European Journal of Obstetrics and Gynecology and Reproductive Biology: X最新文献

{"title":"The effect of an exam-indicated cerclage before 24 weeks of gestation to prevent preterm birth: A systematic review and meta-analysis","authors":"Bouchra Koullali ,&nbsp;Charlotte E. van Dijk ,&nbsp;Charlotte E. Kleinrouweler ,&nbsp;Jacqueline C.E.J.M.P. Limpens ,&nbsp;Ben W. Mol ,&nbsp;Martijn A. Oudijk ,&nbsp;Eva Pajkrt","doi":"10.1016/j.eurox.2025.100372","DOIUrl":"10.1016/j.eurox.2025.100372","url":null,"abstract":"<div><div>The effect of an exam-indicated cerclage (EIC) remains uncertain due to limited evidence from reviews covering pregnancies beyond this timeframe. With the 24-week mark serving as an international threshold for neonatal care initiation, the aim of this systematic review was to evaluate the available literature on the effectiveness of an EIC before 24 weeks of gestation. MEDLINE, EMBASE, Web of Science, CENTRAL, clinicaltrials.gov and WHO-ICTRP were searched for randomized controlled trials, cohort and case-control studies comparing EIC with expectant management in singleton pregnancies with cervical dilation ≤ 5 cm between 14 and 24 weeks of gestation to prevent preterm birth (PTB) &lt; 37 weeks of gestation. Secondary outcomes included obstetrical and neonatal outcomes. Quality assessment was preformed using Newcastle-Ottawa Scale. Analyses were conducted using R(studio) version 3.6.1. and outcomes stated as odds ratios (OR) with 95 % confidence intervals (CI). Prospero: #CRD42019137400. The search yielded 787 potential studies. Four studies non-randomized (retrospective) could be included. Quality assessment showed overall good quality. The main weaknesses were retrospective designs, small sample sizes and the poor comparability of the intervention and control groups. The study population resulted in 215 women, among whom 163 (76 %) underwent cerclage placement and 52 (24 %) were expectantly managed. EIC compared with expectant management was associated with significant lower rates of PTB before 37 weeks (71.2 % vs 94.2 %; OR 0.11; 95 % CI 0.03–0.35), 34 weeks (49.1 % vs 86.5 %; OR 0.10; 95 % CI 0.03–0.31), 32 weeks (43.0 % vs 80.0 %; OR 0.13; 95 % CI 0.04–0.43), 28 weeks (43.0 % vs 75.0 %; OR 0.19; 95 % CI 0.07–0.51) and 24 weeks (23.3 % vs 50 %; OR 0.29; 95 % CI 0.13–0.65) of gestation, significant prolongation of the pregnancy (mean difference 39.14 days; 95 %CI 30.58–47.71; p-value &lt;0.0001) and a greater gestational age at delivery (mean difference 4.91 weeks; 95 % CI 2.32–7.49; p-value 0.0002) compared to expectant management. The current literature suggests that EIC before 24 weeks of gestation is associated with improved pregnancy outcomes compared to expectant management. The results are limited by the lack of randomised trials and studied neonatal outcomes plus the potential for bias in the included studies.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"25 ","pages":"Article 100372"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143427562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Apolipoprotein L1 genetic variants and risk of preeclampsia and preterm birth among U.S. Black women","authors":"Shanshan Sheehy ,&nbsp;David Friedman ,&nbsp;Chunyu Liu ,&nbsp;Kathryn L. Lunetta ,&nbsp;Gary Zirpoli ,&nbsp;Julie R. Palmer","doi":"10.1016/j.eurox.2025.100365","DOIUrl":"10.1016/j.eurox.2025.100365","url":null,"abstract":"<div><h3>Background</h3><div>Preeclampsia and preterm birth disproportionally affects Black women, but the current understanding of genetic predisposition to preeclampsia and preterm birth is rudimentary. It has been hypothesized that carriers of high-risk genetic variants in the apolipoprotein L1 gene (<em>APOL1</em>) may have an increased risk of preeclampsia and preterm birth. These genetic variants are found only among individuals of recent African ancestry. Previous studies have been small and have yielded inconsistent results.</div></div><div><h3>Objective</h3><div>To examine whether <em>APOL1</em> genetic variants are associated with risk of preeclampsia or preterm birth.