Current Pathobiology Reports最新文献_第3页

Impact of Alcohol on Bone Health, Homeostasis and Fracture repair. 酒精对骨骼健康、平衡和骨折修复的影响

Current Pathobiology Reports Pub Date : 2020-09-01 Epub Date: 2020-07-28 DOI: 10.1007/s40139-020-00209-7

Jonathan M Eby, Farah Sharieh, John J Callaci

{"title":"Impact of Alcohol on Bone Health, Homeostasis and Fracture repair.","authors":"Jonathan M Eby, Farah Sharieh, John J Callaci","doi":"10.1007/s40139-020-00209-7","DOIUrl":"10.1007/s40139-020-00209-7","url":null,"abstract":"Purpose of review: Alcohol use continues to rise globally. We review the current literature on the effect of alcohol on bone health, homeostasis and fracture repair to highlight what has been learned in people and animal models of alcohol consumption.Recent findings: Recently, forkhead box O (FoxO) has been found to be upregulated and activated in mesenchymal stem cells (MSC) exposed to alcohol. FoxO has also been found to modulate Wnt/β-catenin signaling, which is necessary for MSC differentiation. Recent evidence suggests alcohol activates FoxO signaling, which may be dysregulating Wnt/β-catenin signaling in MSCs cultured in alcohol.Summary: This review highlights the negative health effects learned from people and chronic and episodic binge alcohol consumption animal models. Studies using chronic alcohol exposure or alcohol exposure then bone fracture repair model have explored several different cellular and molecular signaling pathways important for bone homeostasis and fracture repair, and offer potential for future experiments to explore additional signaling pathways that may be dysregulated by alcohol exposure.","PeriodicalId":37014,"journal":{"name":"Current Pathobiology Reports","volume":"8 3","pages":"75-86"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987106/pdf/nihms-1615869.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25519520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing the Proteostasis Network in Alcohol-associated Liver Disease 利用蛋白质稳定网络治疗酒精相关性肝病

Current Pathobiology Reports Pub Date : 2020-07-17 DOI: 10.1007/s40139-020-00211-z

Asmita K Choudhury, P. Mandrekar

引用次数: 0

The Regulatory Role of miRNAs in Ethanol-induced TLR4 Activation and Neuroinflammation miRNA在乙醇诱导的TLR4激活和神经炎症中的调节作用

Current Pathobiology Reports Pub Date : 2020-05-16 DOI: 10.1007/s40139-020-00208-8

M. Pascual, J. Ureña-Peralta, C. Guerri

引用次数: 0

Understanding Molecules that Mediate Leukocyte Extravasation 了解介导白细胞外渗的分子

Current Pathobiology Reports Pub Date : 2020-05-06 DOI: 10.1007/s40139-020-00207-9

Nakisha S. Rutledge, W. Muller

引用次数: 3

Diabetic vasculopathy: macro and microvascular injury. 糖尿病血管病变：大血管和微血管损伤。

Current Pathobiology Reports Pub Date : 2020-03-01 Epub Date: 2020-01-27 DOI: 10.1007/s40139-020-00205-x

Roberto I Mota, Samuel E Morgan, Edward M Bahnson

{"title":"Diabetic vasculopathy: macro and microvascular injury.","authors":"Roberto I Mota, Samuel E Morgan, Edward M Bahnson","doi":"10.1007/s40139-020-00205-x","DOIUrl":"10.1007/s40139-020-00205-x","url":null,"abstract":"Purpose of review: Diabetes is a common and prevalent medical condition as it affects many lives around the globe. Specifically, type-2 Diabetes (T2D) is characterized by chronic systemic inflammation alongside hyperglycemia and insulin resistance in the body, which can result in atherosclerotic legion formation in the arteries and thus progression of related conditions called diabetic vasculopathies. T2D patients are especially at risk for vascular injury; adjunct in many of these patients heir cholesterol and triglyceride levels reach dangerously high levels and accumulate in the lumen of their vascular system.Recent findings: Microvascular and macrovascular vasculopathies as complications of diabetes can accentuate the onset of organ illnesses, thus it is imperative that research efforts help identify more effective methods for prevention and diagnosis of early vascular injuries. Current research into vasculopathy identification/treatment will aid in the amelioration of diabetes-related symptoms and thus reduce the large number of deaths that this disease accounts annually.Summary: This review aims to showcase the evolution and effects of diabetic vasculopathy from development to clinical disease as macrovascular and microvascular complications with a concerted reference to sex-specific disease progression as well.","PeriodicalId":37014,"journal":{"name":"Current Pathobiology Reports","volume":"8 1","pages":"1-14"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351096/pdf/nihms-1552458.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38151659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Strategies for Corneal Wound Angiogenesis 角膜创伤血管生成的治疗策略

