Allergo Journal International最新文献_第5页

Course of growth and nutritional status in Swiss children with food allergies 瑞士食物过敏儿童的生长过程和营养状况

Allergo Journal International Pub Date : 2024-06-11 DOI: 10.1007/s40629-024-00289-6

Rebekka Gerber, Andre Meichtry, Klazine van der Horst, Alice Koehli, Caroline Roduit, Felicitas Bellutti Enders, Isabel Skypala, Mary Hickson, Julia Eisenblaetter

{"title":"Course of growth and nutritional status in Swiss children with food allergies","authors":"Rebekka Gerber, Andre Meichtry, Klazine van der Horst, Alice Koehli, Caroline Roduit, Felicitas Bellutti Enders, Isabel Skypala, Mary Hickson, Julia Eisenblaetter","doi":"10.1007/s40629-024-00289-6","DOIUrl":"10.1007/s40629-024-00289-6","url":null,"abstract":"<p>Studies suggest that children with immunoglobulin E (IgE)-mediated food allergies (FA) are at risk of impaired growth, especially those with cow’s milk or multiple FA. However, there is limited long-term data available on this topic. This analysis presents the growth of Swiss children for the first year after FA diagnosis.</p><p>This is a secondary analysis of data from a multicentered study following food allergic children (0–10 years) over 1 year post diagnosis, comparing those who received dietary counselling with those who did not. Growth z‑scores were calculated based on World Health Organization (WHO) standards, using data reported by caregivers. To analyze data, linear mixed models with between-subject factors related to dietary counselling, number of FA, and cow’s milk allergy were fitted to the data.</p><p>In the 48 children (median age 16 months) studied, we observed an increasing prevalence of wasting (weight-for-length/height z‑score < 2; 2–10%) and a lower prevalence of stunting (length/height-for-age < 2; 0–2%) over the 1‑year period. Twelve months after diagnosis, all median z‑scores showed an increase. Linear mixed model analysis did not find any significant within-subject and between-subject effects on growth.</p><p>Children with IgE-mediated FA can have normal growth if children with cow’s milk allergy or multiple food allergies receive dietary counselling. Routine length/height and weight measurements should be taken to identify individual malnutrition and to initiate tailored nutritional interventions. Larger studies with longer duration are needed to assess further growth development in children with IgE-mediated food allergies.</p>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"33 6","pages":"171 - 179"},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-024-00289-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141356894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Classification of molds and definition of mold contamination 霉菌的分类和霉菌污染的定义

Allergo Journal International Pub Date : 2024-05-21 DOI: 10.1007/s40629-024-00292-x

Thomas Gabrio, Guido Fischer

{"title":"Classification of molds and definition of mold contamination","authors":"Thomas Gabrio, Guido Fischer","doi":"10.1007/s40629-024-00292-x","DOIUrl":"10.1007/s40629-024-00292-x","url":null,"abstract":"<div><p>The term “molds” is defined and relevant sources of molds are given. The conditions and growth of mold fungi are explained. The determination of mould spores and colony-forming units (CFU) in the air is briefly explained and it is made clear that the total spore count is relevant for assessing the sensitizing and allergenic effect of moulds. Outdoor air-associated moulds such as <i>Alternaria alternata, Aspergillus fumigatus, Cladosporium herbarum</i> and <i>Penicillium chrysogenum</i> (mx1 mould mixture) are of particular importance due to their high degree of sensitization. Their concentration in the air is determined by the vegetation and is therefore dependent on the season. In people who were tested for mx1, sensitization to <i>Alternaria alternata</i> (m6) was predominantly observed for the individual allergens. For many indoor-associated moulds, no (valid) commercially available test extracts for the detection of sensitization, so-called allergy tests, are available. Allergy test results of mold mixtures, such as mx1, cannot be used to determine an indoor mold allergy, nor can the results of mold measurements in the rooms used by the respective persons be used for a risk assessment in the event of an existing mold infestation in the interior. The classification of mold fungi is explained.</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"33 4","pages":"110 - 123"},"PeriodicalIF":0.0,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141114600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The German guideline on medical clinical diagnostics for indoor mold exposure: key messages 德国室内霉菌暴露医学临床诊断指南：关键信息

