Allergo Journal International最新文献_第6页

Children with cow’s milk allergy: prediction of oral immunotherapy response in clinical practice 牛奶过敏儿童:临床口服免疫治疗反应的预测

Allergo Journal International Pub Date : 2023-06-14 DOI: 10.1007/s40629-023-00252-x

Maria Angela Tosca, Roberta Olcese, Chiara Trincianti, Matteo Naso, Irene Schiavetti, Giorgio Ciprandi

引用次数: 0

Assessing the relevance of allergenic pollen in indoor environments—current knowledge base and research needs 评估室内环境中致敏花粉的相关性——当前的知识库和研究需求。

Allergo Journal International Pub Date : 2023-06-13 DOI: 10.1007/s40629-023-00251-y

Sascha Nehr, Regina M. B. O. Duarte, Antoine S. Almeida, Lukas Baus, Karl-Christian Bergmann

{"title":"Assessing the relevance of allergenic pollen in indoor environments—current knowledge base and research needs","authors":"Sascha Nehr, Regina M. B. O. Duarte, Antoine S. Almeida, Lukas Baus, Karl-Christian Bergmann","doi":"10.1007/s40629-023-00251-y","DOIUrl":"10.1007/s40629-023-00251-y","url":null,"abstract":"<div><h2>Summary</h2><div><p>Airborne pollen allergens—a relevant component of bioaerosols and, therefore, of airborne particulate matter—are considered an important metric in air quality assessments. Although the measurement of airborne pollen allergen concentrations in outdoor environments (namely, in urban areas) has been recognized as a key environmental health indicator, no such obligation exists for indoor environments (dwellings or occupational settings). However, people spend most of their daily time (80–90%) indoors, where the majority of their exposure to air pollution, including pollen allergens, occurs. Nonetheless, the relative importance of airborne pollen allergen exposure indoors differs from outdoors because of differences in pollen loads, sources, dispersion, and degree of penetration from the outdoor surroundings, as well as the differences in the allergenic pollen profiles. In this brief review, we mined the literature over the last 10 years to summarize what existing measurements reveal about the relevance of airborne allergenic pollen in indoor environments. The research priorities on this topic are presented, highlighting the challenges and the motivations for obtaining pollen data in built environments which are key to understand the extent and mechanisms of human exposure to airborne pollen allergens. Thus, we provide a comprehensive assessment of the relevance of airborne allergenic pollen in indoor environments, highlighting knowledge gaps and research needs related to their health effects.</p></div></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-023-00251-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9705645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vegan diet—alternative protein sources as potential allergy risk 素食——潜在过敏风险的替代蛋白质来源

Allergo Journal International Pub Date : 2023-06-08 DOI: 10.1007/s40629-023-00248-7

Uta Jappe MD, MSc

{"title":"Vegan diet—alternative protein sources as potential allergy risk","authors":"Uta Jappe MD, MSc","doi":"10.1007/s40629-023-00248-7","DOIUrl":"10.1007/s40629-023-00248-7","url":null,"abstract":"<div><h3>Background</h3><p>As a vegan diet is per definition a plant-based diet, consumers rely on plant protein sources in order to substitute animal proteins. Plant protein sources commonly used in this context are the following: cereals, like wheat (<i>Triticum aestivum, Triticum durum</i>), oat flakes; pseudo cereals like quinoa; nuts and oil seeds like cashew (<i>Anacardium occidentale</i>), hazelnut (<i>Corylus avellana</i>), walnut (<i>Juglans regia</i>); seeds like psyllium seeds (<i>Plantago ovata</i>), sesame (<i>Sesamum indicum</i>), and chia seed (<i>Salvia hispanica</i>).</p><h3>Methods</h3><p>In order to assess the allergy risk posed by vegan diet, a literature search focusing on the composition of this particular diet and whether the respective foods are potentially allergenic was performed.</p><h3>Results</h3><p>At first glance, it is evident for allergologists that these protein sources are well-known allergen sources. Particularly nuts and legumes harbour storage proteins, oleosins, and lipid transfer proteins that as such are associated with severe allergic reactions to food. In addition, there is increasing evidence that the simultaneous consumption of several of these foods may produce a summation effect where many single allergens of high allergenic potential sum up, thereby inducing anaphylaxis. Furthermore, food processing—or the lack of it—puts patients with pollen-associated food allergy at risk to react to some of the plant foods used in vegan diets.</p><h3>Conclusion</h3><p>Therefore, individuals with a history of atopy should be educated regarding the allergy risk of a vegan diet.</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-023-00248-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49608409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low-risk cefalexin allergies are associated with inpatient prescribing of second-line non-beta-lactam antibiotics 低风险头孢氨苄过敏与住院患者开具二线非β-内酰胺类抗生素处方有关

