IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2025-09-24 DOI: 10.1021/acs.est.5c05446

Mengting Qi, Ye Li, Yuxuan Fu, Zhenyang Song, Qiuxun Lin, Yifan Pan, Lijun Hou, Xiaofei Li, Min Liu

{"title":"Enhanced Coupling of Fe(II) Oxidation and Nitrate Reduction Benefits Chemoautotrophic Carbon Fixation in Estuarine and Coastal Sediments","authors":"Mengting Qi, Ye Li, Yuxuan Fu, Zhenyang Song, Qiuxun Lin, Yifan Pan, Lijun Hou, Xiaofei Li, Min Liu","doi":"10.1021/acs.est.5c05446","DOIUrl":"https://doi.org/10.1021/acs.est.5c05446","url":null,"abstract":"Fe(II) has exerted a profound impact on chemoautotrophic carbon fixation (CCF); however, how NO3– mediates Fe(II) oxidation and the CCF process in estuarine and coastal sediments remains poorly understood. Here, the coupling mechanisms of microbially mediated NO3–-reducing Fe(II) oxidation and the CCF process were examined through anoxic incubation experiments. Three field sites of Xitan, Dongtan, and Luchaogang spanning the environmental gradients of salinity, NO3–, and Fe(II) in the Yangtze Estuary were investigated. Microbial NO3– reduction was significantly enhanced in the presence of Fe(II), with accompanying yields of NO2– and N2O. The CCF rates increased by 4.3–31% under Fe(II) addition alone and increased by 69–156% under the combination of Fe(II) and NO3–, indicating that Fe(II) oxidation enhanced by NO3– reduction favors the chemoautotrophic process. Secondary bacteria-iron mineral complexes were produced during microbial NO3– reduction, facilitating cell encrustation formation and carbon preservation. Fe(II) and NO3– were observed to increase diversities and abundances of denitrifying and carbon-fixing communities, which were biological factors mediating the favored denitrification and CCF rates. In addition, the enhanced networks and connections of denitrifying and carbon-fixing communities suggested that Fe(II) could be a crucial intermediator linking denitrification and chemoautotrophic processes. These results highlighted that the enhanced coupling of Fe(II) oxidation and NO3– reduction benefits the chemoautotrophic process, which plays a crucial role in simultaneously alleviating nitrogen pollution and carbon emissions in estuaries and coastal environments.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"40 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145133459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Environmental Assessment of Three Urine Recycling Scenarios: Influence of Treatment Configurations and Life Cycle Modeling Approaches. 三种尿液回收方案的比较环境评估：处理配置和生命周期建模方法的影响。

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2025-09-24 DOI: 10.1021/acs.est.5c09248

Abdulhamid Aliahmad,Prithvi Simha,Björn Vinnerås,Jennifer McConville

{"title":"Comparative Environmental Assessment of Three Urine Recycling Scenarios: Influence of Treatment Configurations and Life Cycle Modeling Approaches.","authors":"Abdulhamid Aliahmad,Prithvi Simha,Björn Vinnerås,Jennifer McConville","doi":"10.1021/acs.est.5c09248","DOIUrl":"https://doi.org/10.1021/acs.est.5c09248","url":null,"abstract":"Urine recycling is an emerging promising approach for enhancing resource recovery and mitigating environmental impacts in sanitation systems. This study presents a comparative life cycle assessment (LCA) of a urine dehydration system implemented at three levels of decentralization: (i) toilet-level units within bathrooms; (ii) basement-level units serving multiple households; and (iii) centralized neighborhood-scale facilities using dedicated sewers for off-site processing. Each configuration is assessed using both consequential and attributional system models across five impact categories: global warming potential, acidification, freshwater and marine eutrophication, and cumulative energy demand. The basement-level system consistently shows the lowest impacts, with up to 50% lower global warming potential than the other configurations. Centralized treatment is the most energy-efficient per liter of urine treated, but the sewer infrastructure burden offsets this advantage. Sensitivity analysis shows that substituting sulfuric acid for citric acid and achieving >52% heat recovery can yield net-negative emissions at the basement level. The choice of the LCA system model strongly affects results: attributional with substitution yields net-negative impacts, whereas consequential provides more conservative but robust estimates. The findings underscore the need for methodological transparency in LCA and provide guidance for scaling sustainable decentralized urine recycling.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"38 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145127242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Solar Photovoltaic Development in West Africa Will Face Million-Ton Waste Challenges, and Off-Grid Systems Will Dominate. 西非太阳能光伏发展将面临百万吨废弃物的挑战，离网系统将占主导地位。