Allergo Journal International Pub Date : 2024-05-07 DOI: 10.1007/s40629-024-00294-9

Julia Hurraß, Gerhard A. Wiesmüller

引用次数: 0

What effect do mycotoxins, cell wall components, enzymes and other mold components and metabolites have on our health? 霉菌毒素、细胞壁成分、酶和其他霉菌成分及代谢物对我们的健康有什么影响？

Allergo Journal International Pub Date : 2024-05-07 DOI: 10.1007/s40629-024-00295-8

Julia Hurraß, Rabea Teubel, Guido Fischer, Birger Heinzow, Gerhard A. Wiesmüller

引用次数: 0

Allergen-specific immunotherapy for mold allergies 针对霉菌过敏的过敏原特异性免疫疗法

Allergo Journal International Pub Date : 2024-04-23 DOI: 10.1007/s40629-024-00293-w

Randolf Brehler, Uta Rabe

{"title":"Allergen-specific immunotherapy for mold allergies","authors":"Randolf Brehler, Uta Rabe","doi":"10.1007/s40629-024-00293-w","DOIUrl":"10.1007/s40629-024-00293-w","url":null,"abstract":"<div><p>Molds are ubiquitous in our environment and are considered by the population to be the most important indoor pollutant problem [1]. The current 2023 update to the AWMF mold guideline [1] is intended to allay or channel fears and provide assistance for a sensible diagnosis and treatment decision.</p><p>The detection of an IgE-mediated allergy implies for allergists Allergen immunotherapy (AIT) as an established treatment option. However, compared to the well-validated AIT with pollen and house dust mites, the decision to use AIT with mold extracts must be weighed more heavily between the benefits and risks.</p><p>Spores of <i>Alternaria alternata</i> are found in high concentrations in the outdoor air. Due to the high allergenic potential and the small size of the spores, an Alternaria allergy often leads to bronchial asthma, especially in children. The effectiveness of AIT with Alternaria extracts has been tested in several studies; for other molds, especially those from the indoor environment, the efficacy and applicability is very limited.</p><p>In terms of differential diagnosis, it must be borne in mind that molds can not only cause common allergic reactions but can also be responsible for allergic bronchopulmonary mycoses/aspergillosis (ABPA), Aspergillus bronchitis, exogenous allergic alveolitis (EAA), invasive aspergillosis, mycoses and rhinosinusitis. Very high concentrations, which can occur particularly in workplaces, can also result in toxic effects (“organic dust toxic syndrome”); molds are also held responsible for mucous membrane irritation, odor effects and mood disorders [1].</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"33 4","pages":"101 - 105"},"PeriodicalIF":0.0,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-024-00293-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140669406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

First report of lymphocyte transformation test positivity in a delayed allergic reaction to ticagrelor 首次报告替卡格雷迟发性过敏反应中的淋巴细胞转化试验阳性结果

Allergo Journal International Pub Date : 2024-04-22 DOI: 10.1007/s40629-024-00284-x

Emilio Narváez-Fernández, Valeria Herrera-Lasso, Lucía Quintana-Castanedo, Miguel González-Muñoz, Ana Fiandor

引用次数: 0

Toxicokinetics of aluminium—novel insights in an old adjuvant 铝的毒物动力学--对一种古老佐剂的新认识

Allergo Journal International Pub Date : 2024-04-17 DOI: 10.1007/s40629-024-00288-7

Karin Weisser

引用次数: 0

Skin tests, serological IgE detection, basophil test—what is available, useful and helps to clarify a mold allergy? 皮肤测试、血清 IgE 检测、嗜碱性粒细胞测试--有哪些方法可用、有用并有助于明确霉菌过敏？