Allergo Journal International Pub Date : 2023-06-06 DOI: 10.1007/s40629-023-00250-z

Melinda Jiang MD, Stephen Bacchi PhD, Lydia Lam, Antoinette Lam, Joshua M. Inglis MBBS, Toby Gilbert MB BCh BAO, Samuel Gluck PhD, Sepehr Shakib PhD, Chino Yuson MBBS, William Smith PhD

{"title":"Low-risk cefalexin allergies are associated with inpatient prescribing of second-line non-beta-lactam antibiotics","authors":"Melinda Jiang MD, Stephen Bacchi PhD, Lydia Lam, Antoinette Lam, Joshua M. Inglis MBBS, Toby Gilbert MB BCh BAO, Samuel Gluck PhD, Sepehr Shakib PhD, Chino Yuson MBBS, William Smith PhD","doi":"10.1007/s40629-023-00250-z","DOIUrl":"10.1007/s40629-023-00250-z","url":null,"abstract":"<div><h3>Background</h3><p>Cefalexin is a commonly prescribed oral antibiotic, with a similar side chain to amoxicillin. The objectives of this study were to (1) describe the frequency and nature of previously recorded cefalexin adverse reaction (AR) labels in the electronic medical record (EMR) in a medical inpatient cohort, (2) evaluate the accuracy of these labels and (3) examine the association between a cefalexin allergy label and the antibiotics prescribed during an inpatient admission.</p><h3>Methods</h3><p>Consecutive admissions under general medicine in a tertiary hospital over a 1-year period were included in this retrospective cohort study. Data regarding cefalexin adverse reaction (AR) history, and antibiotics prescribed during admission were collected from the EMR. Cefalexin allergy descriptions were reviewed using expert criteria to determine whether the described reaction was most consistent with allergy or intolerance.</p><h3>Results</h3><p>The number of admissions included in this study was 12,134. Of the 224 (1.9%) admissions with a recorded cefalexin AR, 196 (87.5%) had a label of allergy and 28 (12.5%) of intolerance. Following the application of expert criteria, 43 (21.9%) of cefalexin allergy labels were found to be consistent with intolerance. The presence of a low-risk cefalexin allergy was associated with an increased likelihood of receiving non-penicillin antibiotics including clindamycin and ciprofloxacin.</p><h3>Conclusion</h3><p>Cefalexin AR are common, and frequently incorrectly classified in the electronic medical record with consequences for in-hospital antibiotic prescribing and antimicrobial stewardship.</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-023-00250-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47776185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antiallergic activity of Skimmia anquetilia on ovalbumin-induced allergic rhinitis, dermatitis, paw oedema and mast cell degranulation 槲皮草对卵清蛋白致变应性鼻炎、皮炎、足跖水肿及肥大细胞脱颗粒的抗过敏作用

Allergo Journal International Pub Date : 2023-06-05 DOI: 10.1007/s40629-023-00247-8

