European Journal of Obstetrics and Gynecology and Reproductive Biology: X最新文献

{"title":"Investigation the therapeutic effect of mindfulness-based cognitive-behavioral counseling in pregnant women with body image dissatisfaction: A randomized controlled trial","authors":"Mehnoosh Farahabadi ,&nbsp;Abbas Amanollahi ,&nbsp;Bahman Cheraghian ,&nbsp;Zahra Abbaspoor","doi":"10.1016/j.eurox.2025.100387","DOIUrl":"10.1016/j.eurox.2025.100387","url":null,"abstract":"<div><h3>Background and aims</h3><div>Dissatisfaction with body image during pregnancy is a common issue in the general population and can pose risks for both the mother and the child. The aim of this study was to investigate the therapeutic effect of mindfulness-based cognitive-behavioral counseling in pregnant women with body image dissatisfaction: A randomized controlled trial.</div></div><div><h3>Methods</h3><div>In this study, 50 pregnant women who were over 26 weeks pregnant were randomly assigned to intervention and control groups. In the intervention group, Mindfulness-based cognitive behavioral therapy was taught to pregnant women over 8 consecutive sessions, while the control group received no intervention. Body image concerns questionnaire was completed by both groups before and after the intervention, and data were analyzed using descriptive statistics and multivariate analysis of covariance.</div></div><div><h3>Results</h3><div>The results showed that before the intervention, the mean and standard deviation of body image concern scores in the intervention group was 58.36 ± 3.13 and in the control group, was 58.08 ± 3.31, but after the end of the intervention, in the intervention group it decreased to 41.40 ± 2.85 (p &lt; 0.001), while in the control group, it decreased (57.64 ± 3.42) slightly (P = 0.951). The total scores for body image concern in the intervention group were significantly lower compared to the control group (p &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>Mindfulness-based cognitive behavioral therapy can help reduce body image concerns in pregnant women. Therefore, it is recommended that mental health professionals utilize this approach to improve the psychological and physical well-being of pregnant women and assist them in modifying their attitudes towards body image.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"26 ","pages":"Article 100387"},"PeriodicalIF":1.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143834917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory myofibroblastic tumour of cervix: Uncommon pathology in an unlikely location – A literature review","authors":"B. Bhardwaj ,&nbsp;P. Guleria ,&nbsp;A. Tevatia ,&nbsp;M. Pethan ,&nbsp;S. Sharma ,&nbsp;M. Rana","doi":"10.1016/j.eurox.2025.100375","DOIUrl":"10.1016/j.eurox.2025.100375","url":null,"abstract":"<div><h3>Background</h3><div>Inflammatory myofibroblastic tumours (IMTs) of the uterine cervix are extremely rare, benign mesenchymal neoplasms, characterized by the proliferation of myofibroblasts within an inflammatory background. IMTs most commonly occur in the lungs and abdomen, and their occurrence in the female genital tract, particularly the uterine cervix, is exceedingly rare. The optimal management of these tumours remains under investigation due to the limited number of reported cases.</div></div><div><h3>Objectives</h3><div>This literature review aims to provide an overview of the clinical presentation, diagnostic challenges and management strategies of uterine cervical IMTs. This review focuses on the roles of histopathology, immunohistochemistry (IHC) and molecular analysis in diagnosing these tumours, and discusses treatment outcomes and follow-up strategies.</div></div><div><h3>Methods</h3><div>A comprehensive review of the literature was conducted using PubMed, Google Scholar and other relevant databases. Relevant case reports and studies published between 2000 and 2024 were included. The primary outcomes assessed were clinical presentation, diagnostic features, treatment modalities and recurrence/metastasis rates.</div></div><div><h3>Results</h3><div>Eleven reports of IMTs of the uterine cervix were identified in the literature search, and six of these were included in this review. Clinical presentation primarily includes abnormal uterine bleeding (AUB), often with symptoms of menorrhagia and dysmenorrhoea. Imaging studies and histopathological examination play key roles in diagnosis, with IHC markers such as smooth muscle actin, desmin and anaplastic lymphoma kinase (ALK)-1 being used frequently. Surgical resection remains the mainstay of treatment, with some cases also benefiting from targeted therapy for recurrent or metastatic disease.