Allergo Journal International最新文献

{"title":"Oral immunotherapy as a treatment for cocoa allergy","authors":"Juliette Caron MD, MS, Bouchra Mahjoub MD, Sophie Carra MD, MS, Paul-Emile Bara MD, Sidonie Bonne-Grardel MD, Anne Herman MD, PhD, Florence Libon MD, PhD, Christine Delebarre-Sauvage MD.","doi":"10.1007/s40629-025-00333-z","DOIUrl":"10.1007/s40629-025-00333-z","url":null,"abstract":"","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"34 7","pages":"281 - 283"},"PeriodicalIF":0.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145341378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Managing a suspected allergy to laboratory rats and mice in clinical routine: a case report","authors":"Juliette Caron, Antoine Vrancken, Florence Libon, Patricia Rannaud-Bartaire, Christine Delebarre-Sauvage","doi":"10.1007/s40629-025-00330-2","DOIUrl":"10.1007/s40629-025-00330-2","url":null,"abstract":"","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"34 7","pages":"279 - 280"},"PeriodicalIF":0.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145341357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful treatment of anaphylaxis to sulfites with sulfite-containing adrenaline auto-injector","authors":"Jolien Isabel Kessels MD,&nbsp;Jan Gutermuth MD PhD,&nbsp;Martine Grosber MD","doi":"10.1007/s40629-025-00328-w","DOIUrl":"10.1007/s40629-025-00328-w","url":null,"abstract":"<p>Anaphylaxis is a potentially life-threatening type 1 hypersensitivity reaction mediated by specific IgE. Culprit allergens frequently include foods, drugs, and insect venom. Sulfites are widely used as additives in food processing but also occur naturally in high concentrations in certain foods. Additionally, they are added as preservatives to aqueous cosmetic and medical solutions. Sulfites have been reported to cause a variety of allergic reactions including anaphylaxis. Here, we present a case of a patient with repetitive anaphylactic reactions to sulfites in food. An allergy workup showed a positive prick test to sodium metabisulfite and a positive oral provocation test. Our patient was successfully treated for anaphylaxis with a sulfite-containing adrenaline auto-injector, suggesting the benefits of adrenaline outweigh the theoretical risks in an acute anaphylactic setting.</p>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"34 4","pages":"107 - 109"},"PeriodicalIF":0.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145166377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mastocytosis in the age of precision medicine","authors":"Frank Siebenhaar,&nbsp;Randolf Brehler,&nbsp;Deborah Christen,&nbsp;Karin Hartmann,&nbsp;Sabine Altrichter,&nbsp;Marcus Joest,&nbsp;Kristin aufm Kampe,&nbsp;Claudia C. V. Lang,&nbsp;Undine Lippert,&nbsp;Norbert Mülleneisen,&nbsp;Hagen Ott,&nbsp;Jens Panse,&nbsp;Polina Pyatilova,&nbsp;Peter Schmid-Grendelmeier,&nbsp;Petra Staubach,&nbsp;Stefani Röseler,&nbsp;Franziska Ruëff,&nbsp;Dagmar von Bubnoff,&nbsp;Nikolas von Bubnoff,&nbsp;Nicola Wagner,&nbsp;Torsten Zuberbier,&nbsp;Marcus Maurer,&nbsp;Friederike Bärhold,&nbsp;Ludger Klimek,&nbsp;Knut Brockow","doi":"10.1007/s40629-025-00327-x","DOIUrl":"10.1007/s40629-025-00327-x","url":null,"abstract":"<p>Mastocytosis encompasses a spectrum of clonal mast cell disorders characterized by the proliferation and accumulation of atypical mast cells in various organs, including the skin, bone marrow, and gastrointestinal tract. Initially described in 1869 as a cutaneous manifestation, the systemic variant (SM), involving additional organs, was documented in 1949. Clinical distinctions are made between indolent SM (ISM), where mediator-related symptoms predominate, and more aggressive forms, in which organ dysfunction is the primary concern. In recent decades, there has been continuous progress in elucidating the pathogenesis, classification, and management of mastocytosis, aided by specialized networks such as the European Competence Network Mastocytosis (ECNM) and the German Competence Network on Mastocytosis (Kompetenznetzwerk Mastozytose e. V.). A significant therapeutic advancement has been the development of targeted tyrosine kinase inhibitors, including midostaurin and avapritinib, which have been utilized for several years in treating aggressive SM. Recently, avapritinib in lower dosage was also approved for ISM patients with moderate to severe symptoms. For patients with milder forms of ISM, a symptom-oriented basic therapy is recommended. The diagnosis of SM requires interdisciplinary collaboration and strict adherence to established diagnostic criteria. Moreover, innovative patient-centered approaches, such as the MASTHAVE® app, support ongoing follow-up and have the potential to enhance quality of life. Long-term research efforts are increasingly directed toward developing personalized therapies that target the molecular mechanisms underlying the disease.</p>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"34 3","pages":"57 - 68"},"PeriodicalIF":0.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-025-00327-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143883597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergen immunotherapy for stinging nettle allergy","authors":"Norbert Mülleneisen,&nbsp;Annika Völkel,&nbsp;Katharina Kürn,&nbsp;Stephanie Salge,&nbsp;Manfred Springob,&nbsp;Jens Callegari,&nbsp;Friederike Magnet","doi":"10.1007/s40629-025-00326-y","DOIUrl":"10.1007/s40629-025-00326-y","url":null,"abstract":"<p>Nettle pollen is a rare but regionally relevant allergen against which successful allergen immunotherapy (AIT) can be carried out. The risk of confusion with glasswort (<i>Parietaria judaica</i>) must be considered regionally and, if necessary, excluded through an enzyme allergosorbent test (EAST). Patients report the usual symptoms of rhinitis, but often also shortness of breath (nettle allergy as a trigger for allergic asthma). In our study, mild local side effects at the injection site were shown with AIT, but this did not lead to discontinuation of treatment in any patient. Sensitization to stinging nettle pollen is usually a comorbidity in polysensitized patients.