环境科学与技术最新文献

{"title":"Biogeochemical Controls on Latitudinal (42°N to 70°S) and Depth Distribution of Organophosphate Esters in the Atlantic and Southern Oceans.","authors":"Núria Trilla-Prieto, Naiara Berrojalbiz, Jon Iriarte, Antonio Fuentes-Lema, Cristina Sobrino, Maria Vila-Costa, Begoña Jiménez, Jordi Dachs","doi":"10.1021/acs.est.4c12555","DOIUrl":"10.1021/acs.est.4c12555","url":null,"abstract":"<p><p>Large-scale oceanic assessments are key for determining the persistence and long-range transport potential of organic pollutants, but there is a dearth of these for organophosphate esters (OPEs), widely used as flame retardants and plasticizers. This work reports the latitudinal distribution (42°N-70°S) and vertical profiles (from the surface to 2000 m depth) of OPEs in the Atlantic and Southern Oceans and explores their biogeochemical controls. The latitudinal gradient shows higher surface OPE concentrations near the equator than at higher latitudes, consistent with the prevailing oceanic and atmospheric circulation, and measured wet deposition events. At the deep chlorophyll maximum depth, there was an inverse correlation between the concentrations of the OPEs and phytoplankton biomass, with the lowest concentrations in the Southern Ocean, consistent with the role of the biological pump depleting the levels of the OPEs from the photic zone. OPE latitudinal trends in the deep ocean (2000 m depth) resembled those at the surface with maximum intertropical concentrations. Analysis derived from OPE concentrations at the bottom of the photic zone and in the minimum oxygen layer suggested a complex dynamic biogeochemical cycling driven by transport, degradation, and redissolution of OPEs with depth. OPEs are persistent enough to reach all oceanic compartments, but a quantitative resolution of the sources, sinks, seasonality, and biogeochemical cycles will require future research.</p>","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":" ","pages":"5585-5595"},"PeriodicalIF":10.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emission of Perfluoroalkyl Acids and Perfluoroalkyl Ether Carboxylic Acids to the Atmosphere from a Fluorochemical Industrial Park in China","authors":"Bo Sha, Joost Dalmijn, Jana H. Johansson, Matthew E. Salter, Ian T. Cousins","doi":"10.1021/acs.est.4c11394","DOIUrl":"https://doi.org/10.1021/acs.est.4c11394","url":null,"abstract":"This study investigated the particle size distribution and atmospheric transport potential of perfluoroalkyl carboxylic acids (PFCAs) and certain perfluoroalkyl ether carboxylic acids (PFECAs) emitted from a mega fluoropolymer industrial park (FIP) in China. Ambient aerosols sampled in a residential area near the FIP were separated by a cascade impactor into five size fractions (&lt;0.15 to 12.15 μm). Homologues of PFCAs (C5–C11) and five PFECAs were frequently detected in the samples (detection frequencies 40–100%), albeit not in all size fractions. Perfluorooctanoic acid (PFOA) exhibited the highest concentrations (6.5 to 2900 pg m^–3). A noticeable mass mode in the &gt;1 μm size range was observed for PFCAs and PFECAs in the samples that were directly influenced by wind from the direction of the FIP. Based on the PFOA concentrations in the aerosol samples, the emission rate of PFOA to air from the FIP was estimated to be 0.4–1.3 t year^–1. Modeling results demonstrated that around 67% of the PFOA air emission was transported in the atmosphere above 1500 m in a 7 day continuous emission scenario, implying that the PFOA on &lt;12.15 μm particles undergoes long-range atmospheric transport after being emitted from the FIP.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"14 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143695538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sulfamethoxazole Transformation by Heat-Activated Persulfate: Linking Transformation Products Patterns with Carbon and Nitrogen Isotope Fractionation.","authors":"Xiao Liu, Jimmy Köpke, Caglar Akay, Steffen Kümmel, Gwenaël Imfeld","doi":"10.1021/acs.est.4c09732","DOIUrl":"10.1021/acs.est.4c09732","url":null,"abstract":"<p><p>Sulfamethoxazole (SMX) is a frequently detected antibiotic in groundwater, raising environmental concerns. Persulfate oxidation is used for micropollutant removal. To investigate SMX transformation by persulfate, experiments were conducted using heat-activated persulfate at pH 3, 7, and 10. TP269a (SMX-hydroxylamine) and TP178 were identified as the dominant TPs across the pH levels. The exclusive formation of 4-nitroso-SMX, 4-nitro-SMX, and TP518 at pH 3 highlighted the role of SO₄^•- in attacking the NH₂. At pH 7 and 10, 3A5MI emerged as the dominant TP. Carbon isotopic fractionation (ε_C = -1.3 ± 0.5‰, -1.1 ± 0.4‰, and -1.1 ± 0.3‰ at pH 3, 7, and 10) remained consistent across pH levels, caused by the formation of TP178 involving C-S bond cleavage. An inverse nitrogen isotope fractionation at pH 3 (ε_N = +0.68 ± 0.11‰) was associated with SO₄^•--induced single-electron transfer. Conversely, normal nitrogen isotope fractionation at pH 10 (ε_N = -0.27 ± 0.04‰) was associated with N-H bond cleavage by H abstraction through HO^• and N-S bond cleavage. The inverse nitrogen isotope fractionation at pH 7 indicated that the dominant pathway involved SO₄^•- reactions, accounting for 74%. Overall, the results highlight the potential of CSIA to elucidate SMX oxidation pathways.