The effect of pentoxifylline and different types of exercise training on coagulation factors in a rat endometriosis model

IF 1.5 Q3 OBSTETRICS & GYNECOLOGY

European Journal of Obstetrics and Gynecology and Reproductive Biology: X Pub Date : 2024-02-21 DOI:10.1016/j.eurox.2024.100292

Zahra Salehpoor , Mohamad Rezapourmoghadam , Nader Tanideh , Maryam Koushkie Jahromi

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Abstract

Objectives

This study evaluated the effects of high-intensity interval training (HIIT), moderate-intensity continuous training (MICT), and pentoxifylline (PTX) on coagulation factors, including the amount and percentage of lymphocytes, PLC, PLR, aPTT, PT, PT.I.N. R in a model of rats with endometriosis.

Methods

Endometriosis was surgically induced in female SpragueDawley rats. The rats with confirmed endometrial implants were divided into control, MICT, pentoxifylline (D), HIIT+D, and MICT+D, HIIT groups. D and exercise interventions were performed for eight weeks. Then, the macroscopic size of endometriosis lesions was measured, and inflammatory factors (count and percentage of lymphocytes) and coagulation factors, including PLC, PLR, aPTT, PT, PT.I.N. R, and PLR in blood samples were evaluated.

Results

D significantly decreased the volume of lesions and significantly increased PT and PT.I.N. R in blood. HIIT decreased the volume of lesions and significantly increased PT. MICT did not cause significant effects on the target variables. MICT+D decreased the volume of lesions. HIIT+D significantly decreased the volume of lesions and PLC and increased aPTT as well as the count and percentage of lymphocytes, PT, and PT.I.N. R, and decreased PLR.

Conclusions

All interventions(except for MICT) especially HIIT+D and D by priority, induced a significant effect on reducing some indices of inflammation and coagulation.

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喷托塞林和不同类型的运动训练对大鼠子宫内膜异位症模型凝血因子的影响

方法用手术诱导雌性 SpragueDawley 大鼠患子宫内膜异位症。将确诊子宫内膜植入的大鼠分为对照组、MICT 组、戊氧地胆素组（D）、HIIT+D 组和 MICT+D 组、HIIT 组。D组和运动干预组均持续八周。然后，测量子宫内膜异位症病灶的宏观大小，评估血液样本中的炎症因子（淋巴细胞计数和百分比）和凝血因子，包括 PLC、PLR、aPTT、PT、PT.I.N.R 和 PLR。HIIT 减少了病变体积，并明显增加了 PT。MICT 对目标变量无明显影响。MICT+D减少了病变体积。结论所有干预措施（除 MICT 外），尤其是 HIIT+D 和 D（优先），对降低炎症和凝血的某些指标有明显作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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