{"title":"Vision Impairments in Young Adults with Down Syndrome.","authors":"Yolanda Martin-Perez, Guadalupe Gonzalez-Montero, Angel L Gutierrez-Hernandez, Vanesa Blázquez-Sánchez, Celia Sánchez-Ramos","doi":"10.3390/vision7030060","DOIUrl":"https://doi.org/10.3390/vision7030060","url":null,"abstract":"<p><p>People with Down syndrome have more visual problems than the general population. They experience premature ageing, and they are expected to also have an acceleration in worsening visual function. A prospective observational study which includes visual acuity, refractive error, accommodation, binocular and colour vision was performed on young adults with (<i>n</i> = 69) and without (<i>n</i> = 65) Down syndrome and on a senior group (<i>n</i> = 55) without Down syndrome. Results showed significant differences in visual acuity between groups (<i>p</i> < 0.001), and it can be improved with a new prescription in 40% of the participants with Down syndrome. Regarding the accommodative state, no significant differences were found between groups of young people. Concerning binocular vision, 64.7% of strabismus was observed in the group with Down syndrome (<i>p</i> < 0.001). Visual abnormalities are significant in young adults with Down syndrome and are different from those of older people without Down syndrome, some of which can be improved by providing the optimal prescription as well as regular eye examinations.</p>","PeriodicalId":36586,"journal":{"name":"Vision (Switzerland)","volume":"7 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41153665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vinod Kumar, Andrey Igorevich Bezzabotnov, Zarina Shaykuliyevna Rustamova, Galina Nikolaevna Dushina, Kamal Abdulmuhsen Abu Zaalan, Ahmad Saleh Soliman Shradqa, Mikhail Aleksandrovich Frolov
{"title":"Clinical and Optical Coherence Tomography Evidence of Aqueous Humor Flow from the Suprachoroidal Space to Conjunctival Lymphatics.","authors":"Vinod Kumar, Andrey Igorevich Bezzabotnov, Zarina Shaykuliyevna Rustamova, Galina Nikolaevna Dushina, Kamal Abdulmuhsen Abu Zaalan, Ahmad Saleh Soliman Shradqa, Mikhail Aleksandrovich Frolov","doi":"10.3390/vision7030059","DOIUrl":"https://doi.org/10.3390/vision7030059","url":null,"abstract":"<p><p>A surgical technique was developed to enhance aqueous humor (AH) flow through the non-trabecular outflow pathway by rerouting it from the anterior chamber (AC) to the suprachoroidal space (SCS) without detaching the ciliary body from the scleral spur. Medium- and long-term surgical outcomes were retrospectively analyzed in a case series of 58 glaucoma patients. At 6, 12, and 24 months, the mean IOP decreased from 27.8 ± 8.3 to 14.9 ± 5.0 mmHg, median 15.0 (25th percentile (p<sup>25</sup>)13.0; 75th percentile (p<sup>75</sup>) 18.0) and 15.2 ± 3.3 mmHg, and hypotensive medication use reduced from a median (p<sup>25</sup>; p<sup>75</sup>) of 3 (2; 3) to 0 (0; 2), 0 (0; 2), and 0 (0; 1.5), respectively. Intra- and postoperative complications were few and manageable. Following surgery, no bleb formation occurred in any of the cases (as confirmed by optical coherence tomography). Conjunctival lymphatic vessels (CLVs) developed in 50% of eyes (29/58). Clinically, they developed directly from sclera and had no connection to the surgical site. Analysis further showed that the development of CLVs and their longer visibility period had poor prognostic value for IOP control. If the fluid flow from the SCS to CLVs was resistance-free, no CLV development was evident. However, if any resistance existed in the flow, the fluid accumulated in lymphatics, resulting in their engorgement. The proposed technique was safe and effective in decreasing IOP in glaucoma patients by enhancing AH flow from the SCS to CLVs via connecting intrascleral microchannels.</p>","PeriodicalId":36586,"journal":{"name":"Vision (Switzerland)","volume":"7 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41131797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An Exploratory Assessment of Self-Reported Satisfaction with Infrastructure and Out-of-Home Activities for People with Vision Impairments.","authors":"Mohammad M Hamed, Maisaa A Masoud","doi":"10.3390/vision7030058","DOIUrl":"https://doi.org/10.3390/vision7030058","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study is to assess the satisfaction levels of people with VI with regard to infrastructure and outdoor activities. Furthermore, this study aims to develop an assessment model for the levels of difficulty in using public transport.</p><p><strong>Methods: </strong>Participants in a standardized survey questionnaire included 74 participants with VI. Three assessment-ordered probit models were estimated based on self-reported responses.