IF 12.2 1区环境科学与生态学

环境科学与技术 Pub Date : 2026-10-20 Epub Date: 2026-10-08 DOI: 10.1021/acs.est.6c10850

Imre Salma, Máté Vörösmarty, Árpád Farkas

{"title":"Aerosol Deposition in the Human Respiratory System from Distinct Urban Sources Using Multiple Exposure Metrics","authors":"Imre Salma, Máté Vörösmarty, Árpád Farkas","doi":"10.1021/acs.est.6c10850","DOIUrl":"10.1021/acs.est.6c10850","url":null,"abstract":"Targeting specific aerosol sources offers more effectiveair-qualitycontrol than focusing solely on ambient concentrations. Using sourceapportionment, major contributors to particle number concentrationsin the diameter range of 6–1000 nm in urban background of Budapest,Hungary were identified, and their size distributions applied in lungdeposition modelling under reference breathing conditions. In thisstudy, we find that most particles penetrate to the deep lung witha maximum deposition at airway generations 17 to 21 depending on physicalactivity. Deposition fractions vary substantially by source, rangingfrom 76% (new particle formation) to 27% (solid fuel combustion).Exercise enhances overall deposition, and redistributes the depositedparticles within the respiratory tract by decreasing extra-thoracicdeposition and increasing the alveolar fraction. Our results alsoshow that deposition rates are more sensitive to physical activitythan deposition fractions. These deposition curves exhibit a levelling-offtendency in the extra-thoracic region, while continuing to increasein the lung. Particle number and particle surface area depositioncurves are similar in shape, although the relative importance of aerosolsources and the most affected respiratory regions differ. We pointthat surface-density deposition rates are three orders of magnitudehigher in the nose and mouth than in the lung.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"60 41","pages":"29515–29526"},"PeriodicalIF":12.2,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149151407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Persistent Desorption, Aging, and Secondary VOC Formation from Biomass-Burning Emissions on Indoor Surfaces 室内表面生物质燃烧排放物的持续解吸、老化和二次VOC形成

IF 12.2 1区环境科学与生态学

环境科学与技术 Pub Date : 2026-10-20 Epub Date: 2026-10-03 DOI: 10.1021/acs.est.6c05801

Shiqian Long, Xiaoqiao Jiao, Wenting Yuan, Weilin Huang, Wangchao Zhao, Bo Yang, Lifang Zhang, Li Zhou, Jiwen Xu, Huifan Deng, Chen Wang

{"title":"Persistent Desorption, Aging, and Secondary VOC Formation from Biomass-Burning Emissions on Indoor Surfaces","authors":"Shiqian Long, Xiaoqiao Jiao, Wenting Yuan, Weilin Huang, Wangchao Zhao, Bo Yang, Lifang Zhang, Li Zhou, Jiwen Xu, Huifan Deng, Chen Wang","doi":"10.1021/acs.est.6c05801","DOIUrl":"10.1021/acs.est.6c05801","url":null,"abstract":"Biomass burning (BB) degrades indoorair quality boththrough directemissions and via smoke sorption onto surfaces, resulting in persistentpollutant re-emission and transformation. However, the dynamics ofthis multiphase process remain unclear. This study investigates there-emission, chemical aging, and secondary product formation of smokeresidues on three representative indoor surfaces (glass, cotton, andgypsum). Smoke-contaminated surfaces re-emitted 120–180 distinctvolatile organic compounds (VOCs). After 2 weeks of ventilation, themedian emission rates of various VOCs from porous cotton and gypsum(3.3 and 4.2 μg m–2 h–1)far exceeded that from glass (0.06 μg m–2 h–1), reflecting their greater sorption capacity andlonger pollutant persistence. The emission increased by factors of7 and 4 on glass and cotton when relative humidity (RH) rose from20% to 80%, attributed to enhanced initial sorption. Smoke-sorbedgypsum showed a strong ozone (O3) uptake coefficient ((1.6± 0.2) × 10–5 at 50 ppb O3,20% RH), approximately 20 times that on glass, confirming its roleas a key indoor O3 sink. Heterogeneous transformation ofsurface residues produced secondary VOCs, including aldehydes andcarboxylic acids, further deteriorating indoor air quality. Thesefindings demonstrate the critical and prolonged influence of surface-retainedBB emissions on indoor air chemistry.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"60 41","pages":"29468–29478"},"PeriodicalIF":12.2,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149091530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Taming Biotic-Abiotic Interface with Atomic Defects for Efficient Hydrogen Production from Wastewater 利用原子缺陷驯化生物-非生物界面用于废水高效制氢