</div></div><div><h3>Study design</h3><div>We conducted a retrospective case-control study of 6616 Black women from the Black Women’s Health Study, a cohort of self-identified Black women in the U.S. Genotype data on <em>APOL1</em> risk alleles for this case control study were obtained through new genotyping and existing genetic data from a prior case control study of breast cancer using the Illumina Infinium Global Diversity Array or Multi Ethnic Genotyping Array. Primary analyses evaluated risk based on a recessive model, comparing women who carried two <em>APOL1</em> risk alleles to women who carried zero or one risk allele. We used multivariable logistic regression models to examine associations among 1473 participants with a history of preeclampsia (cases) and 5143 parous women who had not experienced preeclampsia (controls), and among 1296 participants who had a history of preterm birth and 5320 without such history.</div></div><div><h3>Results</h3><div>The odds ratio (OR) of preeclampsia for two <em>APOL1</em> risk alleles vs. zero or one risk allele was 0.99 (95 % confidence interval (CI): 0.74, 1.32) after adjustment for principal components, genotype platform, and age in 1995. For preterm birth, the comparable multivariable OR was 1.04 (95 % CI: 0.86, 1.25).</div></div><div><h3>Conclusions</h3><div>This large prospective study from a general population of Black women found no evidence of an association of <em>APOL1</em> genotype with risk of either preeclampsia or preterm birth.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"25 ","pages":"Article 100365"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decreasing trend of gastroschisis prevalence in the United States from 2014 through 2022: Is attributed to declining birth rates in young, high-risk gravidae","authors":"Hiba J. Mustafa ,&nbsp;Nikan Zargarzadeh ,&nbsp;Kevin L. Moss ,&nbsp;May Abiad ,&nbsp;Brian Gray ,&nbsp;Kjersti M. Aagaard ,&nbsp;Terry L. Buchmiller ,&nbsp;Erin E. Perrone ,&nbsp;Alireza A. Shamshirsaz","doi":"10.1016/j.eurox.2025.100374","DOIUrl":"10.1016/j.eurox.2025.100374","url":null,"abstract":"<div><h3>Objectives</h3><div>To investigate the prevalence trend of gastroschisis in the United States between 2014 and 2022.</div></div><div><h3>Methods</h3><div>A cross-sectional retrospective analysis of the Centers for the United States live births between 2014 and 2022. Pregnancies and neonatal singleton live births with documented isolated gastroschisis were included. Neonates with other major congenital anomalies and known chromosomal abnormalities were excluded. Prevalence per 10,000 live births along with 95 % confidence intervals was estimated.</div></div><div><h3>Results</h3><div>Among 32,088,301 singleton live births, 6804 cases of isolated gastroschisis were identified (Point prevalence: 2 in 10,000 live births). A significant decline in gastroschisis prevalence was observed, decreasing from 2.86 per 10,000 live births in 2014–1.55 per 10,000 live births in 2022 (<em>P</em> &lt; 0.001). The risk of gastroschisis was significantly higher in teen and nulliparous gravidae, with prepregnancy tobacco use, and among socially vulnerable populations (underweight, &lt; 12th-grade education, Medicaid, non-Hispanic Indigenous Americans). The drop in gastroschisis births from 2014 to 2022, compared to non-gastroschisis births, is more significant in maternal age &lt; 20 years, nulliparous, BMI &lt; 18.5, and in smokers prior to pregnancy than in the overall population (P = 0.02, 0.0008, &lt;0.0001, &lt;0.0001, and 0.01 respectively). All of the associated maternal factors had a significant decline in prevalence (<em>P</em> &lt; 0.001), which may influence the decreasing trend of gastroschisis. There was no perceived considerable impact of the COVID-19 pandemic on gastroschisis trends.</div></div><div><h3>Conclusions</h3><div>The study highlights a notable decline in gastroschisis prevalence mostly attributable to a declining birth rate in the highest at-risk strata, suggesting recent increases in birth rates among these at-risk gravidae may reverse the trend of declining gastroschisis disease prevalence. These findings support the need for ongoing further research to understand effective means of sustaining this decreasing trend.