European Journal of Obstetrics and Gynecology and Reproductive Biology: X最新文献

{"title":"Long working hours and obstetric complications: A cross-sectional study among female doctors","authors":"Hasna Adil ,&nbsp;Mehwish Maqsood ,&nbsp;Hasina M. Kadri ,&nbsp;Hafsa Ahmed ,&nbsp;Muhammad F. Iqbal ,&nbsp;Misbah Nizamani ,&nbsp;Tooba Hussain ,&nbsp;Nabiha Syed ,&nbsp;Lawiza Asghar","doi":"10.1016/j.eurox.2024.100302","DOIUrl":"10.1016/j.eurox.2024.100302","url":null,"abstract":"<div><h3><strong>Objective</strong></h3><p>To investigate the effects of long working hours on pregnancy complications and obstetric outcomes among female doctors working in tertiary care hospitals of Karachi.</p></div><div><h3><strong>Study design</strong></h3><p>A cross-sectional study was conducted on 149 female MBBS graduates (mean age: 33.5 ± 7.3 years) who had conceived at least once, currently working in two tertiary-care hospitals of Karachi. Data was collected through a self-administered questionnaire containing questions regarding demography and course of 1st pregnancy of the participants including working hours, antenatal and natal complications. Means and standard deviations were calculated for continuous variables with frequencies and percentages for categorical variables. The association between long working hours and different antenatal and natal complications was investigated using Chi-square test and T-test.</p></div><div><h3><strong>Results</strong></h3><p>Out of 149 participants included in final analysis, 85.9 % doctors gave birth to alive babies while 12.8 % had miscarriages and 1.3 % had stillbirth. Mean working hours during the three trimesters were found to be 53.76, 53.66 and 48.7, respectively. 43 % doctors experienced at least one antenatal complication during their pregnancy. Women who worked more than or equal to 55 h per week during 1st, 2nd and 3rd trimester of their pregnancy experienced more antenatal complications than women who worked less than 55 h (p-value=0.042, 0.021 and 0.018 respectively). 61.7 % females experienced at least one natal complication, most common of which was induction of Labour (39.1 %). Natal complications were significantly associated with increased workload during 2nd trimester (mean 58 vs 46 h, p-value 0.040). Doctors belonging to surgical specialty had 2.7 times higher risk of developing at least one natal complication than doctors of medical specialty (95 % Cl: 1.235–5.870).</p></div><div><h3><strong>Conclusion</strong></h3><p>Long working hours during pregnancy are associated with antenatal complications among female doctors. Natal complications were only significantly related to long working hours during 2nd trimester of pregnancy, however, female surgeons are more prone to develop natal complications than doctors belonging to medical specialties.</p></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"22 ","pages":"Article 100302"},"PeriodicalIF":0.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S259016132400022X/pdfft?md5=d9d0f157374d32358b09663eab33030e&pid=1-s2.0-S259016132400022X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140271857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between rs1799724 of TNF- α gene and early onset preeclampsia in Chinese: A pilot study","authors":"Yujie Wang ,&nbsp;Jianheng Bao ,&nbsp;Shaofang Hua ,&nbsp;Lirong Yin","doi":"10.1016/j.eurox.2024.100303","DOIUrl":"10.1016/j.eurox.2024.100303","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the association between polymorphisms of TNF- α (rs1799724, rs1800629), VEGF (rs3025039) and VEGFR1 (rs 722503) and early onset preeclampsia (EOPE) in Chinese.</p></div><div><h3>Methods</h3><p>A total of 132 EOPE patients from January 2016 to December 2018 at the Second Hospital of Tianjin Medical University were selected as the EOPE group, and 156 normal pregnant patients as the Control group. In both groups, 5 ml of peripheral venous blood was obtained after admission. The characteristics of genotype and allele distribution at the four SNPs in the study subjects were examined by matrix-assisted laser desorption ionization time-of-flight mass spectrometric genotyping.</p></div><div><h3>Results</h3><p>The genotype frequency distribution and allele frequency distribution of rs1799724 were significantly different between the EOPE group and the Control group (<em>P</em> = 0.002，<em>P</em> = 0.003). The T allele was statistically associated with the development of EOPE under a dominant genetic model (<em>P</em> = 0.001). The genotype and allele frequency distributions of rs1800629, rs3025039, and rs 722503 did not differ significantly between the EOPE group and the Control group (<em>P</em> &gt; 0.05). There was no linkage disequilibrium among rs1799724, rs1800629 and rs3025039 loci, the corresponding haploid cannot be formed.