European Journal of Obstetrics and Gynecology and Reproductive Biology: X最新文献

{"title":"The interaction of breastfeeding and genetic factors on childhood obesity","authors":"Mahsa Danaie ,&nbsp;Maryam Yeganegi ,&nbsp;Seyed Alireza Dastgheib ,&nbsp;Reza Bahrami ,&nbsp;Fatemeh Jayervand ,&nbsp;Amirhossein Rahmani ,&nbsp;Maryam Aghasipour ,&nbsp;Mohammad Golshan-Tafti ,&nbsp;Sepideh Azizi ,&nbsp;Zahra Marzbanrad ,&nbsp;Ali Masoudi ,&nbsp;Amirmasoud Shiri ,&nbsp;Mohamad Hosein Lookzadeh ,&nbsp;Mahmood Noorishadkam ,&nbsp;Hossein Neamatzadeh","doi":"10.1016/j.eurox.2024.100334","DOIUrl":"10.1016/j.eurox.2024.100334","url":null,"abstract":"<div><p>Childhood obesity represents a pressing global public health concern due to its widespread prevalence and its close connection to early-life exposure to risk factors. The onset of obesity is contingent upon the interplay of genetic composition, lifestyle choices, and environmental as well as nutritional elements encountered during both fetal development and early childhood. This paper critically examines research discoveries in this area and concisely outlines the influence of breastfeeding on genetic predispositions associated with childhood obesity. Studies have demonstrated that breastfeeding has the potential to reduce childhood obesity by impacting anthropometric indicators. Moreover, the duration of breastfeeding is directly correlated with the degree to which it alters the risk of childhood obesity. Current explorations into the link between genetic factors transmitted through breast milk and childhood obesity predominantly focus on genes like FTO, Leptin, RXRα, PPAR-γ, and others. Numerous research endeavors have suggested that an extended period of exclusive breastfeeding is tied to a diminished likelihood of childhood obesity, particularly if sustained during the initial six months. The duration of breastfeeding also correlates with gene methylation, which could serve as the epigenetic mechanism underpinning breastfeeding's preventative influence against obesity. In summary, the thorough evaluation presented in this review underscores the intricate nature of the association between breastfeeding, genetic factors, and childhood obesity, providing valuable insights for future research efforts and policy formulation.</p></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"23 ","pages":"Article 100334"},"PeriodicalIF":1.5,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590161324000541/pdfft?md5=fc5604297b57e1fd0f42fda90afdae01&pid=1-s2.0-S2590161324000541-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141984782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Motherhood on a precarious path: Pregnancy following breast carcinoma – Case report","authors":"Perković Pavo ,&nbsp;Culej Bošnjak Diana ,&nbsp;Bertović Žunec Ivan ,&nbsp;Lučić Dejana ,&nbsp;Duić Željko ,&nbsp;Bursać Danijel","doi":"10.1016/j.eurox.2024.100335","DOIUrl":"10.1016/j.eurox.2024.100335","url":null,"abstract":"<div><p>Women of childbearing age frequently express a desire for pregnancy even after a diagnosis of breast cancer and after undergoing treatment. The average age of primiparous women is rising and gynecologists and oncologists are faced with inquiries about pursuing childbearing after the diagnosis of breast cancer. We present a case of a 39 year old women who came to our clinic in 39th week of gestation, gave vaginal birth to a vigorous neonatus and underwent into dyspnea just two hours after the delivery. She voluntarily disclosed her advanced stage of breast cancer diagnosis, as she feared it could lead to the termination of her pregnancy. After she was released from the hospital, she did not attend any follow-up appointments at our clinic, hence we have no knowledge whether she contacted her oncologist or the outcome of her primary disease.