European Journal of Obstetrics and Gynecology and Reproductive Biology: X最新文献

{"title":"Vaginal assisted NOTES hysterectomy in The Netherlands; A prospective cohort study","authors":"Ilse P.W. Bekkers ,&nbsp;Rebecca Henschen ,&nbsp;Nicol A.C. Smeets ,&nbsp;Huib A.A.M. van Vliet ,&nbsp;Anne Damoiseaux ,&nbsp;Martine M.L.H. Wassen","doi":"10.1016/j.eurox.2024.100323","DOIUrl":"https://doi.org/10.1016/j.eurox.2024.100323","url":null,"abstract":"<div><h3>Objectives</h3><p>Vaginal assisted Natural Orifice Transluminal Endoscopic Surgery (NOTES) combines the benefits of vaginal and endoscopic surgery. This study presents the results of the first vaginal assisted NOTES hysterectomies (VANH) in The Netherlands.</p></div><div><h3>Study design</h3><p>A prospective cohort study was performed in two non-academic teaching hospitals in The Netherlands. Data was collected from patients who underwent a VANH for benign indications between August 2019 and April 2023. Baseline characteristics and data of intra- and postoperative surgical outcomes were recorded and analysed. The VANHs were performed by four experienced vaginal and endoscopic gynaecological surgeons.</p></div><div><h3>Results</h3><p>A total of 200 patients underwent a VANH. Indications were dysfunctional menstrual bleeding (61 %; n = 122), abnormal cervical cytology (15.5 %; n = 31), abdominal pain (11.5 %; n = 23), post ablation/sterilization pain syndrome (3.5 %; n = 7), uterine fibroids (5.0 %; n = 10), atypical endometrial hyperplasia (2.5 %; n = 5) and Lynch or BRCA gene mutation carriers (1.0 %, n = 2). The mean surgical time was 61.4 min ( ± 22.8 min) with a mean blood loss of 88 mL ( ± 89 mL) and a mean uterine weight of 150 g ( ± 112 g). In 2.0 % (n = 4) of the cases a conversion was necessary. Same day discharge (SDD) was feasible in 80.2 % (n = 105) of the patients planned in day-care. In 2.0 % (n = 4) an intra-operative complication and in 9.0 % (n = 18) a post-operative complication occurred.</p></div><div><h3>Conclusion</h3><p>This study shows vNOTES to be a safe and feasible surgical technique and can be safely implemented with appropriate patient selection and skilled surgeons. It highlights the importance of surgeon awareness of the challenges inherent in the initial stages of the implementation of a new surgical technique when performing their first vNOTES procedures. Additional randomized clinical trials are needed to show superiority of vNOTES compared to traditional surgery.</p></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"23 ","pages":"Article 100323"},"PeriodicalIF":1.5,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590161324000437/pdfft?md5=0bfd474c70d340125e0ce04231f1b406&pid=1-s2.0-S2590161324000437-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141582322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthcare professionals' willingness to utilize a mobile health application for adverse drug reaction reporting in a limited resource setting: An input for digital health, 2023","authors":"Abiy Tasew Dubale ,&nbsp;Abiyu Abadi Tareke ,&nbsp;Fikadu Wake Butta ,&nbsp;Adamu Ambachew Shibabaw ,&nbsp;Ermias Bekele Eniyew ,&nbsp;Mohammedjud Hassen Ahmed ,&nbsp;Sisay Yitayih Kassie ,&nbsp;Addisalem Workie Demsash ,&nbsp;Alex Ayenew Chereka ,&nbsp;Geleta Nenko Dube ,&nbsp;Agmasie Damtew Walle ,&nbsp;Gemeda Wakgari Kitil","doi":"10.1016/j.eurox.2024.100324","DOIUrl":"https://doi.org/10.1016/j.eurox.2024.100324","url":null,"abstract":"<div><h3>Background</h3><p>Adverse drug reactions (ADRs) are a significant public health concern, particularly in limited resource settings where underreporting is prevalent due to various challenges. Mobile health applications (mHealth apps) offer a promising solution to enhance pharmacovigilance by facilitating easier and more efficient ADR reporting. However, despite the increasing availability and use of mHealth apps, there is a lack of evidence on healthcare professionals' willingness to adopt them for ADR reporting in resource-constrained environments. Therefore, this study aimed to assess the willingness of healthcare professionals in Ethiopia to utilize mobile health applications for adverse drug reaction reporting and identify associated factors.</p></div><div><h3>Methods</h3><p>We carried out a cross-sectional study involving 422 healthcare professionals working in institutional settings. We gathered data through a pretested questionnaire that participants completed themselves. We inputted the data using Epi Data V.4.6 and analyzed it using SPSS V.26. Our analysis involved conducting multivariable logistic regression to identify the factors influencing the likelihood of healthcare professionals using mobile applications to report adverse drug reactions.