</p></div><div><h3>Conclusions</h3><p>The rs1799724 of TNF- α gene is a genetic susceptibility locus for EOPE and may be a potential predictors of preeclampsia.</p></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"22 ","pages":"Article 100303"},"PeriodicalIF":0.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590161324000231/pdfft?md5=d9318f47c0035f1ccc794905a652b444&pid=1-s2.0-S2590161324000231-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140272283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"History of HPV in HPV-positive elderly women","authors":"Ruth S. Hermansson ,&nbsp;Gabriella Lillsunde-Larsson ,&nbsp;Gisela Helenius ,&nbsp;Mats G. Karlsson ,&nbsp;Malin Kaliff ,&nbsp;Matts Olovsson ,&nbsp;Annika K. Lindström","doi":"10.1016/j.eurox.2024.100297","DOIUrl":"https://doi.org/10.1016/j.eurox.2024.100297","url":null,"abstract":"<div><h3>Background</h3><p>The aim of this study was to examine the natural course of HPV infection in women of 60 years and older who were HPV positive at inclusion, and any association between HPV positivity in historical samples and dysplasia outcome.</p></div><div><h3>Methods</h3><p>Eighty-nine women aged 60–82 years, who tested positive for HPV between 2012 and 2016 were included. Sampling for cytology and/or histology was also performed. HPV genotyping was carried out on archived material back to 1999.</p></div><div><h3>Results</h3><p>Of the 89 HPV-positive women 16 had HSIL, 34 had LSIL and 39 were benign at inclusion. Of the women with HSIL, 50.0% had the same HPV type in the archive samples, 12.5% had another type, and 37.5% were HPV negative. Among the 34 women with LSIL, 47.1% had the same HPV type in archive samples, 5.8% had another type, and 47.1% were HPV negative. Of the 39 women without dysplasia at inclusion, 25.6% had the same HPV type in archive samples, 5.1% had another HPV type and 69.2% were HPV negative.</p></div><div><h3>Conclusion</h3><p>Surprisingly few of the elderly women thus seem to have a history with the same or any HPV infection the years before being diagnosed with an HPV infection and dysplasia. The significance of an HPV infection for dysplasia development in elderly women is still not fully understood.</p></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"22 ","pages":"Article 100297"},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590161324000176/pdfft?md5=1dec2fb38ec1033e9e881cbed686a8de&pid=1-s2.0-S2590161324000176-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140103421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the Hungarian version of the Prolapse and Incontinence Knowledge Questionnaire (PIKQ)","authors":"Éva Szatmári ,&nbsp;Alexandra Makai ,&nbsp;Eszter Ambrus ,&nbsp;Márta Hock","doi":"10.1016/j.eurox.2024.100296","DOIUrl":"10.1016/j.eurox.2024.100296","url":null,"abstract":"<div><h3>Objective</h3><p>The Prolapse and Incontinence Knowledge Questionnaire (PIKQ) is a self-administered, reliable and valid instrument which assess knowledge regarding urinary incontinence and pelvic organ prolapse. There is no validated Hungarian version of this questionnaire; therefore the aim of this study was to develop a reliable, valid and culturally sensitive Hungarian version of the PIKQ.</p></div><div><h3>Study design</h3><p>A cross-sectional study was conducted from March to October 2022 with a sample of 459 women. The PIKQ, which consists of the urinary incontinence and pelvic organ prolapse scales, was translated into Hungarian in accordance with international guidelines. The validity and reliability of the final version of the Hungarian PIKQ was evaluated using construct validity, comparison with known-groups, internal consistency and test-retest reliability.</p></div><div><h3>Results</h3><p>Regarding construct validity, all fit indices were found acceptable. Healthcare workers had significantly higher knowledge about urinary incontinence and pelvic organ prolapse (p &lt; 0.001) compared to women who had not worked in a medical field. The Hungarian PIKQ had an adequate internal consistency with Cronbach alpha of 0.785 for the urinary incontinence scale and 0.826 for the pelvic organ prolapse scale. The correlation coeffcients between the test and retest was 0.931 for the urinary incontinence scale and 0.964 for the pelvic organ prolapse scale.</p></div><div><h3>Conclusion</h3><p>The Hungarian version of the PIKQ is a reliable and valid tool to measure the level of knowledge about urinary incontinence and pelvic organ prolapse among Hungarian speaking women.