IF 12.2 1区环境科学与生态学

环境科学与技术 Pub Date : 2026-10-20 Epub Date: 2026-10-06 DOI: 10.1021/acs.est.6c04332

Furong Guo, Minzi Liao, Jiahao Wang, Hao Zhang, Jundi Cheng, Chenglin Hao, Sicong Ma, Biao Zhou, Bing Zhou, Jinming Luo, Yitao Pan, Yancai Yao, Hao Li, Lizhi Zhang

{"title":"Taming Biotic-Abiotic Interface with Atomic Defects for Efficient Hydrogen Production from Wastewater","authors":"Furong Guo, Minzi Liao, Jiahao Wang, Hao Zhang, Jundi Cheng, Chenglin Hao, Sicong Ma, Biao Zhou, Bing Zhou, Jinming Luo, Yitao Pan, Yancai Yao, Hao Li, Lizhi Zhang","doi":"10.1021/acs.est.6c04332","DOIUrl":"10.1021/acs.est.6c04332","url":null,"abstract":"Sluggish interfacial kinetics at the bio-abiotic junctionfundamentallybottleneck the efficiency of microbial electrochemical hydrogen productionfrom wastewater, as electronic barriers and rigid water networks obstructthe seamless transport of electrons and protons. We surmount thesesynergistic challenges by coupling Shewanella oneidensis MR-1 with vacancy-engineered pyrite (FeS2), achievingan impressive H2 evolution rate of 1.92 mmol h–1 with high operational stability (100 h at 60 mA cm–2). In situ spectroscopy and molecular dynamics (MD)simulations suggest that under-coordinated Fe sites associated withsulfur vacancies facilitate electron transfer through coordination-assistedinteractions with microbial cytochromes, while localized charge polarizationdisrupts the ordered four-coordinate water network to facilitate interfacialproton transfer. A solar-powered prototype treating authentic foodwaste leachate demonstrates a 4.7% solar-to-hydrogen efficiency. Life-cycleand techno-economic analyses confirm the system’s sustainability,yielding a net profit of $0.70 per ton of wastewater and a minimizedcarbon emissions potential of 0.33 kg CO2 equivalent. Thiswork establishes vacancy-enabled biotic-abiotic interface engineeringas a transformative strategy for optimizing interfacial microenvironmentsin high-performance noble-metal-free bio-electrochemical energy recovery.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"60 41","pages":"29618–29628"},"PeriodicalIF":12.2,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149091981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatially Refined Analysis of Emission Burdens and Equity from Light-, Medium-, and Heavy-Duty Vehicle Traffic in the United States 美国轻型、中型和重型车辆交通排放负担和公平性的空间精细分析

IF 12.2 1区环境科学与生态学

环境科学与技术 Pub Date : 2026-10-20 Epub Date: 2026-10-07 DOI: 10.1021/acs.est.6c12227

Brittany Antonczak, Clare Nelson, Tammy M. Thompson, Mindi W. DePaola, Gregory Rowangould

{"title":"Spatially Refined Analysis of Emission Burdens and Equity from Light-, Medium-, and Heavy-Duty Vehicle Traffic in the United States","authors":"Brittany Antonczak, Clare Nelson, Tammy M. Thompson, Mindi W. DePaola, Gregory Rowangould","doi":"10.1021/acs.est.6c12227","DOIUrl":"10.1021/acs.est.6c12227","url":null,"abstract":"We estimate block-levelemission intensities of nitrogen oxides(NOX) and fine particulate matter (PM2.5) fromon-road vehicle traffic for every census block in the United States,combining MOVES-based emission factors with street level traffic data.We use this spatially refined, computationally efficient, and policy-sensitivemetric to evaluate emissions burden. Despite comprising less than11% of vehicle kilometers traveled, we find that medium- and heavy-dutytrucks account for 46% of NOX and 50% of PM2.5 emission burden nationally ─ with PM2.5 burdenfrom trucks dominated by exhaust emissions while tire and brake wearconstitute nearly half of light-duty vehicle PM2.5 burden.People of color face emission burdens averaging 40% above the nationalmean, with Asian populations exceeding 60%, and lower-income populationsface 20–25% higher burdens. Statistically significant racial-ethnicor income disparities are present in 85–89% of US counties.Critically, these disparities are not confined to large metropolitanareas. They are widespread across both urban and rural counties nationwide.We also show that spatial aggregation substantially attenuates estimateddisparities of burdened groups, underscoring the importance of spatiallyrefined analysis.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"60 41","pages":"29527–29539"},"PeriodicalIF":12.2,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149092384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

