环境科学与技术最新文献_第5页

Sulfidation of Magnetite for Superior Dechlorination of Trichloroethene

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2025-02-04 DOI: 10.1021/acs.est.4c07127

Ariel Nunez Garcia, Matt Lee, Lei Ding, Xiguang Liang, Chengqi Wang, Feng He, Denis M. O’Carroll

{"title":"Sulfidation of Magnetite for Superior Dechlorination of Trichloroethene","authors":"Ariel Nunez Garcia, Matt Lee, Lei Ding, Xiguang Liang, Chengqi Wang, Feng He, Denis M. O’Carroll","doi":"10.1021/acs.est.4c07127","DOIUrl":"https://doi.org/10.1021/acs.est.4c07127","url":null,"abstract":"The reported contributions of magnetite to the abiotic natural attenuation of chlorinated ethenes have generated interest in its potential for soil and groundwater remediation. In this study, we investigated the impact of the two-step sulfidation method on the physicochemical properties and reactivity of magnetite with trichloroethene (TCE). We systematically evaluated the effect of different sulfur precursors (dithionite, thiosulfate, and sulfide) and sulfur-to-iron ([S/Fe]dosed) molar ratios on the reactivity. Results were compared to those of sulfidated nZVI (S-nZVI) as a benchmark for assessing the efficacy of sulfidated magnetite (S–Fe3O4). The findings indicated limited reactivity of magnetite when sulfidated with dithionite and thiosulfate. However, sulfidation with sulfide yielded reaction rates comparable to those of S-nZVI, particularly at lower [S/Fe]dosed ratios. At higher [S/Fe]dosed ratios (>0.1), sulfide-sulfidated magnetite (S–Fe3O4_S) exhibited reaction rates surpassing those of S-nZVI, with the major dechlorination product being acetylene. Nonetheless, reusability experiments demonstrated that the performance of S–Fe3O4 diminished with aging. These results show that S–Fe3O4_S achieved complete transformation of TCE to acetylene, with reaction rates comparable to S-nZVI. Given its lower cost of production, engineered S–Fe3O4_S remediation systems could serve as a more affordable alternative for in situ chemical reduction of TCE with further research and development.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"133 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143083987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detoxification of Carbonaceous Species for Efficient Perfluorocarbon Hydrolysis

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2025-02-04 DOI: 10.1021/acs.est.4c11326

Xiaojian Wang, Junwei Fu, Hang Zhang, Jialin Zheng, Heping Chen, Kang Liu, Lihong Jing, Xueqing Xing, Zhang Lin, Liyuan Chai, Min Liu

{"title":"Detoxification of Carbonaceous Species for Efficient Perfluorocarbon Hydrolysis","authors":"Xiaojian Wang, Junwei Fu, Hang Zhang, Jialin Zheng, Heping Chen, Kang Liu, Lihong Jing, Xueqing Xing, Zhang Lin, Liyuan Chai, Min Liu","doi":"10.1021/acs.est.4c11326","DOIUrl":"https://doi.org/10.1021/acs.est.4c11326","url":null,"abstract":"Thermocatalytic hydrolysis of perfluorocarbons (PFCs) is a promising way to reduce their emission and environmental hazards. However, hydrolysis of PFCs, such as CF4, usually suffers from a drastic activity decline during the induction period, which seriously hinders its conversion performances and practical applications. In this work, we found that the carbonaceous (*COO) species account for the activity decline during the induction period, and their detoxification could promote PFC hydrolysis at low temperature. In situ diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) shows that the poisoning signals belong to *COO species on the surface of γ-Al2O3 during CF4 catalytic hydrolysis. The adsorption configuration of *CFOH intermediate is the key to the formation of poisoned *COO species. By introducing Ni sites with strong *CFOH adsorption capacity into γ-Al2O3, the *CFOH at the Al active site can transfer to the adjacent Ni site to avoid the formation of poisoned *COO species, which was proved by DRIFTS and density functional theory. As a result, the optimal 0.1Ni/γ-Al2O3 (10% Ni loaded γ-Al2O3) catalyst achieved 100% CF4 conversion without any activity decline at 570 °C for over 300 h, much higher than that of ∼55% CF4 conversion on pure γ-Al2O3 at the same temperature. This work provides new insights into the detoxification of thermocatalytic PFC hydrolysis at low temperatures.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"38 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143083988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to “Winter Polycyclic Aromatic Hydrocarbon-Bound Particulate Matter from Peri-urban North China Promotes Lung Cancer Cell Metastasis”

