Current Pathobiology Reports最新文献_第2页

Mathematical Modeling and Simulations for Developing Nanoparticle-Based Cancer Drug Delivery Systems: A Review 基于纳米颗粒的癌症药物传递系统的数学建模与仿真研究综述

Current Pathobiology Reports Pub Date : 2021-01-06 DOI: 10.1007/s40139-020-00219-5

Nitin Sahai, M. Gogoi, N. Ahmad

引用次数: 19

Chemokine-Based Therapeutics for the Treatment of Inflammatory and Fibrotic Convergent Pathways in COVID-19. 基于趋化因子的疗法治疗COVID-19的炎症和纤维化趋同途径。

Current Pathobiology Reports Pub Date : 2021-01-01 Epub Date: 2021-12-08 DOI: 10.1007/s40139-021-00226-0

Dana R Julian, Megan A Kazakoff, Akhil Patel, Jesse Jaynes, Monte S Willis, Cecelia C Yates

{"title":"Chemokine-Based Therapeutics for the Treatment of Inflammatory and Fibrotic Convergent Pathways in COVID-19.","authors":"Dana R Julian, Megan A Kazakoff, Akhil Patel, Jesse Jaynes, Monte S Willis, Cecelia C Yates","doi":"10.1007/s40139-021-00226-0","DOIUrl":"https://doi.org/10.1007/s40139-021-00226-0","url":null,"abstract":"Coronavirus disease 2019 (COVID-19) is an infectious disease caused by the SARS-CoV-2 betacoronavirus and has taken over 761,426 American lives as of the date of publication and will likely result in long-term, if not permanent, tissue damage for countless patients. COVID-19 presents with diverse and multisystemic pathologic processes, including a hyperinflammatory response, acute respiratory distress syndrome (ARDS), vascular injury, microangiopathy, tissue fibrosis, angiogenesis, and widespread thrombosis across multiple organs, including the lungs, heart, kidney, liver, and brain. C-X-C chemokines contribute to these pathologies by attracting inflammatory mediators, the disruption of endothelial cell integrity and function, and the initiation and propagation of the cytokine storm. Among these, CXCL10 is recognized as a critical contributor to the hyperinflammatory state and poor prognosis in COVID-19. CXCL10 is also known to regulate growth factor-induced fibrosis, and recent evidence suggests the CXCL10-CXCR3 signaling system may be vital in targeting convergent pro-inflammatory and pro-fibrotic pathways. This review will explore the mechanistic role of CXCL10 and related chemokines in fibrotic complications associated with COVID-19 and the potential of CXCL10-targeted therapeutics for early intervention and long-term treatment of COVID-19-induced fibrosis.","PeriodicalId":37014,"journal":{"name":"Current Pathobiology Reports","volume":" ","pages":"93-105"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39596651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

The Pathobiological Basis for Thrombotic Complications in COVID-19: a Review of the Literature. COVID-19血栓性并发症的病理生物学基础:文献综述

Current Pathobiology Reports Pub Date : 2021-01-01 DOI: 10.1007/s40139-021-00228-y

Lara Hoteit, Andrew-Paul Deeb, Elizabeth A Andraska, Christof Kaltenmeier, Hamza O Yazdani, Samer Tohme, Matthew D Neal, Roberto I Mota

{"title":"The Pathobiological Basis for Thrombotic Complications in COVID-19: a Review of the Literature.","authors":"Lara Hoteit, Andrew-Paul Deeb, Elizabeth A Andraska, Christof Kaltenmeier, Hamza O Yazdani, Samer Tohme, Matthew D Neal, Roberto I Mota","doi":"10.1007/s40139-021-00228-y","DOIUrl":"https://doi.org/10.1007/s40139-021-00228-y","url":null,"abstract":"Purpose of review: COVID-19 has rapidly evolved into a global pandemic infecting over two hundred and forty-four million individuals to date. In addition to the respiratory sequelae and systemic infection that ensues, an alarming number of micro and macrovascular thrombotic complications have been observed. This review examines the current understanding of COVID-19-associated thrombotic complications, potential mechanisms, and pathobiological basis for thromboses development.Recent findings: The endothelium plays a major role in the process due to direct and indirect injury. The immune system also contributes to a pro-thrombotic environment with immune cell dysregulation leading to excessive formation of cytokines, also called cytokine storm, and an eventual promotion of a hypercoagulable environment, known as immunothrombosis. Additionally, neutrophils play an important role by forming neutrophil extracellular traps, which are shown to be pro-thrombotic and further enhanced in COVID-19 patients. A disruption of the fibrinolysis system has also been observed.Summary: Multiple pathways likely contribute synergistically to form a pro-thrombotic milieu. A better understanding of these factors and the complex interplay between them will lead to the improvement of diagnostic and therapeutic interventions.","PeriodicalId":37014,"journal":{"name":"Current Pathobiology Reports","volume":"9 4","pages":"107-117"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10803361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Toxicology of Nanoparticles in Drug Delivery. 纳米颗粒在药物传递中的毒理学研究。

