Open Neuroimaging Journal最新文献_第10页

Smaller regional gray matter volume in homeless african american cocaine-dependent men: a preliminary report. 无家可归的非裔美国可卡因依赖者的区域灰质体积较小:初步报告。

Open Neuroimaging Journal Pub Date : 2011-01-01 Epub Date: 2011-10-28 DOI: 10.2174/1874440001105010057

Rosalyn E Weller, Luke E Stoeckel, Jesse B Milby, Mark Bolding, Donald B Twieg, Robert C Knowlton, Malcolm J Avison, Zhaohua Ding

{"title":"Smaller regional gray matter volume in homeless african american cocaine-dependent men: a preliminary report.","authors":"Rosalyn E Weller, Luke E Stoeckel, Jesse B Milby, Mark Bolding, Donald B Twieg, Robert C Knowlton, Malcolm J Avison, Zhaohua Ding","doi":"10.2174/1874440001105010057","DOIUrl":"https://doi.org/10.2174/1874440001105010057","url":null,"abstract":"Models of addiction include abnormalities in parts of the brain involving executive function/inhibitory control. Although previous studies have reported evidence of structural abnormalities in cocaine-dependent individuals, none have specifically targeted the homeless. The present preliminary study investigated brain structure in such an understudied group, homeless, crack-cocaine-dependent African American men (n = 9), comparing it to that in healthy controls (n = 8). Structural data were analyzed using voxel based morphometry (VBM) and a regions of interest (ROI) analysis. Homeless cocaine-dependent individuals had smaller gray matter volume in dorsolateral prefrontal cortex, anterior cingulate, the cerebellum, insula, and superior temporal gyrus. Most of these areas subserve executive function or inhibitory control. These results are similar to those found in most previous studies of non-homeless cocaine-dependent individuals. Reduced gray matter in executive function/inhibitory control regions of the brain in cocaine-dependent individuals may be a preexisting risk factor for the development of addiction and/or a consequence of drug abuse.","PeriodicalId":37431,"journal":{"name":"Open Neuroimaging Journal","volume":"5 ","pages":"57-64"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1874440001105010057","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30298531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Loss of Coherence of Low Frequency Fluctuations of BOLD FMRI in Visual Cortex of Healthy Aged Subjects. 健康老年人视觉皮层BOLD FMRI低频波动的相干性丧失。

Open Neuroimaging Journal Pub Date : 2011-01-01 Epub Date: 2011-11-04 DOI: 10.2174/1874440001105010105

Lirong Yan, Yan Zhuo, Bo Wang, Danny J J Wang

{"title":"Loss of Coherence of Low Frequency Fluctuations of BOLD FMRI in Visual Cortex of Healthy Aged Subjects.","authors":"Lirong Yan, Yan Zhuo, Bo Wang, Danny J J Wang","doi":"10.2174/1874440001105010105","DOIUrl":"https://doi.org/10.2174/1874440001105010105","url":null,"abstract":"Aging effects on blood-oxygen-level-dependent (BOLD) functional MRI (fMRI) have been studied using task induced hemodynamic responses with controversial findings. The present study systematically investigated the normal aging effect in the visual cortex using 3 indices of low frequency fluctuations of resting state BOLD fMRI, i.e., amplitude of low frequency fluctuations (ALFF), regional homogeneity (ReHo) and functional connectivity (FC). These 3 resting state measurements were compared with task induced BOLD activation in the visual cortex of 2 groups of 10 young and 10 elderly subjects. Our results showed reduced functional connectivity and regional homogeneity of low frequency fluctuations of BOLD fMRI in aged subjects as compared to young subjects. While the mean magnitude of BOLD activation and the mean amplitude of low frequency fluctuations of BOLD fMRI did not vary between the 2 age groups, larger variances were observed in both measures in aged subjects. These data suggest that normal aging may be associated with \"loss of coherence\" of low frequency fluctuations of resting state BOLD fMRI in the visual cortex, and may affect task induced BOLD response through increased inter- and intra-subject variability.","PeriodicalId":37431,"journal":{"name":"Open Neuroimaging Journal","volume":"5 ","pages":"105-11"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1874440001105010105","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30363160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 38

Spatially extended FMRI signal response to stimulus in non-functionally relevant regions of the human brain: preliminary results. 人类大脑非功能性相关区域对刺激的空间扩展FMRI信号反应:初步结果。