</p></div><div><h3>Results</h3><p>The study involved 389 healthcare professionals. Approximately 301 (77.4 %) of them expressed willingness to utilize mobile applications for reporting adverse drug reactions. The willingness to utilize mobile applications was significantly associated with the type of mobile phone (smart: AOR 3.56; 95 % CI 2.15–5.67), basic computer training (AOR 4.43; 95 % CI 2.27–8.64), mobile health-related training (AOR 1.96; 95 % CI 1.01–3.79), attitude (AOR 4.01; 95 % CI 2.19–7.35), perceived ease of use (AOR 2.91; 95 % CI 1.59–5.23), and perceived usefulness (AOR 2.10; 95 % CI 1.15–3.85).</p></div><div><h3>Conclusions</h3><p>Overall, there was a high proportion of healthcare professionals willing to use mobile devices for reporting drug adverse reactions. Their willingness correlated with factors such as the type of mobile phone, perceived ease of use, attitude, training, and perceived usefulness of mobile applications. With the increasing use of smartphones, motivation among healthcare professionals is rising. Basic computer and mHealth-related training are crucial for enhancing the acceptability of such applications and should be incorporated into future implementations. Taking these factors into account could offer insights into the design and implementation of mobile applications for adverse drug reactions in Ethiopia.</p></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"23 ","pages":"Article 100324"},"PeriodicalIF":1.5,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590161324000449/pdfft?md5=365420b190e9ac0bbaeeba9aecf522ca&pid=1-s2.0-S2590161324000449-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141540579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual dysfunction in migraine-affected women: A prospective cross-sectional controlled study","authors":"Remah M. Kamel ,&nbsp;Baraatu A. Dantata ,&nbsp;Hadiza Halilu ,&nbsp;Hafsah M. Ahmed ,&nbsp;Khadijah H. Muzaffar ,&nbsp;Nishat T. Maria ,&nbsp;Hussain R. Alsadeq","doi":"10.1016/j.eurox.2024.100319","DOIUrl":"https://doi.org/10.1016/j.eurox.2024.100319","url":null,"abstract":"<div><h3>Introduction</h3><p>Female sexual dysfunction (FSD) is a common health problem that is inadequately investigated in Arabic countries, especially Saudi Arabia.</p></div><div><h3>Aim</h3><p>To assess the prevalence and trace predictors of FSD in Saudi women who suffered from migraine headaches comparable to healthy women.</p></div><div><h3>Patients and methods</h3><p>A prospective cross-sectional, controlled study involved 400 Saudi women complaining of migraine (<em>Case Group</em>) and another 400 healthy-looking Saudi women (<em>Control Group</em>) during three months; from January 1^st, to March 31st 2023, in Jeddah city, Saudi Arabia. Data was collected by using a pre-structured Female Sexual Function Index (FSFI) questionnaire, Female Sexual Distress Scale (FSDS), Migraine Screen Questionnaire (MS-Q), with an evaluation of the severity of pain by Visual Analogue Scale (VAS), and its impact on daily activity by using both; Headache Impact Test (HIT-6) and Migraine Disability Assessment (MIDAS) Questionnaire.</p></div><div><h3>Results</h3><p>A total of 800 Saudi women were recruited. Their ages ranged from 18 to 45 years old. Women with abnormally low FSFI scores were 375 (93.75 %) out of 400 with migraine and 85 (21.25 %) out of 400 without migraine. The lowest FSFI scores were mainly for desire (2.75 ± 1.05) and arousal domains (3.0 ± 1.12) followed by sexual satisfaction (3.25 ± 1.30) and orgasmic domains (3.5 ± 1.15). The foremost predictive factor behind low FSFI scores and associated FSD in our study was migraine (<em>P</em> &lt; 0.00001). Additional predictors of statistical significance were low educational level (<em>P</em> &lt; 0.01), urban residency (<em>P</em> &lt; 0.02), high parity (<em>P</em> &lt; 0.02), chronic illness such as diabetes (<em>P</em> &lt; 0.01), and bad habits such as smoking (<em>P</em> &lt; 0.03)</p></div><div><h3>Conclusion</h3><p>A significant correlation exists between migraine and female sexual dysfunction (FSD). Desire and arousal dysfunctions were the most significantly affected domains followed by satisfaction and orgasmic problems.