</div></div><div><h3>Conclusion</h3><div>IMTs of the uterine cervix are rare but are increasingly recognized in clinical practice. They are typically benign with a low risk of malignancy, although local recurrence is possible, especially in cases of incomplete resection. Diagnosis relies heavily on histopathological and molecular analysis, with ALK gene rearrangements being an important molecular finding. While surgical excision remains the primary treatment, ongoing research into targeted therapies, including ALK inhibitors, offers promising avenues for management. This review emphasizes the need for long-term follow-up given the potential for recurrence.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"26 ","pages":"Article 100375"},"PeriodicalIF":1.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143644531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The landscape of ovarian cancer surgery in Italy: Data from PNE","authors":"Laura Grazia Zompì ,&nbsp;Cerbone Marco ,&nbsp;Pietro Quarto ,&nbsp;Christopher Clark ,&nbsp;Tommaso Difonzo ,&nbsp;Salvatore Lopez ,&nbsp;Vera Loizzi ,&nbsp;Cormio Gennaro","doi":"10.1016/j.eurox.2025.100383","DOIUrl":"10.1016/j.eurox.2025.100383","url":null,"abstract":"<div><h3>Objective</h3><div>Ovarian cancer (OC) in Italy is tenth in incidence among tumors in females, and it is the cause of 30 % of deaths due to gynecological tumors. The objective of this study is to evaluate the volume of patients undergoing surgical treatment for OC in Italian hospital facilities.</div></div><div><h3>Methods</h3><div>An analysis of hospitalization volumes due to OC in Italian medical facilities in 2022 based on the Piano Nazionale Esiti was performed. Centers were divided into 3 categories, according to the annual number of hospitalizations due to OC (above 30, between 20 and 29, below 20); the percentage of patients treated in each category of hospitals was calculated. Additionally, an evaluation of the active mobility (meaning the number of patients living outside the region but receiving treatment in the region taken into examination) and passive mobility (meaning the number of patients living inside the examined region but choosing to receive treatment in centers located outside of the region itself) was carried out for each region.</div></div><div><h3>Results</h3><div>The study showed that, in 11 Italian regions, most of OC cases are treated in medical centers with patient volumes of less than 20 cases per year. Only in 6 regions, OC cases are mostly treated in larger centers; in these same regions, the highest percentages of active mobility are recorded. Finally, in 6 Italian regions, passive mobility exceeds 50 % of regional cases.</div></div><div><h3>Conclusions</h3><div>Nowadays, the landscape of OC treatment in Italy is extremely heterogeneous. In most regions, patients receive treatment in low volume centers; concurrently, huge volumes of patients hailing from the entire national territory are treated in a limited number of centers.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"26 ","pages":"Article 100383"},"PeriodicalIF":1.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143799188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Could blastocysts derived from abnormal fertilized zygotes be used? A systematic review and meta-analysis","authors":"Yiqing Wu ,&nbsp;Jinglei Xue ,&nbsp;Mixue Tu ,&nbsp;Yifeng Liu ,&nbsp;Dan Zhang","doi":"10.1016/j.eurox.2025.100381","DOIUrl":"10.1016/j.eurox.2025.100381","url":null,"abstract":"<div><h3>Objectives</h3><div>Current guidelines advise against using embryos derived from mono-pronuclei (1PN) or non-pronuclei (0PN) zygotes for clinical purposes. Nevertheless, recent studies have demonstrated that 1PN and 0PN zygotes can lead to healthy births. This study aimed to investigate the pregnancy outcomes of 1PN and 0PN blastocysts.</div></div><div><h3>Methods</h3><div>PubMed, EMBASE, Web of Science and Cochrane databases were searched up to 14 March 2024. Eligible studies enrolled participants transferring 0PN or 1PN blastocysts, with two pronuclei (2PN) blastocysts used as the control. Clinical pregnancy rate, miscarriage rate and live birth rate were the main outcomes. The results were presented as odds ratios (OR) with 95 % confidence intervals (CI) using random-effect models with the Mantel–Haenszel method. Additionally, a stratified analysis was conducted based on the type of fertilization. The Newcastle–Ottawa scale (NOS) was used to evaluate the quality of the included studies.