Orchestration of inflammation in contact allergy by innate immune and cellular stress responses

Q3 Medicine

Allergo Journal International Pub Date : 2023-11-09 DOI:10.1007/s40629-023-00275-4

Stefan F. Martin, Anne-Catherine Rühl-Muth, Philipp R. Esser

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引用次数: 0

Abstract

Background

Inflammation is central to the initiation of immune responses and to the pathogenesis of many diseases such as allergic contact dermatitis (ACD). ACD is an inflammatory skin disease caused by low molecular weight organic chemicals and metal ions. The immune system plays a decisive role. After protein binding, the triggering chemicals act as contact allergens that are recognized by specific T cells. Before this can happen, however, the chemicals must trigger inflammation in the skin, without which the adaptive immune system in particular is not activated.

Methods

In recent years, the inflammatory mechanisms of contact allergy have been studied at the cellular and molecular level in vivo and in vitro.

Results

Contact allergens activate the innate immune system and additionally cellular stress responses, which in interaction are responsible for skin inflammation. In this context, inflammation is required for both initial sensitization and elicitation of ACD.

Conclusion

Skin inflammation in ACD is orchestrated by the interplay of the innate immune system and cellular stress responses.

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先天性免疫和细胞应激反应协调接触性过敏中的炎症反应

背景炎症是引发免疫反应和过敏性接触性皮炎（ACD）等许多疾病的发病机制的核心。过敏性接触性皮炎是一种由低分子量有机化学物质和金属离子引起的炎症性皮肤病。免疫系统起着决定性作用。在与蛋白质结合后，诱发化学物质成为接触过敏原，并被特异性 T 细胞识别。结果接触性过敏原激活了先天性免疫系统，此外还激活了细胞应激反应，两者相互作用导致了皮肤炎症。结论 ACD 中的皮肤炎症是先天性免疫系统和细胞应激反应相互作用的结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Allergo Journal International Medicine-Immunology and Allergy

CiteScore

4.60

自引率

0.00%

发文量

期刊介绍： Allergo Journal International is the official Journal of the German Society for Applied Allergology (AeDA) and the Austrian Society for Allergology and Immunology (ÖGAI). The journal is a forum for the communication and exchange of ideas concerning the various aspects of allergy (including related fields such as clinical immunology and environmental medicine) and promotes German allergy research in an international context. The aim of Allergo Journal International is to provide state of the art information for all medical and scientific disciplines that deal with allergic, immunological and environmental diseases. Allergo Journal International publishes original articles, reviews, short communications, case reports, and letters to the editor. The articles cover topics such as allergic, immunological and environmental diseases, the latest developments in diagnosis and therapy as well as current research work concerning antigens and allergens and aspects related to occupational and environmental medicine. In addition, it publishes clinical guidelines and position papers approved by expert panels of the German, Austrian and Swiss Allergy Societies. All submissions are reviewed in single-blind fashion by at least two reviewers. Originally, the journal started as a German journal called Allergo Journal back in 1992. Throughout the years, English articles amounted to a considerable portion in Allergo Journal. This was one of the reasons to extract the scientific content and publish it in a separate journal. Hence, Allergo Journal International was born and now is the international continuation of the original German journal. Nowadays, all original content is published in Allergo Journal International first. Later, selected manuscripts will be translated and published in German and included in Allergo Journal.