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2025-09-24 DOI: 10.1021/acs.est.5c06339

Di Dong,Onis Emem,Litao Liu,Burak Sen,Kasper Rasmussen,Norbert Edomah,Josephine Kaviti Musango,Yvette Baninla,Olga Sergienko,Gang Liu

{"title":"Solar Photovoltaic Development in West Africa Will Face Million-Ton Waste Challenges, and Off-Grid Systems Will Dominate.","authors":"Di Dong,Onis Emem,Litao Liu,Burak Sen,Kasper Rasmussen,Norbert Edomah,Josephine Kaviti Musango,Yvette Baninla,Olga Sergienko,Gang Liu","doi":"10.1021/acs.est.5c06339","DOIUrl":"https://doi.org/10.1021/acs.est.5c06339","url":null,"abstract":"Solar photovoltaic (PV), especially off-grid systems, is a low-hanging fruit option among various renewable energy technology choices to address universal energy access, energy security, and climate challenges for vulnerable regions like West Africa. West Africa dominates in the uptake of solar PV solutions, while little attention has been paid to the potential PV waste generation. In this study, we developed a technology-specific, prospective material flow analysis model to investigate material stocks and flows of both on-grid and off-grid solar PV systems for 15 West African countries up to 2050. We show that the cumulative solar PV waste generation ranges from 2.3 to 7.8 million tons by 2050 in West Africa under different scenarios, around 70% of which comes from off-grid PV systems. The potential secondary materials supply ranges from 213 to 704 kilotons, which have potential economic value amounting to 143-475 million dollars or material equivalent to produce 6-19 GW of solar PV capacity. These results call for urgent policy attention, technology development, and infrastructure investment for future PV waste management and highlight the significance of addressing off-grid PV waste in Africa.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"90 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145127265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Supply Chain Assessment of Water Scarcity and Management Measures in Chinese Cities Based on Water Quantity and Quality. 基于水量和水质的中国城市水资源短缺供应链评价及管理对策

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2025-09-23 DOI: 10.1021/acs.est.5c07293

Yunlei She,Jiayang Chen,Qi Zhou,Siyi Wei,Mimi Gong,Qianzi Wang,Ke Yu,Yuanzhen Li,Yong Zhao,Shen Qu

{"title":"Supply Chain Assessment of Water Scarcity and Management Measures in Chinese Cities Based on Water Quantity and Quality.","authors":"Yunlei She,Jiayang Chen,Qi Zhou,Siyi Wei,Mimi Gong,Qianzi Wang,Ke Yu,Yuanzhen Li,Yong Zhao,Shen Qu","doi":"10.1021/acs.est.5c07293","DOIUrl":"https://doi.org/10.1021/acs.est.5c07293","url":null,"abstract":"China is facing the dual pressure of water scarcity, in terms of both quantity and quality. Existing studies often ignore the monthly variation in water quality and lack an integrated prefectural-level assessment of quantity-quality-environmental flow requirement (EFR) water scarcity. Moreover, conventional methods for estimating water scarcity risk depend on subjective assumptions and ignore adaptive behaviors, limiting accuracy. This study developed a multiagent complex network model integrating monthly data on water quality from 3,646 national monitoring stations, municipal water use inventories, and EFR constraints to assess water scarcity-induced supply chain losses. Findings show that incorporating water quality restrictions increases water-scarce cities from 81 to 89, the shortage volume by 17.7%, and losses by 5%. Several cities, such as Lanzhou, Shanghai, Zhengzhou, and Taiyuan, have experienced a localized water scarcity with significant impacts. Water quality-related losses are concentrated in the industrialized northern plains. We evaluated three management strategies: water quality improvement, reclaimed water use, and the Water Diversion Project. Their combined implementation reduced water scarcity in 62 cities and generated benefits of 39-40.7 billion Chinese Yuan. This study quantifies the impacts of water scarcity on cross-regional and cross-sectoral supply chains and provides essential evidence for guiding sustainable and resilient water management.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"99 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145127270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Facet on Oxygen Vacancy Properties in δ-MnO2 for Stable and Efficient Catalytic Ozone Decomposition. Facet对δ-MnO2稳定高效催化臭氧分解氧空位性质的影响