Allergo Journal International Pub Date : 2024-04-04 DOI: 10.1007/s40629-024-00287-8

Monika Raulf, Sabine Kespohl

{"title":"Skin tests, serological IgE detection, basophil test—what is available, useful and helps to clarify a mold allergy?","authors":"Monika Raulf,  Sabine Kespohl","doi":"10.1007/s40629-024-00287-8","DOIUrl":"10.1007/s40629-024-00287-8","url":null,"abstract":"<div><p>The prevalence of sensitization to molds is low in healthy people, but significant in asthmatics. As it has not yet been possible to establish a cause-and-effect relationship between the presence of mold allergens and the occurrence of allergic symptoms, there is a great deal of uncertainty. The update of the S2k guideline “Medical–clinical diagnostics for indoor mold exposure” should help to objectify the topic. Based on the recommendations listed there for the diagnosis of suspected IgE-mediated mold allergy, this article presents the possibilities of skin tests, IgE determinations, and other in vitro test options, but also their limitations in clarifying the cause. Potential possibilities include component-resolved allergy diagnostics, while the limitations include the difficult standardization of test allergen extracts due to the complex allergen source and the insufficient commercial availability of the test extracts. A diagnostic algorithm is presented as a tool for a systematic approach to patients with suspected mold-associated respiratory allergy.</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"33 4","pages":"133 - 139"},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-024-00287-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140744458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aspergillus-associated diseases from an infectious diseases and allergological perspective 从传染病和过敏学角度看曲霉相关疾病

Allergo Journal International Pub Date : 2024-03-22 DOI: 10.1007/s40629-024-00286-9

Jannik Stemler, Julia A. Nacov, Rosanne Sprute, Oliver A. Cornely, Marcus Joest, Sven Becker, Ludger Klimek

{"title":"Aspergillus-associated diseases from an infectious diseases and allergological perspective","authors":"Jannik Stemler, Julia A. Nacov, Rosanne Sprute, Oliver A. Cornely, Marcus Joest, Sven Becker, Ludger Klimek","doi":"10.1007/s40629-024-00286-9","DOIUrl":"10.1007/s40629-024-00286-9","url":null,"abstract":"<div><p><i>Aspergillus</i>-associated diseases are rare and pose challenges for practitioners. Diagnosis is complex and requires rational, targeted, and multidisciplinary collaboration, as well as a high degree of expertise and an individualized approach. For the infectious diseases physician, the focus is on the question of infection or colonization. In severely immunocompromised patients, invasive aspergillosis occurs, which most frequently affects the lungs (IPA) and is characterized by invasive, destructive growth. This acute clinical picture is associated with a high mortality rate. Chronic pulmonary aspergillosis (CPA) develops on the basis of pre-existing changes in lung structure caused by other pulmonary diseases and often requires surgical treatment. Another chronic form is allergic bronchopulmonary aspergillosis (ABPA). It is often associated with bronchiectasis in patients with bronchial asthma or cystic fibrosis. Sinus mycoses are divided into non-invasive and invasive forms, which can occur in immunocompromised patients and most commonly affect the maxillary sinus. Here, local surgical measures are an obligatory part of treatment, whereas the non-invasive form usually has an allergic component. In addition, drug-based antifungal and/or anti-inflammatory therapy is used for all entities.</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"33 4","pages":"140 - 152"},"PeriodicalIF":0.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-024-00286-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140214422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of a fast challenge test with iodinated contrast media in allergic patients with anaphylaxis 对过敏性休克患者进行碘化造影剂快速挑战试验的评估

Allergo Journal International Pub Date : 2024-03-06 DOI: 10.1007/s40629-024-00285-w

Francisco Vega MD PhD, Azahara Lopez-Raigada MD, M. Victoria Mugica MD PhD, Rodrigo Jimenez-Saiz PhD, Carlos Blanco MD PhD

引用次数: 0