Current Pathobiology Reports Pub Date : 2020-01-21 DOI: 10.1007/s40139-020-00206-w

Sumana R. Chintalapudi

引用次数: 0

Leveraging Computational Modeling to Understand Infectious Diseases. 利用计算模型来理解传染病。

Current Pathobiology Reports Pub Date : 2020-01-01 Epub Date: 2020-09-24 DOI: 10.1007/s40139-020-00213-x

Adrianne L Jenner, Rosemary A Aogo, Courtney L Davis, Amber M Smith, Morgan Craig

{"title":"Leveraging Computational Modeling to Understand Infectious Diseases.","authors":"Adrianne L Jenner, Rosemary A Aogo, Courtney L Davis, Amber M Smith, Morgan Craig","doi":"10.1007/s40139-020-00213-x","DOIUrl":"https://doi.org/10.1007/s40139-020-00213-x","url":null,"abstract":"Purpose of review: Computational and mathematical modeling have become a critical part of understanding in-host infectious disease dynamics and predicting effective treatments. In this review, we discuss recent findings pertaining to the biological mechanisms underlying infectious diseases, including etiology, pathogenesis, and the cellular interactions with infectious agents. We present advances in modeling techniques that have led to fundamental disease discoveries and impacted clinical translation.Recent findings: Combining mechanistic models and machine learning algorithms has led to improvements in the treatment of Shigella and tuberculosis through the development of novel compounds. Modeling of the epidemic dynamics of malaria at the within-host and between-host level has afforded the development of more effective vaccination and antimalarial therapies. Similarly, in-host and host-host models have supported the development of new HIV treatment modalities and an improved understanding of the immune involvement in influenza. In addition, large-scale transmission models of SARS-CoV-2 have furthered the understanding of coronavirus disease and allowed for rapid policy implementations on travel restrictions and contract tracing apps.Summary: Computational modeling is now more than ever at the forefront of infectious disease research due to the COVID-19 pandemic. This review highlights how infectious diseases can be better understood by connecting scientists from medicine and molecular biology with those in computer science and applied mathematics.","PeriodicalId":37014,"journal":{"name":"Current Pathobiology Reports","volume":"8 4","pages":"149-161"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40139-020-00213-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38431903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Advances in Diffusion and Perfusion MRI for Quantitative Cancer Imaging. 扩散和灌注MRI在肿瘤定量成像中的研究进展。

Current Pathobiology Reports Pub Date : 2019-12-01 DOI: 10.1007/s40139-019-00204-7

Mehran Baboli, Jin Zhang, Sungheon Gene Kim

{"title":"Advances in Diffusion and Perfusion MRI for Quantitative Cancer Imaging.","authors":"Mehran Baboli, Jin Zhang, Sungheon Gene Kim","doi":"10.1007/s40139-019-00204-7","DOIUrl":"https://doi.org/10.1007/s40139-019-00204-7","url":null,"abstract":"Purpose of review: This article is to review recent technical developments and their clinical applications in cancer imaging quantitative measurement of cellular and vascular properties of the tumors.Recent findings: Rapid development of fast Magnetic Resonance Imaging (MRI) technologies over last decade brought new opportunities in quantitative MRI methods to measure both cellular and vascular properties of tumors simultaneously.Summary: Diffusion MRI (dMRI) and dynamic contrast enhanced (DCE)-MRI have become widely used to assess the tissue structural and vascular properties, respectively. However, the ultimate potential of these advanced imaging modalities has not been fully exploited. The dependency of dMRI on the diffusion weighting gradient strength and diffusion time can be utilized to measure tumor perfusion, cellular structure, and cellular membrane permeability. Similarly, DCE-MRI can be used to measure vascular and cellular membrane permeability along with cellular compartment volume fractions. To facilitate the understanding of these potentially important methods for quantitative cancer imaging, we discuss the basic concepts and recent developments, as well as future directions for further development.","PeriodicalId":37014,"journal":{"name":"Current Pathobiology Reports","volume":"7 4","pages":"129-141"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40139-019-00204-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10741332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Next Generation Techniques for Determination of Protein-Protein Interactions: Beyond the Crystal Structure. 确定蛋白质-蛋白质相互作用的新一代技术：超越晶体结构