</p></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"22 ","pages":"Article 100296"},"PeriodicalIF":0.0,"publicationDate":"2024-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590161324000164/pdfft?md5=96dbf8642d1bb0efb52fb4b40d5b4f35&pid=1-s2.0-S2590161324000164-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140087765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Enhanced Recovery after Surgery (ERAS) protocol on maternal outcomes following emergency caesarean delivery: A randomized controlled trial","authors":"Rajlaxmi Mundhra ,&nbsp;Dipesh Kumar Gupta ,&nbsp;Anupama Bahadur ,&nbsp;Ajit Kumar ,&nbsp;Rakesh Kumar","doi":"10.1016/j.eurox.2024.100295","DOIUrl":"10.1016/j.eurox.2024.100295","url":null,"abstract":"<div><h3>Background</h3><p>With ever increasing rates of emergency caesarean deliveries (CD),incorporating the ERAS protocol might provide a perfect window of opportunity to increase maternal comfort during the postsurgical period, but also improve outcomes and facilitate optimal return of physiological function.</p></div><div><h3>Objective</h3><p>To determine whether an ERAS pathway at emergency caesarean birth would permit a reduction in postoperative length of stay and improve postoperative patient satisfaction.</p></div><div><h3>Material &amp; methods</h3><p>Patients undergoing emergent caesarean delivery at ≥ 34 weeks of gestation were randomized to ERAS or conventional care. The primary outcome was to compare postoperative length of hospital stay. Secondary outcome variables included first oral intake, passage of flatus/defecation, first ambulation, first urination after catheter removal and postoperative pain scores in both groups.</p></div><div><h3>Results</h3><p>We randomized 142 women (71 each in ERAS versus Conventional arm) undergoing emergency cesarean delivery. Incorporation of ERAS protocol resulted in shorter length of hospital stay (73.92 ± 8.96 in conventional arm vs 53.87 ± 15.02 in ERAS arm; p value &lt;.0001). Significant difference was seen in visual analogue scoring during initial ambulation and rest on day 0 and day 1 between ERAS and conventional arms with mean scores being lower in ERAS arm compared to Conventional arm (p value &lt;.05). In terms of quality of life, ERAS arm had better quality of life compared to conventional arm</p></div><div><h3>Conclusion</h3><p>Incorporation of ERAS protocol in emergency caesarean definitely improves patient outcome in terms of early resumption of activities with better quality of life.</p></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"22 ","pages":"Article 100295"},"PeriodicalIF":0.0,"publicationDate":"2024-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590161324000152/pdfft?md5=21154d4551496141fd68d76d065b5457&pid=1-s2.0-S2590161324000152-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140085495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of exercise attitudes of women of reproductive age in pregnancy","authors":"Feyza Aktaş Reyhan","doi":"10.1016/j.eurox.2024.100294","DOIUrl":"https://doi.org/10.1016/j.eurox.2024.100294","url":null,"abstract":"<div><h3>Objective</h3><p>This study was conducted to evaluate the exercise attitudes of women of reproductive age during pregnancy.</p></div><div><h3>Method</h3><p>The descriptive study was conducted with 326 women who applied to the gynecology outpatient clinics of a state hospital between September and November 2023. Data were collected with the \"Personal Information Form\" and \"Exercise Attitudes in Pregnant Women Scale\". Statistical analyses were analyzed at p &lt; .05 significance level with the independent samples t test method.</p></div><div><h3>Results</h3><p>Most of the participants (85.6%) stated that they did not know the benefits of exercise during pregnancy and did not exercise during pregnancy (89.6%). The mean exercise attitude scale score of the participants was 135.42 ± 25.90. A significant difference was found between the participants' education level, exercising outside pregnancy, attending a pregnancy school, knowing the benefits of exercise during pregnancy and exercising during pregnancy and all sub-dimension scores (p &lt; .05).</p></div><div><h3>Conclusion</h3><p>In the study, it was observed that the participants had positive attitudes towards exercise during pregnancy, although their knowledge and behaviors were insufficient. Women's attitudes towards exercise should be determined by health professionals and women's positive attitudes, knowledge and behaviors should be improved by organizing trainings and exercise programs starting from pre-pregnancy.