Allergo Journal International最新文献

筛选
英文 中文
Allergen characteristics, quality, major allergen content and galenics for mite allergen-specific immunotherapy preparations 螨过敏原特异性免疫治疗制剂的过敏原特性、质量、主要过敏原含量和galenics
Allergo Journal International Pub Date : 2022-11-24 DOI: 10.1007/s40629-022-00233-6
Randolf Brehler, Ludger Klimek
{"title":"Allergen characteristics, quality, major allergen content and galenics for mite allergen-specific immunotherapy preparations","authors":"Randolf Brehler,&nbsp;Ludger Klimek","doi":"10.1007/s40629-022-00233-6","DOIUrl":"10.1007/s40629-022-00233-6","url":null,"abstract":"<div><h2>Summary</h2><div><p>House dust mite extracts for allergen-specific immunotherapy (AIT) require in Germany as other common allergens (pollen from sweet grasses [except maize], birch, alder, hazel; bee and wasp venom) marketing authorisation according to the German Therapy Allergen Ordinance (“Therapieallergene-Verordnung”, [TAV]). Mite allergen extracts that have been approved and also those which are in the approval process are subject to government batch testing. Batch test passing is a prerequisite for marketability. Appropriate quality, efficacy, and safety are prerequisites for the approval of house dust mite extracts. Five HDM allergen extracts from four manufacturers are currently approved in Germany for subcutaneous or sublingual therapy; further extracts are in the approval process. The allergen strength of different products is not comparable; manufacturers use company-specific units to describe the strength. Of the three known major allergens (Group 1 allergens: Der p 1, Der f 1, Group 2 allergens: Der p 2, Der f 2 and Group 23: Der p 23, Der f 23) only Group 1 and Group 2 allergens are usually used to standardize the extracts. Group 23 allergens are localized in the outer membrane of mite faeces, and elution requires special extraction methods. To be efficacious in a single patient an allergen extracts used for AIT must contain all allergen components against which the patient is sensitised. Based on post hoc analyses of large clinical studies, it has been proven for house dust mite tablets that Der p 23 is also contained. In Germany, the Paul Ehrlich Institute is responsible for the approval of therapeutic allergens. For the marketing authorisation information on production procedures, and quality are necessary efficacy and safety (positive benefit risk ratio) of the product must be demonstrated in clinical trials according to the current state of the art.</p></div></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-022-00233-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45926735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biology of house dust mites and storage mites 室内尘螨和仓库尘螨的生物学
Allergo Journal International Pub Date : 2022-11-15 DOI: 10.1007/s40629-022-00231-8
Karl-Christian Bergmann
{"title":"Biology of house dust mites and storage mites","authors":"Karl-Christian Bergmann","doi":"10.1007/s40629-022-00231-8","DOIUrl":"10.1007/s40629-022-00231-8","url":null,"abstract":"<div><h2>Summary</h2><div><p>House dust mites and storage mites have a high allergenic potential and lead to sensitization through the formation of specific IgE antibodies. Due to their preferred residence in houses, they belong to the group of house mites, which are referred to as “domestic mites” in English. Their anatomy and biology account for their amazing adaptability to changing environmental situations (including temperature, humidity, food) and make it understandable that measures to reduce their abundance are usually difficult to implement in practice.</p></div></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-022-00231-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48434841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Frequency of sensitizations and allergies to house dust mites 对室内尘螨过敏和过敏的频率
Allergo Journal International Pub Date : 2022-11-07 DOI: 10.1007/s40629-022-00229-2
Karl-Christian Bergmann
{"title":"Frequency of sensitizations and allergies to house dust mites","authors":"Karl-Christian Bergmann","doi":"10.1007/s40629-022-00229-2","DOIUrl":"10.1007/s40629-022-00229-2","url":null,"abstract":"<div><h2>Summary</h2><div><p>Domestic mites is the term used to describe dust mites and storage mites that prefer to live in houses and to which many people develop sensitization through the formation of specific IgE antibodies due to the high allergenic potency of mite allergens. As a result, mites can trigger allergic diseases of the upper and lower respiratory tract as well as cross-reactions to other allergens. Sensitization to house mites is widespread in the German population. About 11 million adults are sensitized in Germany (15.9%). Men are more frequently affected than women, and sensitizations occur more frequently in large cities and with higher socioeconomic status. Sensitizations are less frequent in old age. They can lead to diagnostic problems as clinically silent sensitizations, which is the case in about 40% of sensitizations.</p></div></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-022-00229-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46091250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