Open Neuroimaging Journal Pub Date : 2011-01-01 Epub Date: 2011-05-11 DOI: 10.2174/1874440001105010024

John Kornak, Deborah A Hall, Mark P Haggard

{"title":"Spatially extended FMRI signal response to stimulus in non-functionally relevant regions of the human brain: preliminary results.","authors":"John Kornak, Deborah A Hall, Mark P Haggard","doi":"10.2174/1874440001105010024","DOIUrl":"https://doi.org/10.2174/1874440001105010024","url":null,"abstract":"The blood-oxygenation level dependent (BOLD) haemodynamic response function (HDR) in functional magnetic resonance imaging (fMRI) is a delayed and indirect marker of brain activity. In this single case study a small BOLD response synchronised with the stimulus paradigm is found globally, i.e. in all areas outside those of expected activation in a single subject study. The nature of the global response has similar shape properties to the archetypal BOLD HDR, with an early positive signal and a late negative response typical of the negative overshoot. Fitting Poisson curves to these responses showed that voxels were potentially split into two sets: one with dominantly positive signal and the other predominantly negative. A description, quantification and mapping of the global BOLD response is provided along with a 2 × 2 classification table test to demonstrate existence with very high statistical confidence. Potential explanations of the global response are proposed in terms of 1) global HDR balancing; 2) resting state network modulation; and 3) biological systems synchronised with the stimulus cycle. Whilst these widespread and low-level patterns seem unlikely to provide additional information for determining activation in functional neuroimaging studies as conceived in the last 15 years, knowledge of their properties may assist more comprehensive accounts of brain connectivity in the future.","PeriodicalId":37431,"journal":{"name":"Open Neuroimaging Journal","volume":"5 ","pages":"24-32"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/68/60/TONIJ-5-24.PMC3109590.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30008328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Imaging Stroke Evolution after Middle Cerebral Artery Occlusion in Non-human Primates. 非人类灵长类动物大脑中动脉闭塞后脑卒中演化成像。

Open Neuroimaging Journal Pub Date : 2011-01-01 Epub Date: 2011-11-18 DOI: 10.2174/1874440001105010216

H E D'Arceuil, Alex J de Crespigny

引用次数: 2

Quantitative MRI of cerebral arterial blood volume. 脑动脉血容量定量MRI。

Open Neuroimaging Journal Pub Date : 2011-01-01 Epub Date: 2011-11-04 DOI: 10.2174/1874440001105010136

Tae Kim, Seong-Gi Kim

{"title":"Quantitative MRI of cerebral arterial blood volume.","authors":"Tae Kim, Seong-Gi Kim","doi":"10.2174/1874440001105010136","DOIUrl":"https://doi.org/10.2174/1874440001105010136","url":null,"abstract":"Baseline cerebral arterial blood volume (CBV(a)) and its change are important for potential diagnosis of vascular dysfunctions, the determination of functional reactivity, and the interpretation of BOLD fMRI. To quantitative measure baseline CBV(a) non-invasively, we developed arterial spin labeling methods with magnetization transfer (MT) or bipolar gradients by utilizing differential MT or diffusion properties of tissue vs. arteries. Cortical CBV(a) of isoflurane-anesthetized rats was 0.6 - 1.4 ml/100 g. During 15-s forepaw stimulation, CBV(a) change was dominant, while venous blood volume change was minimal. This indicates that the venous CBV increase may be ignored for BOLD quantification for a stimulation duration of less than 15 s. By incorporating BOLD fMRI with varied MT effects in a cat visual cortical layer model, the highest ΔCBV(a) was observed at layer 4, while the highest BOLD signal was detected at the surface of the cortex, indicating that CBV(a) change is highly specific to neural activity. The CBV(a) MRI techniques provide quantified maps, thus, may be valuable tools for routine determination of vessel viability and function, as well as the identification of vascular dysfunction.","PeriodicalId":37431,"journal":{"name":"Open Neuroimaging Journal","volume":"5 ","pages":"136-45"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a9/2b/TONIJ-5-136.PMC3256580.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30393116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Magnetic resonance characterization of ischemic tissue metabolism. 缺血组织代谢的磁共振表征。

Open Neuroimaging Journal Pub Date : 2011-01-01 Epub Date: 2011-11-04 DOI: 10.2174/1874440001105010066