60 Years of Biogeochemistry and Remediation Science 生物地球化学与修复科学60年

IF 12.2 1区环境科学与生态学

环境科学与技术 Pub Date : 2026-10-20 DOI: 10.1021/acs.est.6c15296

Paul G. Tratnyek, Heileen Hsu-Kim, Sukhwan Yoon

引用次数: 0

Resource-Oriented Wastewater Treatment through Quorum Quenching─Integration of AnMBR and Donnan Dialysis 群体淬灭资源型废水处理─AnMBR与Donnan透析的集成

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2026-10-20 DOI: 10.1021/acs.est.6c05848

Hongyu Zhang,Yuxuan Wan,Liqiu Zhang,Huarong Yu,Haiyang Yang,Fangshu Qu

{"title":"Resource-Oriented Wastewater Treatment through Quorum Quenching─Integration of AnMBR and Donnan Dialysis","authors":"Hongyu Zhang,Yuxuan Wan,Liqiu Zhang,Huarong Yu,Haiyang Yang,Fangshu Qu","doi":"10.1021/acs.est.6c05848","DOIUrl":"https://doi.org/10.1021/acs.est.6c05848","url":null,"abstract":"Aligned with United Nations Sustainable Development Goal 6, water treatment is shifting from pollution removal to resource recovery and circularity. An integration of AnMBR and a Donnan dialysis (DD) (AnMBR-DD) was proposed to simultaneously recover methane and ammonium, and quorum quenching (QQ) was further incorporated to mitigate membrane fouling and enhance process efficiency. The COD removal efficiency was stably maintained above 80%, and the methane conversion efficiency reached 51.6%. The effluent NH4+-N concentration was controlled at 3–5 mg/L, with a recovery efficiency of 47.1% in the AnMBR-DD. The QQ effectively alleviated biofouling on the ultrafiltration membrane in the AnMBR and ion exchange membrane in the DD, while improving methane production and ammonia recovery by 20.6% and 6.6%, respectively. These improvements were mainly attributed to QQ-induced reductions in extracellular polymeric substances (EPS), which weakened microbial adhesion and decreased biofilm compactness. Life cycle assessment showed that coupled methane and ammonium recovery in AnMBR-DD-QQ were the decided advantages in alleviating the environmental impact. These results highlight the great potential of AnMBR-DD-QQ as a resource-oriented wastewater treatment strategy.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"2 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149221689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Evolution of Dissolved Organic Nitrogen from Photoaged Nitrogen-Containing Microplastics Reveals Amine Structures as Key Nitrosamine Precursors 光老化含氮微塑料中溶解有机氮的分子演化揭示了胺结构是亚硝胺的关键前体

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2026-10-20 DOI: 10.1021/acs.est.6c12418

Run Zhou,Jiayi Shi,Yuanren Jiang,Zhuo Gao,Fei Yang,Kecheng Zhu,Hanzhong Jia

{"title":"Molecular Evolution of Dissolved Organic Nitrogen from Photoaged Nitrogen-Containing Microplastics Reveals Amine Structures as Key Nitrosamine Precursors","authors":"Run Zhou,Jiayi Shi,Yuanren Jiang,Zhuo Gao,Fei Yang,Kecheng Zhu,Hanzhong Jia","doi":"10.1021/acs.est.6c12418","DOIUrl":"https://doi.org/10.1021/acs.est.6c12418","url":null,"abstract":"Although dissolved organic nitrogen (DON) is continuously released and transformed as nitrogen-containing microplastics (N-MPs) age, the evolution of this replenished pool and its reactivity during downstream chloramination remains unresolved. Here, we tracked the compositional evolution of DON molecules in polyamide (PA) and polyacrylonitrile (PAN) suspensions under UV irradiation using a nitrogen atom-based molecular classification strategy (N1–N5). After 7 d of irradiation-induced molecular reorganization, N1–N5 molecules accounted for 87% and 79% of the molecular signal intensity in PA-DOM and PAN-DOM, respectively. Eight annotated compounds followed increasing, decreasing, or transient accumulation trajectories, revealing simultaneous molecular accumulation and depletion. Reaction-network analysis further showed that N1–N5 molecules progressively became the dominant reactants, and these trajectories were dominated by oxidation and accompanied by increasingly frequent amine-related transformation links. Structural analysis revealed amide-rich N1–N2 and N-heterocycle-rich N3–N5 molecules, while secondary and tertiary amines occurred across all N1–N5 classes. As this molecular reorganization progressed, N-MP-DON level dropped, but substantially enhanced N-nitrosodimethylamine and N-nitrosodiethylamine formation, and potential precursor identification was strongly associated with amine structures, rather than nitrogen atom number. Overall, our study highlights N-MP-DON as a potential source of nitrosamine precursors, and the need to carefully consider amine-containing additives use in plastic manufacturing.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"16 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149221691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ebullition-Enhanced Release of Microplastics from Aquatic Sediment to Overlying Water: An Overlooked Transport Pathway 微塑料从水生沉积物到上覆水的气泡增强释放：一个被忽视的运输途径