</p></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"23 ","pages":"Article 100335"},"PeriodicalIF":1.5,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590161324000553/pdfft?md5=e7bef92dac97b519b9dbb0b6a7126a5b&pid=1-s2.0-S2590161324000553-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141978252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A letter to editor – Critical appraisal on “Determining the cost-effectiveness of follitropin alfa biosimilar compared to follitropin alfa originator in women undergoing fertility treatment in France.”","authors":"Juan-Enrique Schwarze,&nbsp;Vivek Chaudhari,&nbsp;Susana Montenegro,&nbsp;Claire Castello-Bridoux,&nbsp;Cristina Masseria,&nbsp;Claudia Roeder","doi":"10.1016/j.eurox.2024.100332","DOIUrl":"10.1016/j.eurox.2024.100332","url":null,"abstract":"","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"23 ","pages":"Article 100332"},"PeriodicalIF":1.5,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590161324000528/pdfft?md5=c407e7e87d3c67784cca53efd5afe1c7&pid=1-s2.0-S2590161324000528-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141952533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Letter to Editor from Juan-Enrique Schwarze and colleagues – Critical appraisal on “Determining the cost-effectiveness of follitropin alfa biosimilar compared to follitropin alfa originator in women undergoing fertility treatment in France”","authors":"Matthieu Lehmann,&nbsp;Jean-Luc Pouly,&nbsp;Paul Barrière,&nbsp;Lauren Amy Boland,&nbsp;Samuel George Bean,&nbsp;Julian Jenkins","doi":"10.1016/j.eurox.2024.100331","DOIUrl":"10.1016/j.eurox.2024.100331","url":null,"abstract":"","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"23 ","pages":"Article 100331"},"PeriodicalIF":1.5,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590161324000516/pdfft?md5=2b65bc3d6a296da8b629d076c992742b&pid=1-s2.0-S2590161324000516-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141962936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An eight-year analysis of robotic surgery in morbidly obese women with endometrial cancer in a tertiary center in Singapore","authors":"Sabrina Lasini Gruhl,&nbsp;Muhammad Ashraf Yusoff,&nbsp;Hui Men Selina Chin,&nbsp;Ravichandran Nadarajah","doi":"10.1016/j.eurox.2024.100330","DOIUrl":"10.1016/j.eurox.2024.100330","url":null,"abstract":"<div><h3>Introduction</h3><p>Surgical management of endometrial cancer is a total hysterectomy, bilateral salphingo-oophorectomy and pelvic lymph node dissection (THBSO-PLND), which is a challenging surgery in the morbidly obese. Data on morbidly obese women undergoing robotic surgery is limited in Asia. We share our experience in Singapore and aim to demonstrate that robotic surgery is safe and effective in morbidly obese women with endometrial cancer.</p></div><div><h3>Materials and Methods</h3><p>We performed a retrospective analysis of patients with BMI &gt; 40 kg/m2, who underwent robotic surgery from January 2016 to September 2023 at the Singapore General Hospital. We recruited a total of 33 patients who underwent robotic surgery for endometrial malignancy and analysed surgical outcomes, operative complications, and survival rates.</p></div><div><h3>Results</h3><p>The average age of patients was 53 years and mean BMI 45.7. The average operative time was 232 min and average blood loss 184 ml. 3 patients had THBSO while 27 underwent THBSO-PLND. None required conversion to laparotomy. 4 patients required a mini-laparotomy for the retrieval of bulky uterus. 12 required adhesiolysis. 6 patients had additional omentectomy done. The average inpatient stay was 4.8 days. The 1-year mortality rate is 0. However, 1 patient passed away 13 months after surgery due to complications from bowel obstruction and another passed away 39 months later due to disease recurrence. 1 patient readmitted on POD6 due to post-op ileus and another for port-site hematoma. Both were managed conservatively.</p></div><div><h3>Conclusion</h3><p>Robotic surgery is a safe and effective alternative surgical tool for women who are morbidly obese with endometrial cancer.</p></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"23 ","pages":"Article 100330"},"PeriodicalIF":1.5,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590161324000504/pdfft?md5=533f4891b235450f57d371260dc3bcd9&pid=1-s2.0-S2590161324000504-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141962432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Did we observe changes in obstetric interventions in SARS-CoV-2 infected pregnant women at the beginning of COVID-pandemic in Belgium? Results of a nationwide population-based study.","authors":"An Vercoutere ,&nbsp;Judith Racapé ,&nbsp;Mbiton Joel Zina ,&nbsp;Sophie Alexander ,&nbsp;Karolien Benoit ,&nbsp;Michel Boulvain ,&nbsp;Régine Goemaes ,&nbsp;Charlotte Leroy ,&nbsp;Virginie