马甲束状动脉中动脉闭塞(MCAO)后梗死形成和梗死周围扩散抑制的动态扩散磁共振成像。

Pub Date : 2011-01-01 Epub Date: 2011-11-18 DOI:10.2174/1874440001105010153
Helen E D'Arceuil, Alex de Crespigny
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引用次数: 3

摘要

动态扩散MRI用于观察食蟹猕猴脑超急性卒中的形成。在透视引导下,将微导管置入大脑中动脉。动物立即被转移到1.5T临床扫描仪。微导管灌注富氧17水时动态t2加权成像绘制MCA段灌注区域。在向微导管注射胶栓子期间,使用扩散加权回波平面成像进行连续扩散测量,时间分辨率为15秒。病灶核心内表观扩散系数下降。脑卒中诱导后,一波短暂性弥散性衰退立即通过外周非受累脑传播。传播速度和模式与扩张性梗死周去极化(PID)一致。在高等非人类灵长类动物脑栓塞性中风后检测到的PIDs支持了一种假设,即抑郁症可能发生在人类闭塞性中风后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Dynamic Diffusion Magnetic Resonance Imaging of Infarct Formation and Peri-infarct Spreading Depression after Middle Cerebral Artery Occlusion (MCAO) in macacca fasicularis.

Dynamic Diffusion Magnetic Resonance Imaging of Infarct Formation and Peri-infarct Spreading Depression after Middle Cerebral Artery Occlusion (MCAO) in macacca fasicularis.

Dynamic Diffusion Magnetic Resonance Imaging of Infarct Formation and Peri-infarct Spreading Depression after Middle Cerebral Artery Occlusion (MCAO) in macacca fasicularis.

Dynamic Diffusion Magnetic Resonance Imaging of Infarct Formation and Peri-infarct Spreading Depression after Middle Cerebral Artery Occlusion (MCAO) in macacca fasicularis.

Dynamic diffusion MRI was used to visualize hyperacute stroke formation in the brain of a cynomolgus macaque. Under fluoroscopic guidance, a microcatheter was placed into the middle cerebral artery (MCA). The animal was immediately transferred to a 1.5T clinical scanner. Dynamic T2-weighted imaging during bolus injection of Oxygen-17 enriched water through the microcatheter mapped out the territory perfused by the MCA segment. Serial diffusion measurements were made using diffusion-weighted echo-planar imaging, with a temporal resolution of 15 seconds, during injection of a glue embolus into the microcatheter. The apparent diffusion coefficient declined within the lesion core. A wave of transient diffusion decline spread through peripheral uninvolved brain immediately following stroke induction. The propagation speed and pattern is consistent with spreading peri-infarct depolarizations (PID). The detection of PIDs following embolic stroke in a higher nonhuman primate brain supports the hypothesis that spreading depressions may occur following occlusive stroke in humans.

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