IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2025-09-26 DOI: 10.1021/acs.est.5c07557

Bin Chen,Hong Chen,Zhishan Quan,Wei He,Visakan Kadirkamanathan,Jose L Casamayor,Wei W Xing

{"title":"SemaNet: Bridging Words and Numbers for Predicting Missing Environmental Data in Life Cycle Assessment.","authors":"Bin Chen,Hong Chen,Zhishan Quan,Wei He,Visakan Kadirkamanathan,Jose L Casamayor,Wei W Xing","doi":"10.1021/acs.est.5c07557","DOIUrl":"https://doi.org/10.1021/acs.est.5c07557","url":null,"abstract":"Life Cycle Assessment (LCA) is one of the most used methodologies for evaluating environmental impact, but its effective application is severely limited by missing data, an issue that existing methods for Life Cycle Inventory (LCI) data completion cannot address effectively. This paper proposes a paradigm shift: rather than depending exclusively on numerical correlations, we leverage the extensive contextual information inherent in process descriptions via pretrained language models, establishing a semantic bridge between qualitative descriptions and quantitative environmental flows. Our semantic-based neural network framework, SemaNet, achieves superior performance in predicting missing LCI values, surpassing existing state-of-the-art methods in various evaluation metrics. The results are significant: while existing approaches fail completely under high data sparsity, our method achieves high accuracy even with 100% missing numerical data while reducing computational requirements by 99% through the use of semantic filtering. This new method for LCI data completion significantly reduces the data collection efforts and time for LCA practitioners, making reliable and faster environmental impact assessment feasible, even when primary data does not exist, thus facilitating reliable sustainability assessment across industrial sectors.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"11 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photodegradation Driven by Visible Light Exceeds Biodegradation across a Range of Environmental Conditions during the Initial Hours after an Oil Spill. 在石油泄漏后的最初几个小时内，由可见光驱动的光降解在一系列环境条件下超过生物降解。

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2025-09-26 DOI: 10.1021/acs.est.5c06941

Alice C Ortmann,Brian Robinson,Ho-Yin Poon,Thomas L King

{"title":"Photodegradation Driven by Visible Light Exceeds Biodegradation across a Range of Environmental Conditions during the Initial Hours after an Oil Spill.","authors":"Alice C Ortmann,Brian Robinson,Ho-Yin Poon,Thomas L King","doi":"10.1021/acs.est.5c06941","DOIUrl":"https://doi.org/10.1021/acs.est.5c06941","url":null,"abstract":"Degradation of oil compounds, mediated by microbes or abiotic factors, after a spill into aquatic environments is important for ecosystem recovery; however, factors controlling these processes in natural waters remain poorly characterized. Six experiments representing a range of environmental conditions measured the loss of n-alkanes and polycyclic aromatic compounds (PACs) from a crude oil over 72 h due to biodegradation and abiotic processes when exposed to visible light. On average, 22.8% (±12.6) of n-alkanes and 32.7% (±14.0) of PACs were removed in the live incubations compared to 19.1% (±19.3) of n-alkanes and 31.7% (±12.3) of PACs when microbial activity was inhibited by the addition of mercuric chloride. Substantial biodegradation was only observed in the warm, freshwater incubation. Additional experiments determined that most of the abiotic degradation could be attributed to photodegradation mediated by visible light. No clear link was observed between the environmental conditions and abiotic losses of oil compounds, indicating complex interactions between light, photosensitizers, and organisms. These experiments demonstrate that a significant proportion of the n-alkanes and PACs may be removed from a surface oil spill through photodegradation mediated by both visible and UV light, along with biodegradation, within a few days.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"86 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydrophilicity and Material Type Govern the Aqueous Release of Rubber-Derived Chemicals: Insights from Extractables and Leachables of Road-Related Materials. 亲水性和材料类型决定橡胶衍生化学品的水释放：来自道路相关材料的可萃取物和可浸出物的见解。

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2025-09-26 DOI: 10.1021/acs.est.5c09371

Yue-Hong Liu,Yu-Xian Mei,Zheng Huang,Xiang-Ming Zheng,Min Huang,Hai-Yan Zhang,Jian-Liang Zhao,Guang-Guo Ying