Van Leeuw ,&nbsp;Elena Costa ,&nbsp;Sara Derisbourg ,&nbsp;Jean-Christophe Goffard ,&nbsp;Kristien Roelens ,&nbsp;Griet Vandenberghe ,&nbsp;Caroline Daelemans ,&nbsp;on behalf of the B.OSS collaborative group","doi":"10.1016/j.eurox.2024.100328","DOIUrl":"10.1016/j.eurox.2024.100328","url":null,"abstract":"<div><h3>Background</h3><p>Pregnant women are more vulnerable to the severe effects of COVID-19 compared to their non-pregnant peers. Early in the pandemic, there was a rise in cesarean deliveries and preterm births among infected pregnant women. This study aims to evaluate whether there were any changes in obstetric interventions during the first two waves of the pandemic in Belgium.</p></div><div><h3>Methods</h3><p>Between March 2020 and February 2021, the Belgian Obstetric Surveillance System (B.OSS) conducted an extensive, nationwide population-based registry study, that included nearly all births to women with a confirmed SARS-CoV-2 infection within six weeks before hospitalization in Belgium. The perinatal outcomes of these women were analyzed and compared with pre-pandemic regional perinatal data.</p></div><div><h3>Results</h3><p>A total of 923 SARS-CoV-2 infected pregnant women were admitted to the hospital; 9.3 % were hospitalized for severe COVID-19, while the remaining were hospitalized for obstetric reasons. Infected women had a higher median BMI, a higher incidence of diabetes, and a greater proportion were overweight or obese compared to the reference group (p &lt; 0.001). While the majority of women gave birth vaginally, symptomatic women and those with a severe infection had slightly higher rates of cesarean delivery, though not statistically significant after adjusting for confounders. Only severely ill women had an increased risk of preterm delivery (aOR 2.3; 95 %CI [1.2–2.5]; p = 0.02) and of induced labor (OR 1.8; 95 %CI [1.1–2.8]; p = 0.01). The use of general anesthesia for cesarean delivery was more common in the infected group (OR 2.6; 95 %CI [1.6–4.1]; p &lt; 0.001).</p></div><div><h3>Conclusions</h3><p>Obstetric interventions, such as cesarean delivery and induction, remained at pre-pandemic levels. However, a SARS-CoV-2 infection appears to have increased medically induced preterm delivery and the use of general anesthesia for cesarean delivery.</p></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"23 ","pages":"Article 100328"},"PeriodicalIF":1.5,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590161324000486/pdfft?md5=a47b1b565ec932211f98c390ea19651d&pid=1-s2.0-S2590161324000486-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141950510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of cardiotocography with combined APGAR scores and diagnostic performance of umbilical cord parameters in predicting low combined APGAR scores – A prospective Cohort study","authors":"Soumyashree Paikaray ,&nbsp;Saubhagya Kumar Jena ,&nbsp;Deepthy Balakrishnan ,&nbsp;Pankaj Kumar Mohanty","doi":"10.1016/j.eurox.2024.100329","DOIUrl":"10.1016/j.eurox.2024.100329","url":null,"abstract":"<div><h3>Objectives</h3><p>Combined Apgar score includes utilization of interventions such as <strong>C</strong>ontinuous positive airway pressure, <strong>O</strong>xygen, <strong>M</strong>ask and Bag ventilation<strong>, I</strong> ntubation and ventilation<strong>, Ne</strong> onatal chest compression, <strong>D</strong>rugs, and newborn assessment. It has been proposed as a substitute for conventional Apgar score which is the gold standard for evaluating newborns right after birth but is impacted by medical interventions and preterm. Combined Apgar scores were examined to check for correlation with CTG tracing and umbilical cord blood parameters which gives an objective assessment of fetal hypoxia, in response to the demand for a more accurate tool for evaluating the neonate and to be used for medico-legal purposes. The study's objectives were to (1) determine the association of combined Apgar scores with suspicious and pathological CTG (2) the association of umbilical cord parameters with low combined Apgar scores and the diagnostic performance of these parameters in predicting low combined Apgar scores.</p></div><div><h3>Study design</h3><p>A prospective observational cohort study was conducted in a tertiary care center in East India. 