</p></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"23 ","pages":"Article 100319"},"PeriodicalIF":1.5,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590161324000395/pdfft?md5=241e349117c2201354bf37c78797bbcf&pid=1-s2.0-S2590161324000395-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141482867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of artificial intelligence in cosmetic and functional gynecology: Stepping into the third millennium","authors":"Giovanni Buzzaccarini ,&nbsp;Rebecca Susanna Degliuomini ,&nbsp;Andrea Etrusco ,&nbsp;Andrea Giannini ,&nbsp;Antonio D’Amato ,&nbsp;Katerina Gkouvi ,&nbsp;Nicolas Berreni ,&nbsp;Navneet Magon ,&nbsp;Massimo Candiani ,&nbsp;Stefano Salvatore","doi":"10.1016/j.eurox.2024.100322","DOIUrl":"https://doi.org/10.1016/j.eurox.2024.100322","url":null,"abstract":"<div><p>Cosmetic and functional gynecology have gained popularity among patients, but the scientific literature in this field, particularly regarding the cosmetic aspect, is lacking. The use of evidence-based medicine is crucial to validate diagnostic tools and treatment protocols. However, the advent of artificial intelligence (AI) offers a promising solution to address this issue. ChatGPT, a sophisticated language model, can revolutionize AI in medicine, enabling accurate diagnosis, personalized treatment plans, and expedited research analysis. Cosmetic and functional gynecology can leverage AI to develop the field and improve evidence gathering. AI can aid in precise and personalized diagnosis, implement standardized assessment tools, simulate treatment outcomes, and assess under-skin anatomy through virtual reality. AI tools can assist clinicians in diagnosing and comparing difficult cases, calculate treatment risks, and contribute to standardization by collecting global evidence and generating guidelines. The use of AI in cosmetic and functional gynecology holds significant potential to advance the field and improve patient outcomes. This novel combination of AI and gynecology represents a groundbreaking development in medicine, emphasizing the importance of appropriate and correct AI usage.</p></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"23 ","pages":"Article 100322"},"PeriodicalIF":1.5,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590161324000425/pdfft?md5=a7d2f0a4aa766bc14a62f1a6b9278f53&pid=1-s2.0-S2590161324000425-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141487117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological analysis of giant ovarian tumors","authors":"Brahmana Askandar Tjokroprawiro,&nbsp;Khoirunnisa Novitasari,&nbsp;Renata Alya Ulhaq,&nbsp;Hanif Ardiansyah Sulistya","doi":"10.1016/j.eurox.2024.100318","DOIUrl":"10.1016/j.eurox.2024.100318","url":null,"abstract":"<div><h3>Objective</h3><p>This study aims to analyze giant ovarian tumors' clinical and pathological characteristics.</p></div><div><h3>Material and Methods</h3><p>This was an analytical observational study. Medical records of all patients with giant ovarian tumors who underwent surgery between January 2020 and June 2022 at Dr. Soetomo Academic Hospital, Surabaya, Indonesia, were analyzed.</p></div><div><h3>Results</h3><p>We analyzed 63 patients with ovarian tumors measuring &gt; 20 cm who underwent surgery at Dr. Soetomo Academic Hospital, Surabaya, Indonesia. The mean tumor size was 25.9 cm (largest size was 41 cm). There was no significant difference in tumor size between benign and malignant giant ovarian tumors (p = 0.261). Based on histopathological results, 66.67 % of giant ovarian tumors were malignant, 26.98 % were benign, and 6.35 % were borderline. Among the malignant tumors, the epithelial type accounted for 69 % of cases. Most giant ovarian tumors originated in the left adnexa (68.25 %). There was no significant difference in patient age (p = 0.511), tumor size (p = 0.168), malignancy (p = 0.303), and histopathological type (p = 0.232) regardless of adnexal side. CA125 levels did not differ significantly between malignant and benign giant ovarian tumors (p = 0.604). There was no correlation between malignant ovarian tumor size and CA125 levels, while there was a significant difference between CA125 levels and the adnexal side (p = 0.010).</p></div><div><h3>Conclusions</h3><p>Most giant ovarian tumors were malignant, diagnosed at an early stage, and predominantly epithelial type. CA125 levels did not correlate with the size of malignant ovarian tumors. Most giant ovarian tumors originate in the left adnexa.