</p></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"21 ","pages":"Article 100294"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590161324000140/pdfft?md5=9e0efb059905fb7a4617c7d6c0581afa&pid=1-s2.0-S2590161324000140-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140062241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Maternal and fetal outcomes in mothers with non-congenital mitral valve stenosis and healthy control","authors":"Sima sobhani shari ,&nbsp;Tubi Kazemi ,&nbsp;Ali Bidokhti ,&nbsp;Seyed Mohammad Riahi","doi":"10.1016/j.eurox.2024.100290","DOIUrl":"https://doi.org/10.1016/j.eurox.2024.100290","url":null,"abstract":"<div><h3>Background</h3><p>Physiological changes during pregnancy cause complications in mothers with mitral stenosis and their infants. This study was designed to assess maternal and fetal pregnancy outcomes in women with rheumatic mitral valve stenosis and compare them with the control group.</p></div><div><h3>Materials and methods</h3><p>This study is a case-control study on 153 pregnant women, including 51 with mitral stenosis (MS) and 102 without MS as the control group, between 2007–2022. For each studied patient, two control participants were selected and matched in residence, age, and year of pregnancy. SPSS version 22 was used for data analysis.</p></div><div><h3>Results</h3><p>The mean age was 31.7 ± 4.6 years in cases and 31.6 ± 4.7 in the healthy controls. Demographic variables were not significantly different between the case and control groups. The rate of stillbirth (5.9% vs. 0.0%), %), NICU admission (13.7% vs. 2.0%), and IUGR (5.9% vs. 0.0%) were higher in the fetal case group compared with the control group. On the other hand, maternal outcomes, including pulmonary edema (13.7% vs. 0.0%), ICU admission (23.5% vs. 0.0%), limb edema (15.7% vs. 0.0%), dyspnea (37.3% vs. 0.0%), pulmonary hypertension (9.8% vs. 0.0%), palpitations (21.1% vs. 0.0%) and hospital admission during pregnancy (37.2% vs. 4.9%) were statistically more common in the case groups.</p></div><div><h3>Conclusions</h3><p>Pregnancy is associated with significant fetomaternal morbidities in women with mitral valve heart disease. So they need a multidisciplinary approach in preconception and antenatal care.</p></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"22 ","pages":"Article 100290"},"PeriodicalIF":0.0,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590161324000103/pdfft?md5=e8a1d714855518d564aa20ba2ad760d6&pid=1-s2.0-S2590161324000103-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140160884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of pentoxifylline and different types of exercise training on coagulation factors in a rat endometriosis model","authors":"Zahra Salehpoor ,&nbsp;Mohamad Rezapourmoghadam ,&nbsp;Nader Tanideh ,&nbsp;Maryam Koushkie Jahromi","doi":"10.1016/j.eurox.2024.100292","DOIUrl":"https://doi.org/10.1016/j.eurox.2024.100292","url":null,"abstract":"<div><h3>Objectives</h3><p>This study evaluated the effects of high-intensity interval training (HIIT), moderate-intensity continuous training (MICT), and pentoxifylline (PTX) on coagulation factors, including the amount and percentage of lymphocytes, PLC, PLR, aPTT, PT, PT.I.N. R in a model of rats with endometriosis.</p></div><div><h3>Methods</h3><p>Endometriosis was surgically induced in female Sprague<img>Dawley rats. The rats with confirmed endometrial implants were divided into control, MICT, pentoxifylline (D), HIIT+D, and MICT+D, HIIT groups. D and exercise interventions were performed for eight weeks. Then, the macroscopic size of endometriosis lesions was measured, and inflammatory factors (count and percentage of lymphocytes) and coagulation factors, including PLC, PLR, aPTT, PT, PT.I.N. R, and PLR in blood samples were evaluated.</p></div><div><h3>Results</h3><p>D significantly decreased the volume of lesions and significantly increased PT and PT.I.N. R in blood. HIIT decreased the volume of lesions and significantly increased PT. MICT did not cause significant effects on the target variables. MICT+D decreased the volume of lesions. HIIT+D significantly decreased the volume of lesions and PLC and increased aPTT as well as the count and percentage of lymphocytes, PT, and PT.I.N. R, and decreased PLR.</p></div><div><h3>Conclusions</h3><p>All interventions(except for MICT) especially HIIT+D and D by priority, induced a significant effect on reducing some indices of inflammation and coagulation.