无家可归的非裔美国可卡因依赖者的区域灰质体积较小:初步报告。

Q4 Medicine
Open Neuroimaging Journal Pub Date : 2011-01-01 Epub Date: 2011-10-28 DOI:10.2174/1874440001105010057
Rosalyn E Weller, Luke E Stoeckel, Jesse B Milby, Mark Bolding, Donald B Twieg, Robert C Knowlton, Malcolm J Avison, Zhaohua Ding
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引用次数: 16

摘要

成瘾的模型包括大脑执行功能/抑制控制部分的异常。虽然以前的研究报告了可卡因依赖者结构异常的证据,但没有一个是专门针对无家可归者的。本初步研究调查了这样一个研究不足的群体,无家可归的,可卡因依赖的非洲裔美国人(n = 9)的大脑结构,并将其与健康对照组(n = 8)进行比较。结构数据使用基于体素的形态测量学(VBM)和感兴趣区域(ROI)分析。无家可归的可卡因依赖者在背外侧前额皮质、前扣带、小脑、脑岛和颞上回的灰质体积较小。这些区域大多是执行功能或抑制性控制的附属。这些结果与之前大多数对非无家可归的可卡因依赖者的研究结果相似。可卡因依赖个体大脑执行功能/抑制控制区灰质减少可能是成瘾发展和/或药物滥用后果的预先存在的风险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Smaller regional gray matter volume in homeless african american cocaine-dependent men: a preliminary report.

Smaller regional gray matter volume in homeless african american cocaine-dependent men: a preliminary report.

Smaller regional gray matter volume in homeless african american cocaine-dependent men: a preliminary report.

Models of addiction include abnormalities in parts of the brain involving executive function/inhibitory control. Although previous studies have reported evidence of structural abnormalities in cocaine-dependent individuals, none have specifically targeted the homeless. The present preliminary study investigated brain structure in such an understudied group, homeless, crack-cocaine-dependent African American men (n = 9), comparing it to that in healthy controls (n = 8). Structural data were analyzed using voxel based morphometry (VBM) and a regions of interest (ROI) analysis. Homeless cocaine-dependent individuals had smaller gray matter volume in dorsolateral prefrontal cortex, anterior cingulate, the cerebellum, insula, and superior temporal gyrus. Most of these areas subserve executive function or inhibitory control. These results are similar to those found in most previous studies of non-homeless cocaine-dependent individuals. Reduced gray matter in executive function/inhibitory control regions of the brain in cocaine-dependent individuals may be a preexisting risk factor for the development of addiction and/or a consequence of drug abuse.

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来源期刊
Open Neuroimaging Journal
Open Neuroimaging Journal Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
0.70
自引率
0.00%
发文量
3
期刊介绍: The Open Neuroimaging Journal is an Open Access online journal, which publishes research articles, reviews/mini-reviews, and letters in all important areas of brain function, structure and organization including neuroimaging, neuroradiology, analysis methods, functional MRI acquisition and physics, brain mapping, macroscopic level of brain organization, computational modeling and analysis, structure-function and brain-behavior relationships, anatomy and physiology, psychiatric diseases and disorders of the nervous system, use of imaging to the understanding of brain pathology and brain abnormalities, cognition and aging, social neuroscience, sensorimotor processing, communication and learning.
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