The long road from the first symptoms of mite allergy to mite-specific immunotherapy 从最初的螨过敏症状到螨特异性免疫疗法的漫长道路
Allergo Journal International Pub Date : 2022-10-19 DOI: 10.1007/s40629-022-00230-9
Norbert Mülleneisen MD, Manfred Springob, Stephanie Salge, Annika Völkel, Friederike Magnet, Jens Callegari
{"title":"The long road from the first symptoms of mite allergy to mite-specific immunotherapy","authors":"Norbert Mülleneisen MD,&nbsp;Manfred Springob,&nbsp;Stephanie Salge,&nbsp;Annika Völkel,&nbsp;Friederike Magnet,&nbsp;Jens Callegari","doi":"10.1007/s40629-022-00230-9","DOIUrl":"10.1007/s40629-022-00230-9","url":null,"abstract":"<div><h2>Summary</h2><div><p>The path from first symptoms to initiation of allergen-specific immunotherapy (AIT) is too long in our survey, at just under 12 years. Even from diagnosis to AIT, it still takes 8.5 years. The reasons are manifold. The complaints are mostly sneezing (75%), runny and stuffy nose (65 and 63%, respectively), itching of the eyes and nose (59%), but also breathing difficulties (40%). Most of our patients were polysensitized (78%) and had asthma (63%). AIT should be considered earlier in mite allergic patients.</p></div></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43307439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Tree of heaven (Ailanthus altissima) pollen—a possible new source of sensitization in Central Europe 天树(Ailanthus altissima)花粉-中欧可能的致敏新来源
Allergo Journal International Pub Date : 2022-10-07 DOI: 10.1007/s40629-022-00228-3
Matthias Werchan, Dominik Flener, Karl-Christian Bergmann
{"title":"Tree of heaven (Ailanthus altissima) pollen—a possible new source of sensitization in Central Europe","authors":"Matthias Werchan,&nbsp;Dominik Flener,&nbsp;Karl-Christian Bergmann","doi":"10.1007/s40629-022-00228-3","DOIUrl":"10.1007/s40629-022-00228-3","url":null,"abstract":"","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-022-00228-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43989994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of protracted eosinopenia after a single subcutaneous dose of benralizumab 单次皮下注射benralizumab后长期嗜酸性粒细胞减少1例
Allergo Journal International Pub Date : 2022-09-27 DOI: 10.1007/s40629-022-00227-4
Joana Miranda MD, José Luís Plácido MD, Luís Amaral MD
{"title":"A case of protracted eosinopenia after a single subcutaneous dose of benralizumab","authors":"Joana Miranda MD,&nbsp;José Luís Plácido MD,&nbsp;Luís Amaral MD","doi":"10.1007/s40629-022-00227-4","DOIUrl":"10.1007/s40629-022-00227-4","url":null,"abstract":"","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-022-00227-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40386970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Allergens from house dust and storage mites 来自房屋灰尘和储藏螨的过敏原
Allergo Journal International Pub Date : 2022-09-27 DOI: 10.1007/s40629-022-00226-5
Susanne Vrtala
{"title":"Allergens from house dust and storage mites","authors":"Susanne Vrtala","doi":"10.1007/s40629-022-00226-5","DOIUrl":"10.1007/s40629-022-00226-5","url":null,"abstract":"<div><h2>Summary</h2><div><p>House dust mites are among the most important allergy triggers worldwide. While mites of the genus <i>Dermatophagoides </i>occur almost worldwide, the tropical mite <i>Blomia tropicalis </i>and storage mites are only of importance for certain areas or groups of people. The most important allergens of <i>Dermatophagoides pteronyssinus </i>are Der p 1, Der p 2, and Der p 23 with immunoglobulin E (IgE)-binding frequencies of more than 70% and high allergenic activity. Also of importance are Der p 5, Der p 7, and Der p 21, which have IgE-binding frequencies of about 30%. According to the current state of knowledge, these six allergens are the allergens of clinical relevance which are also required for diagnosis and immunotherapy with individual components.</p></div></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-022-00226-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44374483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Expert consensus on prophylactic treatment of hereditary angioedema 遗传性血管性水肿预防性治疗专家共识
Allergo Journal International Pub Date : 2022-09-02 DOI: 10.1007/s40629-022-00223-8
Jens Greve,  Tamar Kinaciyan, Marcus Maurer, Barbara Dillenburger, Andreas Recke, Clemens Schöffl