{"title":"Hydrophilicity and Material Type Govern the Aqueous Release of Rubber-Derived Chemicals: Insights from Extractables and Leachables of Road-Related Materials.","authors":"Yue-Hong Liu,Yu-Xian Mei,Zheng Huang,Xiang-Ming Zheng,Min Huang,Hai-Yan Zhang,Jian-Liang Zhao,Guang-Guo Ying","doi":"10.1021/acs.est.5c09371","DOIUrl":"https://doi.org/10.1021/acs.est.5c09371","url":null,"abstract":"Rubber-derived chemicals (RDCs) are primarily released into the environment from tires, posing significant risks to the ecosystem. However, there is limited knowledge about the emerging RDC components and release from a broader range of road-related materials. In the current study, we performed a comprehensive investigation into the RDC formulations and leaching behaviors of six road-related materials. The mass fraction in extractables followed the descending order: tires (average ∑35RDC 1080 μg/g) > speed bumps (90.3 μg/g) > traffic cones (37.4 μg/g) > water pipes (4.25 μg/g) > asphalt concrete (0.37 μg/g) > foam boards (0.33 μg/g). N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine, 1,3-benzothiazole, and N,N'-dicyclohexylurea emerged as the top three RDCs. While RDCs in leachables exhibited lower levels, the average leaching ratios from tires, speed bumps, water pipes, and asphalt concrete into rainwater exceeded 65%, indicating substantial leaching potential. The hydrophilicity (log KOW) of RDCs played a key role in their leaching behavior, with compounds exhibiting lower log KOW values demonstrating higher leaching efficiency. The annual emissions of tire wear particles and RDCs thereof in China were estimated at 1,282,537 and 1385 tons, respectively. Our study illustrated that road-related materials are crucial contributors to urban RDC pollution, highlighting the urgent need for developing environmentally friendly materials.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"42 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-Term Exposure to Ultrafine Particulate and Cardiovascular Diseases: A Large-Scale, Multicenter Study in China. 中国长期接触超细颗粒物与心血管疾病：一项大规模、多中心的研究

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2025-09-26 DOI: 10.1021/acs.est.5c02544

Tingting Yang,Yixiang Zhu,Renhua Zhang,Jianqin Zhong,Zixuan Xu,Leilei Liu,Cong Liu,Renjie Chen,Qiaolan Liu,Yuemei Feng,Yi Liu,Duoji Zhuoma,Deqiang Mao,Haidong Kan,Feng Hong

{"title":"Long-Term Exposure to Ultrafine Particulate and Cardiovascular Diseases: A Large-Scale, Multicenter Study in China.","authors":"Tingting Yang,Yixiang Zhu,Renhua Zhang,Jianqin Zhong,Zixuan Xu,Leilei Liu,Cong Liu,Renjie Chen,Qiaolan Liu,Yuemei Feng,Yi Liu,Duoji Zhuoma,Deqiang Mao,Haidong Kan,Feng Hong","doi":"10.1021/acs.est.5c02544","DOIUrl":"https://doi.org/10.1021/acs.est.5c02544","url":null,"abstract":"Ultrafine particulate matter (UFP) has been identified as a significant environmental risk for public health, yet the cardiovascular effects of long-term UFP exposure have been insufficiently explored. This study based on data from 98,797 participants across five provinces/regions in southwest China and UFP data from a high-resolution atmospheric chemistry model examined the associations between long-term UFP exposure and the prevalence of cardiovascular diseases (CVDs) in China. The findings reveal elevated prevalence of total and specific CVDs associated with a 3-year average UFP exposure. Specifically, the odds ratio for total CVDs was 1.17 (95% CI: 1.09, 1.24) for each interquartile range increase (5667 particles/cm3) in the 3-year average of UFP exposure. Additionally, UFP exposure was associated with significant increases in the prevalence of stroke (33%), coronary heart disease (19%), and hypertension (11%). The exposure-response relationships indicate no threshold for the cardiovascular effects of UFP exposure with linear increases in risks even at lower exposure levels. Older populations, minority groups, and urban residents experience a higher prevalence of CVDs associated with long-term UFP exposure. This large-scale, multicenter study in China provides novel epidemiological evidence that long-term UFP exposures increase the prevalence of total and several specific CVDs. The findings address a critical gap in understanding the cardiovascular effects of UFPs in developing countries with high exposure levels.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"53 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrating Dam-Induced Effects into a Bayesian eDNA-Hydrodynamic Model to Improve Fish Monitoring in Regulated Rivers 将大坝诱导效应纳入贝叶斯edna -水动力模型以改善管制河流鱼类监测

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2025-09-25 DOI: 10.1021/acs.est.5c08083