</p></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"21 ","pages":"Article 100292"},"PeriodicalIF":0.0,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590161324000127/pdfft?md5=2bfe9b72a17cadafb6e53c1690c09d5f&pid=1-s2.0-S2590161324000127-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139936596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between estrogen receptor and programmed death ligand-1 in type I endometrial cancer","authors":"Setyo Teguh Waluyo ,&nbsp;Brahmana Askandar Tjokroprawiro ,&nbsp;Anny Setijo Rahaju","doi":"10.1016/j.eurox.2024.100293","DOIUrl":"10.1016/j.eurox.2024.100293","url":null,"abstract":"<div><h3>Objective</h3><p>To determine the effect of estrogen receptor (ER) on programmed death-ligand 1 (PD-L1) expression in type I endometrial cancer (EC).</p></div><div><h3>Material and Methods</h3><p>This retrospective study included 85 patients with type I EC who underwent surgery at Dr. Soetomo Hospital between 2018 and 2022. A random sampling technique was employed. Immunohistochemistry (IHC) with ER and PD-L1 antibodies was performed on all samples. In this study, ER expression served as the independent variable, while PD-L1 expression was considered the dependent variable. Data analysis was performed using Spearman's rank correlation coefficient test.</p></div><div><h3>Results</h3><p>Out of the 85 patients with type I EC, 58 (68.2%) exhibited positive and 27 (31.8%) exhibited negative ER expression. Meanwhile positive PD-L1 expression was seen in 67 (78.8%) and 18 (21.2%) exhibited negative PD-L1 expression. The study revealed a strong negative correlation between ER and PD-L1 expression in EC (rho value = −0.886, p-value = 0.0001).</p></div><div><h3>Conclusion</h3><p>ER downregulates PD-L1 in type I EC. The findings of this study can be used as reference data and as the basis for further research, especially investigations of the prognostic and immunotherapeutic value of ER and PD-L1 expression in type I EC.</p></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"21 ","pages":"Article 100293"},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590161324000139/pdfft?md5=a8e2819dd0df6a08c7f6592abc15b6a8&pid=1-s2.0-S2590161324000139-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139966712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in cervical length during the second trimester among normal weight, overweight and obese women: A systematic review and meta-analysis","authors":"Michail Panagiotopoulos,&nbsp;Vasilios Pergialiotis,&nbsp;Konstantina Trimmi,&nbsp;Antonia Varthaliti,&nbsp;Antonios Koutras,&nbsp;Panagiotis Antsaklis,&nbsp;Georgios Daskalakis","doi":"10.1016/j.eurox.2024.100291","DOIUrl":"10.1016/j.eurox.2024.100291","url":null,"abstract":"<div><h3>Objective</h3><p>Maternal obesity has been previously linked to increased risk of preterm birth; however, the actual pathophysiology behind this observation remains unknown. Cervical length seems to differentiate among overweight, obese and extremely obese patients, compared to normal weight women. However, to date the actual association between body mass index and cervical length remains unknown. In this systematic review, accumulated evidence is presented to help establish clinical implementations and research perspectives.</p></div><div><h3>Methods</h3><p>We searched Medline, Scopus, the Cochrane Central Register of Controlled Trials CENTRAL, Google Scholar, and Clinicaltrials.gov databases from inception till February 2023. Observational studies that reported on women undergone ultrasound assessment of their cervical length during pregnancy were included, when there was data regarding their body mass index. Statistical meta-analysis was performed with RStudio. The quality of the included studies was assessed using the Newcastle-Ottawa Quality Assessment Scale (NOS).</p></div><div><h3>Results</h3><p>Overall, 20 studies were included in this systematic review and 12 in the meta-analysis. Compared to women with normal weight, underweight women were not associated with increased risk of CL &lt; 15 mm or &lt; 30 mm and their mean CL was comparable (MD −1.51; 95% CI −3.07, 0.05). Overweight women were found to have greater cervical length compared to women with normal weight (MD 1.87; 95% CI 0.52, 3.23) and had a lower risk of CL &lt; 30 mm (OR 0.65; 95% CI 0.47, 0.90).</p></div><div><h3>Conclusion</h3><p>Further research into whether BMI is associated with cervical length in pregnant women is deemed necessary, with large, well-designed, prospective cohort studies with matched control group.</p></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"21 ","pages":"Article 100291"},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590161324000115/pdfft?md5=920c2ba8a8bd706734302603fd01bb31&pid=1-s2.0-S2590161324000115-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139887382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}