2350 consecutive laboring mothers who had completed 34 weeks of gestation underwent cardiotocography according to institutional protocol and those with suspicious and pathological CTG who delivered within 1 h of abnormal CTG were recruited. Arterial blood was analyzed and the newborn was evaluated immediately after delivery with a combined Apgar scoring system</p></div><div><h3>Results</h3><p>Of the 2350 women, 50.7 % and 49.3 %, respectively, exhibited suspicious and abnormal CTG tracings. CTG was reported to have low diagnostic accuracy and specificity, with a sensitivity of 66.7 % and 88.9 %, respectively, in detecting combined Apgar at 1 and 5 min. The combined Apgar score at five minutes showed a strong association with acidosis. There was a statistically significant correlation between low combined Apgar and excess lactate and base at one and five minutes. With 100 % sensitivity and 95 % specificity, high lactate levels &gt; 4.1 mM/L were found to predict newborn encephalopathy.</p></div><div><h3>Conclusion</h3><p>Umbilical cord blood parameters were found to be correlated with low combined Apgar scores. Combined Apgar scores may be a more useful tool for neonatal assessment and long-term morbidity of newborns. Additional research is required to determine whether it can take the role of conventional Apgar scores in clinical practice.</p></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"23 ","pages":"Article 100329"},"PeriodicalIF":1.5,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590161324000498/pdfft?md5=e1044f59aea71a8eb1043bb5561fe0d5&pid=1-s2.0-S2590161324000498-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141838926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of patient-reported experiences in disclosing genetic prenatal testing: Findings from a large-scale survey on pregnant women","authors":"Amerigo Ferrari ,&nbsp;Federico Pennestrì ,&nbsp;Manila Bonciani ,&nbsp;Giuseppe Banfi ,&nbsp;Milena Vainieri ,&nbsp;Rossella Tomaiuolo","doi":"10.1016/j.eurox.2024.100327","DOIUrl":"10.1016/j.eurox.2024.100327","url":null,"abstract":"<div><h3>Introduction</h3><p>Pregnant women can choose from different prenatal genetic tests throughout their maternity journey. We aim to investigate the clinical, societal, and economic determinants influencing the selection of different options (non-invasive, invasive, or both).</p></div><div><h3>Methods</h3><p>A systematic survey focusing on maternity pathways was launched by the Region of Tuscany, Italy, to collect data on pregnant women’s experience, outcomes and satisfaction levels. Drawing from this survey, we retrospectively analyzed data on women who filled out the second-trimester questionnaire between March 2019 and February 2023 (n = 27,337), providing complete data on relevant variables. Logistic regression models were applied to identify the factors contributing to a higher likelihood of opting for non-invasive prenatal testing (NIPT) and invasive testing.</p></div><div><h3>Results</h3><p>Among the participants, 42.7 % chose only NIPT, 3.8 % opted for invasive tests exclusively, 1.3 % underwent both tests, and 52.2 % did not pursue any genetic testing. NIPT was more often chosen by older, Italian, highly educated, nulliparous women, who perceived better health, were employed (versus unemployed), had higher economic status, planned pregnancy, received hospital-based care (versus counseling center), under gynecologist supervision (versus midwife), not opted for combined testing and received pregnancy vaccinations. Conversely, invasive testing was more prevalent among older women but less common among those who were nulliparous, had Italian nationality, and had a perceived better health status. This group also tended to experience unplanned and high-risk pregnancy, did not take folate during pregnancy, received public hospital-based assistance, less frequently chose combined tests or NIPT, and had frequent delays in examinations.</p></div><div><h3>Conclusions</h3><p>Various factors beyond clinical considerations influence the selection of a prenatal test. Therefore, NIPT pathways should include balanced, high-quality information about benefits and limitations, ensuring laboratory specialists' active and integrated involvement in decision-making.