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Current Pathobiology Reports最新文献

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LRP1 in the Vascular Wall 血管壁中的LRP1
Current Pathobiology Reports Pub Date : 2022-07-09 DOI: 10.1007/s40139-022-00231-x
Zeyu Liu, E. Andraska, David Akinbode, W. Mars, R. M. Alvidrez
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引用次数: 0
Dynamics and Sensitivity of Signaling Pathways. 信号通路的动力学和敏感性。
Current Pathobiology Reports Pub Date : 2022-06-01 DOI: 10.1007/s40139-022-00230-y
Michael A Kochen, Steven S Andrews, H Steven Wiley, Song Feng, Herbert M Sauro
{"title":"Dynamics and Sensitivity of Signaling Pathways.","authors":"Michael A Kochen,&nbsp;Steven S Andrews,&nbsp;H Steven Wiley,&nbsp;Song Feng,&nbsp;Herbert M Sauro","doi":"10.1007/s40139-022-00230-y","DOIUrl":"https://doi.org/10.1007/s40139-022-00230-y","url":null,"abstract":"<p><strong>Purpose of review: </strong>Signaling pathways serve to communicate information about extracellular conditions into the cell, to both the nucleus and cytoplasmic processes to control cell responses. Genetic mutations in signaling network components are frequently associated with cancer and can result in cells acquiring an ability to divide and grow uncontrollably. Because signaling pathways play such a significant role in cancer initiation and advancement, their constituent proteins are attractive therapeutic targets. In this review, we discuss how signaling pathway modeling can assist with identifying effective drugs for treating diseases, such as cancer. An achievement that would facilitate the use of such models is their ability to identify controlling biochemical parameters in signaling pathways, such as molecular abundances and chemical reaction rates, because this would help determine effective points of attack by therapeutics.</p><p><strong>Recent findings: </strong>We summarize the current state of understanding the sensitivity of phosphorylation cycles with and without sequestration. We also describe some basic properties of regulatory motifs including feedback and feedforward regulation.</p><p><strong>Summary: </strong>Although much recent work has focused on understanding the dynamics and particularly the sensitivity of signaling networks in eukaryotic systems, there is still an urgent need to build more scalable models of signaling networks that can appropriately represent their complexity across different cell types and tumors.</p>","PeriodicalId":37014,"journal":{"name":"Current Pathobiology Reports","volume":"10 2","pages":"11-22"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10035447/pdf/nihms-1878426.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9199493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Platelet-Neutrophil Interactions and Thrombo-inflammatory Complications in Type 2 Diabetes Mellitus 2型糖尿病的血小板-中性粒细胞相互作用和血栓炎性并发症
Current Pathobiology Reports Pub Date : 2022-03-01 DOI: 10.1007/s40139-022-00229-5
Nishith M. Shrimali, Sakshi Agarwal, A. Tiwari, P. Guchhait
{"title":"Platelet-Neutrophil Interactions and Thrombo-inflammatory Complications in Type 2 Diabetes Mellitus","authors":"Nishith M. Shrimali, Sakshi Agarwal, A. Tiwari, P. Guchhait","doi":"10.1007/s40139-022-00229-5","DOIUrl":"https://doi.org/10.1007/s40139-022-00229-5","url":null,"abstract":"","PeriodicalId":37014,"journal":{"name":"Current Pathobiology Reports","volume":"10 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46688725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of Nanoscale Delivery Systems in Tissue Engineering 纳米递送系统在组织工程中的作用
Current Pathobiology Reports Pub Date : 2021-08-20 DOI: 10.1007/s40139-021-00225-1
Biji Balakrishnan
{"title":"Role of Nanoscale Delivery Systems in Tissue Engineering","authors":"Biji Balakrishnan","doi":"10.1007/s40139-021-00225-1","DOIUrl":"https://doi.org/10.1007/s40139-021-00225-1","url":null,"abstract":"","PeriodicalId":37014,"journal":{"name":"Current Pathobiology Reports","volume":"9 1","pages":"119 - 132"},"PeriodicalIF":0.0,"publicationDate":"2021-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40139-021-00225-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46734388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Magnetic Nanostructures for Cancer Theranostic Applications 用于癌症治疗的磁性纳米结构
Current Pathobiology Reports Pub Date : 2021-07-22 DOI: 10.1007/s40139-021-00224-2
M. Gogoi
