Allergo Journal International最新文献_第7页

Low-risk cefalexin allergies are associated with inpatient prescribing of second-line non-beta-lactam antibiotics 低风险头孢氨苄过敏与住院患者开具二线非β-内酰胺类抗生素处方有关

Allergo Journal International Pub Date : 2023-06-06 DOI: 10.1007/s40629-023-00250-z

Melinda Jiang MD, Stephen Bacchi PhD, Lydia Lam, Antoinette Lam, Joshua M. Inglis MBBS, Toby Gilbert MB BCh BAO, Samuel Gluck PhD, Sepehr Shakib PhD, Chino Yuson MBBS, William Smith PhD

{"title":"Low-risk cefalexin allergies are associated with inpatient prescribing of second-line non-beta-lactam antibiotics","authors":"Melinda Jiang MD, Stephen Bacchi PhD, Lydia Lam, Antoinette Lam, Joshua M. Inglis MBBS, Toby Gilbert MB BCh BAO, Samuel Gluck PhD, Sepehr Shakib PhD, Chino Yuson MBBS, William Smith PhD","doi":"10.1007/s40629-023-00250-z","DOIUrl":"10.1007/s40629-023-00250-z","url":null,"abstract":"<div><h3>Background</h3><p>Cefalexin is a commonly prescribed oral antibiotic, with a similar side chain to amoxicillin. The objectives of this study were to (1) describe the frequency and nature of previously recorded cefalexin adverse reaction (AR) labels in the electronic medical record (EMR) in a medical inpatient cohort, (2) evaluate the accuracy of these labels and (3) examine the association between a cefalexin allergy label and the antibiotics prescribed during an inpatient admission.</p><h3>Methods</h3><p>Consecutive admissions under general medicine in a tertiary hospital over a 1-year period were included in this retrospective cohort study. Data regarding cefalexin adverse reaction (AR) history, and antibiotics prescribed during admission were collected from the EMR. Cefalexin allergy descriptions were reviewed using expert criteria to determine whether the described reaction was most consistent with allergy or intolerance.</p><h3>Results</h3><p>The number of admissions included in this study was 12,134. Of the 224 (1.9%) admissions with a recorded cefalexin AR, 196 (87.5%) had a label of allergy and 28 (12.5%) of intolerance. Following the application of expert criteria, 43 (21.9%) of cefalexin allergy labels were found to be consistent with intolerance. The presence of a low-risk cefalexin allergy was associated with an increased likelihood of receiving non-penicillin antibiotics including clindamycin and ciprofloxacin.</p><h3>Conclusion</h3><p>Cefalexin AR are common, and frequently incorrectly classified in the electronic medical record with consequences for in-hospital antibiotic prescribing and antimicrobial stewardship.</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"33 3","pages":"73 - 79"},"PeriodicalIF":0.0,"publicationDate":"2023-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-023-00250-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47776185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antiallergic activity of Skimmia anquetilia on ovalbumin-induced allergic rhinitis, dermatitis, paw oedema and mast cell degranulation 槲皮草对卵清蛋白致变应性鼻炎、皮炎、足跖水肿及肥大细胞脱颗粒的抗过敏作用

Allergo Journal International Pub Date : 2023-06-05 DOI: 10.1007/s40629-023-00247-8