Neha Kukreti, Havagiray R. Chitme, Vinay Kumar Varshney

{"title":"Antiallergic activity of Skimmia anquetilia on ovalbumin-induced allergic rhinitis, dermatitis, paw oedema and mast cell degranulation","authors":"Neha Kukreti,  Havagiray R. Chitme, Vinay Kumar Varshney","doi":"10.1007/s40629-023-00247-8","DOIUrl":"10.1007/s40629-023-00247-8","url":null,"abstract":"<p>Asthma, allergic rhinitis, acute dermatitis, allergic skin reactions, hypersensitivity reactions and other autoimmune illnesses remain difficult to treat. The purpose of this study was to prepare <i>Skimmia anquetilia</i> (SA) extracts and test their antiallergenic characteristics in various types of animal models. A total of nine groups of five animals each were used in this investigation. Ovalbumin (OA) was used as an allergen to sensitise the animals and bring about atopic dermatitis, allergic rhinitis, paw oedema and mast cell degranulation. Doses of 100, 200 and 400 mg/kg/day of essential oil and hydroalcoholic extracts were administered to the animals for testing.</p><p>Gas chromatography–mass spectrometry (GC-MS) analysis identified active constituents including α‑pinene, α‑phellandrene, geijerene, 3‑carene, β‑ocimene and others. SA extract treatment resulted in improved overall health and reduced nasal allergy symptoms such rubbing, sneezing and redness. Essential oil from the SA plant reduced eosinophil infiltration into bronchioalveolar fluid. The platelet and mean platelet volumes returned to normal after treatment with SA essential oil and hydroalcoholic extract. When administered, SA completely counteracted the spleen-enlargement effects of ovalbumin. Inhibition of ovalbumin-induced histopathological alterations in skin, lungs and spleen was achieved with administration of SA essential oil and extract.</p><p>This study concludes that the essential oil of SA has better promising results compared to extract for treating atopic dermatitis, allergic rhinitis, stabilising mast cell membranes, preventing entry of eosinophils into the lungs and maintaining skin, spleen and lung architecture. The authors suggest that further work is required to be done to isolate SA’s active ingredients and assess their detailed mechanism of action.</p>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47121930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Closeups of a not-so-domestic mite tritonymph 一个不太家养的三音母螨的特写

Allergo Journal International Pub Date : 2023-05-08 DOI: 10.1007/s40629-023-00249-6

Rustem Uzbekov, Ayache Bouakaz, Michiel Postema

引用次数: 0

Management of contact dermatitis 接触性皮炎的治疗

Allergo Journal International Pub Date : 2023-03-20 DOI: 10.1007/s40629-023-00246-9

Heinrich Dickel

{"title":"Management of contact dermatitis","authors":"Heinrich Dickel","doi":"10.1007/s40629-023-00246-9","DOIUrl":"10.1007/s40629-023-00246-9","url":null,"abstract":"<div><p>As a widespread disease, contact dermatitis affects all age groups with a high prevalence and incidence. In addition to a reduction in the quality of life, it causes considerable health and socioeconomic costs. Essentially, five subtypes can be distinguished, namely irritant contact dermatitis, phototoxic contact dermatitis, allergic contact dermatitis with its two special forms of hematogenous and aerogenous contact dermatitis, photoallergic contact dermatitis, and protein contact dermatitis. The diagnosis is based on a detailed history and clinical skin findings as well as the exposure-related performance of allergological in vivo and in vitro tests. Once the contact substance—irritant or allergen—has been identified, the key to therapeutic success lies in its strict avoidance. Symptomatic therapy of contact dermatitis should always be individualized and based on the stage of eczema. Topical glucocorticoids are considered first-line therapy for both irritant and allergic contact dermatitis. The always accompanying basic therapy with skin care products plays a central role for sustainable therapeutic success. Systemic therapy is considered when topical therapy is ineffective or not feasible. In this context, the short-term use of systemic glucocorticoids should be limited to extensive or clinically severe acute contact dermatitis and exacerbations of chronic contact dermatitis. The efficacy of the use of newer biologics and Janus kinase inhibitors in contact dermatitis is currently being evaluated in several clinical trials.</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-023-00246-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49304877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Conocarpus trees have low allergenicity potential in patients suffering from asthma and allergic rhinitis living in southwestern Iran 在伊朗西南部患有哮喘和变应性鼻炎的患者中，松果树具有较低的致敏性

Allergo Journal International Pub Date : 2023-02-21 DOI: 10.1007/s40629-022-00239-0