IF 12.2 1区环境科学与生态学

环境科学与技术 Pub Date : 2026-10-20 Epub Date: 2026-10-05 DOI: 10.1021/acs.est.6c06432

Shengdong Liu, Zhuoqing Zhou, Yang Li, Xinghui Xia, Xinjie Wang, Jiahe Zhang, Baoshan Xing, Shoichiro Hamamoto, Peng Zhang, Wen Zhang

{"title":"Ebullition-Enhanced Release of Microplastics from Aquatic Sediment to Overlying Water: An Overlooked Transport Pathway","authors":"Shengdong Liu, Zhuoqing Zhou, Yang Li, Xinghui Xia, Xinjie Wang, Jiahe Zhang, Baoshan Xing, Shoichiro Hamamoto, Peng Zhang, Wen Zhang","doi":"10.1021/acs.est.6c06432","DOIUrl":"10.1021/acs.est.6c06432","url":null,"abstract":"Microplastics(MPs) in aquatic systems are typicallyattributedto wastewater, runoff and atmospheric inputs, whereas the remobilizationof sediment-associated MPs by benthic gas ebullition remains poorlyunderstood. Here, we show that air-purged ebullition mobilized fourcommon MPs, polyethylene (PE), polyethylene terephthalate (PET), polyvinylchloride (PVC), and polylactic acid (PLA), from sediments into theoverlying water, with release ratios of 8.9%–12.1% over 9 d.Suspended MP concentrations in the overlying water increased rapidlyduring the first 48 h, followed by slower release and eventual plateauing,with the decelerating release behavior empirically described by apower-law model. Theoretical calculations suggest that aggregationwith suspended sediment can reduce the flotation velocities of MPsfrom 9.38–9.99 cm·s–1 to 8.64–9.95cm·s–1. Combined experimental observationsand theoretical analyses support a coupled flotation mechanism involvingMPs attachment to rising bubbles, bubble-driven flow that counteractsgravitational settling, and transient pressure gradients. These processescould convert sediments from a long-term sink into a secondary sourceof MPs during ebullition. Overall, this study identifies benthic gasebullition as an underappreciated pathway for MP remobilization andprovides a mechanistic framework for understanding the fate and transportof sediment-associated MPs in aquatic environments.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"60 41","pages":"29583–29595"},"PeriodicalIF":12.2,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149091518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Niche Divergence-Based Identification of Microbial Indicators Tracking Cyanobacterial Bloom Succession: A Metagenomic and Machine Learning Framework 基于生态位差异的微生物指标识别跟踪蓝藻华演替：一个宏基因组和机器学习框架

IF 12.2 1区环境科学与生态学

环境科学与技术 Pub Date : 2026-10-20 Epub Date: 2026-10-03 DOI: 10.1021/acs.est.6c04563

Kaiwen Yang, Zhen Xie, Wei Li, Yi Ren, Xiao Yi Chen, Xinze Wang, Hongyan Ren, Shunzi Xiong, Xiaojun Zhang