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2025-02-04 DOI: 10.1021/acs.est.4c13857

Huifeng Yue, Yang Yun, Rui Gao, Guangke Li, Nan Sang

{"title":"Correction to “Winter Polycyclic Aromatic Hydrocarbon-Bound Particulate Matter from Peri-urban North China Promotes Lung Cancer Cell Metastasis”","authors":"Huifeng Yue, Yang Yun, Rui Gao, Guangke Li, Nan Sang","doi":"10.1021/acs.est.4c13857","DOIUrl":"https://doi.org/10.1021/acs.est.4c13857","url":null,"abstract":"We recently found that the incorrect representative images were used in Figure 3. The error affects only the presentation of representative images and not the underlying calculations. None of the conclusions of the work is affected. The wound healing assay of 0.3 μg/mL PM10 at 24 h and 10 μg/mL PM2.5 and PM10 at 24 h in Figure 3A and the transwell image panels of the 3 and 10 μg/mL PM2.5 groups in Figure 3B have been corrected in the version of Figure 3 presented here. Figure 3. Effects of winter PM on A549 cell migration and invasion. (A) Effect of winter PM on A549 cell migration determined by a wound healing assay (200× magnification). A549 cells were treated with winter PM at various concentrations (0, 0.1, 0.3, 1, 3, and 10 μg/mL) for different times (0, 6, 12, and 24 h), and the micrographs show representative images of cell migration. (B) Effect of winter PM on A549 cell invasion as detected by the cell invasion assay (400× magnification). A549 cells were incubated with winter PM at various concentrations (0, 0.1, 0.3, 1, 3, and 10 μg/mL) for 24 h; subsequently, the invasive ability was evaluated using the cell invasion assay. The top section includes micrographs of the representative images of cell migration under different treatment conditions, and the bottom panel shows the calculation of the mean number of invasive cells in each group. For PM2.5, *p < 0.05 and **p < 0.01 vs the control group; for PM10, #p < 0.05 vs the control group. This article has not yet been cited by other publications.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"76 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143083989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing Source Apportionment of Atmospheric Particles: Integrating Morphology, Size, and Chemistry Using Electron Microscopy Technology and Machine Learning

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2025-02-04 DOI: 10.1021/acs.est.4c10964

Peng Zhao, Pusheng Zhao, Ziwei Zhan, Qili Dai, Gary S. Casuccio, Jian Gao, Jiang Li, Yanyun He, Huimin Qian, Xiaohui Bi, Jianhui Wu, Bin Jia, Xiao Liu, Yinchang Feng

{"title":"Advancing Source Apportionment of Atmospheric Particles: Integrating Morphology, Size, and Chemistry Using Electron Microscopy Technology and Machine Learning","authors":"Peng Zhao, Pusheng Zhao, Ziwei Zhan, Qili Dai, Gary S. Casuccio, Jian Gao, Jiang Li, Yanyun He, Huimin Qian, Xiaohui Bi, Jianhui Wu, Bin Jia, Xiao Liu, Yinchang Feng","doi":"10.1021/acs.est.4c10964","DOIUrl":"https://doi.org/10.1021/acs.est.4c10964","url":null,"abstract":"To further reduce atmospheric particulate matter concentrations, there is a need for a more precise identification of their sources. The SEM-EDS technology (scanning electron microscopy and energy-dispersive X-ray spectroscopy) can provide high-resolution imaging and detailed compositional analysis for particles with relatively stable physical and chemical properties. This study introduces an advanced source apportionment pipeline (RX model) that uniquely combines computer-controlled scanning electron microscopy with computer vision and machine learning to trace particle sources by integrating single-particle morphology, size, and chemical information. In the evaluation using a virtual data set with known source contributions, the RX model demonstrated high accuracy, with average errors of 0.60% for particle number and 1.97% for mass contribution. Compared to the chemical mass balance model, the RX model’s accuracy and stability improved by 75.6 and 73.4%, respectively, and proved effective in tracing Fe-containing particles in the atmosphere of a steel city in China. This study indicates that particle morphology can serve as an effective feature for determining its source. The findings highlight the potential of electron microscopy technology coupled with computer vision and machine learning techniques to enhance our understanding of atmospheric pollution sources, offering valuable insights for PM health risk assessment and evidence-based policy-making.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"134 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143124476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrafine Particulate Matter Exacerbates the Risk of Delayed Neural Differentiation: Modulation Role of METTL3-Mediated m6A Modification