</div></div><div><h3>Results</h3><div>In total, 270 articles were identified, with 16 ultimately included in the meta-analysis. In total, 57,835 cycles were analysed: 1071 cycles in the 1PN group, 2324 cycles in the 0PN group, and 54,440 cycles in the 2PN group. The results indicated that 1PN or 0PN blastocysts were associated with lower clinical pregnancy rates and live birth rates than 2PN blastocysts. Interestingly, there was no significant difference in live birth rate between 1PN blastocysts and 2PN blastocysts in patients undergoing intracytoplasmic sperm injection (ICSI), nor between 0PN blastocysts and 2PN blastocysts in patients undergoing in-vitro fertilization (IVF).</div></div><div><h3>Conclusion</h3><div>Careful consideration should be given to the utilization of 1PN and 0PN blastocysts, especially if an improved methodology of non-invasive assessment of fertilization is available. At the very least, 1PN blastocysts in patients undergoing ICSI and 0PN blastocysts in patients undergoing IVF represent viable fertility options for patients facing abnormal fertilization in clinical practice.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"26 ","pages":"Article 100381"},"PeriodicalIF":1.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143686979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of delivery at 48 hours or more in pregnant women with preterm prelabor rupture of membrane: A retrospective cohort study","authors":"Chatuporn Duangkum ,&nbsp;Suphawan Pattamathamakul ,&nbsp;Sukanya Chaiyarach ,&nbsp;Piyamas Saksiriwuttho ,&nbsp;Jen Sothornwit ,&nbsp;Pongsatorn Paopongsawan ,&nbsp;Kittisak Sawanyawisuth ,&nbsp;Sathida Chantanaviliai ,&nbsp;Manasicha Pongsamakthai","doi":"10.1016/j.eurox.2025.100393","DOIUrl":"10.1016/j.eurox.2025.100393","url":null,"abstract":"<div><h3>Objective</h3><div>Expectant management is an option for preterm prelabor rupture of the membrane (PPROM) between 34 0/7 and 36 6/7 weeks of gestation. Even though expectant delivery in PPROM is justified, there is limited data on predictors of PPROM delivered <u>&gt;</u> 48 hrs in a real-world setting. Therefore, this study aimed to find clinical predictors for delivery <u>&gt;</u> 48 hrs in women with PPROM as well as clinical outcomes in clinical practice.</div></div><div><h3>Materials and methods</h3><div>This was a retrospective cohort study conducted at two tertiary care hospitals. The inclusion criteria were a singleton pregnancy with PPROM and planned expectant management. Clinical data were retrieved from the hospitals’ databases. Eligible pregnant women were categorized into two groups: PPROM delivered &lt; 48 hrs or PPROM delivered <u>&gt;</u> 48 hrs. The primary outcome was factors predictive of PPROM delivered <u>&gt;</u> 48 hrs.</div></div><div><h3>Results</h3><div>During the study period, 519 pregnant women met the study criteria. Of those, 90 pregnant women (17.34 %) had PPROM delivered <u>&gt;</u> 48 hrs. Factors independently associated with PPROM delivered <u>&gt;</u> 48 hrs were maternal age ≥ 19 years (adjusted odds ratio [aOR] 0.95, 95 % CI [0.91, 0.99]) and oligohydramnios (aOR 2.41, 95 % CI [1.45, 4.00]). Regarding maternal and neonatal outcomes, the PPROM delivered <u>&gt;</u> 48 hrs group had lower neonatal birth weights (2245 g vs. 2490 g; p &lt; 0.001) than the PPROM delivered &lt; 48 hrs group. However, neonatal outcomes, including respiratory distress, sepsis, neonatal intensive care unit admission, early jaundice, hypoglycemia, positive pressure ventilation, and early respiratory support, were not different.</div></div><div><h3>Conclusions</h3><div>Clinical predictors for PPROM delivered <u>&gt;</u> 48 hrs in a real-world setting were maternal age and presence of oligohydramnios. Maternal and neonatal outcomes in the PPROM delivered <u>&gt;</u> 48 hrs were almost comparable with the PPROM delivered &lt; 48 hrs. PPROM delivered <u>&gt;</u> 48 hrs may be safe and can be a treatment option for PPROM. However, further studies may be required in terms of generalizability as this study was conducted retrospectively in tertiary care hospitals in Thailand.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"26 ","pages":"Article 100393"},"PeriodicalIF":1.