{"title":"Niche Divergence-Based Identification of Microbial Indicators Tracking Cyanobacterial Bloom Succession: A Metagenomic and Machine Learning Framework","authors":"Kaiwen Yang, Zhen Xie, Wei Li, Yi Ren, Xiao Yi Chen, Xinze Wang, Hongyan Ren, Shunzi Xiong, Xiaojun Zhang","doi":"10.1021/acs.est.6c04563","DOIUrl":"10.1021/acs.est.6c04563","url":null,"abstract":"Cyanobacterial harmful algal blooms (CyanoHABs) posesignificantenvironmental and public health risks through toxin production, antibioticresistance gene dissemination, and the disruption of biogeochemicalcycles. Although extensive metagenomic investigations have exploredmicrobial interactions between Cyanobacteria andcoexisting members, the potential of incorporating functional indicatorsinto early CyanoHAB monitoring systems remains underexplored. In thisstudy, we employed metagenomic binning combined with machine learningapproaches to analyze seasonal cyanobacterial succession and coexistingmicrobial communities across 19 sites in Erhai Lake across four seasons.We documented distinct niche shifts driven by the spatiotemporal heterogeneityin seasonal cyanobacterial succession alongside the formation of uniqueniches triggered by this asynchrony. Specialized microbial members(SN-MAGs) were identified as candidate bioindicators associated withearly-stage cyanobacterial proliferation. Functional profiling showed r/K selection and metabolic adaptations in these SN-MAGs,including stress resistance and altered carbon metabolism, linkedto cyanobacterial dynamics. Machine learning models leveraging thesefeatures were constructed and retrospectively evaluated. Cross-lakevalidation using an independent Lake Taihu dataset confirmed associationsamong these features and microbial community shifts preceding Microcystis proliferation. Our findings highlight the potentialvalue of the dynamics of specific bacteria as a sensitive indicatorof cyanobacterial dynamics. Moreover, we propose that these identifiedfunctional markers could potentially be developed into targeted molecularassays (e.g., qPCR assays), offering possible utility in predicting Microcystis population expansion.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"60 41","pages":"29569–29582"},"PeriodicalIF":12.2,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149091521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Multidimensional Framework for Integrated Toxicity Assessment and Prioritization of Naphthenic Acids in Marine Medaka (Oryzias melastigma): Neurotoxicity and Mechanistic Insights 海洋Medaka （Oryzias melastigma）中环烷酸综合毒性评估和优先排序的多维框架：神经毒性和机制见解

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2026-10-20 DOI: 10.1021/acs.est.6c11718

Jizhuang Chu,Shixuan Cui,Yumiao Zhou,Qiang Kong,Ying Wang,Yijing Xia,Huanxin Zhang

{"title":"A Multidimensional Framework for Integrated Toxicity Assessment and Prioritization of Naphthenic Acids in Marine Medaka (Oryzias melastigma): Neurotoxicity and Mechanistic Insights","authors":"Jizhuang Chu,Shixuan Cui,Yumiao Zhou,Qiang Kong,Ying Wang,Yijing Xia,Huanxin Zhang","doi":"10.1021/acs.est.6c11718","DOIUrl":"https://doi.org/10.1021/acs.est.6c11718","url":null,"abstract":"Petroleum pollution poses a major challenge to global environmental health. Petroleum-derived naphthenic acids (NAs) are frequently detected in marine environments, yet their multidimensional toxicity and mechanisms remain poorly understood. Here, we developed an integrated toxicity framework combining bioassays, toxicity screening, computational simulations, transcriptomics, and bioinformatics to characterize NAs toxicity in marine medaka (Oryzias melastigma). A concentration gradient spanning environmentally detected levels to higher-effect concentrations (0.015–30 mg/L) revealed developmental defects, cardiac suppression, behavioral disruption, and metabolic dysfunction. CRITIC–AHP-based prioritization identified neurotoxicity as the predominant toxicity dimension, with cyclopentylpropionic acid (CPPA) and cyclohexylpropionic acid (CHPA) identified as major contributors. Mechanistically, these compounds were associated with distinct candidate pathways involving CXCR3-CXCL10 neuroinflammatory responses and DPP10-Kv4.2 ion homeostasis disruption. Their divergent toxicity profiles may be associated with differences in hydrophobicity and molecular flexibility. Rescue experiments supported these pathways, restoring swimming velocity by 60.32% and 62.09%, respectively. Furthermore, NAs induced neurobehavioral alterations and transcriptional signatures overlapping with Alzheimer’s disease-associated genes, with 14 and 12 candidate genes identified for CPPA and CHPA. Collectively, this study provides a cross-scale perspective linking physicochemical properties, toxicity pathways, and adverse outcomes of NAs, offering a conceptual approach for toxicity screening and mechanism elucidation of contaminants.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"11 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149221685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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