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2025-02-04 DOI: 10.1021/acs.est.4c09310

Rui Wang, Yutong Liu, Lifan Fan, Nanxin Ma, Qiqi Yan, Chen Chen, Wenhao Wang, Zhihua Ren, Xia Ning, Tingting Ku, Nan Sang

{"title":"Ultrafine Particulate Matter Exacerbates the Risk of Delayed Neural Differentiation: Modulation Role of METTL3-Mediated m6A Modification","authors":"Rui Wang, Yutong Liu, Lifan Fan, Nanxin Ma, Qiqi Yan, Chen Chen, Wenhao Wang, Zhihua Ren, Xia Ning, Tingting Ku, Nan Sang","doi":"10.1021/acs.est.4c09310","DOIUrl":"https://doi.org/10.1021/acs.est.4c09310","url":null,"abstract":"Air pollution, especially from ultrafine particles (PM0.1, ≤0.1 μm), is increasingly recognized for its detrimental effects on health. The influence of PM0.1 on neurodevelopmental disorders and its underlying mechanisms remain incompletely understood but are of significant concern. Through an investigation using mouse embryonic stem cells (mESCs), our study has uncovered disruptions in cell cycle dynamics, reduced neural precursor formation, and impaired neurogenesis during mESC neural differentiation as a result of PM0.1-induced neurodevelopmental toxicity. By employing N6-methyladenosine (m6A) methylated RNA immunoprecipitation sequencing and bioinformatics, we identified Zic1 as a key target of PM0.1-induced developmental disturbances. Our mechanistic findings indicate that PM0.1 enhances m6A methylation of Zic1 by upregulating Mettl3, leading to decreased mRNA stability and expression of this gene. Furthermore, the efficacy of the METTL3 inhibitor in alleviating nerve differentiation impairments emphasizes the significance of this pathway. In addition, source analysis, molecular docking, and toxicity analyses show that PAHs with higher ring structures in PM0.1 from combustion sources competitively bind to METTL3, potentially exacerbating neurodevelopmental toxicity. This study not only underscores the severe impact of PM0.1 on neurodevelopment but also reveals the pivotal role of m6A modification in mediating these effects, providing valuable insights and potential therapeutic targets for mitigating PM0.1-related health risks.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"76 6 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143124477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visible Light Boosted the Reduction of Cr(VI) in the Absence of Conventional Reductants in Frozen Solutions: The Overlooked Role of Inorganic Anions

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2025-02-04 DOI: 10.1021/acs.est.4c11811

Yunyi Li, Wenshuai Zhou, Peng Zhen, Jialiang Liang, Fuyang Liu, Yun Shen, Meiping Tong

{"title":"Visible Light Boosted the Reduction of Cr(VI) in the Absence of Conventional Reductants in Frozen Solutions: The Overlooked Role of Inorganic Anions","authors":"Yunyi Li, Wenshuai Zhou, Peng Zhen, Jialiang Liang, Fuyang Liu, Yun Shen, Meiping Tong","doi":"10.1021/acs.est.4c11811","DOIUrl":"https://doi.org/10.1021/acs.est.4c11811","url":null,"abstract":"The conversion of Cr(VI) in frozen solutions is a mysterious process in the water environment. It has traditionally been believed that the reduction of Cr(VI) can only occur through interaction with traditional reducing agents like natural organic matters (NOMs) and Fe(II), with H2O merely acting as a solvent. However, this study reveals that visible light can induce the reduction of Cr(VI) by H2O even without conventional reducing agents. Specifically, within the narrow liquid-like layer between ice crystals, there is a significant increase in concentrations of protons, Cr(VI), and anions (Cl–, SO42–, and NO3–), which promotes the formation of various complexes between Cr(VI) and anions. DFT results reveal 11 types of stable Cr(VI)-anion complexes in solution, with six exhibiting visible light absorption properties. Quadrupole time-of-flight (QTOF) mass spectrometry confirms that the abundance of these six complexes (Cl–CrO2–Cl, Cr2O6–Cl, Cl–Cr2O5–Cl, Cr2O6–OSO3H, HO3SO–Cr2O5–OSO3H, and Cr2O6–ONO2) correlates with the extent to which visible light promotes Cr(VI) reduction, thus highlighting their crucial role as photoreactive intermediate complexes during this conversion process. These findings suggest that H2O in frozen solutions should no longer be regarded solely as a solvent but also as a reactant, thereby inspiring deeper insights into frozen solution chemistry.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"8 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143124478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interception History Drives Colloid Transport Variance in Porous Media