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"25 ","pages":"Article 100374"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143419902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological, economic and humanistic burden of cervical intraepithelial neoplasia in Europe: A systematic literature review","authors":"Ugne Sabale ,&nbsp;Miriam Reuschenbach ,&nbsp;Jitender Takyar ,&nbsp;Arju Dhawan ,&nbsp;Adam Hall ,&nbsp;D. Vittal ,&nbsp;Gurkiran Saggu ,&nbsp;Alessandro Ghelardi ,&nbsp;Marta del Pino ,&nbsp;Andrzej Nowakowski ,&nbsp;Stefano Valente","doi":"10.1016/j.eurox.2024.100360","DOIUrl":"10.1016/j.eurox.2024.100360","url":null,"abstract":"<div><h3>Introduction</h3><div>High-grade cervical intraepithelial neoplasia (CIN) is a premalignant lesion of the cervix caused by persistent human papillomavirus (HPV) infection, which can lead to cervical cancer. Despite ongoing primary prevention efforts, considerable burden of illness remains. This study assessed the epidemiological, economic, and humanistic burden associated with high-grade CIN among adult women in Europe.</div></div><div><h3>Methods</h3><div>Systematic literature reviews (SLRs) were conducted for epidemiological, economic, and humanistic burden, in adult women with high-grade CIN in the broader European region. Search strategies were aligned to Cochrane and PRISMA guidelines. Databases searched included Medline®, Embase®, and Cochrane databases (2012–2022). Conference proceedings were also searched (2018–2022). Outcomes of interest included incidence, prevalence, HPV genotype, cost burden, resource use and quality of life burden.</div></div><div><h3>Results</h3><div>Evidence from 41 epidemiological, 11 economic burden, and 8 humanistic burden studies was included. Incidence of high-grade CIN was 31–186/100,000 women-years in a screened population, with prevalence rates of 0.1–2.2 %. Incidence and prevalence of high-grade CIN peaked among women aged 25–39 years. In women with high-grade CIN, high-risk genotypes were among those most commonly identified, including HPV16/18 (57.0–58.7 %), HPV16 (47.4–52.0 %), HPV18 (4.0–15.0 %) and HPV 31/33/45 (38 %). Cost burden and healthcare resource utilization was higher for CIN3 vs. CIN2. High-grade CIN significantly impaired quality of life, across multiple domains vs. healthy population.</div></div><div><h3>Conclusion</h3><div>High-grade CIN was associated with considerable burden in Europe. These findings reveal the multifaceted nature of the impact incurred by women with high-grade CIN, and highlight some of the key areas of unmet need among this patient population.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"25 ","pages":"Article 100360"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11773262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of adult stem cells in obstetrics and gynecology: A scoping review","authors":"Andi Kurniadi ,&nbsp;Muhammad Ary Zucha ,&nbsp;Ardhanu Kusumanto ,&nbsp;Siti Salima ,&nbsp;Ali Budi Harsono","doi":"10.1016/j.eurox.2025.100367","DOIUrl":"10.1016/j.eurox.2025.100367","url":null,"abstract":"<div><h3>Background</h3><div>Advancements in regenerative medicine have led to the applicability of stem cell technology in various diseases. Stem cells that have self-renewable abilities may differentiate into several cell types to provide therapeutic potential. Among different stem cells, adult stem cells are considered as the safest with remarkable potential for therapeutic application. In this review, we provide current available evidence regarding the application of adult stem cells in medicine, especially in the field of obstetrics and gynecology.</div></div><div><h3>Objective</h3><div>This scoping review aims to map and describe the current research on adult stem cell application in obstetrics and gynecology.</div></div><div><h3>Methods</h3><div>We performed a systematic search on PubMed, Google Scholar, and Cochrane Library in August 2024 to identify research articles involving adult stem cells in the field of obstetrics and gynecology. We used the Deduplicate website to filter articles based on keywords that met our inclusion and exclusion criteria. The results were presented based on recommendations from the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews.</div></div><div><h3>Results</h3><div>We found 42 articles that met the inclusion criteria. Some studies were clinical studies, whereas the majority were preclinical studies. We categorized the articles into clinical and preclinical studies to understand their applicability in human subjects.</div></div><div><h3>Conclusions</h3><div>Adult stem cell therapy is a candidate treatment for several pathologies in obstetrics and gynecology. The promising results of adult stem cell therapy, especially in degenerative gynecologic diseases, may lead to further application of the technology in the near future.