人类大脑非功能性相关区域对刺激的空间扩展FMRI信号反应:初步结果。

Q4 Medicine
Open Neuroimaging Journal Pub Date : 2011-01-01 Epub Date: 2011-05-11 DOI:10.2174/1874440001105010024
John Kornak, Deborah A Hall, Mark P Haggard
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引用次数: 8

摘要

功能磁共振成像(fMRI)中的血氧水平依赖(BOLD)血流动力学反应功能(HDR)是脑活动的延迟和间接标志物。在这个单一的案例研究中,在全球范围内发现了与刺激范式同步的小BOLD反应,即在单个受试者研究中预期激活的区域之外的所有区域。全局响应的性质与原型BOLD HDR具有相似的形状属性,具有早期的积极信号和晚期的负面响应,典型的负面超调。拟合这些响应的泊松曲线表明,体素可能被分成两组:一组以积极信号为主,另一组以消极信号为主。提供了全球BOLD响应的描述、量化和映射,以及2 × 2分类表检验,以非常高的统计置信度证明存在。全球响应的潜在解释如下:1)全球HDR平衡;2)静息状态网络调制;3)生物系统与刺激周期同步。虽然这些广泛和低水平的模式似乎不太可能为过去15年设想的功能性神经影像学研究中确定激活提供额外的信息,但对它们特性的了解可能有助于未来更全面地描述大脑连接。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Spatially extended FMRI signal response to stimulus in non-functionally relevant regions of the human brain: preliminary results.

Spatially extended FMRI signal response to stimulus in non-functionally relevant regions of the human brain: preliminary results.

Spatially extended FMRI signal response to stimulus in non-functionally relevant regions of the human brain: preliminary results.

Spatially extended FMRI signal response to stimulus in non-functionally relevant regions of the human brain: preliminary results.

The blood-oxygenation level dependent (BOLD) haemodynamic response function (HDR) in functional magnetic resonance imaging (fMRI) is a delayed and indirect marker of brain activity. In this single case study a small BOLD response synchronised with the stimulus paradigm is found globally, i.e. in all areas outside those of expected activation in a single subject study. The nature of the global response has similar shape properties to the archetypal BOLD HDR, with an early positive signal and a late negative response typical of the negative overshoot. Fitting Poisson curves to these responses showed that voxels were potentially split into two sets: one with dominantly positive signal and the other predominantly negative. A description, quantification and mapping of the global BOLD response is provided along with a 2 × 2 classification table test to demonstrate existence with very high statistical confidence. Potential explanations of the global response are proposed in terms of 1) global HDR balancing; 2) resting state network modulation; and 3) biological systems synchronised with the stimulus cycle. Whilst these widespread and low-level patterns seem unlikely to provide additional information for determining activation in functional neuroimaging studies as conceived in the last 15 years, knowledge of their properties may assist more comprehensive accounts of brain connectivity in the future.

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来源期刊
Open Neuroimaging Journal
Open Neuroimaging Journal Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
0.70
自引率
0.00%
发文量
3
期刊介绍: The Open Neuroimaging Journal is an Open Access online journal, which publishes research articles, reviews/mini-reviews, and letters in all important areas of brain function, structure and organization including neuroimaging, neuroradiology, analysis methods, functional MRI acquisition and physics, brain mapping, macroscopic level of brain organization, computational modeling and analysis, structure-function and brain-behavior relationships, anatomy and physiology, psychiatric diseases and disorders of the nervous system, use of imaging to the understanding of brain pathology and brain abnormalities, cognition and aging, social neuroscience, sensorimotor processing, communication and learning.
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