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2025-02-03 DOI: 10.1021/acs.est.4c06509

Sabrina N. Volponi, Bashar M. Al-Zghoul, Giovanni Porta, Diogo Bolster, William P. Johnson

{"title":"Interception History Drives Colloid Transport Variance in Porous Media","authors":"Sabrina N. Volponi, Bashar M. Al-Zghoul, Giovanni Porta, Diogo Bolster, William P. Johnson","doi":"10.1021/acs.est.4c06509","DOIUrl":"https://doi.org/10.1021/acs.est.4c06509","url":null,"abstract":"Colloid transport in porous media is traditionally predicted using the principle of constant fractional removal for each grain passed, such that concentrations decrease exponentially with transport distance. This approach successfully describes transport when repulsive barriers to attachment are absent. However, repulsive barriers characterize environmental contexts wherein attachment upon grain interception is inhibited, causing colloid concentrations to decay nonexponentially with distance from the source and thwarting prediction. The pervasiveness of these nonexponential trends across wide-ranging experiments suggests that a fundamental process is at play. Here, we propose a paradigm shift by considering constant fractional loss with each interception rather than with each grain passed. We show that by recognizing the history of grain interceptions, a pathway is revealed toward a simple and predictive framework in which nonexponential trends emerge. This shift in perspective offers the possibility of colloid transport prediction in settings that were previously infeasible using classic filtration theory, with potential applications in contexts ranging from environmental (e.g., groundwater aquifer protection) to biomedical (e.g., drug delivery).","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"61 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143083990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atomic Hydrogen in Hydrogenolysis: Converting and Detoxifying Carbon-Heteroatom Bonds via Paired Electrolysis

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2025-02-03 DOI: 10.1021/acs.est.4c11680

Qiancheng Wang, Jianqiao Xu, Shuai Wu, Mu Wang, Xingyun Zhuang, Guofang Tian, Fu Xu, Jianyun Liu, Gong Zhang, Jinghong Li

{"title":"Atomic Hydrogen in Hydrogenolysis: Converting and Detoxifying Carbon-Heteroatom Bonds via Paired Electrolysis","authors":"Qiancheng Wang, Jianqiao Xu, Shuai Wu, Mu Wang, Xingyun Zhuang, Guofang Tian, Fu Xu, Jianyun Liu, Gong Zhang, Jinghong Li","doi":"10.1021/acs.est.4c11680","DOIUrl":"https://doi.org/10.1021/acs.est.4c11680","url":null,"abstract":"The presence of carbon-heteroatom bonds (C–N, C–O, and C–S) significantly enhances the stability and toxicity of pollutants. Hydroxyl radicals (•OH)-mediated electrochemical processes show promise; however, the bond energies associated with carbon-heteroatom bonds exceed 200 kJ/mol, which constrains the effectiveness of oxidative degradation and detoxification. We have developed a paired electrolysis process coupling hydrogen atom (H*) generation at the cathode with •OH production at the anode. The involvement of H* and •OH in this system was first confirmed by using methylene blue (MB) as an electrochemical probe. When applied to the degradation of glyphosate (GP), which contains C–N bonds, the paired electrolysis process achieved removal efficiencies for COD, TOC, and toxicity that were twice those of individual oxidation processes. The degradation kinetics also exhibited performance that was double that of individual oxidation processes. Mass spectrometry and theoretical calculations confirmed that hydrogenolysis of H* effectively attacks high-energy C–N bonds, thereby circumventing the rate-limiting steps associated with standalone •OH oxidation, enhancing pollutant degradation and reducing toxicity. When applied to pollutants containing C–O and C–S bonds, the paired electrolysis process demonstrated improvements in COD, TOC, and toxicity removal of approximately 30%, 10%, and 20%, respectively, showcasing its multifunctionality and scalability. Seven days of practical wastewater experiments further validated the effectiveness and durability of this technology.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"12 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143083991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging PFAS Exposure Is More Potent in Altering Childhood Lipid Levels Mediated by Mitochondrial DNA Copy Number

IF 10.8 1区环境科学与生态学

环境科学与技术 Pub Date : 2025-02-03 DOI: 10.1021/acs.est.4c1309510.1021/acs.est.4c13095

Peiwei Xu, Min Nian, Jie Xiang, Xinhan Zhang, Ping Cheng, Dandan Xu, Yuan Chen, Xiaofeng Wang, Zhijian Chen*, Xiaoming Lou* and Mingliang Fang*,