Jerry S Cheung, Xiaoying Wang, Phillip Zhe Sun

引用次数: 5

Tracking development of the corpus callosum in fetal and early postnatal baboons using magnetic resonance imaging. 利用磁共振成像技术跟踪胎儿和出生后早期狒狒胼胝体的发育。

Open Neuroimaging Journal Pub Date : 2011-01-01 Epub Date: 2011-11-18 DOI: 10.2174/1874440001105010179

Kimberley A Phillips, Peter Kochunov

{"title":"Tracking development of the corpus callosum in fetal and early postnatal baboons using magnetic resonance imaging.","authors":"Kimberley A Phillips, Peter Kochunov","doi":"10.2174/1874440001105010179","DOIUrl":"https://doi.org/10.2174/1874440001105010179","url":null,"abstract":"Although the maturation of the corpus callosum (CC) can serve as a sensitive marker for normative antenatal and postnatal brain development, little is known about its development across this critical period. While high-resolution magnetic resonance imaging can provide an opportunity to examine normative brain development in humans, concerns remain over the exposure of developing fetuses to non-essential imaging. Nonhuman primates can provide a valuable model for normative brain maturation. Baboons share several important developmental characteristics with humans, including a highly orchestrated pattern of cerebral development. Developmental changes in total CC area and its subdivisions were examined across the antenatal (weeks 17 - 26 of 28 weeks total gestation) and early postnatal (to week 32) period in baboons (Papio hamadryas anubis). Thirteen fetal and sixteen infant baboons were studied using high-resolution MRI. During the period of primary gyrification, the total area of the CC increased by a magnitude of five. By postnatal week 32, the total CC area attained only 51% of the average adult area. CC subdivisions showed non-uniform increases in area, throughout development. The splenium showed the most maturation by postnatal week 32, attaining 55% of the average adult value. The subdivisions of the genu and anterior midbody showed the least maturation by postnatal week 32, attaining 50% and 49% of the average adult area. Thus, the CC of baboons shows continued growth past the postnatal period. These age-related changes in the developing baboon CC are consistent with the developmental course in humans.","PeriodicalId":37431,"journal":{"name":"Open Neuroimaging Journal","volume":"5 ","pages":"179-85"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30393086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Methods for fine scale functional imaging of tactile motion in human and nonhuman primates. 人类和非人类灵长类动物触觉运动精细尺度功能成像方法。

Open Neuroimaging Journal Pub Date : 2011-01-01 Epub Date: 2011-11-18 DOI: 10.2174/1874440001105010160

Robert M Friedman, Barbara C Dillenburger, Feng Wang, Malcum J Avison, John C Gore, Anna W Roe, Li Min Chen

{"title":"Methods for fine scale functional imaging of tactile motion in human and nonhuman primates.","authors":"Robert M Friedman, Barbara C Dillenburger, Feng Wang, Malcum J Avison, John C Gore, Anna W Roe, Li Min Chen","doi":"10.2174/1874440001105010160","DOIUrl":"https://doi.org/10.2174/1874440001105010160","url":null,"abstract":"In the visual and auditory systems specialized neural pathways use motion cues to track object motion and self-motion, and use differential motion cues for figure-ground segregation. To examine the neural circuits that encode motion in the somatosensory system, we have developed neuroimaging methods to study motion processing in human and nonhuman primates. We have implemented stimulus presentation paradigms to examine neural encoding of apparent motion percepts. These paradigms are designed to be compatible with fMRI, optical imaging, and electrophysiological methods, thereby permitting direct comparison of data derived across neurofunctional scales. An additional motivation for using a common tactile motion stimulation paradigm is to bridge two disparate bodies of work, that derived from neuroimaging studies in humans and another from neuroimaging, neurophysiological and neuroanatomical studies in monkeys. Here, we demonstrate that such an approach through the use of optical imaging and 9.4 Tesla fMRI experiments in monkeys, and 7 Tesla fMRI experiments in humans is effective in revealing neural regions activated by tactile motion stimuli. These methods span spatial scales capable of detecting 100 μm sized domains to those that would reveal global whole brain circuits. Armed with such capabilities, our long-term goals are to identify directionally selective areas and directionally se-lective functional domains and understand the global pathways within which they reside. Such knowledge would have great impact on our thinking regarding not only tactile motion processing, but also general strategies underlying somatosensory cortical processing.","PeriodicalId":37431,"journal":{"name":"Open Neuroimaging Journal","volume":"5 ","pages":"160-71"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30393084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Dynamic Diffusion Magnetic Resonance Imaging of Infarct Formation and Peri-infarct Spreading Depression after Middle Cerebral Artery Occlusion (MCAO) in macacca fasicularis. 马甲束状动脉中动脉闭塞(MCAO)后梗死形成和梗死周围扩散抑制的动态扩散磁共振成像。