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"25 ","pages":"Article 100367"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143174884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the interplay of Caesarean delivery and genetic influences on intelligence and anxiety traits in offspring findings from genome-wide association studies","authors":"Bita Fallahpour ,&nbsp;Mahsa Danaei ,&nbsp;Maryam Yeganegi ,&nbsp;Fatemeh Jayervand ,&nbsp;Sepideh Azizi ,&nbsp;Heewa Rashnavadi ,&nbsp;Seyed Alireza Dastgheib ,&nbsp;Reza Bahrami ,&nbsp;Amirhossein Shahbazi ,&nbsp;Ali Masoudi ,&nbsp;Kazem Aghili ,&nbsp;Fatemeh Nematzadeh ,&nbsp;Hossein Neamatzadeh","doi":"10.1016/j.eurox.2025.100377","DOIUrl":"10.1016/j.eurox.2025.100377","url":null,"abstract":"<div><h3>Background</h3><div>Recent research suggests that genetic factors linked to Caesarean delivery may influence variations in children's intelligence and anxiety traits. This review synthesizes findings from genome-wide association studies (GWAS) to examine these associations, clarifying that it does not establish causation.</div></div><div><h3>Methods</h3><div>This review systematically aggregated findings from GWAS studying the impact of Caesarean delivery on intelligence and anxiety traits. A thorough literature search was performed in key scientific databases like PubMed and Scopus, using various keywords related to delivery methods, cognitive traits, and psychological outcomes from 2005, when the first GWAS was published, through December 1, 2024. The inclusion criteria focused on original research articles published in English, excluding studies involving non-human subjects or without empirical data. The quality of the studies was assessed using a modified STROBE checklist adapted for GWAS.</div></div><div><h3>Results</h3><div>Five GWAS identified 36 significant genetic loci associated with intelligence and anxiety traits in offspring related to Caesarean delivery. In terms of verbal intelligence, four alleles were found to be significantly linked to decreased scores, with allele rs1276529-G associated with a mean reduction of −2.04 units (p = 1E-6). Conversely, allele rs705670-G correlated with an increase in performance intelligence scores, resulting in a mean elevation of 2.3 units (p = 3E-7). Several alleles exhibited a negative correlation with overall intelligence, particularly rs17800861-A, which was associated with a mean decrease of 3.32 units (p = 7E-7). Significant risk alleles for anxiety were also identified, including rs62389045-C, linked to a 117 % increase in the risk of anxiety symptoms (p = 4E-8). Furthermore, in the context of self-injury, 17 risk alleles were identified, with allele rs117077436-C demonstrating an odds ratio of 11.34 (p = 3E-9).</div></div><div><h3>Conclusion</h3><div>This study highlights multiple genetic loci associated with verbal performance, overall intelligence, and susceptibility to anxiety, revealing significant variations in offspring delivered via Caesarean section. While certain alleles are linked to increased risks of anxiety and self-injurious behavior, the results underscore the presence of genetic predispositions influencing cognitive and psychological outcomes. It is essential to emphasize that GWAS findings indicate associations rather than causal relationships. Further exploration into the biological mechanisms and environmental interactions that underlie these complex traits is warranted.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"25 ","pages":"Article 100377"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143562278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accurate birth weight prediction from fetal biometry using the Gompertz model","authors":"Chandrani Kumari ,&nbsp;Gautam I. Menon ,&nbsp;Leelavati Narlikar ,&nbsp;Uma Ram ,&nbsp;Rahul Siddharthan","doi":"10.1016/j.eurox.2024.100344","DOIUrl":"10.1016/j.eurox.2024.100344","url":null,"abstract":"<div><h3>Objectives</h3><div>Monitoring of fetal growth and estimation of birth weight is of clinical importance. During pregnancy, ultrasound fetal biometry values including femur length, head circumference, abdominal circumference, biparietal diameter are measured and used to place fetuses on “growth charts”. There is no simple growth-model-based, predictive formula in use for fetal biometry. Estimation of fetal weight at birth currently depends on ultrasound data taken a short time before birth.