{"title":"Emerging PFAS Exposure Is More Potent in Altering Childhood Lipid Levels Mediated by Mitochondrial DNA Copy Number","authors":"Peiwei Xu, Min Nian, Jie Xiang, Xinhan Zhang, Ping Cheng, Dandan Xu, Yuan Chen, Xiaofeng Wang, Zhijian Chen*, Xiaoming Lou* and Mingliang Fang*, ","doi":"10.1021/acs.est.4c1309510.1021/acs.est.4c13095","DOIUrl":"https://doi.org/10.1021/acs.est.4c13095https://doi.org/10.1021/acs.est.4c13095","url":null,"abstract":"Per- and polyfluoroalkyl substances (PFAS) pose potential health risks to lipid metabolism, but the effects of emerging PFAS alternatives, particularly in children, remain unclear. This cross-sectional study investigated the association between emerging PFAS exposure and lipid levels in 294 Chinese children aged 7–10 years, analyzing blood samples for 14 PFAS and lipid profiles, including triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), apolipoprotein A1 (ApoA1), and apolipoprotein B (ApoB). Exposure to 6:2 Cl-PFESA, PFO4DA, and PFO5DoDA was associated with higher TC, TG, and LDL levels, with PFO4DA increasing the TC by 1.7% and PFO5DoDA increasing the TG by 10.7%. Weighted quantile sum (WQS) regression showed mixed PFAS exposure positively associated with TG (0.08, 95% CI: 0.007, 0.153). PFO4DA had the highest weight for TC (0.468), TG (0.327), LDL (0.57), ApoA1 (0.243), and ApoB (0.466), while PFMOAA had the highest weight for HDL (0.332). Bayesian Kernel Machine Regression (BKMR) analysis confirmed positive associations between the PFAS mixture and TC, TG, LDL, and ApoA1. Mediation analysis revealed that mtDNAcn significantly mediated PFAS exposure’s effect on TG levels, explaining 27.2–74.2% of the total effect. These findings highlight the need for regulatory action to address the emerging PFAS risks.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"59 5","pages":"2484–2493 2484–2493"},"PeriodicalIF":10.8,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging PFAS Exposure Is More Potent in Altering Childhood Lipid Levels Mediated by Mitochondrial DNA Copy Number

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2025-02-03 DOI: 10.1021/acs.est.4c13095

Peiwei Xu, Min Nian, Jie Xiang, Xinhan Zhang, Ping Cheng, Dandan Xu, Yuan Chen, Xiaofeng Wang, Zhijian Chen, Xiaoming Lou, Mingliang Fang

{"title":"Emerging PFAS Exposure Is More Potent in Altering Childhood Lipid Levels Mediated by Mitochondrial DNA Copy Number","authors":"Peiwei Xu, Min Nian, Jie Xiang, Xinhan Zhang, Ping Cheng, Dandan Xu, Yuan Chen, Xiaofeng Wang, Zhijian Chen, Xiaoming Lou, Mingliang Fang","doi":"10.1021/acs.est.4c13095","DOIUrl":"https://doi.org/10.1021/acs.est.4c13095","url":null,"abstract":"Per- and polyfluoroalkyl substances (PFAS) pose potential health risks to lipid metabolism, but the effects of emerging PFAS alternatives, particularly in children, remain unclear. This cross-sectional study investigated the association between emerging PFAS exposure and lipid levels in 294 Chinese children aged 7–10 years, analyzing blood samples for 14 PFAS and lipid profiles, including triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), apolipoprotein A1 (ApoA1), and apolipoprotein B (ApoB). Exposure to 6:2 Cl-PFESA, PFO4DA, and PFO5DoDA was associated with higher TC, TG, and LDL levels, with PFO4DA increasing the TC by 1.7% and PFO5DoDA increasing the TG by 10.7%. Weighted quantile sum (WQS) regression showed mixed PFAS exposure positively associated with TG (0.08, 95% CI: 0.007, 0.153). PFO4DA had the highest weight for TC (0.468), TG (0.327), LDL (0.57), ApoA1 (0.243), and ApoB (0.466), while PFMOAA had the highest weight for HDL (0.332). Bayesian Kernel Machine Regression (BKMR) analysis confirmed positive associations between the PFAS mixture and TC, TG, LDL, and ApoA1. Mediation analysis revealed that mtDNAcn significantly mediated PFAS exposure’s effect on TG levels, explaining 27.2–74.2% of the total effect. These findings highlight the need for regulatory action to address the emerging PFAS risks.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"5 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0