</p>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"34 4","pages":"104 - 106"},"PeriodicalIF":0.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145162879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anaphylaxis to lactase supplements may imitate cow milk allergy","authors":"Lea Denise Wenger,&nbsp;Anna Gschwend,&nbsp;Michael Fricker,&nbsp;Lukas Joerg MD","doi":"10.1007/s40629-025-00324-0","DOIUrl":"10.1007/s40629-025-00324-0","url":null,"abstract":"","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"34 4","pages":"110 - 112"},"PeriodicalIF":0.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-025-00324-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145169896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fundamentals of laboratory diagnostics in allergology","authors":"Christos Arsenis,&nbsp;Styliani Taka,&nbsp; Chrysanthi Skevaki","doi":"10.1007/s40629-025-00323-1","DOIUrl":"10.1007/s40629-025-00323-1","url":null,"abstract":"<p>The diversity of allergic disorders and their associated underlying mechanisms render allergy diagnosis particularly challenging. There is a palette of available in vivo and in vitro tests, while result interpretation must always be made in conjunction with clinical history. The focus of the present article is on laboratory diagnostics, where several diagnostic tests have been developed targeting different parts of the allergic cascade. The results of these tests may indicate the presence of clinical allergy but also provide information on disease severity, treatment options, and therapy responsiveness. First-line testing involves allergen specific IgE (sIgE) antibody measurements, and several considerations are required when choosing the exact test. Among others, the allergens to be tested, the use of allergen extracts versus molecular components, cross-reactivity aspects, cost, and geographical sensitization patterns need to be considered. There are technical distinctions between main commercially available automated platforms, which is often reflected by differences in their test results. Diagnostically challenging cases can be supplemented by tests assessing the key effector cells, i.e., basophils, mast cells, and eosinophils, as well as by tests targeting several of the released mediators, including tryptase, lipids, and histamine. Overall, non-IgE-based laboratory tests need additional standardization and research to support their clinical utility.</p>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"34 2","pages":"21 - 30"},"PeriodicalIF":0.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-025-00323-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing novel test for allergy diagnostics: using today’s biochemical techniques","authors":"Eric Whitters,&nbsp;Kelline Rodems,&nbsp;Yinglei Tao,&nbsp;Tom de Poorter","doi":"10.1007/s40629-025-00325-z","DOIUrl":"10.1007/s40629-025-00325-z","url":null,"abstract":"<div><h3>Background</h3><p>The key to moving beyond “bucket chemistry” in allergy testing is to tightly control the sourcing, analysis, and performance testing of the extracts used. It is imperative that each allergen extract be scrutinized using today’s biochemical techniques as an active part of the qualification process rather than the ones developed almost 30 years ago for the technologies of the 1990s. Characterization of allergens demystifies the source material and provides results in the clinical lab that are less ambiguous and are more closely related with the clinical status of the patient.</p><h3>Methods and results</h3><p>This article delivers a technical overview that outlines the requisite steps for diagnostic companies to characterize, analyze, and qualify allergen extracts, mixtures, and components integrated into their platforms. It also evaluates diverse technologies employed in both singleplex and multiplex diagnostics, highlighting the incorporation of more precisely defined biochemical materials in their product offerings.</p><h3>Conclusion</h3><p>The primary goal of this review is to provide laboratory professionals and clinicians with a systematic approach to ensure that extracts meet stringent performance requirements crucial for dependable allergen-specific IgE testing.</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"34 2","pages":"40 - 45"},"PeriodicalIF":0.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-025-00325-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contact dermatitis: case report of an unusual manifestation in the context of an allergy to methylisothiazolinone","authors":"Sanjive Rey,&nbsp;Flurin Brand,&nbsp; Oliver Fuchs MD PhD","doi":"10.1007/s40629-024-00320-w","DOIUrl":"10.1007/s40629-024-00320-w","url":null,"abstract":"","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"34 3","pages":"81 - 83"},"PeriodicalIF":0.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-024-00320-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143883687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergen immunotherapy based on molecular diagnostics: pediatric aspects","authors":"Paolo Maria Matricardi","doi":"10.1007/s40629-024-00318-4","DOIUrl":"10.1007/s40629-024-00318-4","url":null,"abstract":"","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"34 2","pages":"31 - 39"},"PeriodicalIF":0.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}