</p></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"23 ","pages":"Article 100327"},"PeriodicalIF":1.5,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590161324000474/pdfft?md5=988a75c8571e8e880a22dc222ad0cb87&pid=1-s2.0-S2590161324000474-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141638044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of diclofenac suppository for postoperative pain relief after diagnostic hystero-laparoscopy and dye test: A double-blind, placebo-controlled, randomized trial","authors":"Princeston C. Okam ,&nbsp;Joseph I. Ikechebelu ,&nbsp;George U. Eleje ,&nbsp;Innocent C. Albert ,&nbsp;Boniface C. Okpala ,&nbsp;Chioma F. Okam ,&nbsp;Louis A. Nwajiaku ,&nbsp;Ngozi N. Joe-Ikechebelu ,&nbsp;Chijioke O. Ezeigwe ,&nbsp;Chisom G. Chigbo ,&nbsp;Chigozie G. Okafor","doi":"10.1016/j.eurox.2024.100326","DOIUrl":"https://doi.org/10.1016/j.eurox.2024.100326","url":null,"abstract":"<div><h3>Objective</h3><p>To determine the efficacy and safety of rectal diclofenac for relieving postoperative pain following diagnostic hystero-laparoscopy and dye test (dHLD).</p></div><div><h3>Methods</h3><p>A prospective, double-blind, placebo-controlled, randomized trial was conducted among women who underwent dHLD to evaluate fertility. The women received either rectal diclofenac with intramuscular pentazocine or intramuscular pentazocine with rectal placebo for postoperative analgesia. The median pain scores at different time points were assessed as the primary outcome measures using the Numerical Rating Scale for pain. The secondary outcome measures were analgesic consumption, time at which first analgesic was requested, satisfaction with pain relief and any adverse events.</p></div><div><h3>Results</h3><p>In total, 108 participants were analysed (54 in each group, 1:1 ratio). The median score for postoperative pain was lower for the diclofenac group compared with the placebo group at 4 h (52.53 vs 56.47; <em>p</em> = 0.507), 6 h (50.48 vs 58.52; <em>p</em> = 0.174), 8 h (51.42 vs 57.65; <em>p</em> = 0.296), 10 h (51.35 vs 57.65; <em>p</em> = 0.285) and 12 h (52.45 vs 56.55; <em>p</em> = 0.485) post surgery, although the difference was not significant (<em>p</em> &gt; 0.05). Seventeen participants required rescue analgesia with 30 mg of pentazocine: 11 at 4 h post surgery [5 (62.5 %) vs 6 (66.7 %)], three at 6 h post surgery [2 (25.0 %) vs 1 (11.1 %)], two at 8 h post surgery [1 (12.5 %) vs 1 (11.1 %)], and one at 12 h post surgery [0 vs 1 (11.1 %)] for the diclofenac and placebo groups respectively (<em>p</em> = 0.713). There were no significant differences in postoperative adverse effect profiles, overall patient satisfaction, and need for rescue analgesia between the two groups (<em>p</em> &gt; 0.05).</p></div><div><h3>Conclusions</h3><p>Postoperative use of rectal diclofenac and pentazocine is safe, but did not significantly improve pain scores, patient satisfaction and need for rescue analgesia following dHLD, compared with patients who received pentazocine and placebo. While a multi-modal approach to pain relief following dHLD does not appear to be significantly beneficial, a multi-centre study is needed to confirm or refute these findings.</p></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"23 ","pages":"Article 100326"},"PeriodicalIF":1.5,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590161324000462/pdfft?md5=8e616099d985d966a6e6698f3f717f15&pid=1-s2.0-S2590161324000462-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141606412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Risk factors of early spontaneous preterm birth despite carrying a cervical pessary in singleton pregnancies with a short cervix: Development of a risk prediction model” [Eur J Obstet Gynecol Reprod Biol X 22 (2024) 100305]","authors":"Carme Merced ,&nbsp;Laia Pratcorona ,&nbsp;Teresa Higueras ,&nbsp;Mireia Vargas ,&nbsp;Esther Del Barco ,&nbsp;Judit Solà ,&nbsp;Elena Carreras ,&nbsp;Maria Goya","doi":"10.1016/j.eurox.2024.100325","DOIUrl":"https://doi.org/10.1016/j.eurox.2024.100325","url":null,"abstract":"","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"23 ","pages":"Article 100325"},"PeriodicalIF":1.5,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590161324000450/pdfft?md5=66f280b594d9f65d6508897ede0a2b0a&pid=1-s2.0-S2590161324000450-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141542262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}