</p><p><strong>Results: </strong>Estimation results revealed that the use of public transport is extremely difficult for 83.47% of older participants. In addition, 84.2% of people with albinism have extreme difficulty using public transport. Furthermore, 53.98% of people with restricted horizontal and vertical fields face extreme difficulty using public transport. There was dissatisfaction with outdoor activities among 97.40% of people with macular disease. The results show that 51.70% of people with normal or near-normal horizontal visual fields and restricted vertical planes are satisfied with their level of outdoor activity while 72.65% of people with retinal diseases expressed dissatisfaction with the existing infrastructure.</p><p><strong>Conclusion: </strong>This study revealed that the experiences of people with VI are heterogeneous and depend on their eye condition, access to assistive technology, and socioeconomic characteristics. Results clearly show evidence of heterogeneity among individuals with VI. The combination of horizontal and vertical restrictions yields random parameters, underscoring the heterogeneous experiences of people with VI, influenced by their eye condition and access to assistive devices. Our results have important implications for developing targeted interventions to enhance the mobility of people with VI.</p>","PeriodicalId":36586,"journal":{"name":"Vision (Switzerland)","volume":"7 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41177187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Studies of Vision in Cricket-A Narrative Review.","authors":"Jennifer Swingle Fogt, Nick Fogt","doi":"10.3390/vision7030057","DOIUrl":"https://doi.org/10.3390/vision7030057","url":null,"abstract":"<p><p>Vision is thought to play a substantial role in hitting and fielding in cricket. An understanding of which visual skills contribute during cricket play could inform future clinical training trials. This paper reviews what has been reported thus far regarding the relationship of visual skills to cricket performance and reviews the results of clinical trials in which the impact of visual skills training on cricket performance has been addressed. Fundamental or low-level visual skills, with the exception of color vision and perhaps near stereopsis and dynamic visual acuity, are similar between cricket players and the general population. Simple reaction time has been found to be shorter in cricket players in some but not all studies. While there is mixed or no evidence that the aforementioned visual skills are superior in cricket players compared to non-players, comparisons of eye and head movements and gaze tracking have revealed consistent differences between elite cricket batters and sub-elite batters. Future training studies could examine whether teaching sub-elite batters to emulate the gaze tracking patterns of elite batters is beneficial for batting. Lastly, clinical trials in which visual skills of cricket players have been trained have in many cases resulted in positive effects on visual skills, or judgments required in cricket, or cricket play. However, clinical trials with larger and more diverse groups of participants and correlations to on-field metrics and on-field performance (i.e., domain-specific assessments) are necessary before conclusions can be drawn regarding the efficacy of vision training.</p>","PeriodicalId":36586,"journal":{"name":"Vision (Switzerland)","volume":"7 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41118567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Visual Cognition and the Science of Magic.","authors":"Geoff G Cole, Abbie C Millett","doi":"10.3390/vision7030056","DOIUrl":"https://doi.org/10.3390/vision7030056","url":null,"abstract":"<p><p>A number of authors have argued that the art of conjuring can assist the development of theories and knowledge in visual cognition and psychology more broadly. A central assumption of the so-called science of magic is that magicians possess particular insight into human cognition. In a series of experiments, we tested the Insight hypothesis by assessing three factors that magicians argue are important for a popular illusion. Participants viewed videos of a magician performing the French Drop sleight whilst gaze, motion, and muscular tension were manipulated across experiments. Contrary to what the community of conjurers state, results showed that none of these influenced the perceived success of the effect. We also found that a visual priming technique, one suggested of many and used by an eminent magician, does not influence participant responses. Overall, these findings fail to support the Insight hypothesis. We suggest that scientists of magic have erroneously imbued magicians with insights they do not possess.