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2025-09-23 DOI: 10.1021/acs.est.5c07382

Zhongyu Wang,Mingjia Zhang,Ting Li,Yuyan He,Shule Zhang,Qin Zhong

引用次数: 0

Prolonged Natural Attenuation of N-Nitrosamines in Groundwater–Soil Systems: Insights into Kinetics, Pathways, and Degradation Mechanisms from Microcosm Experiments 地下水-土壤系统中n -亚硝胺的长期自然衰减：微观实验对动力学、途径和降解机制的见解

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2025-09-23 DOI: 10.1021/acs.est.5c06810

Yingjie Chen, Jingxuan Xia, Huanfang Huang, Yang Ding, Yuanyu Shan, Shihua Qi, Guang-Guo Ying, Wenwen Chen, Jian-Liang Zhao

{"title":"Prolonged Natural Attenuation of N-Nitrosamines in Groundwater–Soil Systems: Insights into Kinetics, Pathways, and Degradation Mechanisms from Microcosm Experiments","authors":"Yingjie Chen, Jingxuan Xia, Huanfang Huang, Yang Ding, Yuanyu Shan, Shihua Qi, Guang-Guo Ying, Wenwen Chen, Jian-Liang Zhao","doi":"10.1021/acs.est.5c06810","DOIUrl":"https://doi.org/10.1021/acs.est.5c06810","url":null,"abstract":"Highly carcinogenic N-nitrosamines are frequently detected in groundwater, posing significant health risks to humans. However, knowledge of their attenuation characteristics and degradation mechanisms in the subsurface environment remains limited. Here, we conducted microcosm experiments to investigate the half-lives (T1/2s) of five representative N-nitrosamines in groundwater–soil systems under varying redox conditions, environmental matrices, and carbon source additions. The results revealed that the T1/2s of N-nitrosamines exceed 150 days in groundwater–soil systems with no contamination history and in groundwater environments without soil matrices. However, environmental matrices with long-term exposure to N-nitrosamine contamination demonstrated a shorter T1/2, ranging from a few to several dozen days. Moreover, N-nitrosamine decay rates under aerobic conditions were approximately twice those under anaerobic conditions. Microbial cometabolism was the primary removal mechanism, producing secondary amines, nitrate, and nitrite observed as intermediates, and ammonium as the main product. Variations in microbial community composition were observed across experimental conditions, underscoring the role of specific microbial taxa such as Nitrospirota, Patescibacteria, and Zixibacteria in the degradation process. By integrating product profiling with microbial analysis, this study offers a comprehensive mechanistic understanding of N-nitrosamine degradation. These findings offer insights for developing targeted remediation strategies to mitigate health risks from groundwater contamination.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"61 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145116696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Novel Framework for Airshed Delineation and PM2.5 Estimation across India Using Machine Learning and Spatial Clustering. 使用机器学习和空间聚类的印度空窗描绘和PM2.5估算新框架。

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2025-09-23 DOI: 10.1021/acs.est.5c10087