Open Neuroimaging Journal Pub Date : 2011-01-01 Epub Date: 2011-11-18 DOI: 10.2174/1874440001105010153

Helen E D'Arceuil, Alex de Crespigny

{"title":"Dynamic Diffusion Magnetic Resonance Imaging of Infarct Formation and Peri-infarct Spreading Depression after Middle Cerebral Artery Occlusion (MCAO) in macacca fasicularis.","authors":"Helen E D'Arceuil, Alex de Crespigny","doi":"10.2174/1874440001105010153","DOIUrl":"https://doi.org/10.2174/1874440001105010153","url":null,"abstract":"Dynamic diffusion MRI was used to visualize hyperacute stroke formation in the brain of a cynomolgus macaque. Under fluoroscopic guidance, a microcatheter was placed into the middle cerebral artery (MCA). The animal was immediately transferred to a 1.5T clinical scanner. Dynamic T2-weighted imaging during bolus injection of Oxygen-17 enriched water through the microcatheter mapped out the territory perfused by the MCA segment. Serial diffusion measurements were made using diffusion-weighted echo-planar imaging, with a temporal resolution of 15 seconds, during injection of a glue embolus into the microcatheter. The apparent diffusion coefficient declined within the lesion core. A wave of transient diffusion decline spread through peripheral uninvolved brain immediately following stroke induction. The propagation speed and pattern is consistent with spreading peri-infarct depolarizations (PID). The detection of PIDs following embolic stroke in a higher nonhuman primate brain supports the hypothesis that spreading depressions may occur following occlusive stroke in humans.","PeriodicalId":37431,"journal":{"name":"Open Neuroimaging Journal","volume":"5 ","pages":"153-9"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30393083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The role of neuroimaging in the latent period of blunt traumatic cerebrovascular injury. 神经影像学在钝性外伤性脑血管损伤潜伏期中的作用。

Open Neuroimaging Journal Pub Date : 2011-01-01 Epub Date: 2011-12-01 DOI: 10.2174/1874440001105010225

Rahul Karamchandani, Venkatakrishna Rajajee, Aditya Pandey

{"title":"The role of neuroimaging in the latent period of blunt traumatic cerebrovascular injury.","authors":"Rahul Karamchandani, Venkatakrishna Rajajee, Aditya Pandey","doi":"10.2174/1874440001105010225","DOIUrl":"https://doi.org/10.2174/1874440001105010225","url":null,"abstract":"Introduction: Blunt cerebrovascular injury (BCVI) is found in 1-2.7% of all blunt trauma when appropriate screening criteria are employed. A significant number of patients with BCVI have a latent, or asymptomatic period, in which therapeutic intervention based on the appropriate use of angiographic imaging may decrease the risk of an ischemic stroke. Methods: Case report and review of literature. Results: A 42 year old woman suffered a fall off a motorcycle and was neurologically intact in the emergency room. Fractures involving the transverse foramen of cervical vertebrae were found on non-contrast Computed Tomography (CT) but screening for BCVI with angiographic imaging not performed. She subsequently suffered an ischemic stroke resulting in significant disability. Published studies that address the use of screening criteria for BCVI and subsequent management are reviewed. Conclusion: BCVI results in significant morbidity and mortality attributable to ischemic stroke. There is often a latent period between BCVI and occurrence of ischemic stroke. Specific risk factors can be used to identify patients requiring screening with catheter or CT angiography. Treatment with antithrombotic agents is the mainstay of treatment of BCVI and may reduce the rate of ischemic stroke. Identification and treatment of asymptomatic BCVI in blunt trauma patients may prevent ischemic stroke in a predominantly young population.","PeriodicalId":37431,"journal":{"name":"Open Neuroimaging Journal","volume":"5 ","pages":"225-31"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/02/73/TONIJ-5-225.PMC3256991.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30393483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4