Current Pathobiology Reports Pub Date : 2019-09-01 Epub Date: 2019-07-01 DOI: 10.1007/s40139-019-00198-2

Rachel Carter, Alessandra Luchini, Lance Liotta, Amanda Haymond

{"title":"Next Generation Techniques for Determination of Protein-Protein Interactions: Beyond the Crystal Structure.","authors":"Rachel Carter, Alessandra Luchini, Lance Liotta, Amanda Haymond","doi":"10.1007/s40139-019-00198-2","DOIUrl":"10.1007/s40139-019-00198-2","url":null,"abstract":"Purpose of review: We discuss recent advancements in structural biology methods for investigating sites of protein-protein interactions. We will inform readers outside the field of structural biology about techniques beyond crystallography, and how these different technologies can be utilized for drug development.Recent findings: Advancements in cryo-electron microscopy (cryoEM) and micro-electron diffraction (microED) may change how we view atomic resolution structural biology, such that well-ordered macrocrystals of protein complexes are not required for interface identification. However, some drug discovery applications, such as lead peptide compound generation, may not require atomic resolution; mass spectrometry techniques can provide an expedited path to generation of lead compounds. New crosslinking compounds, more user-friendly data analysis, and novel protocols such as protein painting can advance drug discovery programs, even in the absence of atomic resolution structural data. Finally, artificial intelligence and machine learning methods, while never truly replacing experimental methods, may provide rational ways to stratify potential druggable regions identified with mass spectrometry into higher and lower priority candidates.Summary: Electron diffraction of nanocrystals combines the benefits of both x-ray diffraction and cryoEM, and may prove to be the next generation of atomic resolution protein-protein interface identification. However, in situations such as peptide drug discovery, mass spectrometry techniques supported by advancements in computational methods will likely prove sufficient to support drug discovery efforts. In addition, these methods can be significantly faster than any crystallographic or cryoEM methods for identification of interacting regions.","PeriodicalId":37014,"journal":{"name":"Current Pathobiology Reports","volume":" ","pages":"61-71"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577580/pdf/nihms-1533210.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38526621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in PET Diagnostics for Guiding Targeted Cancer Therapy and Studying In Vivo Cancer Biology. 用于指导癌症靶向治疗和研究体内癌症生物学的 PET 诊断技术的进展。

Current Pathobiology Reports Pub Date : 2019-09-01 Epub Date: 2019-07-25 DOI: 10.1007/s40139-019-00202-9

David A Mankoff, Austin R Pantel, Varsha Viswanath, Joel S Karp

{"title":"Advances in PET Diagnostics for Guiding Targeted Cancer Therapy and Studying In Vivo Cancer Biology.","authors":"David A Mankoff, Austin R Pantel, Varsha Viswanath, Joel S Karp","doi":"10.1007/s40139-019-00202-9","DOIUrl":"10.1007/s40139-019-00202-9","url":null,"abstract":"Purpose of the review: We present an overview of recent advances in positron emission tomography (PET) diagnostics as applied to the study of cancer, specifically as a tool to study in vivo cancer biology and to direct targeted cancer therapy. The review is directed to translational and clinical cancer investigators who may not be familiar with these applications of PET cancer diagnostics, but whose research might benefit from these advancing tools.Recent findings: We highlight recent advances in 3 areas: (1) the translation of PET imaging cancer biomarkers to clinical trials; (2) methods for measuring cancer metabolism in vivo in patients; and (3) advances in PET instrumentation, including total-body PET, that enable new methodologies. We emphasize approaches that have been translated to human studies.Summary: PET imaging methodology enables unique in vivo cancer diagnostics that go beyond cancer detection and staging, providing an improved ability to guide cancer treatment and an increased understanding of in vivo human cancer biology.","PeriodicalId":37014,"journal":{"name":"Current Pathobiology Reports","volume":"7 3","pages":"97-108"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10117535/pdf/nihms-1887255.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10010339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0