</p>","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":" ","pages":"5704-5714"},"PeriodicalIF":10.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic Accounting of Carbon Uptake in the Built Environment","authors":"Elisabeth Van Roijen, Seth Kane, Jin Fan, Josefine A. Olsson, Baishakhi Bose, Thomas P. Hendrickson, Sarah L. Nordahl, Alissa Kendall, Corinne D. Scown, Sabbie A. Miller","doi":"10.1021/acs.est.5c00080","DOIUrl":"https://doi.org/10.1021/acs.est.5c00080","url":null,"abstract":"Transforming building materials from net life-cycle CO₂e emitters to carbon sinks is a key pathway towards decarbonizing the industrial sector. Current life-cycle assessments of materials (particularly “low-carbon” materials) often focus on cradle-to-gate emissions, which can exclude emissions and uptake (i.e., fluxes) later in the materials’ life-cycle. Further, conventional CO₂e emission characterization disregards the dynamic effects of the timing of emissions and uptake on cumulative radiative forcing from processes like manufacturing, biomass growth, and the decadal carbon storage in long-lived building materials. This work presents a framework to analyze the cradle-to-grave CO₂e balance of building materials using a time-dependent global warming potential calculation. We apply this framework in the dynamic accounting of carbon uptake in the built environment (D-CUBE) tool and examine two case studies: concrete and cross-laminated timber (CLT). When accounting for dynamic effects, the long storage time of biogenic carbon in CLT results in reduced warming, while the slow rate of uptake via concrete carbonation does not result in significant reductions in global warming. The D-CUBE tool allows for consistent comparisons across materials and emissions mitigation strategies at varying life-cycle stages and can be adapted to other materials or systems with different lifespans and applications. The flexibility of D-CUBE and the ability to identify CO₂e emission hot-spot life-cycle stages will be instrumental in identifying pathways to achieving net-carbon-sequestering building materials.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"99 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143703139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peroxide Disinfection of Vesicle-Cloaked Murine Norovirus Clusters: Vesicle Membranes Protect Viruses from Inactivation","authors":"Zhenzhen He, Dongxue Wang, Jiahao Chen, Xin Hu, Danmeng Shuai","doi":"10.1021/acs.est.4c13695","DOIUrl":"https://doi.org/10.1021/acs.est.4c13695","url":null,"abstract":"Vesicle-cloaked virus clusters, also known as viral vesicles, exhibit higher infectivity than free viruses and demonstrate persistence in the environment as well as resilience against disinfection. These emerging pathogens represent significant, yet often underestimated, health risks. Our study investigated peroxide disinfection of murine norovirus vesicles, a surrogate for human norovirus vesicles, and elucidated disinfection mechanisms. Peracetic acid, a neutral peroxide, rapidly inactivated murine norovirus vesicles. In contrast, negatively charged peroxides, i.e., peracetate and peroxymonosulfate, exhibited restricted effectiveness in inactivating murine noroviruses within vesicles. The largely intact viruses cloaked within vesicles remained infectious and retained their ability to replicate upon vesicle lysis triggered by mechanical forces, enzymatic activity, or chemical reactions following disinfection. Peroxides primarily targeted vesicle/viral proteins, particularly amino acid residues such as cysteine and methionine, without affecting the viral ORF2 gene fragment or vesicle structures. Disruption of viral internalization, rather than binding, plays a key role in infectivity loss. This work highlights the protective role of vesicle membranes and emphasizes the need for innovative disinfection approaches to effectively target viruses cloaked within vesicles.