</p></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"22 ","pages":"Article 100318"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590161324000383/pdfft?md5=783fc7a3a302fa5dabcbe2bbeb456931&pid=1-s2.0-S2590161324000383-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141135141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Literature review and case report: Rare case of successful prenatal detection of Vein of Galen Malformation (VGAM)","authors":"Danijel Bursać ,&nbsp;Jasminka Stipanović ,&nbsp;Jasenka Zmijanac Partl ,&nbsp;Dejana Lučić ,&nbsp;Daria Hadžić ,&nbsp;Diana Culej Bošnjak ,&nbsp;Željko Duić","doi":"10.1016/j.eurox.2024.100306","DOIUrl":"10.1016/j.eurox.2024.100306","url":null,"abstract":"<div><p>Vein of Galen aneurysmal malformation (VGAM) is a rare vascular anomaly originating during embryonic development, specifically between the 6th and 11th weeks of gestation. This malformation results from abnormal arteriovenous connections between primitive choroidal arteries and the median prosencephalic vein (MPV) of Markowski. Typically, the MPV regresses by the 11th week, but in VGAM, this regression is hindered, leading to persistent abnormal flow and the formation of arteriovenous shunts. We present a case of successful prenatal detection, as well as a comprehensive literature review that summarizes current knowledge, emphasizes the importance of prenatal detection, detailed imaging techniques, understanding clinical presentations, and outlines treatment options. Prenatal detection, crucial for early intervention, has become feasible through ultrasonography and MRI. Fetal MRI has emerged as the gold standard, offering detailed insights into arterial feeders, nidus presence, fistula position, venous drainage, and potential complications. The clinical presentation of VGAM varies with age, and neonates diagnosed in utero may exhibit signs of high-output cardiac failure. Early detection is critical for timely intervention, as untreated VGAMs often result in high mortality rates. Prognosis depends on the severity of heart failure, the number of arteriovenous shunts, and the presence of accompanying fetal abnormalities. Various imaging modalities, including CT angiography and digital subtraction angiography (DSA), aid in the assessment and treatment of VGAM. DSA remains the gold standard for evaluating angioarchitecture and guiding endovascular interventions. The optimal treatment for VGAM is transarterial embolization, offering significant improvements in prognosis. Surgical interventions are limited due to high morbidity and mortality. Management decisions should consider the balance between minimizing neurological damage and achieving maximum embolization effectiveness.</p></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"22 ","pages":"Article 100306"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590161324000267/pdfft?md5=2b00944e5cfc0e35e65aca30d4096766&pid=1-s2.0-S2590161324000267-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140408454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attitudes towards and health consequences of female genital mutilation/cutting: A qualitative study among Somali and Kurdish immigrants and descendants in Denmark","authors":"Ditte S. Linde ,&nbsp;Hawa-Idil Harakow ,&nbsp;Negin Jaafar","doi":"10.1016/j.eurox.2024.100315","DOIUrl":"10.1016/j.eurox.2024.100315","url":null,"abstract":"<div><h3>Objectives</h3><p>There is lack of in-depth knowledge of how immigrants who originate from countries where female genital mutilation/cutting (FGM/C) historically is practiced, perceive the practice after migrating to Europe. The aim of this study was to explore the attitude towards FGM/C among immigrants and descendants and the health consequences of living with FGM/C.</p></div><div><h3>Study design</h3><p>Qualitative methods were used in the form of semi-structured interviews and focus group discussions. Female and male immigrants and descendants in Denmark from Somalia or Kurdish of Iraq/Iran participated in the study. The interview/focus group discussion guides were developed by the European Institute for Gender Equality. Purposely sampling was used, and participants were recruited by use of snowballing through gatekeepers and women’s societies working within the Somali and Kurdish communities.</p></div><div><h3>Results</h3><p>Sixteen persons participated in the study. No descendants had been cut, but all female immigrants had been cut prior to migrating and did not wish to pass on the practice. FGM/C was perceived as a harmful practice with severe sexual and mental health consequences. Women with Somali origin experienced that the practice was falsely associated with their origin, which led to stigmatisation. Women with Kurdish origin lacked healthcare support when suffering sexual consequences of FGM/C. It was generally perceived that the Danish healthcare system lacked cultural sensitivity.</p></div><div><h3>Conclusion</h3><p>FGM/C is negatively perceived among Somali and Kurdish immigrants and descendants in Denmark and not practiced among these groups. The Danish healthcare system should adopt a more culturally sensitive approach when addressing sexual health among immigrants and descendants. Denmark and other European countries should work towards destigmatising the immigrant communities when it comes to FGM/C. Larger European studies with primary data are needed to generalise the findings of this study.