Mohd Zaid,Manoranjan Sahu

{"title":"A Novel Framework for Airshed Delineation and PM2.5 Estimation across India Using Machine Learning and Spatial Clustering.","authors":"Mohd Zaid,Manoranjan Sahu","doi":"10.1021/acs.est.5c10087","DOIUrl":"https://doi.org/10.1021/acs.est.5c10087","url":null,"abstract":"Air pollution continues to pose a major challenge in India, with PM2.5 being a key contributor to serious health risks. Its spatial distribution is influenced by climatic, topographic, and anthropogenic factors, which are often poorly represented in analyses limited to administrative boundaries. This study developed a novel framework for spatial airshed delineation to support effective air quality management. By integration of the PM2.5 concentration, meteorological data, and land characteristics with clustering algorithms, the study proposes seven major airsheds and five transitional regions across India to minimize inconsistencies between neighboring zones. The clustering patterns were found to be consistent across multiple years, allowing for standardized long-term management strategies. These airsheds also facilitated the identification of dominant pollution sources within each region. The national-level machine learning model using the random forest algorithm was developed using MERRA-2 reanalysis data and ground-based observations to estimate PM2.5 concentrations. Incorporating airshed-based clustering into model development significantly improved predictive performance, increasing the R2 from 0.71 to 0.80 and reducing the RMSE from 27.58 μg/m3 to 23.25 μg/m3. Overall, this study provides a robust, data-driven framework for airshed delineation and region-specific PM2.5 modeling, supporting more accurate, actionable, and localized air quality management strategies.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"58 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145127274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chain Length-Dependent Inhibition of Human and Rat Placental Aromatase by Benzalkonium Disinfectants: Experimental, Quantitative Structure-Activity Relationship, and In Silico Docking Insights. 苯扎康铵消毒剂对人和大鼠胎盘芳香酶的链长依赖性抑制：实验、定量构效关系和硅对接见解。

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2025-09-23 DOI: 10.1021/acs.est.5c05481

Yilin Xu,Xiulian Yang,He Zhu,Han Lu,Yunbing Tang,Yinghao Huang,Ren-Shan Ge,Yi Liu,Wei Chen

{"title":"Chain Length-Dependent Inhibition of Human and Rat Placental Aromatase by Benzalkonium Disinfectants: Experimental, Quantitative Structure-Activity Relationship, and In Silico Docking Insights.","authors":"Yilin Xu,Xiulian Yang,He Zhu,Han Lu,Yunbing Tang,Yinghao Huang,Ren-Shan Ge,Yi Liu,Wei Chen","doi":"10.1021/acs.est.5c05481","DOIUrl":"https://doi.org/10.1021/acs.est.5c05481","url":null,"abstract":"Benzalkonium chloride (BAC) compounds are a subclass of cationic surfactants widely used as disinfectants. The current research explored the inhibition of BACs on human and rat aromatase activity, revealing a structure-dependent mechanism. In human placental microsomes, BACs (C10, C12, C14, C16, and C18) significantly suppressed aromatase activity with IC50 and Ki values following the order C10 > C12 > C14 > C16 > C18, indicating that inhibitory potency increases with alkyl chain length. Enzyme kinetics and Lineweaver-Burk analyses suggested mixed/noncompetitive inhibition, where BACs bind both free enzyme and enzyme-substrate complexes. Similar trends were observed in rat aromatase, though only BAC-C12 and BAC-C14 showed significant inhibition. In human BeWo cells, BACs reduced estradiol secretion, with BAC-C12 exhibiting comparable inhibition to BAC-C18 despite lower aromatase inhibition in microsomes, suggesting that membrane permeability also influences cellular effects. Molecular docking revealed that BACs bind near the heme site, forming hydrogen bonds and HY interactions, with binding affinity increasing with chain length (ΔG: C10 > C12 > C14 > C16 > C18) against human aromatase. 3D-QSAR pharmacophore modeling identified HY regions as critical for inhibition of human aromatase. Pharmacokinetics predictions indicated poor intestinal absorption for BAC-C16 and BAC-C18, while BAC-C12 and BAC-C14 showed better solubility. These findings highlight the structural dependence of BAC-mediated aromatase inhibition, with implications for endocrine disruption risk assessment.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"23 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145127268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toxic Switch and Key Effectors of Cu in Zebrafish Gills: Coupling Single-Cell RNA Sequencing and Redox Imaging 斑马鱼鳃中Cu的毒性开关和关键效应物：单细胞RNA测序和氧化还原成像耦合