Yanqi Wu, Yuan Zhang, Fen Guo, Bo Li, Qingping Du, Wei Gao, Xinfei Zhang, Jiezhang Mo, Feilong Li

{"title":"Integrating Dam-Induced Effects into a Bayesian eDNA-Hydrodynamic Model to Improve Fish Monitoring in Regulated Rivers","authors":"Yanqi Wu, Yuan Zhang, Fen Guo, Bo Li, Qingping Du, Wei Gao, Xinfei Zhang, Jiezhang Mo, Feilong Li","doi":"10.1021/acs.est.5c08083","DOIUrl":"https://doi.org/10.1021/acs.est.5c08083","url":null,"abstract":"Dam-induced hydrological changes threaten river biodiversity, underscoring the need for accurate monitoring. Environmental DNA (eDNA) offers a sensitive, noninvasive tool, but most studies overlook dam-driven flow and sediment alterations. Integrating eDNA with hydrological models that account for regulation is crucial to improve biodiversity assessments and guide conservation in modified rivers. Here, we developed a Bayesian framework that integrates prior knowledge of fish eDNA characteristics with hydrodynamic modeling and species distribution modeling, explicitly incorporating dam-induced effects on eDNA settling. Our analysis revealed that 98.8% of fish eDNA-adsorbing particles were ≤30 μm, exhibiting sedimentation velocities between 0.001 and 0.403 mm/s. Mean settling velocities differed markedly between reaches, averaging 0.041 in nondammed sections and 0.073 mm/s under dam influence. Incorporating decay rates and settling velocities into the Bayesian model improved the spatial accuracy of fish genus presence prediction. Relative to conventional hydrological models that do not incorporate dam effects, our approach yielded a 18.3–22.9% gain in predictive performance, with model outputs showing strong concordance with both observed fish distributions and environmental covariate responses. Overall, this study introduces a process-based framework addressing eDNA transport uncertainties in regulated rivers, incorporating hydraulic effects probabilistically, it improves ecological reliability of eDNA monitoring and supports targeted conservation under anthropogenic flow alteration.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"154 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single Species In Vitro Assays with Nitrifying Bacteria and Archaea for Assessing the Toxicity of Pesticides on Soil Microorganisms 硝化细菌和古细菌单种体外试验评价农药对土壤微生物的毒性

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2025-09-25 DOI: 10.1021/acs.est.5c02995

Eleftheria Bachtsevani, Maria Kolovou, Evangelia S. Papadopoulou, Dimitrios G. Karpouzas, Graeme W. Nicol, Christina Hazard

{"title":"Single Species In Vitro Assays with Nitrifying Bacteria and Archaea for Assessing the Toxicity of Pesticides on Soil Microorganisms","authors":"Eleftheria Bachtsevani, Maria Kolovou, Evangelia S. Papadopoulou, Dimitrios G. Karpouzas, Graeme W. Nicol, Christina Hazard","doi":"10.1021/acs.est.5c02995","DOIUrl":"https://doi.org/10.1021/acs.est.5c02995","url":null,"abstract":"Single species tests on surrogate organisms from different trophic levels constitute a cornerstone in aquatic and terrestrial ecotoxicology, representing a major tool for assessing pesticide ecotoxicity. However, there are no assays approved under the EU regulatory framework that specifically target soil microorganisms, despite their pivotal role in ecosystems. This study evaluated the toxicity of pesticides on ammonia-oxidizing microorganisms (AOM), recognized as potential indicators of pesticide toxicity in soil, using a single species in vitro testing system. We assessed the toxicity of ten pesticides of major categories (insecticides, fungicides, herbicides) on a range of ammonia-oxidizing bacteria (AOB), ammonia-oxidizing archaea (AOA) and functionally associated nitrite-oxidizing bacteria (NOB) in liquid cultures, representing all major soil lineages of both groups. Toxicity end points (EC50) were calculated for each strain–pesticide combination. Nitrosotalea sinensis ND2, Nitrosospira briensis and Candidatus Nitrobacter laanbroekii NHB1 were the most sensitive AOA, AOB and NOB, respectively. Fungicides and insecticides were more toxic to AOM than NOB, whereas herbicides had a wide range of toxicity across all groups of nitrifiers. Our study introduces a novel testing approach that includes a range of phylogenetically and ecophysiologically distinct nitrifier strains for assessing pesticides toxicity on soil microorganisms that could potentially, upon standardization, serve as a tier I assay in environmental risk analysis.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"14 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145133456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiscale-Information-Embedded Universal Toxicity Prediction Framework 多尺度信息嵌入通用毒性预测框架