Abbas Fayezi, Mohammad Shahrooei, Mehrangiz Chehrazi, Mehdi Torabi Zadeh

{"title":"Conocarpus trees have low allergenicity potential in patients suffering from asthma and allergic rhinitis living in southwestern Iran","authors":"Abbas Fayezi, Mohammad Shahrooei, Mehrangiz Chehrazi, Mehdi Torabi Zadeh","doi":"10.1007/s40629-022-00239-0","DOIUrl":"10.1007/s40629-022-00239-0","url":null,"abstract":"<div><h3>Purpose</h3><p>Aeroallergens are airborne particles capable of triggering rhinitis and respiratory complications in sensitive individuals. Tree pollen is a major source of aeroallergens and can potentially induce allergic responses in a variety of ways. Thus, studying the allergenicity of urban green spaces is crucial to public health quality. Conocarpus trees have been vastly imported in recent years in Iran for reforestation projects and now have a wide distribution in southern parts of Iran, especially in Khuzestan province. Yet, these plants have not been studied adequately for their allergenic potential. This work aims to evaluate the IgE-mediated skin reactivity to Conocarpus pollen extract in patients suffering from asthma and allergic rhinitis living in southwest Iran.</p><h3>Methods</h3><p>Ninety consecutive patients diagnosed with asthma and allergic rhinitis were selected. Mild cases initially and moderate to severe cases after a period of treatment and follow-up underwent skin prick test (SPT) for Conocarpus pollen extract and several other aeroallergens.</p><h3>Results</h3><p>A skin prick test was performed for all 90 patients presenting asthma and allergic rhinitis symptoms and treated and followed in an outpatient setting. 17% had weakly positive test results for Conocarpus pollen extract. The maximum mean wheal diameter was 4 mm. For comparison, about 48% of the patient were sensitized to Russian thistle, with a maximum mean wheal size of 12 mm. Sensitization to grasses, some other trees, and indoor allergens were also measured.</p><h3>Conclusion</h3><p>Conocarpus trees have a low potential for inducing allergic responses in the studied population. There is no evidence that they have any role in triggering the thunderstorm asthma episodes.</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-022-00239-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42273169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What should be considered during epicutaneous patch testing? 在皮贴测试过程中应该考虑什么？

Allergo Journal International Pub Date : 2023-02-02 DOI: 10.1007/s40629-023-00243-y

Richard Brans, Vera Mahler

{"title":"What should be considered during epicutaneous patch testing?","authors":"Richard Brans,  Vera Mahler","doi":"10.1007/s40629-023-00243-y","DOIUrl":"10.1007/s40629-023-00243-y","url":null,"abstract":"<div><p>Indications for epicutaneous patch testing include the detection or exclusion of allergic contact dermatitis of the skin, transitional mucosa or oral mucosa, suspected delayed-type immune reactions to ingredients of implants, and certain drug reactions (maculopapular exanthema, symmetrical drug-related intertriginous and flexural exanthema [SDRIFE], acute generalized exanthematous pustulosis [AGEP], and fixed drug eruption). When available, allergen preparations that have been pharmaceutically tested and that are approved or marketable as medicinal products should be used. Existing diagnostic gaps can be closed by testing the patient’s own materials in a suitable preparation. Interferences of ultraviolet (UV) light exposure or drugs with patch test reactions have to be considered. In addition to the reading after 48 h and 72 h, a further reading between day 7 (168 h) and day 10 (240 h) is useful, since about 15% of the positive test reactions remain undetected without this late reading. All positive patch test reactions considered allergic must be evaluated with regard to their clinical relevance based on existing exposures.</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-023-00243-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42775324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patients with asthma consulting an allergist differ from those consulting a pulmonologist 哮喘患者向过敏专科医生咨询与向肺科医生咨询不同

Allergo Journal International Pub Date : 2023-02-02 DOI: 10.1007/s40629-023-00244-x

Giorgio Ciprandi MD, Irene Schiavetti PhD, Fabio Luigi Massimo Ricciardolo PhD

引用次数: 0