</div></div><div><h3>Study design</h3><div>Our cohort (“Seethapathy cohort”) consists of ultrasound biometry measurements and other data for 774 pregnant women in Chennai, India, 2015–2017. We use the Gompertz model, a standard model for constrained growth, with just three intuitive parameters, to model the growth of fetal biometry, and a machine learning (ML) model trained on these parameters to predict birth weight (BW).</div></div><div><h3>Results</h3><div>The Gompertz model convincingly fits the growth of fetal biometry values. Two Gompertz parameters—<span><math><msub><mrow><mi>t</mi></mrow><mrow><mn>0</mn></mrow></msub></math></span> (inflection time) and <span><math><mi>c</mi></math></span> (rate of decrease of growth rate)—seem universal to all fetuses, while the third, <span><math><mi>A</mi></math></span>, is an overall scale specific to each fetus, capturing individual variation. On the Seethapathy cohort we can infer <span><math><mi>A</mi></math></span> for each fetus from ultrasound data available by the 24 or 35 weeks. Our ML model predicts birth weight with &lt; 8 % error, outperforming published methods that have access to late-term ultrasound data. The same model gives an 8.4 % error in BW prediction on an independent validation cohort of 365 women.</div></div><div><h3>Conclusions</h3><div>The Gompertz model fits fetal biometry growth and enables birth weight estimation without need of late-term ultrasounds. Aside from its clinical predictive value, we suggest its use for future growth standards, with almost all variation described by a single scale parameter <span><math><mi>A</mi></math></span>.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"24 ","pages":"Article 100344"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142416521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vegetarian diet and pregnancy outcome","authors":"Johanna Kristiina Reijonen ,&nbsp;Kati Maaria Hannele Tihtonen ,&nbsp;Tiina Hannele Luukkaala ,&nbsp;Jukka Tapio Uotila","doi":"10.1016/j.eurox.2024.100345","DOIUrl":"10.1016/j.eurox.2024.100345","url":null,"abstract":"<div><h3>Objective</h3><div>Vegetarian diets are becoming increasingly popular. Our aim was to evaluate the association of a vegetarian diet with pregnancy, labor, and newborn’s outcome.</div></div><div><h3>Study design</h3><div>This retrospective case-control study included 150 women on a vegetarian diet and 300 omnivores. The data were collected from Tampere University Hospital pregnancy database from January 2015 to April 2021. Diet was a self-reported variable. Outcomes of interest were compared between the groups. The frequency of small-for-gestational age (SGA) newborns and low birth weight were primary outcomes. Other parameters concerning pregnancy, labor, and newborn served as secondary outcomes.</div></div><div><h3>Results</h3><div>The rate of SGA at the 10 % cutoff was lower in the vegetarian group. Based on a definition of two standard deviations, SGA did not differ between the vegetarian diet group and the control group. The median birthweight was significantly higher in the vegetarian group. Gestational diabetes (GDM) was more common in the vegetarian group, however the numbers of large for gestational age (LGA) newborns were comparable between the study groups. Labor induction was more common, and the second stage of labor was longer in the vegetarian group. Preterm births (&lt; 32⁺⁰ and &lt; 37⁺⁰ gestational weeks) were more common in the control group. No differences were found in the mean umbilical artery pH value, 1- and 5- minutes Apgar scores or the number of newborns transferred to the neonatal intensive care unit and neonatal ward. The proportions of hypertensive disorders in pregnancy did not differ between the groups.</div></div><div><h3>Conclusion</h3><div>According to our results, a vegetarian diet may be considered safe during pregnancy. It was not associated with an increased risk of pregnancy- or neonatal complications.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"24 ","pages":"Article 100345"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142442880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new uterine endometrium preservation hysteroscopic myomectomy: Introduction of improved procedures and a retrospective analysis of 94 cases","authors":"Wataru Isono ,&nbsp;Masanori Maruyama","doi":"10.1016/j.eurox.2024.100354","DOIUrl":"10.1016/j.eurox.2024.100354","url":null,"abstract":"<div><h3>Objective</h3><div>To reduce the damage of uterine endometrium caused during hysteroscopic myomectomy (HM) for reproductive aged patients, a new uterine endometrium preservation hysteroscopic myomectomy (UEP-HM) has been developed. In this study, we introduced this technique with comparing to the conventional hysteroscopic myomectomy (C-HM).