</p></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"22 ","pages":"Article 100315"},"PeriodicalIF":0.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590161324000358/pdfft?md5=2b4062d38bd7b36f0f3bda2778944c49&pid=1-s2.0-S2590161324000358-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141026843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sonographic vascularity indices' study in ectopic pregnancies, after methotrexate treatment","authors":"Dimitrios Chitzios ,&nbsp;Dimitrios Balaouras ,&nbsp;Panayiota Papasozomenou ,&nbsp;Georgios Balaouras ,&nbsp;Themistoklis Mikos ,&nbsp;Angelos Daniilidis ,&nbsp;Menelaos Zafrakas","doi":"10.1016/j.eurox.2024.100316","DOIUrl":"https://doi.org/10.1016/j.eurox.2024.100316","url":null,"abstract":"<div><h3>Objectives</h3><p>Ectopic pregnancy is a crucial problem in Gynaecology. Previous studies concerning the medical treatment of ectopic pregnancies, have used only β-hCG (beta- human chorionic gonadotropin) values, to monitor the successful response to treatment. The current study was a PhD (Doctorate of Philosophy) thesis research, which has evaluated the vascularity indices’ changes. The values of vascularity indices could be used, in combination with β-hCG values and the gestational sac dimensions, in every medically treated ectopic pregnancy. The results could be used, for monitoring the course of all medically treated ectopic pregnancies.</p></div><div><h3>Study design</h3><p>72 women of reproductive age have taken part in the study. They have been admitted due to secondary amenorrhea, positive β-hCG test, with or without vaginal bleeding. The participants took part voluntarily and were allocated in two groups. The first group consisted of 37 women, who were possible normal or threatened intrauterine pregnancies (control group). The second group consisted of 35 women, whose sonographic findings suggested ectopic pregnancy, and qualified for methotrexate treatment (study group). Sonographic control and measurement of the vascularity indices (PI – RI) (Pulsatility index – Resistance index) of the ectopic pregnancy was conducted, in combination with β-hCG values for every admitted or outpatient woman.</p><p>The dimensions of the gestational sac of both groups were measured during four consecutive periods of time. The control group has shown progressively increasing sac dimensions, whereas, in the study group sac dimensions were more stable or growing gradually smaller. The exception where those ectopic pregnancies that ruptured, which have also shown a gradual enlargement of the sac.</p></div><div><h3>Results</h3><p>The endometrial thickness of the study group was gradually decreasing up to 76 % per day, and the more eminent, but not statistically significant decrease, was observed in the single dose regiment of methotrexate. Moreover, the quantitative PI and RI were evaluated, and the main finding was that there were no statistically significant decreases in any of the two groups. Concerning the study group, methotrexate treatment was successful, since there was a decrease of up to 80 %, whereas a clearly significant correlation was found between the β-hCG levels and the RI.</p></div><div><h3>Conclusion</h3><p>The vascularity indices could be used safely, in combination with β-hCG levels and the decrease of the gestational sac dimensions, as criteria for the evaluation of response to medical treatment of ectopic pregnancies.</p></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"22 ","pages":"Article 100316"},"PeriodicalIF":0.0,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S259016132400036X/pdfft?md5=4b4a8572814ae8f9bb5c2d12dbc5b2ef&pid=1-s2.0-S259016132400036X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140947325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To study the survival outcomes of uncommon recurrences among patients with cervical cancer compared with loco-regional and nodal recurrences at a tertiary care center in North East India – Bridging the knowledge gap in the existing literature.","authors":"Mahendra Kumar ,&nbsp;Upasana Baruah ,&nbsp;Dimpy Begum ,&nbsp;Debabrata Barmon ,&nbsp;Jyotiman Nath ,&nbsp;Duncan Khanikar ,&nbsp;Karthik Chandra Bassetty","doi":"10.1016/j.eurox.2024.100314","DOIUrl":"https://doi.org/10.1016/j.eurox.2024.100314","url":null,"abstract":"<div><h3>Background</h3><p>Recurrence rates of FIGO stage IB-IIA and IIB-IVA cervical cancer <!--> <!-->28–64<!--> <!--> respectively. There is a scarcity of data on the recurrence recurrence pattern for unusual sites and theirrecurrence pattern for unusual sites and its association with survival and prognosis.