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143906363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood pressure in the second and third trimesters of pregnancy and adverse pregnancy outcomes in singleton pregnancies: A bidirectional cohort study","authors":"Liangkun Ma,&nbsp;Yini Li ,&nbsp;Xuanjin Yang ,&nbsp;Ye Li,&nbsp;Suhan Zhang,&nbsp;Mingyue Hu,&nbsp;Yin Sun","doi":"10.1016/j.eurox.2025.100400","DOIUrl":"10.1016/j.eurox.2025.100400","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Although blood pressure in singleton pregnancies is related to multiple adverse pregnancy outcomes, the blood pressure threshold has been controversial.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;To explore the blood pressure reference threshold of singleton pregnant women in the second and third trimesters.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Study design&lt;/h3&gt;&lt;div&gt;A bidirectional single-centre cohort study was undertaken. Clinical data were collected for women with singleton pregnancies who underwent regular antenatal examinations and delivered at Peking Union Medical College Hospital between July 2020 and June 2023. Blood pressure was recorded at 20–24 and 28–32 weeks of gestation, and hypertension and pre-eclampsia were used as the primary outcomes. The percentiles of blood pressure were calculated, and the 95th percentile was used as the upper limit for the second and third trimesters of pregnancy. Poisson regression was used to calculated adjusted relative risk (aRR) and 95 % confidence intervals (CI) were used to analyse the relationship between elevated blood pressure and adverse pregnancy outcomes, and to further explore the impact of changes in blood pressure in the second and third trimesters on pregnancy outcomes. &lt;em&gt;p&lt;/em&gt;-values &lt; 0.05 were considered to indicate significance.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;In total, 7854 pregnant women with singleton pregnancies were included in this study. For pregnant women who did not experience adverse outcomes related to blood pressure, the 95th percentiles of systolic and diastolic blood pressure in the second trimester were 131 mmHg and 80 mmHg, respectively. Corresponding data for the third trimester were 130 mmHg and 80 mmHg, respectively. Therefore, 130/80 mmHg was taken as the upper limit of blood pressure. After excluding confounding factors, regardless of trimester, the risks of gestational hypertension, pre-eclampsia, preterm birth, low birth weight and neonatal intensive care unit (NICU) admission were found to be significantly higher in pregnant women with elevated blood pressure (&lt;em&gt;p&lt;/em&gt; &lt; 0.05). Pregnant women with sustained elevated blood pressure (i.e. in both the second and third trimesters) had aRR values for gestational hypertension, pre-eclampsia, premature birth, low birth weight and NICU admission that were 19.08 (95 % CI 13.04–28.03; &lt;em&gt;p&lt;/em&gt; &lt; 0.001), 11.43 (95 % CI 6.94–18.64; &lt;em&gt;p&lt;/em&gt; &lt; 0.001), 2.53 (95 % CI 1.83–3.42; &lt;em&gt;p&lt;/em&gt; &lt; 0.001), 2.98 (95 % CI 2.05–4.21; &lt;em&gt;p&lt;/em&gt; &lt; 0.001) and 1.79 (95 % CI 1.29–1.79; &lt;em&gt;p&lt;/em&gt; &lt; 0.001) times higher than those of normotensive pregnant women, respectively.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;The blood pressure threshold of singleton pregnant women in the second and third trimesters is 130/80 mmHg. Sustained elevated blood pressure is harmful to the health of mothers and infants. Management and monitoring should be strengthened for pregnant women with elevated blood pressure.&lt;/di","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"26 ","pages":"Article 100400"},"PeriodicalIF":1.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and characteristics of triplet births in a tertiary maternity hospital in China: A retrospective study over two decades","authors":"Yanzhen Zhou,&nbsp;Jinxiu Lin,&nbsp;Zhaozhen Liu,&nbsp;Sheng Lin","doi":"10.1016/j.eurox.2025.100394","DOIUrl":"10.1016/j.eurox.2025.100394","url":null,"abstract":"<div><h3>Background</h3><div>As triplet pregnancies were usually associated with poorer pregnancy outcomes and fetal reduction was coupled with procedure-related complications, many women with triplet pregnancies often opted for expectant management. This retrospective study reported the pregnancy outcomes of women with triplet pregnancies who did not receive artificial fetal reduction over a two-decade period (2002-2021).