</div></div><div><h3>Study Design</h3><div>The data from 94 patients aged 42 or younger who underwent HM (38 cases with UEP-HM and 56 cases with C-HM) for treating single Type 1 or Type 2 submucosal leiomyoma (SL) were analysed retrospectively for comparing the characteristics of both patient and target SL. In this process, we defined the operation time 60 min or over as the longtime operation (LTO) and the SM sized 3 cm or over as the large submucosal leiomyoma (LSL) for detecting the influential factors, including this procedure, on the difficulty of HM. For assisting the prediction of operation time (OT), we investigated the relationship between the OT and the cube of average diameter (AD) of target SL referring with some past reports.</div></div><div><h3>Results</h3><div>Although when comparing UEP and control groups, parity, AD, the number of patients with Type 2 SL, OT, and the number of infertile patients showed significant difference, in the multivariate analysis only LSL showed the significant influence on the possibility of LTO. Next, we compared OT/Cube of AD, which calculated by dividing OT by the cube of AD for evaluating OT from the target SL size and confirmed that there was no difference in those 2 groups (3.7 ± 3.0 (95 %CI: 0.9 - 13.3, n = 38) vs. 3.9 ± 3.2 (95 %CI: 0.4 - 17.3, n = 56), p = 0.79).</div></div><div><h3>Conclusions</h3><div>The new UEP-HM can become an alternative method of C-HM without procedure-specific difficulty. In the future, to investigate the prognosis of this procedure, more patients and further analyses should be accumulated.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"24 ","pages":"Article 100354"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142700178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rapid diagnostic technique based on metabolomics to differentiate between preeclampsia (PE) and chronic kidney disease (CKD) using maternal urine","authors":"Boyan Gao ,&nbsp;Xin Lv ,&nbsp;Jingli Hou ,&nbsp;Xu Zhuang","doi":"10.1016/j.eurox.2024.100348","DOIUrl":"10.1016/j.eurox.2024.100348","url":null,"abstract":"<div><div>Similar clinical manifestations between preeclampsia and chronic kidney diseases can lead to potential misdiagnosis. Therefore, it is crucial to investigate effective diagnostic approaches that can reduce misdiagnosis and ensure the well-being of pregnant women. In this study, urine samples collected from 44 individuals with preeclampsia, 37 individuals with chronic kidney disease, and 37 healthy pregnant women were analyzed using metabolomic and proteomic strategies to distinguish between these two diseases. A total of 15 small molecules were tentatively identified as biomarkers to differentiate these two diseases, including potential internally exposed drugs and their metabolites like labetalol and SN-38, metabolites of exogenous substances like 3-phenylpropyl glucosinolate, and endogenous substances related to metabolism such as isoglobotriaose and chitobiose. Metabolic differences between preeclampsia from healthy pregnant women, as well as the differences between chronic kidney disease and healthy pregnant women were also investigated. Major mechanistic pathways were investigated based on the combination of metabolomic and proteomic, amino acid metabolisms and folate metabolism play key roles in distinguishing preeclampsia and chronic kidney disease. Two patients who were initially diagnosed with chronic kidney disease were found to have a closer association with preeclampsia following metabolomic analysis. Subsequent clinical symptoms and manifestations further supported the diagnosis of preeclampsia, and one of patient's pregnancy was ultimately terminated due to severe preeclampsia. Results of this study contribute to a better understanding of the pathogenesis and clinical diagnosis of preeclampsia, offering insights that could potentially improve future diagnostic and management approaches.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"24 ","pages":"Article 100348"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142442881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}