Current Pathobiology Reports Pub Date : 2021-01-01 Epub Date: 2021-11-24 DOI: 10.1007/s40139-021-00227-z

Swati Sharma, Roza Parveen, Biswa Prasun Chatterji

{"title":"Toxicology of Nanoparticles in Drug Delivery.","authors":"Swati Sharma, Roza Parveen, Biswa Prasun Chatterji","doi":"10.1007/s40139-021-00227-z","DOIUrl":"https://doi.org/10.1007/s40139-021-00227-z","url":null,"abstract":"Nanoparticles have revolutionized biomedicine especially in the field of drug delivery due to their intriguing properties such as systemic stability, level of solubility, and target site specificity. It can, however, be both beneficial and damaging depending on the properties in different environments, thus highlighting the importance of nanotoxicology studies before use in humans. Different types of nanoparticles have been used in drug delivery, and this review summarizes the recent toxicity studies of these nanoparticles. The toxicological evaluation of three widely used nanoparticles in drug delivery that are metal, lipid, and protein nanoparticles has been discussed in detail. Studies have recorded several toxic effects of various nanoparticles such as metal-based nanoparticles have been linked to increased oxidative stress and have the potential to infiltrate the cell nucleus and protein-based nanoparticles have been observed to have hepatotoxicity and nephrotoxicity as their adverse effects. Considering the increasing application of nanoparticles in drug delivery and the growing concerns of regulatory authorities regarding the toxicity of nanocarriers in living organisms, it requires urgent attention to identify the gap in toxicity studies. The review highlights the gap in toxicity studies and potential focus areas to overcome the existing challenges.","PeriodicalId":37014,"journal":{"name":"Current Pathobiology Reports","volume":" ","pages":"133-144"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8611175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39674436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 39

Characterizing Immune Responses in Whole Slide Images of Cancer With Digital Pathology and Pathomics 用数字病理学和病理学表征肿瘤全幻灯片图像中的免疫反应

Current Pathobiology Reports Pub Date : 2020-12-01 DOI: 10.1007/s40139-020-00217-7

Rajarsi Gupta, H. Le, John S. Van Arnam, David Belinsky, Mahmudul Hasan, D. Samaras, T. Kurç, J. Saltz

引用次数: 3

Acceleration of PDE-Based Biological Simulation Through the Development of Neural Network Metamodels. 通过开发神经网络元模型加速基于PDE的生物模拟。

Current Pathobiology Reports Pub Date : 2020-12-01 Epub Date: 2020-11-06 DOI: 10.1007/s40139-020-00216-8