</p>","PeriodicalId":36586,"journal":{"name":"Vision (Switzerland)","volume":"7 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41158956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Effect of Prior Viewing Position and Spatial Scale on the Viewing of Paintings.","authors":"Tobiasz Trawiński, Natalie Mestry, Nick Donnelly","doi":"10.3390/vision7030055","DOIUrl":"https://doi.org/10.3390/vision7030055","url":null,"abstract":"<p><p>The visual inspection of scenes is disrupted when participants are forced to begin inspection away from the centre of an image. The present study explored the effect of the starting point on the visual inspection of paintings. Eye movements were recorded while participants viewed paintings for later identification in a yes/no discrimination task. The viewing of each painting was preceded by the presentation of a pseudo-randomly positioned Navon figure. Participants were instructed using a cue to attend to either the local or global level of the Navon figure. Each painting was split into regions of interest (ROIs) defined by face, theme, and context to allow the analysis of eye movements. These data were directly compared with a subset of those initially reported in our previous study in which the same experiment was run but without the inclusion of the Navon figure. The inclusion of the Navon task lowered the discrimination accuracy in the yes/no discrimination task. More importantly, eye movements to the paintings were disrupted across the entire period over which they were viewed and not just in the period following the offset of the Navon figure. The results show the sensitivity of eye movements to the conditions present at the beginning of viewing. The results have implications for the viewing of paintings (and other images) in the real world, where the starting conditions for inspection cannot be controlled.</p>","PeriodicalId":36586,"journal":{"name":"Vision (Switzerland)","volume":"7 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10534493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41170614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical Outcomes of the Implementation of IOP Monitoring, in and Out of Office Time, to 1500 Patients-A Cohort Study.","authors":"Sevasti Tsironi, Diamantis Almaliotis, Panagiota Ntonti, Georgios Sidiropoulos, Evangelia Theodoridou, Efstratios Theofrastou, Sofia Karachrisafi, Eleni Psimenidou, Anastasia Sarafi, Victoria Kapourani, Frangeskos Loizou, Elie Fadel","doi":"10.3390/vision6040069","DOIUrl":"https://doi.org/10.3390/vision6040069","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to present the clinical outcomes of IOP monitoring in and out of office time and determine its value in our clinical practice.</p><p><strong>Material and methods: </strong>We reviewed the records of 1500 patients (glaucoma suspects or glaucoma patients), who were admitted for IOP monitoring during almost 12 years. All patients were hospitalized because their within-office-hours exams were considered inadequate and inconclusive for decision making.</p><p><strong>Results: </strong>A total of 744 patients (49.6% out of 1500) needed change of treatment. A total of 121 patients (8% out of 1500) were programmed for interventional therapy (laser or surgery). A total of 68 patients (4.5% out of 1500) were declassified as overdiagnosed and overtreated. In 250 patients (16.7% out of 1500), hidden adherence problem appeared. In 720 patients (48% out of 1500), peak IOP occurred during out-of-office hours.</p><p><strong>Conclusions: </strong>IOP phasing is a useful tool in clinical practice. In many cases with inconclusive diagnosis, as well as in patients with advanced or labile glaucomas, IOP monitoring data add complementary information, useful for decision making, and may contribute not only to diagnosis and successful IOP modulation, but also in personalized therapeutic strategy and individual patients' motivation.</p>","PeriodicalId":36586,"journal":{"name":"Vision (Switzerland)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9703959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40700348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nelson Cortes, Marc Demers, Visou Ady, Lamyae Ikan, Christian Casanova
{"title":"Reliable, Fast and Stable Contrast Response Function Estimation.","authors":"Nelson Cortes, Marc Demers, Visou Ady, Lamyae Ikan, Christian Casanova","doi":"10.3390/vision6040062","DOIUrl":"https://doi.org/10.3390/vision6040062","url":null,"abstract":"<p><p>A study was conducted to determine stable cortical contrast response functions (CRFs) accurately and repeatedly in the shortest possible experimentation time. The method consisted of searching for experimental temporal aspects (number and duration of trials and number and distribution of contrasts used) with a model based on inhomogeneous Poisson spike trains to varying contrast levels. The set of values providing both short experimental duration and maximizing fit of the CRFs were saved, and then tested on cats' visual cortical neurons. Our analysis revealed that 4 sets of parameters with less or equal to 6 experimental visual contrasts satisfied our premise of obtaining good CRFs' performance in a short recording period, in which the number of trials seems to be the experimental condition that stabilizes the fit.