双氯芬酸栓剂对诊断性宫腹腔镜检查和染色检查术后止痛的有效性和安全性:双盲、安慰剂对照随机试验

IF 1.5 Q3 OBSTETRICS & GYNECOLOGY
Princeston C. Okam , Joseph I. Ikechebelu , George U. Eleje , Innocent C. Albert , Boniface C. Okpala , Chioma F. Okam , Louis A. Nwajiaku , Ngozi N. Joe-Ikechebelu , Chijioke O. Ezeigwe , Chisom G. Chigbo , Chigozie G. Okafor
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引用次数: 0

摘要

方法 在接受诊断性宫腔镜检查和染色检查(dHLD)的妇女中开展了一项前瞻性、双盲、安慰剂对照、随机试验。这些妇女接受了直肠双氯芬酸与肌肉注射喷他佐辛或肌肉注射喷他佐辛与直肠安慰剂两种术后镇痛方法。主要结果指标是不同时间点的疼痛评分中位数,采用疼痛数字评分量表进行评估。次要结果指标包括镇痛剂消耗量、首次申请镇痛剂的时间、对镇痛效果的满意度以及任何不良反应。结果共分析了 108 名参与者(每组 54 人,1:1 的比例)。174)、术后 8 小时(51.42 vs 57.65;p = 0.296)、术后 10 小时(51.35 vs 57.65;p = 0.285)和术后 12 小时(52.45 vs 56.55;p = 0.485),但差异不显著(p >0.05)。有 17 名参与者需要使用 30 毫克喷他佐辛进行解救性镇痛:双氯芬酸组和安慰剂组分别有 11 人在术后 4 h [5 (62.5 %) vs 6 (66.7 %)]、3 人在术后 6 h [2 (25.0 %) vs 1 (11.1 %)]、2 人在术后 8 h [1 (12.5 %) vs 1 (11.1 %)]、1 人在术后 12 h [0 vs 1 (11.1 %)](p = 0.713)。结论 术后使用直肠双氯芬酸和喷他佐辛是安全的,但与接受喷他佐辛和安慰剂的患者相比,术后使用双氯芬酸和喷他佐辛并不能明显改善疼痛评分、患者满意度和术后抢救性镇痛的需求。虽然 dHLD 后采用多种模式止痛似乎并无明显益处,但仍需进行多中心研究来证实或反驳这些发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Efficacy and safety of diclofenac suppository for postoperative pain relief after diagnostic hystero-laparoscopy and dye test: A double-blind, placebo-controlled, randomized trial

Objective

To determine the efficacy and safety of rectal diclofenac for relieving postoperative pain following diagnostic hystero-laparoscopy and dye test (dHLD).

Methods

A prospective, double-blind, placebo-controlled, randomized trial was conducted among women who underwent dHLD to evaluate fertility. The women received either rectal diclofenac with intramuscular pentazocine or intramuscular pentazocine with rectal placebo for postoperative analgesia. The median pain scores at different time points were assessed as the primary outcome measures using the Numerical Rating Scale for pain. The secondary outcome measures were analgesic consumption, time at which first analgesic was requested, satisfaction with pain relief and any adverse events.

Results

In total, 108 participants were analysed (54 in each group, 1:1 ratio). The median score for postoperative pain was lower for the diclofenac group compared with the placebo group at 4 h (52.53 vs 56.47; p = 0.507), 6 h (50.48 vs 58.52; p = 0.174), 8 h (51.42 vs 57.65; p = 0.296), 10 h (51.35 vs 57.65; p = 0.285) and 12 h (52.45 vs 56.55; p = 0.485) post surgery, although the difference was not significant (p > 0.05). Seventeen participants required rescue analgesia with 30 mg of pentazocine: 11 at 4 h post surgery [5 (62.5 %) vs 6 (66.7 %)], three at 6 h post surgery [2 (25.0 %) vs 1 (11.1 %)], two at 8 h post surgery [1 (12.5 %) vs 1 (11.1 %)], and one at 12 h post surgery [0 vs 1 (11.1 %)] for the diclofenac and placebo groups respectively (p = 0.713). There were no significant differences in postoperative adverse effect profiles, overall patient satisfaction, and need for rescue analgesia between the two groups (p > 0.05).

Conclusions

Postoperative use of rectal diclofenac and pentazocine is safe, but did not significantly improve pain scores, patient satisfaction and need for rescue analgesia following dHLD, compared with patients who received pentazocine and placebo. While a multi-modal approach to pain relief following dHLD does not appear to be significantly beneficial, a multi-centre study is needed to confirm or refute these findings.

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CiteScore
2.20
自引率
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发文量
31
审稿时长
58 days
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