{"title":"Magnetic Nanostructures for Cancer Theranostic Applications","authors":"M. Gogoi","doi":"10.1007/s40139-021-00224-2","DOIUrl":"https://doi.org/10.1007/s40139-021-00224-2","url":null,"abstract":"","PeriodicalId":37014,"journal":{"name":"Current Pathobiology Reports","volume":"9 1","pages":"71 - 78"},"PeriodicalIF":0.0,"publicationDate":"2021-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40139-021-00224-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44583379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The Role of Gold Nanoclusters as Emerging Theranostic Agents for Cancer Management 金纳米簇在癌症治疗中的作用
Current Pathobiology Reports Pub Date : 2021-05-25 DOI: 10.1007/s40139-021-00222-4
Kritika Sood, A. Shanavas
{"title":"The Role of Gold Nanoclusters as Emerging Theranostic Agents for Cancer Management","authors":"Kritika Sood, A. Shanavas","doi":"10.1007/s40139-021-00222-4","DOIUrl":"https://doi.org/10.1007/s40139-021-00222-4","url":null,"abstract":"","PeriodicalId":37014,"journal":{"name":"Current Pathobiology Reports","volume":"9 1","pages":"33 - 42"},"PeriodicalIF":0.0,"publicationDate":"2021-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40139-021-00222-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43960023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
A Reflection on the Mechanism of the Role of Nanoparticles in Increasing the Efficacy of Anti-tumour Properties of Docetaxel 纳米颗粒提高多西他赛抗肿瘤作用机制的思考
Current Pathobiology Reports Pub Date : 2021-05-03 DOI: 10.1007/s40139-021-00223-3
S. Manivannan, S. Nagaraj, S. Narayan
{"title":"A Reflection on the Mechanism of the Role of Nanoparticles in Increasing the Efficacy of Anti-tumour Properties of Docetaxel","authors":"S. Manivannan, S. Nagaraj, S. Narayan","doi":"10.1007/s40139-021-00223-3","DOIUrl":"https://doi.org/10.1007/s40139-021-00223-3","url":null,"abstract":"","PeriodicalId":37014,"journal":{"name":"Current Pathobiology Reports","volume":"9 1","pages":"79 - 91"},"PeriodicalIF":0.0,"publicationDate":"2021-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40139-021-00223-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47691735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Nanomedicine in Cancer Clinics: Are We There Yet? 纳米医学在癌症临床中的应用:我们做到了吗?
Current Pathobiology Reports Pub Date : 2021-03-13 DOI: 10.1007/s40139-021-00220-6
P. Nayak, N. S., Anoop Narayanan, A. K. Badekila, S. Kini
{"title":"Nanomedicine in Cancer Clinics: Are We There Yet?","authors":"P. Nayak, N. S., Anoop Narayanan, A. K. Badekila, S. Kini","doi":"10.1007/s40139-021-00220-6","DOIUrl":"https://doi.org/10.1007/s40139-021-00220-6","url":null,"abstract":"","PeriodicalId":37014,"journal":{"name":"Current Pathobiology Reports","volume":"9 1","pages":"43-55"},"PeriodicalIF":0.0,"publicationDate":"2021-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40139-021-00220-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46152512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Understanding Physico-chemical Interactions of Dendrimers with Guest Molecules for Efficient Drug and Gene Delivery 了解树状大分子与客体分子的物理化学相互作用，以实现有效的药物和基因传递
Current Pathobiology Reports Pub Date : 2021-03-06 DOI: 10.1007/s40139-021-00221-5
A. Shetty, Priyal Chikhaliwala, J. Suryawanshi, S. Chandra
{"title":"Understanding Physico-chemical Interactions of Dendrimers with Guest Molecules for Efficient Drug and Gene Delivery","authors":"A. Shetty, Priyal Chikhaliwala, J. Suryawanshi, S. Chandra","doi":"10.1007/s40139-021-00221-5","DOIUrl":"https://doi.org/10.1007/s40139-021-00221-5","url":null,"abstract":"","PeriodicalId":37014,"journal":{"name":"Current Pathobiology Reports","volume":"9 1","pages":"57-70"},"PeriodicalIF":0.0,"publicationDate":"2021-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40139-021-00221-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41924301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Apprehending Ulcerative Colitis Management With Springing Up Therapeutic Approaches: Can Nanotechnology Play a Nascent Role? 用新兴的治疗方法评估溃疡性结肠炎的治疗：纳米技术能起到令人讨厌的作用吗？
Current Pathobiology Reports Pub Date : 2021-01-06 DOI: 10.1007/s40139-020-00218-6
El Bethel Hmar, Sujata Paul, Nayanmoni Boruah, P. Sarkar, Sudarshana Borah, H. Sharma
{"title":"Apprehending Ulcerative Colitis Management With Springing Up Therapeutic Approaches: Can Nanotechnology Play a Nascent Role?","authors":"El Bethel Hmar, Sujata Paul, Nayanmoni Boruah, P. Sarkar, Sudarshana Borah, H. Sharma","doi":"10.1007/s40139-020-00218-6","DOIUrl":"https://doi.org/10.1007/s40139-020-00218-6","url":null,"abstract":"","PeriodicalId":37014,"journal":{"name":"Current Pathobiology Reports","volume":"9 1","pages":"9-32"},"PeriodicalIF":0.0,"publicationDate":"2021-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40139-020-00218-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46514199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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