</p>","PeriodicalId":36586,"journal":{"name":"Vision (Switzerland)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40567344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"\"Vision Loss\" and COVID-19 Infection: A Systematic Review and Meta-Analysis.","authors":"Matteo Ripa, Lorenzo Motta, Chiara Schipa, Stanislao Rizzo, Liliana Sollazzi, Paola Aceto","doi":"10.3390/vision6040060","DOIUrl":"https://doi.org/10.3390/vision6040060","url":null,"abstract":"<p><strong>Background: </strong>Visual impairment in terms of reduced visual acuity and \"visual loss\" has been reported as an atypical symptom in patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. This systematic review and meta-analysis aims to assess the cumulative incidence of \"visual loss\" during coronavirus disease 2019 (COVID-19) and review the current evidence regarding \"visual loss\" caused by SARS-CoV-2 infection.</p><p><strong>Methods: </strong>We performed a systematic review and meta-analysis of studies following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We systematically searched the PubMed, Embase, and Scopus databases for relevant studies published that clearly described \"vision loss\" and SARS-CoV-2 infection. All studies reporting concomitant \"vision loss\" and laboratory-confirmed SARS-CoV-2 infection were included. Meta-analyses were conducted using the measurement of risk and a 95% confidence interval for each study.</p><p><strong>Results: </strong>Our search identified 1143 manuscripts published in the English language. After study screening, twenty-nine articles were selected: two cross-sectional studies, twenty-four case reports, and three case series. A random-effect meta-analysis demonstrated that the pooled \"visual loss\" cumulative incidence in COVID-19 patients was 0.16 (95% CI 0.12-0.21). The quality rating of the cross-sectional studies averaged four out of the maximum score on the Newcastle-Ottawa scale.</p><p><strong>Conclusions: </strong>COVID-19 infection might cause \"visual loss\". Even if the current evidence is limited, ophthalmological assessment should be promptly provided to all patients experiencing visual impairment symptoms during SARS-CoV-2 infection.</p>","PeriodicalId":36586,"journal":{"name":"Vision (Switzerland)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40566903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fibroblast Growth Factor-2 (FGF-2) Expression in Pterygia Using Cell Spot Arrays.","authors":"Stylianos Mastronikolis, Evangelos Tsiambas, Konstantinos Kagkelaris, Marina Pagkalou, Panagiotis Plotas, Sofianiki Mastronikoli, Dimitrios Roukas, Constantinos D Georgakopoulos","doi":"10.3390/vision6040058","DOIUrl":"https://doi.org/10.3390/vision6040058","url":null,"abstract":"<p><p>Fibroblast growth factor (FGF) is a main regulator of cell differentiation, cell migration and angiogenesis in normal and abnormal conjunctiva epithelia, but specific mechanisms of its aberrant expression are yet to be investigated. In the present study, we investigated FGF-2 protein expression within several pterygia. Using a liquid-based cytology assay, we obtained cell specimens from pterygia and healthy tissues directly from patients. A combination of immunocytochemistry followed by digital image analysis showed significant overexpression of FGF-2 in all the examined pterygia. In 30/60 (50%) cases there were high levels of staining intensity, whereas in the remaining 30/60 (50%) cases there were moderate levels of expression. FGF-2 levels of the control group were significantly lower in comparison with the pterygia group. There was no significant correlation between FGF-2 levels and either sex or location of the pterygium. FGF-2 levels had a significant correlation with morphological characteristics of the pterygia. More specifically, FGF-2 levels were significantly higher in the pterygia with a fleshy morphology. Interestingly, recurrent lesions demonstrated high expression levels. An overexpression of FGF-2 has been observed frequently in pterygia, where it may play a crucial role in determining the lesion's progression. FGF-2 upregulation correlates with the morphology of pterygia and its tendency to recur. Cell spot analysis based on liquid-based cytology is a simple, yet effective, method for detecting a broad spectrum of protein markers and could be useful in analyzing potential pterygia patient samples.</p>","PeriodicalId":36586,"journal":{"name":"Vision (Switzerland)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40566896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}