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"375 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143695815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental Exposure, Epitranscriptomic Perturbations, and Human Diseases","authors":"Songbo Wei, Huan-Yu Tao, Zheng Duan, Yinsheng Wang","doi":"10.1021/acs.est.5c00907","DOIUrl":"https://doi.org/10.1021/acs.est.5c00907","url":null,"abstract":"Epitranscriptomics is a rapidly evolving field, and it examines how chemical modifications on RNA regulate gene expression. Increasing lines of evidence support that exposure to various environmental agents can change substantially chemical modifications on RNA, thereby perturbing gene expression and contributing to disease development in humans. However, the molecular mechanisms through which environmental exposure impairs RNA modification-associated proteins (“reader”, “writer”, and “eraser” or RWE proteins) and alters the landscape of RNA modifications remain poorly understood. Here, we provide our perspectives on the current knowledge about how environmental exposure alters the epitranscriptome, where we focus on dynamic changes in RNA modifications and their regulatory proteins elicited by exposure to environmental agents. We discuss how these epitranscriptomic alterations may contribute to the development of human diseases, especially neurodegeneration and cancer. We also discuss the potential and technical challenges of harnessing RNA modifications as biomarkers for monitoring environmental exposure. Finally, we emphasize the need to integrate multiomics approaches to decipher the complex interplay between environmental exposure and the epitranscriptome and offer a forward-looking viewpoint on future research priorities that may inform public health interventions and environmental regulations.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"2 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143678072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanistic Insights into the Inhibitory Role of Soil Humic Components in Iron (Oxyhydr)oxide Formation: From In Situ Kinetics to Molecular Thermodynamics","authors":"Xinfei Ge, Xin Xiao, Yuyao Zhang, Xiaoying Zhu, Chiheng Chu, Baoliang Chen","doi":"10.1021/acs.est.4c12300","DOIUrl":"https://doi.org/10.1021/acs.est.4c12300","url":null,"abstract":"Due to the close spatial proximity and strong reactivity, soil humic components inevitably participate in iron (Fe) (oxyhydr)oxide formation, holding significant importance in contaminant immobilization, carbon cycling, and nutrient availability. Yet, the regulatory role of different humic components involved in the initial formation of Fe (oxyhydr)oxides is still lacking. In this study, we identified the characteristic formation periods of ferrihydrite (Fh), the initial phase of Fe (oxyhydr)oxides, through real-time monitoring of solution pH and in situ observations of precipitated Fh nanoparticles in the absence and presence of different humic components. The kinetics of Fh formation were quantified at micrometer and nanometer scales using Raman spectroscopy (RS) and atomic force microscopy (AFM), respectively. Results indicated that the extension of induction time, retardation of phase occurrence, and inhibition of nucleation rates for Fh formation were all dependent on the specific humic component with an order of fulvic acid (FA) &gt; humic acid (HA) &gt; humin (HM). Nanoscale data analysis revealed that the thermodynamic barrier to Fh nucleation increased by maximizing the interfacial free energy (γ) of the reaction system. Through molecular bonding quantification, AFM-based dynamic force spectroscopy (DFS) measurements demonstrated a linear relationship between Gibbs free energies (Δ<i>G</i>_b) of soil organic matter (SOM) binding to Fh and γ within the classical nucleation theory (CNT), linking heterogeneous nucleation barriers with organo-mineral bonding. This study is the first to provide in situ evidence of the inhibitory effects of soil humic components on the formation of Fe (oxyhydr)oxides and quantitatively establish that higher energy barriers to nucleation correlate with stronger organo-mineral bonding. This relationship suggests that good organic binders are good inhibitors for mineral formation, offering a novel perspective for predicting the formation and fate of soil minerals through the lens of organo-mineral binding free energies.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"29 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143695644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decidual Disrupting Effects of Low-Dose Benzophenone-Type UV Filters in Human Endometrial Stromal Cells via ER/PR/FOXO1 Signaling","authors":"Tingjie Zhan, Lilai Shen, Yuyao Zhang, Fang Wan, Yu Qiu, Qinyang Jin, Yiqu Wu, Yizhou Huang, Shulin Zhuang","doi":"10.1021/acs.est.4c13355","DOIUrl":"https://doi.org/10.1021/acs.est.4c13355","url":null,"abstract":"Exposure to endocrine disrupting chemicals (EDCs), particularly benzophenone (BP)-type UV filters, has been epidemiologically linked to endometrium-related reproductive risks in women. However, their effects on hormone-driven endometrial events and key receptor signaling at the human cellular level remain unexplored. Herein, using human primary endometrial stromal cells (HESCs), we investigated the disrupting effects of five BP congeners and deciphered the underlying mechanism on decidualization, a functional change of the endometrium preparing for pregnancy. BP-8, its two metabolites, BP-3, and BP-1 at 10 nM significantly disrupted progesterone-dependent decidualization in HESCs, marked by 1.5–1.8-fold and 2.2–2.6-fold upregulation of <i>IGFBP-1</i> and <i>LEFTY</i>, respectively. Decidual transcriptional activators, WNT-FOXO1, were significantly induced by BPs, which are implicated in G2 phase cell arrest (from 3.26% to 8.93%) and apoptosis (from 12.29% to 25.61%). Mechanistically, the inhibition of estrogen receptor α (ERα) effectively alleviated these decidual disrupting effects. BPs increased the transcription of ERα and progesterone receptor (PR) signaling and enhanced nuclear translocation and interaction between ERα and PR during decidualization. The ERα-mediated enhancement of PR signaling activity by BPs was further validated in progesterone response element-luciferase transfected cells. Collectively, our findings elucidate the molecular pathway through which BPs disrupt endometrial decidualization via ERα/PR/FOXO1, providing critical mechanistic insights for the reproductive risk assessment of BPs and structurally related EDCs.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"41 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143695646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detoxification Strategy of Titanium Oxide Nanoparticles Driving Endogenous Molecules Metabolism to Modulate Atrazine Conversion in Lactuca sativa L.","authors":"Yuzhu Weng, Xue Bai, Mengen Kang, Yetong Ji, Haoke Wang, Yi Liu","doi":"10.1021/acs.est.4c12333","DOIUrl":"https://doi.org/10.1021/acs.est.4c12333","url":null,"abstract":"Nanoparticles (NPs) exhibit the potential to enhance plant tolerance to organic pollutant stress, but how they drive endogenous molecules to detoxify contaminants remains to be further investigated. This study clarified the modulatory mechanisms by which foliar or root application of biosynthesized titanium oxide NPs (g-nTiO₂) alleviated atrazine (ATZ) toxicity to <i>Lactuca sativa</i> L. Compared with the ATZ-alone group, 10 mg/L g-nTiO₂ intensified light-harvesting, photoelectron transfer, and reduced oxidative damage, thereby improving growth and inducing metabolic reprogramming. Specifically, g-nTiO₂ activated pathways related to energy supply and defense detoxification, while stabilizing membrane lipid and nitrogen metabolism. Furthermore, the modulation of biomarkers involved in balancing cellular homeostasis and stimulating growth by g-nTiO₂ ultimately boosted lettuce resistance to ATZ and physiological performance. Molecular docking analysis revealed that g-nTiO₂ enhanced the Phase II metabolism of ATZ by glutathione and amino acids through increasing detoxification enzyme activities by 23–44%, which confirmed the driving role of NPs in alleviating ATZ phytotoxicity to lettuce. Collectively, these findings provide a prospective nanoenabled strategy for mitigating crop sensitivity to pesticide residues for safe and sustainable agricultural production.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"9 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143695701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustainable Food Waste Management in Anaerobic Digesters: Prediction of the Organic Load Impact by Metagenome-Scale Metabolic Modeling","authors":"Esteban Orellana, Guido Zampieri, Nicola De Bernardini, Leandro D. Guerrero, Leonardo Erijman, Stefano Campanaro, Laura Treu","doi":"10.1021/acs.est.4c11180","DOIUrl":"https://doi.org/10.1021/acs.est.4c11180","url":null,"abstract":"The increasing urbanization has led to rising waste and energy demands, necessitating innovative solutions. A sustainable food waste management approach involves anaerobic codigestion with sewage sludge, enhancing biogas production while managing waste. Although this technology has been successfully tested, the biological mechanisms determining its efficiency are still poorly understood. This study leverages genome-scale metabolic modeling of 138 metagenome-assembled genomes to explore species interactions in lab-scale anaerobic reactors fed with sewage sludge to increasing proportions of food waste. The models showed positive correlations with experimental biogas production (CH₄: <i>r</i> = 0.54, CO₂: <i>r</i> = 0.66), validating their reliability. The dominant methanogen, <i>Methanothrix</i> sp., adapted its metabolism based on feedstock, affecting methane yields, which ranged from 2.5 to 3 mmol/g of volatile solids·h with sewage sludge to 10–14 mmol/g of VS·h with high food waste. The integration of extracellular enzymes into the models highlighted the role in methane production of pectin degradation, protein hydrolysis, and lipid metabolism, mediated by <i>Proteiniphilum</i> sp., Kiritimatiellae sp., and Olb16 sp. The study identified 475 mutualistic interactions involving amino acid, hydrogen, acetate, and phosphate exchange and 44 competitive interactions in hydrolytic and fermentative processes. These insights can help optimize anaerobic digestion and sustainable waste management in urban settings.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"71 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143695643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}