</div></div><div><h3>Methods</h3><div>Maternal and pregnancy data and perinatal outcomes, including 111 triplets, were obtained from women with triplet pregnancies who received expectant management at Fujian Maternity and Child Health Hospital, including 111 triplets. The patient cohort was divided into two subgroups(Period I, 2002-2011 vs. Period II, 2012-2021).</div></div><div><h3>Results</h3><div>Compared with those in the Period I group, participants in the Period II group reported a better educational background (28.8 vs. 13.8 %, p = 0.024), and occupation status (40.4 vs. 20.6 %, p = 0.012) and a greater percentage of primiparas (57.7 vs. 5.1 %, p &lt; 0.005). However, compared with those in the Period II group, the period I group displayed significantly older gestation age at delivery(p = 0.001), heavier mean birth weight(1583.63 ± 62.14 vs.1830.51 ± 41.95 kg), higher rate of babies taken home(91.6 vs. 84.2 %,p = 0.049), and lower NICU admission rate(47.0 vs. 77.5 %, p &lt; 0.005).</div></div><div><h3>Conclusions</h3><div>Due attention to triplet pregnancies might lower the rate of maternity complications, and antenatal medicines to prevent prematurity could not prolong birth week. Developed neonatal treatment and nursing are adapted to stratified management based on chorionicity. With advancements in maternal healthcare and neonatal treatment, and nursing, expectant management could be a considerable option. Maternal factors such as parity and maternal education status might be correlated with gestational age.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"26 ","pages":"Article 100394"},"PeriodicalIF":1.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144223371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposure to violence and risk of hypertensive disorders in pregnancy: Systematic review and meta-analysis","authors":"Prakasini Satapathy ,&nbsp;Abhay M. Gaidhane ,&nbsp;Nasir Vadia ,&nbsp;Soumya V. Menon ,&nbsp;Kattela Chennakesavulu ,&nbsp;Rajashree Panigrahi ,&nbsp;Ganesh Bushi ,&nbsp;Mahendra Singh ,&nbsp;Sanjit Sah ,&nbsp;Awakash Turkar ,&nbsp;S. Govinda Rao ,&nbsp;Khang Wen Goh ,&nbsp;Muhammed Shabil ,&nbsp;Edward Mawejje","doi":"10.1016/j.eurox.2025.100398","DOIUrl":"10.1016/j.eurox.2025.100398","url":null,"abstract":"<div><h3>Background</h3><div>Hypertensive disorders during pregnancy (HDP) are a significant global health concern, affecting 5–10 % of pregnancies and contributing to maternal and newborn morbidity and mortality. While various factors, including genetics and physiological changes, influence the development of HDP, emerging evidence suggests a strong association with psychosocial stressors, particularly exposure to violence. This meta-analysis aimed to assess the association between exposure to violence and risk of hypertensive disorders in pregnancy.</div></div><div><h3>Methods</h3><div>A literature review was performed across EMBASE, PubMed, and Web of Science from their inception until October 2024. The review included observational studies that examined exposure to various type of violence and their association with hypertensive disorders in pregnancy. Pooled effect estimates, including odds ratios (ORs) and relative risks (RRs) were computed using a random-effects model.</div></div><div><h3>Results</h3><div>Sixteen studies met the inclusion criteria. Meta-analysis revealed that violence exposure during pregnancy was associated with a significantly increased risk of HDP, with a pooled OR of 1.380 (95 % CI: 1.079–1.765) and a pooled RR of 1.235 (95 % CI: 1.074–1.420). Subgroup analysis indicated that cohort studies demonstrated a stronger association (OR: 1.726, 95 % CI: 1.182–2.519) compared to cross-sectional studies (OR: 1.112, 95 % CI: 1.009–1.226).</div></div><div><h3>Conclusion</h3><div>Experiencing violence during pregnancy is significantly linked to a heightened risk of HDP, indicating the need for regular violence screening and early preventive measures in prenatal care. Public health initiatives focused on reducing violence against women, especially during pregnancy, are crucial for improving maternal health and lowering the incidence of hypertensive complications.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"26 ","pages":"Article 100398"},"PeriodicalIF":1.