Neha Kukreti, Havagiray R. Chitme, Vinay Kumar Varshney

{"title":"Antiallergic activity of Skimmia anquetilia on ovalbumin-induced allergic rhinitis, dermatitis, paw oedema and mast cell degranulation","authors":"Neha Kukreti,  Havagiray R. Chitme, Vinay Kumar Varshney","doi":"10.1007/s40629-023-00247-8","DOIUrl":"10.1007/s40629-023-00247-8","url":null,"abstract":"<p>Asthma, allergic rhinitis, acute dermatitis, allergic skin reactions, hypersensitivity reactions and other autoimmune illnesses remain difficult to treat. The purpose of this study was to prepare <i>Skimmia anquetilia</i> (SA) extracts and test their antiallergenic characteristics in various types of animal models. A total of nine groups of five animals each were used in this investigation. Ovalbumin (OA) was used as an allergen to sensitise the animals and bring about atopic dermatitis, allergic rhinitis, paw oedema and mast cell degranulation. Doses of 100, 200 and 400 mg/kg/day of essential oil and hydroalcoholic extracts were administered to the animals for testing.</p><p>Gas chromatography–mass spectrometry (GC-MS) analysis identified active constituents including α‑pinene, α‑phellandrene, geijerene, 3‑carene, β‑ocimene and others. SA extract treatment resulted in improved overall health and reduced nasal allergy symptoms such rubbing, sneezing and redness. Essential oil from the SA plant reduced eosinophil infiltration into bronchioalveolar fluid. The platelet and mean platelet volumes returned to normal after treatment with SA essential oil and hydroalcoholic extract. When administered, SA completely counteracted the spleen-enlargement effects of ovalbumin. Inhibition of ovalbumin-induced histopathological alterations in skin, lungs and spleen was achieved with administration of SA essential oil and extract.</p><p>This study concludes that the essential oil of SA has better promising results compared to extract for treating atopic dermatitis, allergic rhinitis, stabilising mast cell membranes, preventing entry of eosinophils into the lungs and maintaining skin, spleen and lung architecture. The authors suggest that further work is required to be done to isolate SA’s active ingredients and assess their detailed mechanism of action.</p>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"33 3","pages":"80 - 93"},"PeriodicalIF":0.0,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47121930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Closeups of a not-so-domestic mite tritonymph 一个不太家养的三音母螨的特写

Allergo Journal International Pub Date : 2023-05-08 DOI: 10.1007/s40629-023-00249-6

Rustem Uzbekov, Ayache Bouakaz, Michiel Postema

引用次数: 0

Management of contact dermatitis 接触性皮炎的治疗

Allergo Journal International Pub Date : 2023-03-20 DOI: 10.1007/s40629-023-00246-9

Heinrich Dickel

{"title":"Management of contact dermatitis","authors":"Heinrich Dickel","doi":"10.1007/s40629-023-00246-9","DOIUrl":"10.1007/s40629-023-00246-9","url":null,"abstract":"<div><p>As a widespread disease, contact dermatitis affects all age groups with a high prevalence and incidence. In addition to a reduction in the quality of life, it causes considerable health and socioeconomic costs. Essentially, five subtypes can be distinguished, namely irritant contact dermatitis, phototoxic contact dermatitis, allergic contact dermatitis with its two special forms of hematogenous and aerogenous contact dermatitis, photoallergic contact dermatitis, and protein contact dermatitis. The diagnosis is based on a detailed history and clinical skin findings as well as the exposure-related performance of allergological in vivo and in vitro tests. Once the contact substance—irritant or allergen—has been identified, the key to therapeutic success lies in its strict avoidance. Symptomatic therapy of contact dermatitis should always be individualized and based on the stage of eczema. Topical glucocorticoids are considered first-line therapy for both irritant and allergic contact dermatitis. The always accompanying basic therapy with skin care products plays a central role for sustainable therapeutic success. Systemic therapy is considered when topical therapy is ineffective or not feasible. In this context, the short-term use of systemic glucocorticoids should be limited to extensive or clinically severe acute contact dermatitis and exacerbations of chronic contact dermatitis. The efficacy of the use of newer biologics and Janus kinase inhibitors in contact dermatitis is currently being evaluated in several clinical trials.</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"32 3","pages":"57 - 76"},"PeriodicalIF":0.0,"publicationDate":"2023-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-023-00246-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49304877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Conocarpus trees have low allergenicity potential in patients suffering from asthma and allergic rhinitis living in southwestern Iran 在伊朗西南部患有哮喘和变应性鼻炎的患者中，松果树具有较低的致敏性

Allergo Journal International Pub Date : 2023-02-21 DOI: 10.1007/s40629-022-00239-0