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2025-09-25 DOI: 10.1021/acs.est.5c04614

Lianlian Wu, Fanmeng Wang, Yixin Zhang, Ruijiang Li, Yanpeng Zhao, Hongteng Xu, Zhifeng Gao, Song He, Xiaochen Bo

{"title":"Multiscale-Information-Embedded Universal Toxicity Prediction Framework","authors":"Lianlian Wu, Fanmeng Wang, Yixin Zhang, Ruijiang Li, Yanpeng Zhao, Hongteng Xu, Zhifeng Gao, Song He, Xiaochen Bo","doi":"10.1021/acs.est.5c04614","DOIUrl":"https://doi.org/10.1021/acs.est.5c04614","url":null,"abstract":"Hazard identification and labeling of industrial chemicals and their released environmental pollutants are crucial for mitigating ecological and health risks. Comprehensive evaluation of multiple toxicity end points is essential to fully characterize chemical hazards. Existing deep-learning-based toxicity prediction models often exhibit poor generalizability, especially for rare toxicities with sparse data. Most studies fail to capture the three-dimensional (3D) spatial arrangement and stereochemical properties of chemicals, as well as the interrelated nature among end points, hindering accurate toxicity profiling. Here, we propose ToxScan, an SE(3)-equivariant multiscale model, as a universal toxicity prediction framework to address these issues. It incorporates 3D geometry information through a two-level molecular and atomic representation learning protocol. A parallel multiscale modeling and a multitask learning scheme are applied to learn universal toxicological characteristics. Results show that ToxScan achieves 7.8–37.6% improvements over state-of-the-art models for medium-/small-scale end points, demonstrates differentiation of structural analogues with contrasting toxicities, and maintains generalizability to environmental pollutants. Interpretability analysis at the atomic and molecular levels reveals identifiable atomic interaction patterns and potential structural alerts. Case studies reveal its capacity to detect subtle structural determinants while elucidating the mechanisms of pollutants. To facilitate user accessibility, we provide an intuitive web platform (https://funmg.dp.tech/Toxscan) for the rapid prediction of multiple toxicity end points of new compounds.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"61 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of As(III) Methyltransferases and Radical S-Adenosylmethionine Enzymes As（III）甲基转移酶与s -腺苷甲硫氨酸自由基酶的关联

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2025-09-25 DOI: 10.1021/acs.est.5c05830

Jian Chen, Thiruselvam Viswanathan, Barry P. Rosen

{"title":"Association of As(III) Methyltransferases and Radical S-Adenosylmethionine Enzymes","authors":"Jian Chen, Thiruselvam Viswanathan, Barry P. Rosen","doi":"10.1021/acs.est.5c05830","DOIUrl":"https://doi.org/10.1021/acs.est.5c05830","url":null,"abstract":"Microbial arsenic methylation catalyzed by the enzyme arsenite (As(III)) S-adenosylmethionine methyltransferase (ArsM) plays a pivotal role in the arsenic biogeochemical cycle. This produces methylated species and, when coupled with radical SAM (rSAM) enzymes, produces more complex compounds such as arsenosugars and the antibiotic arsinothricin (AST). In this study, we identified an arsM from Chloracidobacterium thermophilum that encodes the enzyme CtArsM and is adjacent to a gene for an rSAM enzyme. Most ArsMs have three domains for SAM binding, As(III) binding, and a C-terminal domain of uncertain function. CtArsM has only the first two domains. CtArsM methylates methylarsenite (MAs(III)) but not As(III) and confers resistance to MAs(III) when expressed in Escherichia coli. At 45 °C, CtArsM rapidly converts 95% of MAs(III) into volatile trimethylarsine (TMAs(III)). Mutational analysis indicates that conserved cysteine residues Cys134 and Cys183 form the MAs(III) binding site, while Cys137 is not required but increases the amount of volatilized arsenic. Mutation of Cys137 shifts the product profile, primarily resulting in dimethylarsinic acid (DMAs(V)). These findings suggest that cysteine modification can modulate ArsM activity, providing a basis for potential applications in arsenic bioremediation. Moreover, ArsM enzymes adjacent to rSAM genes may act synergistically in the biosynthesis of novel organoarsenical antibiotics.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"11 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145133457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multisectoral Optimization of Residual Resource Valorization for the Bioeconomy 生物经济剩余资源增值的多部门优化

