扩散和灌注MRI在肿瘤定量成像中的研究进展。

Q1 Medicine

Current Pathobiology Reports Pub Date : 2019-12-01 DOI:10.1007/s40139-019-00204-7

Mehran Baboli, Jin Zhang, Sungheon Gene Kim

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引用次数: 4

摘要

综述目的:本文综述了近年来肿瘤影像学定量测量肿瘤细胞和血管特性的技术进展及其临床应用。近十年来，快速磁共振成像(MRI)技术的快速发展为定量MRI方法同时测量肿瘤的细胞和血管特性带来了新的机遇。摘要:弥散磁共振成像(dMRI)和动态对比增强磁共振成像(DCE)已被广泛用于评估组织结构和血管特性。然而，这些先进成像模式的最终潜力尚未得到充分利用。dMRI对扩散加权梯度强度和扩散时间的依赖性可以用来测量肿瘤灌注、细胞结构和细胞膜通透性。同样，DCE-MRI可用于测量血管和细胞膜的通透性以及细胞室体积分数。为了便于理解这些潜在的重要癌症定量成像方法，我们讨论了这些方法的基本概念和最新发展，以及未来的发展方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Advances in Diffusion and Perfusion MRI for Quantitative Cancer Imaging.

Purpose of review: This article is to review recent technical developments and their clinical applications in cancer imaging quantitative measurement of cellular and vascular properties of the tumors.

Recent findings: Rapid development of fast Magnetic Resonance Imaging (MRI) technologies over last decade brought new opportunities in quantitative MRI methods to measure both cellular and vascular properties of tumors simultaneously.

Summary: Diffusion MRI (dMRI) and dynamic contrast enhanced (DCE)-MRI have become widely used to assess the tissue structural and vascular properties, respectively. However, the ultimate potential of these advanced imaging modalities has not been fully exploited. The dependency of dMRI on the diffusion weighting gradient strength and diffusion time can be utilized to measure tumor perfusion, cellular structure, and cellular membrane permeability. Similarly, DCE-MRI can be used to measure vascular and cellular membrane permeability along with cellular compartment volume fractions. To facilitate the understanding of these potentially important methods for quantitative cancer imaging, we discuss the basic concepts and recent developments, as well as future directions for further development.

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来源期刊

Current Pathobiology Reports Medicine-Pathology and Forensic Medicine

CiteScore

6.40

自引率

0.00%

发文量

期刊介绍： This journal aims to offer expert review articles on the most important recent research pertaining to biological mechanisms underlying disease, including etiology, pathogenesis, and the clinical manifestations of cellular alteration. By providing clear, insightful, balanced contributions, the journal intends to serve those for whom the elucidation of new techniques and technologies related to pathobiology is essential. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas across the field. Section Editors select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An Editorial Board of more than 20 internationally diverse members reviews the annual table of contents, ensures that topics include emerging research, and suggests topics of special importance to their country/region. Topics covered may include autophagy, cancer stem cells, induced pluripotential stem cells (iPS cells), inflammation and cancer, matrix pathobiology, miRNA in pathobiology, mitochondrial dysfunction/diseases, and myofibroblast.