Lukasz Burzawa, Linlin Li, Xu Wang, Adrian Buganza-Tepole, David M Umulis

{"title":"Acceleration of PDE-Based Biological Simulation Through the Development of Neural Network Metamodels.","authors":"Lukasz Burzawa, Linlin Li, Xu Wang, Adrian Buganza-Tepole, David M Umulis","doi":"10.1007/s40139-020-00216-8","DOIUrl":"10.1007/s40139-020-00216-8","url":null,"abstract":"Purpose of review: Partial differential equation (PDE) mathematical models of biological systems and the simulation approaches used to solve them are widely used to test hypotheses and infer regulatory interactions based on optimization of the PDE model against the observed data. In this review, we discuss the ability of powerful machine learning methods to accelerate the parametric screening of biophysical informed- PDE systems.Recent findings: A major shortcoming in more broad adaptation of PDE-based models is the high computational complexity required to solve and optimize the models and it requires many simulations to traverse the very high-dimensional parameter spaces during model calibration and inference tasks. For instance, when scaling up to tens of millions of simulations for optimization and sensitivity analysis of the PDE models, compute times quickly extend from months to years for sufficient coverage to solve the problems. For many systems, this brute-force approach is simply not feasible. Recently, neural network metamodels have been shown to be an efficient way to accelerate PDE model calibration and here we look at the benefits and limitations in extending the PDE acceleration methods to improve optimization and sensitivity analysis.Summary: We use an example simulation to quantitatively and qualitatively show how neural network metamodels can be accurate and fast and demonstrate their potential for optimization of complex spatiotemporal problems in biology. We expect these approaches will be broadly applied to speed up scientific research and discovery in biology and other systems that can be described by complex PDE systems.","PeriodicalId":37014,"journal":{"name":"Current Pathobiology Reports","volume":"8 4","pages":"121-131"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40139-020-00216-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38965458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Beyond Growth Factors: Macrophage-Centric Strategies for Angiogenesis 超越生长因子:巨噬细胞为中心的血管生成策略

Current Pathobiology Reports Pub Date : 2020-11-10 DOI: 10.1007/s40139-020-00215-9

A. Nolfi, Marissa N. Behun, C. Yates, B. Brown, M. Kulkarni

引用次数: 9

Alcohol-Induced Neuropathy in Chronic Alcoholism: Causes, Pathophysiology, Diagnosis, and Treatment Options 慢性酒精中毒的酒精性神经病变：病因、病理生理学、诊断和治疗选择

Current Pathobiology Reports Pub Date : 2020-10-23 DOI: 10.1007/s40139-020-00214-w

Iga Dudek, D. Hajduga, Cezary Sieńko, Amr Maani, E. Sitarz, M. Sitarz, Alicja Forma

引用次数: 4

Angiogenesis in Wound Healing following Pharmacological and Toxicological Exposures 药理学和毒理学暴露后伤口愈合中的血管生成

Current Pathobiology Reports Pub Date : 2020-09-12 DOI: 10.1007/s40139-020-00212-y

R. Hunter, K. Kivlighan, S. Ruyak, Quiteria Jacquez, K. Zychowski

引用次数: 2

Epigenetic mechanisms underlying pathobiology of alcohol use disorder. 酒精使用障碍病理生物学的表观遗传机制。

Current Pathobiology Reports Pub Date : 2020-09-01 Epub Date: 2020-07-29 DOI: 10.1007/s40139-020-00210-0

Russell S Dulman, Gabriela M Wandling, Subhash C Pandey

{"title":"Epigenetic mechanisms underlying pathobiology of alcohol use disorder.","authors":"Russell S Dulman, Gabriela M Wandling, Subhash C Pandey","doi":"10.1007/s40139-020-00210-0","DOIUrl":"https://doi.org/10.1007/s40139-020-00210-0","url":null,"abstract":"Purpose of review: Chronic alcohol use is a worldwide problem with multifaceted consequences including multiplying medical costs and sequelae, societal effects like drunk driving and assault, and lost economic productivity. These large-scale outcomes are driven by the consumption of ethanol, a small permeable molecule that has myriad effects in the human body, particularly in the liver and brain. In this review, we have summarized effects of acute and chronic alcohol consumption on epigenetic mechanisms that may drive pathobiology of Alcohol Use Disorder (AUD) while identifying areas of need for future research.Recent findings: Epigenetics has emerged as an interesting field of biology at the intersection of genetics and the environment, and ethanol in particular has been identified as a potent modulator of the epigenome with various effects on DNA methylation, histone modifications, and non-coding RNAs. These changes alter chromatin dynamics and regulate gene expression that contribute to behavioral and physiological changes leading to the development of AUD psychopathology and cancer pathology.Summary: Evidence and discussion presented here from preclinical results and available translational studies have increased our knowledge of the epigenetic effects of alcohol consumption. These studies have identified targets that can be used to develop better therapies to reduce chronic alcohol abuse and mitigate its societal burden and pathophysiology.","PeriodicalId":37014,"journal":{"name":"Current Pathobiology Reports","volume":"8 3","pages":"61-73"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40139-020-00210-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25511702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2