiting the definition of group-specific markers. Alternatively, quantitative aspects often have to be used to identify the primary sensitizers. A sufficient number of allergen molecules is now available from cat and dog to unravel the many cases of cat–dog double sensitization. There are still substantial diagnostic gaps concerning allergens from small animals and farm animals, or such allergens are only available for multiplex testing. The lipocalins, a particularly species-rich and heterogeneous allergen family comprising important major and minor allergens from virtually all furry animals, show complex cross-reactivity patterns with each other and have been recently identified as a major cause of polysensitization.</p></div></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-023-00255-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42959064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dermatological differential diagnoses in pet owners 宠物主人的皮肤病鉴别诊断

Allergo Journal International Pub Date : 2023-07-05 DOI: 10.1007/s40629-023-00258-5

Antonia Currie, Sabine Altrichter, Wolfram Hötzenecker

引用次数: 0

Dogs at home and at the workplace: effects on allergies and mental health 家里和工作场所的狗:对过敏和心理健康的影响

Allergo Journal International Pub Date : 2023-06-30 DOI: 10.1007/s40629-023-00257-6

Isabella Pali-Schöll PhD., Rachel Dale, Zsófia Virányi

{"title":"Dogs at home and at the workplace: effects on allergies and mental health","authors":"Isabella Pali-Schöll PhD., Rachel Dale, Zsófia Virányi","doi":"10.1007/s40629-023-00257-6","DOIUrl":"10.1007/s40629-023-00257-6","url":null,"abstract":"<div><h2>Summary</h2><div><p>Since the beginning of domestication, the living conditions which are shared between humans and companion animals have changed dramatically. More time is spent together indoors, not only in urban places, but also in rural areas. Among the positive aspects is the asthma- and allergy-protective effect of living with pets during fetal development and infancy. In addition, there are benefits in terms of social interactions and mental health for humans and, as far as can be assessed, also for companion animals. Animals, especially dogs, are also brought more often to workplaces and schools. Thus, a number of the positive effects on social and health aspects are likely to come to these places of activity as well. Optimal preparation of the workplace for the animal by the owner, as well as instruction of employees and, additionally, training of the animal could help reduce potentially adverse effects. Such negative effects could include interference with work processes (phone calls, meetings, lectures, sales calls), and fear of bites or accident hazards by colleagues. In the sense of a One Health approach, this article focuses on the importance of animals (especially dogs) and humans sharing the home, but also the workplace. The effects on allergic/asthmatic diseases as well as on social and mental factors are particularly highlighted, as the latter may also contribute to these diseases. Only a few studies have examined the effects of contact between adult people, who are not pet owners themselves, with dogs in the work environment; so there is clearly a need for further research.</p></div></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-023-00257-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42886637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Allergy to the cat—from diagnosis to management 猫过敏——从诊断到管理

Allergo Journal International Pub Date : 2023-06-30 DOI: 10.1007/s40629-023-00254-9

Erika Jensen-Jarolim MD, Sebastian Alexander Jensen MD, Karl-Christian Bergmann MD

{"title":"Allergy to the cat—from diagnosis to management","authors":"Erika Jensen-Jarolim MD, Sebastian Alexander Jensen MD,  Karl-Christian Bergmann MD","doi":"10.1007/s40629-023-00254-9","DOIUrl":"10.1007/s40629-023-00254-9","url":null,"abstract":"<div><h3>Background</h3><p>In allergology practice, efficient counselling of cat owners is often frustrating because the topic of allergen avoidance is mostly a “no-go” and there are only few studies on allergen immunotherapy that prove its efficacy. In the end, what patients are mostly offered in allergy consultations are allergen reduction measures and symptomatic therapy.</p><h3>Results</h3><p>Sensitisation to the main cat allergen Fel d 1 occurs more frequently in atopic conditions and then represents a risk for allergic rhinitis and asthma. Current guidelines are therefore cautious about the first-time acquisition of a cat in the first months of life in atopic families. However, sensitisation occurs in many cases even without contact with an own cat at home.</p><p>Conversely, it has been observed in adult patients that in the case of high Fel d 1 exposure immunological tolerance can also develop through the induction of specific IgG4. The fact that many cat allergic patients keep their animals despite diagnosis is, however, partly due to the psychological phenomenon of coping.</p><h3>Conclusion</h3><p>In this review, we present current literature and facts that should make everyday life easier for patients, even without giving up the animal. We also review best practices in the management of cat allergy and present new management options and concepts from the development pipeline that our patients are eagerly awaiting.</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-023-00254-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46089325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advanced glycation end products and allergy 晚期糖基化终产物与过敏

Allergo Journal International Pub Date : 2023-06-28 DOI: 10.1007/s40629-023-00259-4

Masako Toda, Michael Hellwig, Hiroyuki Hattori, Thomas Henle, Stefan Vieths

引用次数: 0

Unilateral relapsing purpura on the leg as a first manifestation of IgG lymphoplasmacytic lymphoma 作为IgG淋巴浆细胞性淋巴瘤首发症状的单侧腿部复发性紫癜

Allergo Journal International Pub Date : 2023-06-23 DOI: 10.1007/s40629-023-00253-w

Ieva Saulite, Lukas Graf, Michael Giger, Ilona Hartmane, Eva Markert, Marcus Schittenhelm, Emmanuella Guenova, Antonio Cozzio

引用次数: 0