Impact of Alcohol on Bone Health, Homeostasis and Fracture repair.

Q1 Medicine

Current Pathobiology Reports Pub Date : 2020-09-01 Epub Date: 2020-07-28 DOI:10.1007/s40139-020-00209-7

Jonathan M Eby, Farah Sharieh, John J Callaci

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引用次数: 0

Abstract

Purpose of review: Alcohol use continues to rise globally. We review the current literature on the effect of alcohol on bone health, homeostasis and fracture repair to highlight what has been learned in people and animal models of alcohol consumption.

Recent findings: Recently, forkhead box O (FoxO) has been found to be upregulated and activated in mesenchymal stem cells (MSC) exposed to alcohol. FoxO has also been found to modulate Wnt/β-catenin signaling, which is necessary for MSC differentiation. Recent evidence suggests alcohol activates FoxO signaling, which may be dysregulating Wnt/β-catenin signaling in MSCs cultured in alcohol.

Summary: This review highlights the negative health effects learned from people and chronic and episodic binge alcohol consumption animal models. Studies using chronic alcohol exposure or alcohol exposure then bone fracture repair model have explored several different cellular and molecular signaling pathways important for bone homeostasis and fracture repair, and offer potential for future experiments to explore additional signaling pathways that may be dysregulated by alcohol exposure.

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酒精对骨骼健康、平衡和骨折修复的影响

审查目的：酒精使用量在全球范围内持续上升。我们回顾了目前有关酒精对骨骼健康、稳态和骨折修复影响的文献，重点介绍了从人类和动物模型中了解到的有关饮酒的最新发现：最近发现，在接触酒精的间充质干细胞（MSC）中，叉头盒O（FoxO）被上调和激活。FoxO 还被发现可调节 Wnt/β-catenin 信号，而 Wnt/β-catenin 信号是间充质干细胞分化所必需的。最近的证据表明，酒精激活了 FoxO 信号转导，这可能使酒精培养的间充质干细胞中的 Wnt/β-catenin 信号转导失调。摘要：这篇综述强调了从人类、慢性和偶发性暴饮暴食酒精动物模型中了解到的对健康的负面影响。利用慢性酒精暴露或酒精暴露后骨骨折修复模型进行的研究探索了对骨平衡和骨折修复非常重要的几种不同的细胞和分子信号通路，并为未来探索可能因酒精暴露而失调的其他信号通路的实验提供了可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Pathobiology Reports Medicine-Pathology and Forensic Medicine

CiteScore

6.40

自引率

0.00%

发文量

期刊介绍： This journal aims to offer expert review articles on the most important recent research pertaining to biological mechanisms underlying disease, including etiology, pathogenesis, and the clinical manifestations of cellular alteration. By providing clear, insightful, balanced contributions, the journal intends to serve those for whom the elucidation of new techniques and technologies related to pathobiology is essential. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas across the field. Section Editors select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An Editorial Board of more than 20 internationally diverse members reviews the annual table of contents, ensures that topics include emerging research, and suggests topics of special importance to their country/region. Topics covered may include autophagy, cancer stem cells, induced pluripotential stem cells (iPS cells), inflammation and cancer, matrix pathobiology, miRNA in pathobiology, mitochondrial dysfunction/diseases, and myofibroblast.