</p></div><div><h3>Objective</h3><p>To study overall survival in patients with distant metastasis compared to local and regional nodal metastasis.</p></div><div><h3>Methods</h3><p>A retrospective study was done from 1/1/2017 to 30/12/22. Cervical cancer patients post primary treatments were included. Survival was analyzed with respect to 3 groups local, regional nodalconducted from 1/1/2017 to 30/12/22. Cervical cancer patients who had received primary post-primary treatments were included. Survival was analyzed with respect to three groups: local, regional nodal, and distant metastasis.</p></div><div><h3>Results</h3><p>225 patients had recurrences <!--> <!--> <!-->post-completion of primary treatment, of which 105 (46.6%)(46.6 %) had local, 46 (20.4%)(20.4 %) had regional nodal, and 74 (33.3<!--> <!-->%) had distant recurrences. The median time for recurrence in local, regional nodal, and atypical recurrences were 9, 9, and 13 months (p value - &lt;0.05), respectively. Treatment included systemic chemotherapy 122 (54.2<!--> <!-->%), metronomic therapy 19 (8.4<!--> <!-->%), palliative radiotherapy 44 (19.5<!--> <!-->%), palliative surgery 8 (3.5<!--> <!-->%) and best supportive care 30 (13.3<!--> <!-->%) patients. Median Time to treatment-death of patients after recurrence in local, nodal and distant recurrences was 17.0 months, 18.0 months and 10.0 months respectively (p value - &lt; 0.05). Overall Survival of patients after primary treatment with local, nodal and distant recurrences was 35.0 months, 47.0 months and 50.0 months respectively (p value &lt;0.05).</p></div><div><h3>Conclusion</h3><p>Local recurrence is most common, followed by regional, nodal, and distant recurrences. Overall survival post recurrence was lowest for distant recurrences and highest for local recurrences however overall survival after primary treatment completion was highest for distant recurrence due to the late presen; however, tation of distant recurrences.</p></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"22 ","pages":"Article 100314"},"PeriodicalIF":0.0,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590161324000346/pdfft?md5=7878f7ff63892c9147810c04da00cf16&pid=1-s2.0-S2590161324000346-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140905847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre-treatment thrombocytosis and ovarian cancer survival: A meta-analysis","authors":"Vasilios Pergialiotis ,&nbsp;Lito Vogiatzi Vokotopoulou ,&nbsp;Dimitrios-Efthymios Vlachos ,&nbsp;Michalis Liontos ,&nbsp;Emmanuel Kontomanolis ,&nbsp;Nikolaos Thomakos","doi":"10.1016/j.eurox.2024.100312","DOIUrl":"https://doi.org/10.1016/j.eurox.2024.100312","url":null,"abstract":"<div><p>An association between thrombocytosis and cancer progression and decreased survival has been observed for various forms of cancer. The aim of this study was to evaluate the impact of pre-treatment thrombocytosis on ovarian cancer survival. Medline, Scopus, Clinicaltrials.gov, Cochrane Central Register of Controlled Trials CENTRAL and Google Scholar were searched systematically for studies that compared survival outcomes of patients with ovarian cancer who had pre-treatment thrombocytosis with survival outcomes of patients with normal platelet counts. Fourteen articles were retrieved, with a total of 5414 patients with ovarian cancer. The methodological quality of included studies ranged between moderate and high. Patients with advanced stage disease were more likely to have pre-treatment thrombocytosis, and this was associated with lower rates of optimal debulking. Thrombocytosis was also associated with increased likelihood of recurrence of ovarian cancer [hazard ratio (HR) 2.01, 95 % confidence interval (CI) 1.34–3.01] and increased risk of death from ovarian cancer (HR 2.29, 95 % CI 1.35–3.90). The incidence of deep vein thrombosis was comparable in both groups (odds ratio 1.62, 95 % CI 0.48–5.46). Considering these findings, it is evident that pre-treatment thrombocytosis in patients with ovarian cancer is associated with increased risk of recurrence and death. Pre-treatment thrombocytosis is a potential sign of advanced stage disease, and may be predictive of suboptimal tumour debulking during surgery. Its association with other factors that affect survival, including platinum resistance and response to targeted therapy, remains poorly explored, although preliminary data suggest a potential correlation.</p></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"22 ","pages":"Article 100312"},"PeriodicalIF":0.0,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590161324000322/pdfft?md5=d2a1e26bd310ac9e72dc9fd0ad5805a9&pid=1-s2.0-S2590161324000322-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140844410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}