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between different types and characteristics of fetal deceleration during labour and neonatal acidemia at delivery: A case-control study","authors":"Maria Fogelberg ,&nbsp;Charlotte Dahlbäck ,&nbsp;Frida Ekengård ,&nbsp;Gisela Rickle ,&nbsp;Andreas Herbst","doi":"10.1016/j.eurox.2025.100389","DOIUrl":"10.1016/j.eurox.2025.100389","url":null,"abstract":"<div><h3>Objective</h3><div>Classification of fetal heart rate (FHR) decelerations as suspicious or pathological differs between current interpretation templates for intrapartum cardiotocography. Decelerations are the most frequent FHR pattern irregularities during labour. The aim of this study was to assess the association between different types and characteristics of decelerations and acidemia at birth.</div></div><div><h3>Methods</h3><div>This case-control study includes 365 cases with cord pH &lt; 7.10 after 1st stage cesarean delivery or pH &lt; 7.05 after vaginal delivery at &gt; 34 + 0 weeks after induced or spontaneous labour, and 730 controls with pH ≥ 7.15. Cardiotocographic recordings from 60 min before birth were scrutinized and decelerations evaluated in detail. Odds ratios (OR) with 95 % confidence intervals for acidemia at birth were determined.</div></div><div><h3>Results</h3><div>The following types of decelerations were associated with acidemia: Late decelerations; OR 9.0 (6.1–13) if &gt; 5, and OR 19 (9.7–37) if repetitive &gt; 20 min, combined decelerations; OR 4.2 (2.7–6.4) if &gt; 5 and OR 6.4 (3.1–13) if repetitive &gt; 20 min, one prolonged deceleration &gt; 5 min; OR 12 (7.9–19), three prolonged decelerations for 3–5 min; OR 10 (4.3–25), and &gt; 5 variable decelerations &gt; 60 s; OR 2.2 (1.6–2.9). For variable decelerations &gt; 60 s, absent variability within decelerations was the only additional characteristic significantly associated with acidemia; OR 5.8 (2.1–16). A strong association with acidemia was noted for a FHR below the baseline ≥ 50 % of the time &gt; 30 min; OR 14 (10−19).</div></div><div><h3>Conclusion</h3><div>Late and prolonged decelerations are strongly, and combined decelerations moderately associated with acidemia. The risk of acidemia is highly increased if FHR is below baseline ≥ 50 % of the time.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"26 ","pages":"Article 100389"},"PeriodicalIF":1.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143886598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Randomized controlled trial of 4.0 mg versus 0.4 mg folic acid supplementation: Follow-up of children at 1 year of age","authors":"Renata Bortolus ,&nbsp;Francesca Filippini ,&nbsp;Sonia Cipriani ,&nbsp;Daniele Trevisanuto ,&nbsp;Federico Marchetti ,&nbsp;Pierpaolo Mastroiacovo ,&nbsp;Fabio Parazzini ,&nbsp;Francesco Cavallin ,&nbsp;on behalf of the Italian Folic Acid Trial Study Group","doi":"10.1016/j.eurox.2025.100370","DOIUrl":"10.1016/j.eurox.2025.100370","url":null,"abstract":"<div><h3>Objective and study design</h3><div>This 1-year follow-up study reports the results on the health status, visits to the paediatrician and hospitalizations of children born from the women recruited in the main randomized controlled trial (RCT) that investigated the effect of periconception folic acid (FA) supplementation of 4.0 mg/day on reducing adverse reproductive outcomes.</div></div><div><h3>Methods</h3><div>The health status of livebirths was evaluated by a trained health care provider (HCP) through a phone interview with the paediatrician (at 1–3–12 months of age) and with the parents (at 12 months of age), using a structured data collection form.</div></div><div><h3>Results</h3><div>Information at 1 year of life could be obtained for 347/376 (92.3 %) newborns included in the original RCT. No statistically significant differences were observed between the two groups regarding weight, health problems, hospitalizations from birth to 1 year of life and developmental milestones, as well as accesses to the emergency ward and parents’worries. Breastfeeding differed significantly at 1, 3 and 12 months of life, with higher proportion of exclusive breastfeeding in the 4.0 mg FA Group.</div></div><div><h3>Conclusion</h3><div>The findings suggest that the periconception FA supplementation of 4.0 mg/day versus 0.4 mg/day, does not affect the health status and hospitalizations from birth to 1 year of life, as well as normal child’s developmental milestones at 1 year of life. The increase in exclusive breastfeeding in the 4.0 mg FA group needs further investigation.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"25 ","pages":"Article 100370"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}