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2025-09-25 DOI: 10.1021/acs.est.5c06495

Ugo Javourez, Aras Ahmadi, Carlos Eduardo Robles Rodriguez, Ligia Tiruta-Barna, Lorie Hamelin

{"title":"Multisectoral Optimization of Residual Resource Valorization for the Bioeconomy","authors":"Ugo Javourez, Aras Ahmadi, Carlos Eduardo Robles Rodriguez, Ligia Tiruta-Barna, Lorie Hamelin","doi":"10.1021/acs.est.5c06495","DOIUrl":"https://doi.org/10.1021/acs.est.5c06495","url":null,"abstract":"Efficient use of constrained biomass and waste resources is a central challenge in circular bioeconomy planning. As biobased technologies increasingly enable the recovery of diverse products and services, identifying optimal valorization strategies becomes a high-dimensional problem. This study proposes a scalable, multisectoral constrained optimization approach for assessing the large-scale allocation of residual biomass under technical and demand constraints, here applied to metropolitan France. Environmental performances of optimal residual biomass valorization strategies were evaluated for 13 streams and 31 valorization pathways targeting nutrient, food, feed, power, and heat recovery across five prospective scenarios. Optimization reduced environmental impacts by 25–60% compared to baseline biomass reuse, albeit with a 5–15% increase in power demand and a substantial shift of crop residues away from soil incorporation. Beyond the French context, findings show that optimal valorization strategies are more sensitive to the scope and performance of valorization technologies than to background scenario variations. By highlighting the enabling conditions under which specific pathways contribute to optimal solutions, the proposed approach offers actionable insights for process ecodesign and bioeconomy policy modeling.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"106 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prenatal OPEs Trimester- and Sex-Specifically Linked to Trajectories of Preschoolers’ Emotional and Behavioral Problems: Insights from Cord Blood Metabolomics 产前OPEs与学龄前儿童情绪和行为问题的轨迹相关：来自脐带血代谢组学的见解

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2025-09-25 DOI: 10.1021/acs.est.5c08732

Yuan Liu, Mengqian Zhang, Yifan Wang, Mengjuan Lu, Xing Wang, Chengli Tang, Han Li, Hong Gan, Juan Tong, Hui Gao, Fangbiao Tao

{"title":"Prenatal OPEs Trimester- and Sex-Specifically Linked to Trajectories of Preschoolers’ Emotional and Behavioral Problems: Insights from Cord Blood Metabolomics","authors":"Yuan Liu, Mengqian Zhang, Yifan Wang, Mengjuan Lu, Xing Wang, Chengli Tang, Han Li, Hong Gan, Juan Tong, Hui Gao, Fangbiao Tao","doi":"10.1021/acs.est.5c08732","DOIUrl":"https://doi.org/10.1021/acs.est.5c08732","url":null,"abstract":"Organophosphate esters (OPEs) are neurotoxic, yet their impact on children’s emotional and behavioral problems (EBPs) trajectories remains understudied, and biological mechanisms are unclear. In a prospective cohort of 2227 mother–child pairs, maternal urinary concentrations of the tris(2-chloroethyl) phosphate (TCEP) and six OPE metabolites were measured across three trimesters. EBPs were assessed at ages 4–6 using the Strengths and Difficulties Questionnaire, with trajectories modeled via latent class growth analysis. The results showed that bis (2-ethylhexyl) phosphate (BEHP) was associated with elevated hyperactivity and total difficulties score trajectories in both sexes. In girls, diphenyl phosphate (DPHP) was positively associated with higher trajectories of emotional problems (OR = 1.39) and bis(1-chloro-2-propyl) phosphate (BCIPP) was associated with higher trajectories of total difficulties score (OR = 1.25), prosocial behavior (OR = 1.45), hyperactivity (OR = 1.80) and peer problems (OR = 1.45). BBOEP showed negative associations with several EBPs trajectories in boys. The second-to-third trimester emerged as a sensitive window. No mixture effects were observed. Exploratory metabolomics analysis of cord blood (p < 0.05) linked DPHP, BEHP and BCIPP to metabolic disturbance, especially lipid-related pathways. In girls, several polyunsaturated fatty acid (PUFA) pathways─linoleic acid, arachidonic acid, and α-linolenic acid metabolism─were key mediators of OPE-induced EBPs trajectories impairments. This study highlights sex- and trimester-specific neurotoxicity of OPEs and provides mechanistic insight from cord blood metabolomics.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"28 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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