Abbas Fayezi, Mohammad Shahrooei, Mehrangiz Chehrazi, Mehdi Torabi Zadeh

{"title":"Conocarpus trees have low allergenicity potential in patients suffering from asthma and allergic rhinitis living in southwestern Iran","authors":"Abbas Fayezi, Mohammad Shahrooei, Mehrangiz Chehrazi, Mehdi Torabi Zadeh","doi":"10.1007/s40629-022-00239-0","DOIUrl":"10.1007/s40629-022-00239-0","url":null,"abstract":"<div><h3>Purpose</h3><p>Aeroallergens are airborne particles capable of triggering rhinitis and respiratory complications in sensitive individuals. Tree pollen is a major source of aeroallergens and can potentially induce allergic responses in a variety of ways. Thus, studying the allergenicity of urban green spaces is crucial to public health quality. Conocarpus trees have been vastly imported in recent years in Iran for reforestation projects and now have a wide distribution in southern parts of Iran, especially in Khuzestan province. Yet, these plants have not been studied adequately for their allergenic potential. This work aims to evaluate the IgE-mediated skin reactivity to Conocarpus pollen extract in patients suffering from asthma and allergic rhinitis living in southwest Iran.</p><h3>Methods</h3><p>Ninety consecutive patients diagnosed with asthma and allergic rhinitis were selected. Mild cases initially and moderate to severe cases after a period of treatment and follow-up underwent skin prick test (SPT) for Conocarpus pollen extract and several other aeroallergens.</p><h3>Results</h3><p>A skin prick test was performed for all 90 patients presenting asthma and allergic rhinitis symptoms and treated and followed in an outpatient setting. 17% had weakly positive test results for Conocarpus pollen extract. The maximum mean wheal diameter was 4 mm. For comparison, about 48% of the patient were sensitized to Russian thistle, with a maximum mean wheal size of 12 mm. Sensitization to grasses, some other trees, and indoor allergens were also measured.</p><h3>Conclusion</h3><p>Conocarpus trees have a low potential for inducing allergic responses in the studied population. There is no evidence that they have any role in triggering the thunderstorm asthma episodes.</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"32 5","pages":"144 - 150"},"PeriodicalIF":0.0,"publicationDate":"2023-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-022-00239-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42273169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What should be considered during epicutaneous patch testing? 在皮贴测试过程中应该考虑什么？

Allergo Journal International Pub Date : 2023-02-02 DOI: 10.1007/s40629-023-00243-y

Richard Brans, Vera Mahler

{"title":"What should be considered during epicutaneous patch testing?","authors":"Richard Brans,  Vera Mahler","doi":"10.1007/s40629-023-00243-y","DOIUrl":"10.1007/s40629-023-00243-y","url":null,"abstract":"<div><p>Indications for epicutaneous patch testing include the detection or exclusion of allergic contact dermatitis of the skin, transitional mucosa or oral mucosa, suspected delayed-type immune reactions to ingredients of implants, and certain drug reactions (maculopapular exanthema, symmetrical drug-related intertriginous and flexural exanthema [SDRIFE], acute generalized exanthematous pustulosis [AGEP], and fixed drug eruption). When available, allergen preparations that have been pharmaceutically tested and that are approved or marketable as medicinal products should be used. Existing diagnostic gaps can be closed by testing the patient’s own materials in a suitable preparation. Interferences of ultraviolet (UV) light exposure or drugs with patch test reactions have to be considered. In addition to the reading after 48 h and 72 h, a further reading between day 7 (168 h) and day 10 (240 h) is useful, since about 15% of the positive test reactions remain undetected without this late reading. All positive patch test reactions considered allergic must be evaluated with regard to their clinical relevance based on existing exposures.</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"32 3","pages":"77 - 82"},"PeriodicalIF":0.0,"publicationDate":"2023-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-023-00243-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42775324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patients with asthma consulting an allergist differ from those consulting a pulmonologist 哮喘患者向过敏专科医生咨询与向肺科医生咨询不同

Allergo Journal International Pub Date : 2023-02-02 DOI: 10.1007/s40629-023-00244-x

Giorgio Ciprandi MD, Irene Schiavetti PhD, Fabio Luigi Massimo Ricciardolo PhD

引用次数: 0

Coronavirus infection in an unvaccinated atopic dermatitis patient under ongoing dupilumab therapy: eczema flare-up, but moderate COVID-19 symptoms 正在接受dupilumab治疗的未接种疫苗的特应性皮炎患者的冠状病毒感染：湿疹脱落，但有中度新冠肺炎症状

Allergo Journal International Pub Date : 2023-02-01 DOI: 10.1007/s40629-023-00245-w

Natalie Anasiewicz MD, Corsin Seeli MD, Marie-Charlotte Brüggen MD, PhD, Matthias Möhrenschlager MD

引用次数: 0

Allergen immunotherapy in house dust mite-associated allergic rhinitis: efficacy of the 300 IR mite tablet 过敏原免疫疗法治疗屋尘螨相关性过敏性鼻炎：300红外螨片的疗效

Allergo Journal International Pub Date : 2023-01-31 DOI: 10.1007/s40629-022-00241-6

Ludger Klimek, Randolf Brehler, Ingrid Casper, Felix Klimek, Jan Hagemann, Mandy Cuevas, Karl-Christian Bergmann