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2025-09-22 DOI: 10.1021/acs.est.5c05966

Wanying Gui, Wen-Xiong Wang

{"title":"Toxic Switch and Key Effectors of Cu in Zebrafish Gills: Coupling Single-Cell RNA Sequencing and Redox Imaging","authors":"Wanying Gui, Wen-Xiong Wang","doi":"10.1021/acs.est.5c05966","DOIUrl":"https://doi.org/10.1021/acs.est.5c05966","url":null,"abstract":"Copper (Cu) pollution poses a great threat to aquatic organisms, with gills serving as the primary interface for toxicant uptake and detoxification. However, the toxic switch leading to massive fish mortality under a low Cu burden in the fish gills remains unresolved. Here, we employed single-cell RNA sequencing (scRNA-seq) to systematically identify the Cu-sensitive cellular and molecular response mechanisms in zebrafish gills by focusing on the toxicity switch and key toxic effectors. Six cell populations significantly changed in the zebrafish gills after Cu exposure. Our results revealed that the Cu redox state switch controlled the activation process of Cu toxicity. This toxic switch involves macrophage, pillar, and HR cells, serving as central regulators through ESAM and COLLAGEN LT, and GALECTIN pathways. Cu redox state transformation gene (Steap4) and Cu transportation genes (Cox17 and slc31a) serve as the potential biomarkers of Cu pollution. The novel in situ fluorescence probes enabled simultaneous visualization of Cu(I)/Cu(II) spatial distribution, validating cluster-specific Cu redox states dynamics. The most prominent toxic effects observed were the respiratory inhibition and epithelial hyperplasia. Intriguingly, Cu overload reprogrammed intercellular communication networks with severe pathological injury. Overall, these findings illustrate an essential role of redox state switch in ecological risk of Cu in aquatic organisms.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"1 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145116698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Indoor Dust Increases the Risk of Iron-Loading Anemia in Mice through Exogenous Iron-Induced Ineffective Erythropoiesis 室内粉尘通过外源性铁诱导的无效红细胞生成增加小鼠铁负荷贫血的风险

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2025-09-22 DOI: 10.1021/acs.est.5c03663

Lingyu Ren, Guo Hou, Li Ma, Hao Wang, Tingting Ku, Guangke Li, Nan Sang

{"title":"Indoor Dust Increases the Risk of Iron-Loading Anemia in Mice through Exogenous Iron-Induced Ineffective Erythropoiesis","authors":"Lingyu Ren, Guo Hou, Li Ma, Hao Wang, Tingting Ku, Guangke Li, Nan Sang","doi":"10.1021/acs.est.5c03663","DOIUrl":"https://doi.org/10.1021/acs.est.5c03663","url":null,"abstract":"Humans spend most of their time indoors, coming into contact with various pollutants through indoor dust. Emerging epidemiological evidence suggests that indoor dust is a potential influencing factor for hematologic disorders, especially anemia. However, the causal relationship between indoor dust and the occurrence of anemia, as well as the underlying mechanisms and the role of its components, remains unclear. In this study, we collected indoor dust samples from an industrial city in northern China to set up a mouse inhalation model at environment-related concentrations and found that the dust exposure increased the risk of anemia by disrupting hematopoietic stem cell differentiation and erythrocyte maturation in the bone marrow (BM), leading to a decreased number of mature erythrocytes in the peripheral blood. Mechanistically, we clarified that these BM hematopoietic disorders arose from iron metabolism disorders, including iron overload and diminished levels of divalent metal transporter 1, transferrin receptor, and ferroportin in the lungs and BM. Furthermore, using stable isotope tracing, we identified that the elevated levels of iron in the lungs partially originated from abiogenic natural particulate matter, indicating that iron in indoor dust could enter the body, leading to iron overload and an increased risk of anemia. These findings provide evidence for understanding the potential risk of anemia induced by exposure to iron-containing indoor dust.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"35 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145116697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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