{"title":"Expert consensus on prophylactic treatment of hereditary angioedema","authors":"Jens Greve,&nbsp; Tamar Kinaciyan,&nbsp;Marcus Maurer,&nbsp;Barbara Dillenburger,&nbsp;Andreas Recke,&nbsp;Clemens Schöffl","doi":"10.1007/s40629-022-00223-8","DOIUrl":"10.1007/s40629-022-00223-8","url":null,"abstract":"<div><h2>Summary</h2><div><p>Hereditary angioedema (HAE) is a chronic, genetic condition which severely impacts those afflicted with intermittent recurrent vascular edema in mucosal and submucosal tissue or in the dermis and subcutis. These swellings adversely impact the wellbeing of patients, both physically and emotionally. Depending on the location, patients present to doctors in a range of disciplines, and not infrequently misdiagnoses occur, such as appendicitis or an allergy, with subsequent incorrect treatment. An HAE attack can also be life-threatening if larynx is affected. However, medications for treating the more common mast cell-induced angioedema are not effective in HAE. Correct diagnosis of the condition, which often first appears in childhood or adolescence, is therefore essential for effective treatment. De novo mutations where the family history is negative are particularly challenging here. However, a range of new treatment options can help HAE patients by preventing attacks and alleviating the burden of the disease. In this review, we summarize the symptoms experienced by patients with HAE as a result of their condition, but also as a result of misdiagnoses and incorrect treatments, as well as the role of preventive treatment (long-term prophylaxis) in improving the quality of life of those affected and their families. In addition, we provide specific information about how HAE can be detected at an early stage in order to be able to refer patients to experts as soon as possible. With reference to the recommendations of the updated WAO/EAACI guidelines (2022), we argue for a stronger role for long-term prophylaxis and the promotion of modern, patient-centered management of HAE using patient-reported outcome measures (PROMs) to manage quality of life and the burden of the disease.</p></div></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-022-00223-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43257289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Treatment with IL5-/IL-5 receptor antagonists in drug reaction with eosinophilia and systemic symptoms (DRESS) IL5-/IL-5受体拮抗剂治疗嗜酸性粒细胞增多症和全身症状的药物反应(DRESS)
Allergo Journal International Pub Date : 2022-08-23 DOI: 10.1007/s40629-022-00224-7
Anna Gschwend PhD, Arthur Helbling MD, Laurence Feldmeyer PhD, Ulrich Mani-Weber MD, Cordula Meincke MD, Kristine Heidemeyer MD, Simon Bossart MD, Lukas Jörg MD
{"title":"Treatment with IL5-/IL-5 receptor antagonists in drug reaction with eosinophilia and systemic symptoms (DRESS)","authors":"Anna Gschwend PhD,&nbsp;Arthur Helbling MD,&nbsp;Laurence Feldmeyer PhD,&nbsp;Ulrich Mani-Weber MD,&nbsp;Cordula Meincke MD,&nbsp;Kristine Heidemeyer MD,&nbsp;Simon Bossart MD,&nbsp;Lukas Jörg MD","doi":"10.1007/s40629-022-00224-7","DOIUrl":"10.1007/s40629-022-00224-7","url":null,"abstract":"<div><h3>Purpose</h3><p>Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe delayed drug hypersensitivity reaction with exanthema, eosinophilia, and organ manifestations. After culprit drug withdrawal, systemic corticosteroids (CS) are the most widely used treatment, often requiring high doses for months. Blocking the IL-5/IL‑5 receptor axis with mepolizumab, reslizumab, and benralizumab is a promising targeted treatment with a good safety profile and no immunosuppressive effect. The aim of this study is to summarize current experience with the anti-IL5/IL-5-receptor therapy in DRESS.</p><h3>Methods</h3><p>A retrospective analysis of all patients diagnosed with DRESS and treated with mepolizumab, reslizumab, or benralizumab in DRESS was performed. In addition, a PubMed–Medline search for publications on DRESS with anti-IL-5/IL‑5 receptor treatment was performed.</p><h3>Results</h3><p>Of the 14 cases identified, 6 patients were treated with mepolizumab, 6 with benralizumab, 1 patient with reslizumab, and 1 patient was switched from benralizumab to mepolizumab. The main indication for an IL‑5 blockade was a therapy-refractory course (7/14 [50.0%]), recurrent relapses (3/14 [21.4%]), and severe organ dysfunction (2/14 [14.3%]). In 13/14 (93%) cases, a rapid clinical improvement with suppression of eosinophilia and reduction of CS could be achieved. In all but two cases under mepolizumab (dose 100–600 mg) or reslizumab (dose according to body weight), two or more doses were necessary until resolution of DRESS. In 4/7 cases under benralizumab, a single 30 mg dose was sufficient.</p><h3>Conclusion</h3><p>Blockade of the IL-5/IL‑5 receptor axis appears to be a promising treatment in DRESS with fast clinical improvement, which may allow more rapid reduction of CS, and a good safety profile. In addition, a summary of recommendations on when to use blockade of the IL-5/IL‑5 receptor axis in DRESS treatment is provided.</p></div>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40629-022-00224-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33444369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Abstracts of the 17th German Allergy Congress, Wiesbaden, 08.–10. September 2022 第17届德国变态反应大会,威斯巴登,08 - 10。2022年9月
Allergo Journal International Pub Date : 2022-08-17 DOI: 10.1007/s40629-022-00225-6
{"title":"Abstracts of the 17th German Allergy Congress, Wiesbaden, 08.–10. September 2022","authors":"","doi":"10.1007/s40629-022-00225-6","DOIUrl":"10.1007/s40629-022-00225-6","url":null,"abstract":"","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47448140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信