{"title":"Allergen immunotherapy in house dust mite-associated allergic rhinitis: efficacy of the 300 IR mite tablet","authors":"Ludger Klimek, Randolf Brehler, Ingrid Casper, Felix Klimek, Jan Hagemann, Mandy Cuevas,  Karl-Christian Bergmann","doi":"10.1007/s40629-022-00241-6","DOIUrl":"10.1007/s40629-022-00241-6","url":null,"abstract":"<div><h3>Background</h3><p>A perennial house dust mite-associated allergic rhinitis has a major impact on the quality of life of patients and is associated with a high socioeconomic burden. The most common symptoms of allergic rhinitis include a runny nose and nasal congestion, sneezing, itching of nose, mouth and/or throat, and/or ocular symptoms. Affected patients often develop allergic bronchial asthma. Therapy options for allergic rhinitis include allergen avoidance, symptomatic treatment, and allergen immunotherapy. Allergen immunotherapy is the only disease-modifying treatment that can permanently alleviate the symptoms of allergic rhinitis. In July 2021, a new sublingual mite tablet was approved in Germany.</p><h3>Methods</h3><p>This review summarizes clinical studies on the 300 IR (index of reactivity) mite tablet in adolescents and adults with house dust mite-associated allergic rhinitis and presents the results.</p><h3>Results</h3><p>In the phase II and phase III studies considered here, different dosages of the mite tablet were investigated. The 300 IR mite tablet showed the best benefit–risk profile and has been approved in Europe, Japan, South Korea, Australia, and New Zealand for the treatment of house dust mite-associated allergic rhinitis.</p><h3>Conclusion</h3><p> Allergen immunotherapy with the 300 IR mite tablet is an effective treatment that relieves allergic symptoms, reduces the need for symptomatic medication, and improves the quality of life in both adults and adolescents with house dust mite-associated allergic rhinitis. At the same time, treatment with the 300 IR mite tablet is well tolerated. Mild to moderate reactions at the application site subside after a few days.</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"32 1","pages":"10 - 17"},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-022-00241-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43680325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

High pan-allergen content in mango and peach in Taiwan 台湾芒果、桃子泛过敏原含量高

Allergo Journal International Pub Date : 2023-01-23 DOI: 10.1007/s40629-022-00240-7

Mey Fann Lee PhD, Yi Hsing Chen MD, PhD, Yu-Wen Chu PhD, Ping Cheng Hsieh MS, Nancy M. Wang PhD

{"title":"High pan-allergen content in mango and peach in Taiwan","authors":"Mey Fann Lee PhD, Yi Hsing Chen MD, PhD, Yu-Wen Chu PhD, Ping Cheng Hsieh MS, Nancy M. Wang PhD","doi":"10.1007/s40629-022-00240-7","DOIUrl":"10.1007/s40629-022-00240-7","url":null,"abstract":"<div><h3>Background</h3><p>Many plant food allergens have been implicated in cross-reactivities and may cause repetitive pan-allergenic exposures, which increase the severity of patients’ allergic symptoms. Identification of allergenic protein levels in food allows for more precise dietary advice. This study aimed to determine LTP, profilin, and PR-10 in the 15 most popular fruits in Taiwan.</p><h3>Methods</h3><p>cDNA encoding profilin (Sola l 1), nonspecific lipid transfer protein (nsLTP, Sola l 3), and pathogenesis-related protein (PR-10, Sola l 4) were cloned into the pQE30, expressed in <i>Escherichia coli</i>, and purified. Extracts of the most popular fruits, including apple, banana, carrot, celery, dragon fruit, hami melon, jujube, kiwi, mango, melon, orange, papaya, peach, persimmon, and tomato, in Taiwan were prepared in PBS. The allergenic protein levels in these extracts were determined by immuno-dot blotting using rabbit anti-rSola l 1, 3, and 4 polyclonal antibodies.</p><h3>Results</h3><p>Among all 15 fruit extracts tested, peach and mango contained the highest levels of profilin, nsLTP, and PR-10. Papaya, melon, and tomato contained low but detectable levels of the three pan-allergens.</p><h3>Conclusion</h3><p>Our data suggest that peach and mango contain the highest levels of important pan-allergens among the 15 common fruits tested, which agrees with epidemiological data.</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":"32 4","pages":"97 - 103"},"PeriodicalIF":0.0,"publicationDate":"2023-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-022-00240-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42080272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0